Publications

2021

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, van Dijk D, Wilen CB. PLoS Biol. 2021 Mar; 2021 Mar 17. PMID: 33730024.
Efficient Differentiation of Human Induced Pluripotent Stem Cells into Endothelial Cells under Xenogeneic-free Conditions for Vascular Tissue Engineering.Luo J, Shi X, Lin Y, Yuan Y, Kural MH, Wang J, Ellis MW, Anderson CW, Zhang SM, Riaz M, Niklason LE, Qyang Y. Acta Biomater. 2021 Jan 1; 2020 Nov 6. PMID: 33166710.
Xenogeneic-free generation of vascular smooth muscle cells from human induced pluripotent stem cells for vascular tissue engineering.Luo J, Lin Y, Shi X, Li G, Kural MH, Anderson CW, Ellis MW, Riaz M, Tellides G, Niklason LE, Qyang Y. Acta Biomater. 2021 Jan 1; 2020 Oct 29. PMID: 33130306.

2020

The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future.Greaney AM, Niklason LE. Tissue Eng Part B Rev. 2020 Nov 9; 2020 Nov 9. PMID: 33045942.
Critical considerations for regeneration of vascularized composite tissues.Shah Mohammadi M, Buchen JT, Pasquina PF, Niklason L, Alvarez LM, Jariwala SH. Tissue Eng Part B Rev. 2020 Oct 29; 2020 Oct 29. PMID: 33115331.
Bioengineered human blood vessels.Niklason LE, Lawson JH. Science. 2020 Oct 9. PMID: 33033191.
Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease.Gutowski P, Gage SM, Guziewicz M, Ilzecki M, Kazimierczak A, Kirkton RD, Niklason LE, Pilgrim A, Prichard HL, Przywara S, Samad R, Tente B, Turek J, Witkiewicz W, Zapotoczny N, Zubilewicz T, Lawson JH. J Vasc Surg. 2020 Oct; 2020 Feb 21. PMID: 32093913.
Challenges and novel therapies for vascular access in haemodialysis.Lawson JH, Niklason LE, Roy-Chaudhury P. Nat Rev Nephrol. 2020 Oct; 2020 Aug 24. PMID: 32839580.
Reduced patency in left-sided arteriovenous grafts in a porcine model.Liu S, Wang T, Wang J, Isaji T, Ono S, Fereydooni A, Taniguchi R, Matsubara Y, Niklason LE, Dardik A. J Vasc Surg. 2020 Jul; 2019 Nov 4. PMID: 31699515.
Microvessel Network Formation and Interactions with Pancreatic Islets in Three-Dimensional Chip Cultures.Rambøl MH, Han E, Niklason LE. Tissue Eng Part A. 2020 May; 2020 Jan 20. PMID: 31724494.
Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing.Greaney AM, Adams TS, Brickman Raredon MS, Gubbins E, Schupp JC, Engler AJ, Ghaedi M, Yuan Y, Kaminski N, Niklason LE. Cell Rep. 2020 Mar 24. PMID: 32209482.
Bioengineering the Blood-gas Barrier.Leiby KL, Raredon MSB, Niklason LE. Compr Physiol. 2020 Mar 12; 2020 Mar 12. PMID: 32163210.
Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs.Luo J, Qin L, Zhao L, Gui L, Ellis MW, Huang Y, Kural MH, Clark JA, Ono S, Wang J, Yuan Y, Zhang SM, Cong X, Li G, Riaz M, Lopez C, Hotta A, Campbell S, Tellides G, Dardik A, Niklason LE, Qyang Y. Cell Stem Cell. 2020 Feb 6; 2020 Jan 16. PMID: 31956039.
Modular design of a tissue engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes.Park J, Anderson CW, Sewanan LR, Kural MH, Huang Y, Luo J, Gui L, Riaz M, Lopez CA, Ng R, Das SK, Wang J, Niklason L, Campbell SG, Qyang Y. Acta Biomater. 2020 Jan 15; 2019 Oct 19. PMID: 31634626.

