Our main research focus includes:


Coordination of Transcription and Splicing

All protein-coding genes are transcribed by RNA polymerase II (Pol II); the resulting pre-mRNA transcripts are spliced by a distinct macromolecular machine, the spliceosome, to produce...


Cajal bodies and the macromolecular assembly of RNPs

Cajal bodies (CBs) were identified more than 100 years ago by Ramon y Cajal in vertebrate neurons. The function of these 0.5-1 mm spherical structures, which like other cellular...

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mRNP formation, composition and function

Genomes encode many hundreds of RNA binding proteins that have roles in transcription, splicing, subcellular localization, stability and translation. Yet we do not have a comprehensive...