The Journal of Nuclear Medicine Front Cover (August 1, 2019) features PET research in radiotracer evaluation of 11C-AS2471907 in the human brain conducted by Jean-Dominique Gallezot, PhD and colleagues at the Yale PET Center. Also featured is a translational research study in radiotracer evaluation of 11C-LSN3172176 conducted by Nabeel Nabulsi, PhD, and Yale PET colleagues. The novel radiotracer 11C-AS2471907 is targeted to the 11β-HSD1 enzyme and may play a key role in the development of drugs for the treatment of depression, anxiety, reduced cognitive function and memory loss. The novel radiotracer 11C-LSN3172176 is targeted to the M1 muscarinic acetylcholine receptor (mAChR) and may assist in drug development for the treatment of Alzheimer’s disease and schizophrenia.
Featured Article of the Month: Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain, Jean-Dominique Gallezot, Nabeel Nabulsi, Shannan Henry, Richard Pracitto, Beata Planeta, Jim Ropchan, Shu-Fei Lin, David Labaree, Michael Kapinos, Anupama Shirali, Teresa Lara-Jaime, Hong Gao, David Matuskey, Mark Walzer, Gerard J. Marek, Susan Bellaire, Nancy Yuan, Richard E. Carson and Yiyun Huang. (J Nucl Med 2019; 60:1140-1146).
Featured Translational Science Article: Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1Muscarinic Acetylcholine Receptors in Nonhuman Primates, Nabeel B. Nabulsi, Daniel Holden, Ming-Qiang Zheng, Frederic Bois, Shu-Fei Lin, Soheila Najafzadeh, Hong Gao, Jim Ropchan, Teresa Lara-Jaime, David Labaree, Anupama Shirali, Lawrence Slieker, Cynthia Jesudason, Vanessa Barth, Antonio Navarro, Nancy Kant, Richard E. Carson and Yiyun Huang (J Nucl Med 2019; 60:1147-1153).
Prof. Yiyun Henry Huang is the senior author of both articles