2011
Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients
Skarica M, Eckstein C, Whartenby K, Calabresi P. Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. Journal Of Neuroimmunology 2011, 235: 70-76. PMID: 21550672, DOI: 10.1016/j.jneuroim.2011.02.010.Peer-Reviewed Original ResearchConceptsNatalizumab therapyPeripheral bloodMonth timepointProportion of CD20Proportion of CD4Number of CD14Multiple sclerosis patientsImmune cell compositionHematopoetic stem cellsPercentage of cellsMechanism of actionNatalizumab treatmentRRMS patientsMS patientsNK cellsSclerosis patientsTreatment onsetCytokine productionImmune compositionImmune modulationImmune cellsT cellsB cellsPatientsTherapy
2006
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity
Chan C, Crafton E, Fan H, Flook J, Yoshimura K, Skarica M, Brockstedt D, Dubensky T, Stins M, Lanier L, Pardoll D, Housseau F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nature Medicine 2006, 12: 207-213. PMID: 16444266, DOI: 10.1038/nm1352.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAntigen PresentationCell Line, TumorCytotoxicity, ImmunologicDendritic CellsGene ExpressionImmunity, InnateIn Vitro TechniquesInterferonsKiller Cells, NaturalListeria monocytogenesMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred DBAMice, KnockoutMice, TransgenicOligodeoxyribonucleotidesConceptsInterferon-producing killer dendritic cellsDendritic cellsKiller dendritic cellsI interferonNK cellsAdaptive immunityAntigen-presenting cell activityMajor histocompatibility complex class IISurface major histocompatibility complex class IIHistocompatibility complex class IIClassical NK cellsPlasmacytoid dendritic cellsTarget cellsAntigen-presenting activityConventional dendritic cellsNatural killer cellsNK target cellsToll-like receptorsType I interferonNK functionLymph nodesNKG2D receptorKiller cellsCostimulatory moleculesCytolytic capacity