2019

Single-cell connectomic analysis of adult mammalian lungs.Raredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE. Sci Adv. 2019 Dec; 2019 Dec 4. PMID: 31840053.
Engineering of human brain organoids with a functional vascular-like system.Cakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH. Nat Methods. 2019 Nov; 2019 Oct 7. PMID: 31591580.
Non-invasive and real-time measurement of microvascular barrier in intact lungs.Engler AJ, Raredon MSB, Le AV, Yuan Y, Oczkowicz YA, Kan EL, Baevova P, Niklason LE. Biomaterials. 2019 Oct; 2019 Jun 30. PMID: 31280072.
Fas ligand and nitric oxide combination to control smooth muscle growth while sparing endothelium.Kural MH, Wang J, Gui L, Yuan Y, Li G, Leiby KL, Quijano E, Tellides G, Saltzman WM, Niklason LE. Biomaterials. 2019 Aug; 2019 May 7. PMID: 31102854.
Utilization of Natural Detergent Potassium Laurate for Decellularization in Lung Bioengineering.Obata T, Tsuchiya T, Akita S, Kawahara T, Matsumoto K, Miyazaki T, Masumoto H, Kobayashi E, Niklason LE, Nagayasu T. Tissue Eng Part C Methods. 2019 Aug. PMID: 31317819.
Epac agonist improves barrier function in iPSC-derived endothelial colony forming cells for whole organ tissue engineering.Yuan Y, Engler AJ, Raredon MS, Le A, Baevova P, Yoder MC, Niklason LE. Biomaterials. 2019 Apr; 2019 Feb 7. PMID: 30754017.
Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation.Kirkton RD, Santiago-Maysonet M, Lawson JH, Tente WE, Dahl SLM, Niklason LE, Prichard HL. Sci Transl Med. 2019 Mar 27. PMID: 30918113.
Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells.Ghaedi M, Niklason LE. Methods Mol Biol. 2019. PMID: 27628133.

2018

Extracellular matrix in lung development, homeostasis and disease.Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. Matrix Biol. 2018 Nov; 2018 Mar 8. PMID: 29524630.
An Ex Vivo Vessel Injury Model to Study Remodeling.Kural MH, Dai G, Niklason LE, Gui L. Cell Transplant. 2018 Sep; 2018 Aug 10. PMID: 30095004.
Vascularization of Natural and Synthetic Bone Scaffolds.Liu X, Jakus AE, Kural M, Qian H, Engler A, Ghaedi M, Shah R, Steinbacher DM, Niklason LE. Cell Transplant. 2018 Aug; 2018 Jul 16. PMID: 30008231.
Arterial Venous Differentiation for Vascular Bioengineering.Niklason L, Dai G. Annu Rev Biomed Eng. 2018 Jun 4; 2018 Apr 11. PMID: 29641908.
Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction.Hoganson DM, Cooper DA, Rich KN, Piekarski BL, Gui L, Gaut JP, Mayer JE, Aikawa E, Niklason LE, Emani SM. Ann Thorac Surg. 2018 Jun; 2018 Mar 3. PMID: 29510094.
Neuropilin-1 Mediated Arterial Differentiation of Murine Pluripotent Stem Cells.Kim D, Lee V, Dorsey TB, Niklason LE, Gui L, Dai G. Stem Cells Dev. 2018 Apr 1; 2018 Mar 13. PMID: 29415620.
Understanding the Extracellular Matrix to Enhance Stem Cell-Based Tissue Regeneration.Niklason LE. Cell Stem Cell. 2018 Mar 1. PMID: 29499149.
Bioengineered lungs generated from human iPSCs-derived epithelial cells on native extracellular matrix.Ghaedi M, Le AV, Hatachi G, Beloiartsev A, Rocco K, Sivarapatna A, Mendez JJ, Baevova P, Dyal RN, Leiby KL, White ES, Niklason LE. J Tissue Eng Regen Med. 2018 Mar; 2017 Nov 28. PMID: 29024475.
Historical Perspective and Future Direction of Blood Vessel Developments.Dimitrievska S, Niklason LE. Cold Spring Harb Perspect Med. 2018 Feb 1; 2018 Feb 1. PMID: 28348177.
Susceptibility of ePTFE vascular grafts and bioengineered human acellular vessels to infection.Kirkton RD, Prichard HL, Santiago-Maysonet M, Niklason LE, Lawson JH, Dahl SLM. J Surg Res. 2018 Jan; 2017 Sep 19. PMID: 29229120.
Controlled gas exchange in whole lung bioreactors.Engler AJ, Le AV, Baevova P, Niklason LE. J Tissue Eng Regen Med. 2018 Jan; 2017 Jun 15. PMID: 28083925.

