Biosimilar-to-Biosimilar Switches Deemed Safe and Effective, Systematic Review Reveals
Switching from one biosimilar medication to another is safe and effective, a new systematic review indicates, even though this clinical practice is not governed by current health authority regulations or guidance. "No reduction in effectiveness or increase in adverse events was detected in biosimilar-to-biosimilar switching studies conducted to date," the review's authors note in their study, published online July 26 in BioDrugs. "The possibility of multiple switches between biosimilars of the same reference biologic is already a reality, and these types of switches are expected to become more common in the future. …although it is not covered by current health authority regulations or guidance," add the authors, led by Hillel P. Cohen, PhD, executive director of scientific affairs at Sandoz, a division of Novartis.Source: Medscape
Using Particles That Are Smaller Than the Head of a Pin to Treat Cancer
Thanks in part to research begun more than a decade ago with funding from Women’s Health Research at Yale, Dr. W. Mark Saltzman is working with colleagues on a way to deploy effective cancer-fighting medication safely with the help of nanoparticles.
Gender and Connecting with Your Health Provider: A Q&A with Dr. Christine J. Ko
Recently, Dr. Christine J Ko wrote a book, published by Routledge, titled “How to Improve Doctor-Patient Connection.” We chatted with Dr. Ko to get her insight into the roles psychology and gender play in health care interactions.
Yale dermatologist seeing skin cancer in younger people
Skin cancer is the most common form of cancer and it is completely preventable. With the Memorial Day weekend almost here and a nice forecast ahead, Yale Medicine Dermatologist Kathleen Suozzi warns people to protect their skin. She does not like a trend she is now treating. “I have patients, I’m seeing patients in their twenties, in their thirties developing skin cancer and this is alarming because we know that once you develop a skin cancer you’re at increased risk for all additional skin cancers,” Suozzi said. Suozzi said to pay attention to what the UV index is if you plan to spend time outdoors. It is the strength of the sunburn-producing ultraviolet radiation. Numbers 8 through 10 mean it is high. She said mid-summer is not the only time when sun danger is high. “In general, the UV indexes we will see around this area will peak around mid-summer, so late July, early August but certainly on spring days we can see higher UV indexes that are looking more like our summer levels.”Source: News 8
Doctors say these pandemic side effects are serious problems—and unlikely ‘to go away anytime soon’
In September 2021, I collapsed from exhaustion. My vision went blurry. Then, my eyelids grew so heavy that I could barely keep them up for milliseconds at a time. Panicked, I stumbled approximately 50 yards toward a nearby friend, and slumped over her shoulders. She guided me to a shady spot under a tree, where I floated in and out of consciousness for about two hours. As far as I knew, I was a healthy guy in my late 20s with no known risks of major health issues. I chalked it up as a one-off. But over the next few months, at unpredictable moments on random days, I’d hit a wall — going from perfectly fine to lying in the fetal position with a crushing headache, in the snap of a finger.Source: CNBC
Raise Your Voice About Your Metastatic Breast Cancer
Breast cancer is a common diagnosis for women of all races. But there are differences along racial lines when it comes to early detection, treatment, and survival rates. The disease is deadliest for non-Hispanic Black women. They’re more likely than women of other races or ethnicities to get diagnosed with metastatic breast cancer (cancer that has spread to other parts of the body), and they have higher odds of having triple-negative breast cancer (TNBC). TNBC is a hard-to-treat form of the disease that spreads fast. Genes and biology play a role in breast cancer. But racial and ethnic minorities face barriers to health care. People of color tend to have less access to health insurance and get fewer referrals to specialty medical care. There’s also evidence that some doctors spend less time with Black people, says Andrea Silber, MD, a breast oncologist and assistant clinical director for health equity and diversity at Yale Cancer Center and Smilow Cancer Hospital.Source: WebMD
Overview Itchy skin is a something we’ve all experienced from time to time, whether from an uncomfortable woolen sweater, seasonal dry skin or, perhaps, as a reaction to certain detergents or personal care products. Sometimes, when an itch lasts long enough—and is severe—it can lead to a condition called prurigo nodularis. A hallmark of prurigo nodularis is the development of firm bumps (called nodules) that intensify the itchiness. People with prurigo nodularis report itching that is so intense it disrupts sleep and prompts so much scratching that the skin begins to bleed. Prurigo nodularis can affect people of any age, though is most common among those in middle age or older. “Prurigo nodularis can be an extremely debilitating condition characterized by a relentless itch,” says Yale Medicine.
Spring Skincare Tips for Common Conditions
It might be time to spring clean your skincare routine. Changing weather patterns and warmer days could cause irritation for patients with conditions like eczema or acne. Yale New Haven Hospital-affiliated dermatologist Jeffrey Cohen, MD, Director of the Interdisciplinary Psoriasis Treatment Program at Yale School of Medicine, explained how to spot signs of trouble and when to seek help.
New trials for alopecia areata treatment are a success
A new study shows that one in three patients with a severe skin disease were able to regrow hair after being treated with a common arthritis drug. The study is based on Phase 3 clinical trials using baricitinib, a Janus kinase (JAK) inhibitor, to treat alopecia areata, an often disfiguring skin disease characterized by rapid loss of scalp hair, and sometimes eyebrows and eyelashes. Phase 3 clinical trials are the final testing hurdle before a new treatment can be considered for U.S. Food and Drug Administration (FDA) approval.
Dermatology, telemedicine and the pandemic: can skin diagnosis be done from a distance?
