2009
Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis
Skarica M, Wang T, McCadden E, Kardian D, Calabresi P, Small D, Whartenby K. Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2009, 182: 4192-4199. PMID: 19299717, PMCID: PMC3727416, DOI: 10.4049/jimmunol.0803631.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisPeripheral dendritic cellsDendritic cellsT cellsSignal transduction inhibitorsAutoimmune encephalomyelitisMultiple sclerosisIFN-gamma-secreting T cellsBone marrow chimera systemAg-specific T cellsTransduction inhibitorsT cell responsesT cell subsetsSignal transduction inhibitionCNS infiltrationCytokine polarizationIL-17IL-23Th1 responseAutoimmune responseCell subsetsCostimulatory moleculesIL-6TNF-alphaCEP-701
2006
Host-Derived Langerhans Cells Persist after MHC-Matched Allografting Independent of Donor T Cells and Critically Influence the Alloresponses Mediated by Donor Lymphocyte Infusions
Durakovic N, Bezak K, Skarica M, Radojcic V, Fuchs E, Murphy G, Luznik L. Host-Derived Langerhans Cells Persist after MHC-Matched Allografting Independent of Donor T Cells and Critically Influence the Alloresponses Mediated by Donor Lymphocyte Infusions. The Journal Of Immunology 2006, 177: 4414-4425. PMID: 16982876, DOI: 10.4049/jimmunol.177.7.4414.Peer-Reviewed Original ResearchConceptsCutaneous lymph nodesDonor lymphocyte infusionDonor T cellsBone marrow transplantationLangerhans cellsLymphocyte infusionMarrow transplantationCell reconstitutionT cellsDendritic cell reconstitutionDonor-derived DCsHost Langerhans cellsSplenic DC subsetsTLR7 ligand imiquimodMinor histocompatibility AgT-cell reconstitutionDLI administrationHost alloresponsesHost DCsLC emigrationDC subsetsLymph nodesCostimulatory moleculesHistocompatibility AgCells persistInterferon-producing killer dendritic cells provide a link between innate and adaptive immunity
Chan C, Crafton E, Fan H, Flook J, Yoshimura K, Skarica M, Brockstedt D, Dubensky T, Stins M, Lanier L, Pardoll D, Housseau F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nature Medicine 2006, 12: 207-213. PMID: 16444266, DOI: 10.1038/nm1352.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAntigen PresentationCell Line, TumorCytotoxicity, ImmunologicDendritic CellsGene ExpressionImmunity, InnateIn Vitro TechniquesInterferonsKiller Cells, NaturalListeria monocytogenesMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred DBAMice, KnockoutMice, TransgenicOligodeoxyribonucleotidesConceptsInterferon-producing killer dendritic cellsDendritic cellsKiller dendritic cellsI interferonNK cellsAdaptive immunityAntigen-presenting cell activityMajor histocompatibility complex class IISurface major histocompatibility complex class IIHistocompatibility complex class IIClassical NK cellsPlasmacytoid dendritic cellsTarget cellsAntigen-presenting activityConventional dendritic cellsNatural killer cellsNK target cellsToll-like receptorsType I interferonNK functionLymph nodesNKG2D receptorKiller cellsCostimulatory moleculesCytolytic capacity