2017

Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y. Biomaterials. 2017 Dec; 2017 Sep 19. PMID: 28942128.
Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.Kristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR. Biomaterials. 2017 Oct; 2017 Jun 22. PMID: 28667900.
Efficient and Functional Endothelial Repopulation of Whole Lung Organ Scaffolds.Le AV, Hatachi G, Beloiartsev A, Ghaedi M, Engler AJ, Baevova P, Niklason LE, Calle EA. ACS Biomater Sci Eng. 2017 Sep 11; 2017 Jun 30. PMID: 33440555.
Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells.Doi R, Tsuchiya T, Mitsutake N, Nishimura S, Matsuu-Matsuyama M, Nakazawa Y, Ogi T, Akita S, Yukawa H, Baba Y, Yamasaki N, Matsumoto K, Miyazaki T, Kamohara R, Hatachi G, Sengyoku H, Watanabe H, Obata T, Niklason LE, Nagayasu T. Sci Rep. 2017 Aug 16; 2017 Aug 16. PMID: 28814761.
Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE. Cell Transplant. 2017 Aug. PMID: 28901188.
Lung regeneration: steps toward clinical implementation and use.Calle EA, Leiby KL, Raredon MB, Niklason LE. Curr Opin Anaesthesiol. 2017 Feb. PMID: 27922848.
A short discourse on vascular tissue engineering.Chang WG, Niklason LE. NPJ Regen Med. 2017; 2017 Mar 27. PMID: 29057097.

2016

Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices.Calle EA, Hill RC, Leiby KL, Le AV, Gard AL, Madri JA, Hansen KC, Niklason LE. Acta Biomater. 2016 Dec; 2016 Sep 29. PMID: 27693690.
Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice.Kristofik N, Calabro NE, Tian W, Meng A, MacLauchlan S, Wang Y, Breuer CK, Tellides G, Niklason LE, Kyriakides TR. Blood. 2016 Sep 22; 2016 Jul 28. PMID: 27471233.
New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx.Dimitrievska S, Gui L, Weyers A, Lin T, Cai C, Wu W, Tuggle CT, Sundaram S, Balestrini JL, Slattery D, Tchouta L, Kyriakides TR, Tarbell JM, Linhardt RJ, Niklason LE. Arterioscler Thromb Vasc Biol. 2016 Sep; 2016 Jul 7. PMID: 27386939.
Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine.Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES. Biomaterials. 2016 Sep; 2016 Jun 16. PMID: 27344365.
Implantable tissue-engineered blood vessels from human induced pluripotent stem cells.Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y. Biomaterials. 2016 Sep; 2016 Jun 14. PMID: 27336184.
Engineered Tissue-Stent Biocomposites as Tracheal Replacements.Zhao L, Sundaram S, Le AV, Huang AH, Zhang J, Hatachi G, Beloiartsev A, Caty MG, Yi T, Leiby K, Gard A, Kural MH, Gui L, Rocco KA, Sivarapatna A, Calle E, Greaney A, Urbani L, Maghsoudlou P, Burns A, DeCoppi P, Niklason LE. Tissue Eng Part A. 2016 Sep. PMID: 27520928.
Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries.Huang AH, Balestrini JL, Udelsman BV, Zhou KC, Zhao L, Ferruzzi J, Starcher BC, Levene MJ, Humphrey JD, Niklason LE. Tissue Eng Part C Methods. 2016 Jun. PMID: 27108525.
Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials.Lawson JH, Glickman MH, Ilzecki M, Jakimowicz T, Jaroszynski A, Peden EK, Pilgrim AJ, Prichard HL, Guziewicz M, Przywara S, Szmidt J, Turek J, Witkiewicz W, Zapotoczny N, Zubilewicz T, Niklason LE. Lancet. 2016 May 14. PMID: 27203778.
Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis.Sun H, Zhu Y, Pan H, Chen X, Balestrini JL, Lam TT, Kanyo JE, Eichmann A, Gulati M, Fares WH, Bai H, Feghali-Bostwick CA, Gan Y, Peng X, Moore MW, White ES, Sava P, Gonzalez AL, Cheng Y, Niklason LE, Herzog EL. Arthritis Rheumatol. 2016 May. PMID: 26749424.
Ventilation-Based Decellularization System of the Lung.Tsuchiya T, Mendez J, Calle EA, Hatachi G, Doi R, Zhao L, Suematsu T, Nagayasu T, Niklason LE. Biores Open Access. 2016; 2016 May 1. PMID: 27186445.
Biomimetic Culture Reactor for Whole-Lung Engineering.Raredon MS, Rocco KA, Gheorghe CP, Sivarapatna A, Ghaedi M, Balestrini JL, Raredon TL, Calle EA, Niklason LE. Biores Open Access. 2016; 2016 Apr 1. PMID: 27088061.
Sterilization of Lung Matrices by Supercritical Carbon Dioxide.Balestrini JL, Liu A, Gard AL, Huie J, Blatt KM, Schwan J, Zhao L, Broekelmann TJ, Mecham RP, Wilcox EC, Niklason LE. Tissue Eng Part C Methods. 2016 Mar; 2016 Jan 29. PMID: 26697757.

