Dr. Kevin C. O’Connor is an Associate Professor of Neurology at Yale School of Medicine. His laboratory studies the immune response that occurs in autoimmune disease and cancer. Dr. O’Connor earned a Bachelor of Science degree in Chemistry from the University of Massachusetts at Amherst and his Ph.D. in Biochemistry at Tufts Medical School. While at Tufts he studied the role of the developing immune system in autoimmune pathology. In 2000 he joined the laboratory of Dr. David Hafler at Harvard Medical School to begin his post-doctoral training. During this period he initiated a program aimed at understanding the role that B cells and autoantibodies play in the pathogenesis of multiple sclerosis (MS). His group helped define the autoantibody repertoire in MS and a number of inflammatory neurologic diseases. In 2007 he became an Assistant Professor of Neurology at Harvard Medical School. He and his team were among the first to characterize tertiary lymphoid tissue in germ cell tumors. They also described the molecular characteristics of plasma cells that populate the muscle tissue of patients with myositis. They refined the role of Epstein-Barr virus in the MS brain and have begun to define the role of humoral immunity in children with MS. Recently, he and his team identified a network of B cells and antibodies that populate the MS central nervous system. His current research is focused on identifying the molecular entities that initiate and sustain the autoimmune response in MS, myositis and cancer. He and his laboratory moved to Yale in early 2010 where they continue these investigations. 


1995-2000, Ph.D., Biochemistry, Tufts University School of Medicine 

1984-1988, B.Sc., Chemistry, University of Massachusetts, Amherst 

Postdoctoral Training:

1999-2003, Postdoctoral fellow, Neuroimmunology, Harvard Medical School

Professional experience:

2010-present Associate Professor of Neurology, Yale School of Medicine

2007-2010 Assistant Professor of Neurology, Harvard Medical School 

2003-2006 Instructor in Neurology, Harvard Medical School 

2003-2010 Associate Immunochemist, Brigham and Women's Hospital 

1995-present Adjunct Lecturer, Tufts University School of Medicine 

1992-1994 Associate Scientist, Ares-Serono Pharmaceuticals  

1988-1991 Applications Chemist, Waters Chromatography-Millipore