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Lab Overview

Welcome to the Murray Lab
Research in the lab, led by John D. Murray, focuses on investigating the dynamics and function of neural circuits, and their dysfunction in psychiatric and neurological disorders. To investigate these issues, we develop modeling, theoretical, and data-analytic approaches to systems neuroscience, in close collaboration with experimentalists. We build biophysically-based neural circuit models that span levels of scale and complexity, ranging from detailed microcircuitry supporting cognitive function, to large-scale brain dynamics. Furthermore, we leverage computational insights from models to advance the study of disorders such as schizophrenia, in a framework for Computational Psychiatry.

Lab News

  • John Murray and Alan Anticevic have edited a new book (with much gratitude to the exceptional contributors!), Computational Psychiatry: Mathematical Modeling of Mental Illness. [Link]
  • Markus Helmer (postdoc) has been awarded a DFG Research Fellowship from the German Research Foundation. Congratulations, Markus!
  • Norman Lam (Physics PhD student) has been awarded a Graduate Scholarship from the the National Sciences and Engineering Research Council (NSERC) of Canada. Congratulations, Norman!
  • The lab has been awarded its first R01 grant from the National Institute of Mental Health.
  • Special Issue in Biological Psychiatry on "Cortical Excitation-Inhibition Balance and Dysfunction in Psychiatric Disorders" (Edited by Alan Anticevic and John Murray) [Link]
  • The Murray Lab was awarded a collaborative grant, with the Anticevic Lab, from the Simons Foundation Autism Research Initiative (SFARI) [Link]

Upcoming Events

  • Mar 10-13: John will give a talk at the Whistler Scientific Workshop on Brain Functional Organization, Connectivity, and Behavior, held at the Sunshine Coast in Noosa, Australia. [LINK]
  • July: John will lecture at the Computational & Cognitive Neuroscience Summer School (CCNSS) in China. [LINK]

Selected recent publications

  • Demirtas M, Burt JB, Helmer M, Ji JL, Adkinson BD, Glasser MF, Van Essen DC, Sotiropoulos S, Anticevic A, Murray JD (In Press) Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics. Neuron [DOI: 10.1016/j.neuron.2019.01.017]
  • Murray JD, Demirtas M, Anticevic A (2018) Biophysical modeling of large-scale brain dynamics and applications for computational psychiatry. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3:777
    [DOI: 10.1016/j.bpsc.2018.07.004]
  • Burt JB, Demirtas M, Eckner WJ, Navejar N, Ji JL, Martin WJ, Bernacchia A, Anticevic A, Murray JD (2018) Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography. Nature Neuroscience 21:1251
    [DOI: 10.1038/s41593-018-0195-0]
  • Murray JD*, Jaramillo JH*, Wang X-J (2017) Working memory and decision making in a fronto-parietal circuit model. Journal of Neuroscience 37:12167
    [DOI: 10.1523/JNEUROSCI.0343-17.2017]
  • Lam NH, Borduqui T, Hallak J, Roque AC, Anticevic A, Krystal JH, Wang X-J, Murray JD (2017) Effects of altered excitation-inhibition balance on decision making in a cortical circuit model.bioRxiv 10.1101/100347
    [DOI: 10.1101/100347]
  • Murray JD, Bernacchia A, Roy NA, Constantinidis C, Romo R, Wang X-J (2017) Stable population coding for working memory coexists with heterogeneous neural dynamics in prefrontal cortex. Proceedings of the National Academy of Sciences 114:394
    [DOI: 10.1073/pnas.1619449114]