2015

Production of decellularized porcine lung scaffolds for use in tissue engineering.Balestrini JL, Gard AL, Liu A, Leiby KL, Schwan J, Kunkemoeller B, Calle EA, Sivarapatna A, Lin T, Dimitrievska S, Cambpell SG, Niklason LE. Integr Biol (Camb). 2015 Dec; 2015 Oct 1. PMID: 26426090.
Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli.Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS. Tissue Eng Part A. 2015 Nov; 2015 Oct 1. PMID: 26414101.
Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16.Qian H, Xu X, Niklason LE. Oncotarget. 2015 Aug 7. PMID: 26299918.
Design and Use of a Novel Bioreactor for Regeneration of Biaxially Stretched Tissue-Engineered Vessels.Huang AH, Lee YU, Calle EA, Boyle M, Starcher BC, Humphrey JD, Niklason LE. Tissue Eng Part C Methods. 2015 Aug; 2015 Mar 20. PMID: 25669988.
Fate of distal lung epithelium cultured in a decellularized lung extracellular matrix.Calle EA, Mendez JJ, Ghaedi M, Leiby KL, Bove PF, Herzog EL, Sundaram S, Niklason LE. Tissue Eng Part A. 2015 Jun; 2015 May 4. PMID: 25789725.
Osteogenic performance of donor-matched human adipose and bone marrow mesenchymal cells under dynamic culture.Wu W, Le AV, Mendez JJ, Chang J, Niklason LE, Steinbacher DM. Tissue Eng Part A. 2015 May. PMID: 25668104.
Quantification of extracellular matrix proteins from a rat lung scaffold to provide a molecular readout for tissue engineering.Hill RC, Calle EA, Dzieciatkowska M, Niklason LE, Hansen KC. Mol Cell Proteomics. 2015 Apr; 2015 Feb 8. PMID: 25660013.
Extracellular matrix as a driver for lung regeneration.Balestrini JL, Niklason LE. Ann Biomed Eng. 2015 Mar; 2014 Oct 25. PMID: 25344351.
Development of Lung Epithelium from Induced Pluripotent Stem Cells.Ghaedi M, Niklason LE, Williams J. Curr Transplant Rep. 2015 Mar 1. PMID: 26052480.
Click-coated, heparinized, decellularized vascular grafts.Dimitrievska S, Cai C, Weyers A, Balestrini JL, Lin T, Sundaram S, Hatachi G, Spiegel DA, Kyriakides TR, Miao J, Li G, Niklason LE, Linhardt RJ. Acta Biomater. 2015 Feb; 2014 Nov 20. PMID: 25463496.
Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo.Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Biomaterials. 2015 Feb; 2014 Nov 26. PMID: 25433608.
Efficient intratracheal delivery of airway epithelial cells in mice and pigs.Gui L, Qian H, Rocco KA, Grecu L, Niklason LE. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15. PMID: 25416381.
PCH-2 regulates Caenorhabditis elegans lifespan.Qian H, Xu X, Niklason LE. Aging (Albany NY). 2015 Jan. PMID: 25635513.
Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor.Sivarapatna A, Ghaedi M, Le AV, Mendez JJ, Qyang Y, Niklason LE. Biomaterials. 2015; 2015 Mar 24. PMID: 25890758.
A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium.Raredon MS, Ghaedi M, Calle EA, Niklason LE. Cell Med. 2015 Oct 1; 2014 Dec 12. PMID: 26858899.

