Yale Cancer Center Researchers Awarded Grants by Breast Cancer Research Foundation
The Breast Cancer Research Foundation (BCRF) Scientific Advisory Board and its Board of Directors recently announced its 2022 research grants, including six funded grants at Yale Cancer Center and Smilow Cancer Hospital awarded to Mehra Golshan, MD, MBA, Melinda Irwin, PhD, MPH, Ian Krop, MD, PhD, Lajos Pusztai, MD, DPhil, David Rimm, MD, PhD, and Eric Winer, MD to support their research.
New Haven cancer doctors working to draw people of color into clinical trials
Minorities make up about 10 percent to 12 percent of the participants in clinical trials at Smilow, which recruits participants from across Connecticut, said Dr. Roy Herbst, chief of medical oncology. But, given that New Haven is about two-thirds black or Hispanic, both Herbst and Silber would like to increase the number of minorities who can benefit from new drugs. “We want to bring the best care to all people; we want to bring access to all people,” said Herbst, who said he’d like to at least double the percentage of minorities in Smilow’s trials of cancer drugs.Source: New Haven Register
Subtype of triple negative breast cancer responds better to chemotherapy
Researchers at Yale Cancer Center have identified a new subtype of triple negative breast cancer that shows significantly improved response to chemotherapy. Patients with the newly defined subtype — BRCA-deficient triple negative breast cancer — had significantly higher survival rates with chemotherapy.
Dr. Lajos Pusztai named Susan G. Komen Scholar and Awarded Leadership Grant
Yale Cancer Center scientist and physician Lajos Pusztai, M.D., has been named to a group of breast cancer leaders from around the world advising Susan G. Komen on the organization’s multiple endeavors. Pusztai, professor of medicine (medical oncology); chief of breast medical oncology; and co-director of Yale Cancer Center’s genetics, genomics and epigenetics program, is one of just 44 breast cancer experts to receive the honor since 2010.
Immunotherapy Trial for Triple Negative Breast Cancer
In late 2015, Yale Cancer Center launched a clinical trial using an immunotherapy drug for patients with early-stage triple negative breast cancer (TNBC), a less common and aggressive type of breast cancer. In the Q&A below, Principal Investigator, Lajos Pusztai, MD, chief of breast medical oncology, discusses the trial and the potential of immunotherapy for treating breast cancer.
Thalidomide Use In Gastrointestinal Bleeding
Angiodysplasia, a type of benign vascular lesion made up of dilated blood vessels, is a common source of gastrointestinal bleeding from the small intestine. A recent editorial from Yale Internal Medicine’s Loren Laine, MD, professor of medicine and chief of digestive diseases, in the New England Journal of Medicine highlights novel findings from a recent multicenter, double-blind, randomized clinical trial evaluating thalidomide in the treatment of angiodysplasia-related bleeding.
New Advanced Diagnostic Tests Lab to Perform, Interpret Clinical-Grade Molecular Testing of Biomarkers
The Yale Advanced Diagnostic Tests Laboratory in the Department of Pathology, is a new unit of Yale Pathology Laboratories, offers access to novel molecular tests to external users, performing and interpreting clinical grade and high-quality molecular analysis of human tissue samples.
Implicit Bias From Providers Inhibits HCV Treatment
A new study reveals significant insights into the challenges that can occur for hepatitis C virus (HCV) micro-elimination efforts in people with HIV (PWH). Due to the opioid epidemic, the prevalence of co-infection with HIV and HCV has been increasing. If left untreated, HCV infection can lead to liver damage, cancer, and death. Although HIV requires lifelong therapy, HCV can be cured with a few months of oral medications.
Alcohol Research Conference Fosters Collaboration Across Specialties
Now in its second year, the Yale Conference for Alcohol Research and Education (YCARE) was held on September 30, 2023. Offering a comprehensive agenda of talks, panel discussions, and poster presentations, the all-day event brought together Yale's researchers, clinicians, and other stakeholders under the banner of alcohol research. Bubu Banini, MD, PhD, assistant professor of medicine (digestive diseases), Yale School of Medicine (YSM), spearheaded the conference, along with co-directors David Fiellin, MD, professor of medicine (general medicine) and emergency medicine, YSM, and public health, Yale School of Public Health; Graeme Mason, PhD, professor of radiology and biomedical imaging and of psychiatry, YSM; and Sherry McKee, PhD, professor of psychiatry, YSM.
Yale Contributions Shape ASN Kidney Week 2023
In the world of nephrology, there's one event that stands out above the rest, drawing thousands of professionals from around the globe—the American Society of Nephrology's Kidney Week. This annual event features a rich array of sessions, speakers, and insights into the ever-evolving field of kidney care. This year, Kidney Week takes place in Philadelphia, Pa., with over 12,000 planned attendees.
Preventing Worsening Asthma in Inner-city Patients
A new perspective published in the Annals of Allergy, Asthma, and Immunology sheds light on strategies to prevent asthma exacerbations in inner-city patients. Previous research has demonstrated that living in an inner-city is an independent risk factor for Emergency Department visits and hospitalizations from asthma.
Improved Measurement of Glomeruli in Kidney Scarring
A new research study explores patterns in kidney structures to better understand focal segmental glomerulosclerosis, a condition where scar tissue develops in parts of the kidney. These findings offer insights into more accurate measurement of kidney structures like the glomeruli, which could ultimately lead to improved diagnosis and prognosis for patients with focal segmental glomerulosclerosis.
Using Interactive Animated Flipped-classroom Modules to Better Teach Dementia Care
A new medical education study demonstrates how a modular, flipped-classroom curriculum using character animations can better train nursing students to deliver effective care to patients with dementia and other cognitive disorders.
Immune Sensing of Allergens Promotes Avoidance Behavior
A new study published in Nature demonstrates how the immune system plays a role in the development of behaviors to avoid food allergens. Previous research has suggested that the immune system may be involved in behavioral modification beyond simply protecting the body from infectious diseases.
“Complete Academic Physician” Dr. Karl Insogna Retires From Clinical Duties
During his childhood in Wolcott, Conn., Karl Insogna’s parents instilled in him a few life lessons. Insogna, MD, FACP, Ensign Professor of Medicine (Endocrinology); director, Yale Bone Center; and associate director, Yale Center for X-Linked Hypophosphatemia; was taught to strive to leave the world a better place than you found it, and to do something to help others.
Africa on the Global Stage: Analyzing 30 Years of African-Led Clinical Trials in Cardiovascular Medicine
In order to understand the limitations faced by African investigators in modern cardiology research, a group of researchers, led by Internal Medicine Resident Abdelrahman Abushouk, MD, analyzed 30 years of African-led clinical trials in cardiovascular medicine.