In the spring and summer of 2020, as the COVID-19 pandemic was taking root, most medical disciplines had shifted some in-person visits to telemedicine. The ability to see a provider at a distance has transformed how people can access health care, especially when it comes to superficial conditions—those that are visible on the surface of the body. Not every specialty benefited equally from the advantages telemedicine offered, but physicians practicing dermatology quickly embraced the technology’s potential while mitigating its shortcomings. Are In-Person Visits Vital to Diagnosing Dermatological Conditions? It may seem obvious that dermatology is a specialty that is particularly reliant on in-person patient examinations. Dermatologists have long been wary of missing critical information and skeptical of technology’s ability to offer meaningful live imagery. The pandemic, however, has changed that.
How to treat male pattern baldness and why you might be more susceptible than most
A receding hairline or thinning hair on the top of the head is a sign of male pattern baldness.Chalffy/Getty Images Male pattern baldness is inevitable for some and can start early before you even turn 21. Medication, laser therapy, and hair transplants can help you regrow some of that lost hair. Not all of your hair will grow back, but you may get some of it back with proper treatment. Visit Insider's Health Reference library for more advice. Male pattern baldness — or androgenetic alopecia — accounts for more than 95% of hair loss in men, making it the most common type of hair loss. About 25% of men who suffer from it will start losing hair before the age of 21. The condition is not harmful to your health, and treatment is unnecessary if you are content with your appearance. Moreover, there's no way to prevent hair loss, but some medicines can slow it down. Here's what you need to know about the causes, symptoms, and treatment for male pattern baldness.Source: Business Insider
A little hair loss is normal for women — here's when it's a sign of an underlying condition
Losing between 50 and 100 hairs every day is normal, but shedding significantly more than that can signal a problem. Roughly one-third of women experience hair loss at some point in their lives, and it becomes increasingly likely as you age. In fact, 55% of women experience some form of hair loss by age 70. Fortunately, hair loss is generally not considered dangerous, according to Jeffrey M. Cohen, MD, Yale Medicine dermatologist. However, Cohen says it can be a sign of an underlying medical condition that does present health risks, such as hypothyroidism. Additionally, he notes that hair loss can cause a psychological impact and be emotionally taxing for those who identify as women, which can lead to anxiety and depression. Here's what to know about common causes of hair loss in women, as well as how it can be treated and prevented.Source: Insider
How much sunlight you really need to get enough vitamin D
The sun is our most common source of vitamin D since it's rarely found in foods. In fact, when exposed to ultraviolet B (UVB) rays, our skin produces vitamin D naturally. Yet, about 35% of adults in America have a vitamin D deficiency. Important: Adults need about 15 micrograms of vitamin D daily to meet nutrient requirements. And that's a problem since vitamin D is important for strengthening and maintaining bones, supporting a healthy immune system, and breaking down glucose in the body, says David J. Leffell, MD, chief of Yale Medicine Dermatologic Surgery and professor of dermatology at Yale School of Medicine. Here's how to make sure you're getting enough of it from the sun.Source: Insider
How often should I shower?
So you want to know how often you should be showering. We have answers. Now, you may not like all our answers, but we’re not here to help you win an argument about personal hygiene or determine whether the latest lightly rinsed celebrity is being weird or not. We’re here to give you the facts you need to stay clean the best you can. Come on, how often do I need to shower? There’s not one right answer, but a range of right answers. Generally, people shower somewhere between every other day and twice a day, depending on their personal preference and how their skin reacts to getting hosed down, says Jeffrey Cohen, a dermatologist and assistant professor at the Yale School of Medicine. So if you’re in that range, you’re doin’ fine.Source: Popular Science
Psoriasis Causes, Plus 7 Things That Can Cause Symptom Flare-Ups, According to Dermatologists
A psoriasis flare-up can be uncomfortable, both physically and emotionally—and all the more frustrating when it strikes at an inopportune time. While the cause of psoriasis isn't exactly clear, there's some evidence that your immune system and the genes you inherit play a role, says National Psoriasis Foundation (NPF). But those factors don't tell the whole story. Understanding what's triggering your psoriasis flare-ups can help you gain better control, says the American Academy of Dermatology (AAD). We asked dermatologists to unpack the complexities of how those itchy, painful patches come to be. Here's what to know about the causes and triggers of psoriasis.Source: Health
7 ways to get rid of and prevent forehead wrinkles, according to dermatologists
Forehead wrinkles and fine lines are a normal and unavoidable part of aging. "As we age, we lose collagen, and this can also contribute to fine lines and wrinkles becoming more apparent," says Marisa Garshick, MD, FAAD, a dermatologist at MDCS Dermatology. Medical term: Collagen is a naturally occurring protein that keeps the skin firm. Although aging reduces collagen production in the body, environmental factors like sun exposure and cigarette smoke can also damage collagen fibers in the body, which accelerates the aging process and causes wrinkles to develop. While forehead wrinkles shouldn't be something you're ashamed of, if you want to reduce their appearance, there are plenty of ways to do so.Source: Insider
How to differentiate harmless sunspots from skin cancer
Sunspots are flat, dark spots that appear on parts of your skin that you frequently expose to the sun, such as your face, hands, arms, shoulders, and feet. While anyone can develop these spots, they are particularly common in people with light skin over the age of 40, especially those who spend a lot of time in the sun. Genetics also play a role, so having a family history of sunspots can make you more likely to get them. Note: Sunspots are also known as age spots, solar lentigines, and liver spots although they don't have anything to do with liver function. Sunspots are permanent marks that are harmless, so you don't need to remove them for health reasons. However, if you don't like their appearance, there are steps you can take to lighten them. Here are some tips on how to prevent sunspots and reduce their appearance, as well as how to differentiate a sunspot from something more serious like skin cancer.Source: Insider