2014

Tissue-engineered vascular grafts created from human induced pluripotent stem cells.Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang AH, Niklason L. Stem Cells Transl Med. 2014 Dec; 2014 Nov 5. PMID: 25378654.
Influence of pH on extracellular matrix preservation during lung decellularization.Tsuchiya T, Balestrini JL, Mendez J, Calle EA, Zhao L, Niklason LE. Tissue Eng Part C Methods. 2014 Dec; 2014 Jun 3. PMID: 24735501.
Arterial shear stress reduces eph-b4 expression in adult human veins.Model LS, Hall MR, Wong DJ, Muto A, Kondo Y, Ziegler KR, Feigel A, Quint C, Niklason L, Dardik A. Yale J Biol Med. 2014 Sep; 2014 Sep 3. PMID: 25191151.
Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. Cell Stem Cell. 2014 Aug 7. PMID: 25105578.
The use of optical clearing and multiphoton microscopy for investigation of three-dimensional tissue-engineered constructs.Calle EA, Vesuna S, Dimitrievska S, Zhou K, Huang A, Zhao L, Niklason LE, Levene MJ. Tissue Eng Part C Methods. 2014 Jul; 2014 Jan 16. PMID: 24251630.
Engineering of arteries in vitro.Huang AH, Niklason LE. Cell Mol Life Sci. 2014 Jun; 2014 Jan 8. PMID: 24399290.
Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds.Mendez JJ, Ghaedi M, Steinbacher D, Niklason LE. Tissue Eng Part A. 2014 Jun; 2014 Apr 28. PMID: 24393055.
Strategies for whole lung tissue engineering.Calle EA, Ghaedi M, Sundaram S, Sivarapatna A, Tseng MK, Niklason LE. IEEE Trans Biomed Eng. 2014 May; 2014 Mar 28. PMID: 24691527.
Construction of tissue-engineered small-diameter vascular grafts in fibrin scaffolds in 30 days.Gui L, Boyle MJ, Kamin YM, Huang AH, Starcher BC, Miller CA, Vishnevetsky MJ, Niklason LE. Tissue Eng Part A. 2014 May; 2014 Feb 6. PMID: 24320793.
Future prospects for tissue engineered lung transplantation: decellularization and recellularization-based whole lung regeneration.Tsuchiya T, Sivarapatna A, Rocco K, Nanashima A, Nagayasu T, Niklason LE. Organogenesis. 2014 Apr-Jun; 2014 Jan 31. PMID: 24488093.
Fibroblast engraftment in the decellularized mouse lung occurs via a β1-integrin-dependent, FAK-dependent pathway that is mediated by ERK and opposed by AKT.Sun H, Calle E, Chen X, Mathur A, Zhu Y, Mendez J, Zhao L, Niklason L, Peng X, Peng H, Herzog EL. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15; 2013 Dec 13. PMID: 24337923.
Vascular Tissue Engineering: Building Perfusable Vasculature for Implantation.Gui L, Niklason LE. Curr Opin Chem Eng. 2014 Feb 1. PMID: 24533306.
Small-diameter vascular graft engineered using human embryonic stem cell-derived mesenchymal cells.Sundaram S, Echter A, Sivarapatna A, Qiu C, Niklason L. Tissue Eng Part A. 2014 Feb. PMID: 24125588.
A call to craft.Raredon MS, Niklason LE. Sci Transl Med. 2014 Jan 8. PMID: 24401937.
Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor.Ghaedi M, Mendez JJ, Bove PF, Sivarapatna A, Raredon MS, Niklason LE. Biomaterials. 2014 Jan; 2013 Oct 19. PMID: 24144903.

2013

Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix.Ghaedi M, Calle EA, Mendez JJ, Gard AL, Balestrini J, Booth A, Bove PF, Gui L, White ES, Niklason LE. J Clin Invest. 2013 Nov; 2013 Oct 25. PMID: 24135142.
The effect of age on human adipose-derived stem cells.Wu W, Niklason L, Steinbacher DM. Plast Reconstr Surg. 2013 Jan. PMID: 22965240.

2012

Microfluidic artificial "vessels" for dynamic mechanical stimulation of mesenchymal stem cells.Zhou J, Niklason LE. Integr Biol (Camb). 2012 Dec. PMID: 23114826.
Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation.Booth AJ, Hadley R, Cornett AM, Dreffs AA, Matthes SA, Tsui JL, Weiss K, Horowitz JC, Fiore VF, Barker TH, Moore BB, Martinez FJ, Niklason LE, White ES. Am J Respir Crit Care Med. 2012 Nov 1; 2012 Aug 30. PMID: 22936357.
Engineered zinc-finger proteins can compensate genetic haploinsufficiency by transcriptional activation of the wild-type allele: application to Willams-Beuren syndrome and supravalvular aortic stenosis.Zhang P, Huang A, Morales-Ruiz M, Starcher BC, Huang Y, Sessa WC, Niklason LE, Giordano FJ. Hum Gene Ther. 2012 Nov. PMID: 22891920.
Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report.Zhang P, Huang A, Ferruzzi J, Mecham RP, Starcher BC, Tellides G, Humphrey JD, Giordano FJ, Niklason LE, Sessa WC. Arterioscler Thromb Vasc Biol. 2012 Mar; 2011 Nov 17. PMID: 22095981.
Allogeneic human tissue-engineered blood vessel.Quint C, Arief M, Muto A, Dardik A, Niklason LE. J Vasc Surg. 2012 Mar; 2011 Nov 4. PMID: 22056286.
Cardiovascular regenerative biology.Badylak SF, Hirschi KK, Niklason LE. Cells Tissues Organs. 2012; 2011 Oct 12. PMID: 22179179.
Smooth muscle and other cell sources for human blood vessel engineering.Sundaram S, Niklason LE. Cells Tissues Organs. 2012; 2011 Oct 25. PMID: 22041291.
Matrix composition and mechanics of decellularized lung scaffolds.Petersen TH, Calle EA, Colehour MB, Niklason LE. Cells Tissues Organs. 2012; 2011 Apr 18. PMID: 21502745.

2011

An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia.Prichard HL, Manson RJ, DiBernardo L, Niklason LE, Lawson JH, Dahl SL. J Cardiovasc Transl Res. 2011 Oct; 2011 Jul 12. PMID: 21748530.
Engineering biological-based vascular grafts using a pulsatile bioreactor.Huang AH, Niklason LE. J Vis Exp. 2011 Jun 14; 2011 Jun 14. PMID: 21694696.
Decellularized tissue-engineered blood vessel as an arterial conduit.Quint C, Kondo Y, Manson RJ, Lawson JH, Dardik A, Niklason LE. Proc Natl Acad Sci U S A. 2011 May 31; 2011 May 12. PMID: 21571635.
Building stronger microvessels.Niklason LE. Nat Biotechnol. 2011 May. PMID: 21552239.
Development of novel biodegradable polymer scaffolds for vascular tissue engineering.Gui L, Zhao L, Spencer RW, Burghouwt A, Taylor MS, Shalaby SW, Niklason LE. Tissue Eng Part A. 2011 May; 2011 Jan 16. PMID: 21143045.
Bioengineered vascular grafts: can we make them off-the-shelf?Dahl SL, Blum JL, Niklason LE. Trends Cardiovasc Med. 2011 Apr. PMID: 22626247.
Procedure for lung engineering.Calle EA, Petersen TH, Niklason LE. J Vis Exp. 2011 Mar 8; 2011 Mar 8. PMID: 21445030.
Readily available tissue-engineered vascular grafts.Dahl SL, Kypson AP, Lawson JH, Blum JL, Strader JT, Li Y, Manson RJ, Tente WE, DiBernardo L, Hensley MT, Carter R, Williams TP, Prichard HL, Dey MS, Begelman KG, Niklason LE. Sci Transl Med. 2011 Feb 2. PMID: 21289273.