Neha Arun
About
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Biography
Neha Arun is a Microbiology PhD candidate and Ruth L. Kirschstein NRSA (F31) Fellow in the lab of Dr. Walther Mothes at Yale University.
Her research focuses on broadly reactive strategies to eliminate the persistent reservoir of HIV-1-infected cells, which remains a major barrier to a cure. She investigates how antibodies recognizing the HIV-1 envelope glycoprotein (Env) engage Fc-receptors on innate immune cells to trigger the clearance of infected cells. By examining the molecular features that initiate Fc-effector functions across different immune cell types, her work seeks to inform therapeutic strategies that optimize viral reservoir elimination.
Prior to joining Yale, Neha was a Stamps Scholar at the University of Illinois Urbana-Champaign. She graduated summa cum laude in 2023 with a BS in Molecular & Cellular Biology, receiving Highest Distinction for her thesis, “Structural and biochemical mechanisms of HIV latency reactivation in monocytes, macrophages, and T-cells,” in the lab of Dr. Collin Kieffer. Her research is driven by a long-term commitment to developing accessible antiviral strategies by interrogating the virus-host interface.
Departments & Organizations
Education & Training
- PhD
- Yale University, Microbiology
- BS
- University of Illinois Urbana-Champaign, Molecular and Cellular Biology
- Dr. Walter A. and Loretta M. Zygmunt Microbiology Scholar
- University of Illinois Urbana-Champaign (2022)
- Summer Undergraduate Research Fellow
- Mayo Clinic (2021)
- School of MCB Summer Undergraduate Research Fellow
- University of Illinois Urbana-Champaign (2020)
Research
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Overview
Medical Research Interests
ORCID
0009-0005-0111-2973- View Lab Website
Mothes Lab
Research at a Glance
Yale Co-Authors
Esen Sefik, PhD
Haris Mirza, MBBS, PhD
Michael Chiorazzi, MD, PhD
Richard Flavell, PhD, FRS
Stephanie Halene, MD, Dr Med
William Philbrick, PhD
Publications
2025
Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow
Sefik E, Philbrick W, Zhang F, Agrawal K, Van Lee B, Sam J, Karatepe K, Zheng Y, Liang K, Peng S, Mirza H, Rangavajhula A, Simon P, Arun N, Babu P, Eynon E, Chiorazzi M, Shan L, Halene S, Luo H, Rongvaux A, Kluger Y, Flavell R. Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2426546122. PMID: 40956886, PMCID: PMC12478129, DOI: 10.1073/pnas.2426546122.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBone marrowHuman CD47Human granulocyte-macrophage progenitorsHuman immune developmentMature human monocytesHuman neutrophilsHumanized mouse modelNeutrophil extracellular trap formationHuman hematopoietic stemGranulocyte-macrophage progenitorsHuman M-CSFHuman immune responseGenetically modified miceResponse to inflammationExtracellular trap formationHuman bone marrowCD47 promoterHuman immune systemPhysiological levelsNK cellsHumanized miceDendritic cellsHematopoietic stemMyeloid lineageHuman hematopoiesis
2024
Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation.
Blanco A, Coronado RA, Arun N, Ma K, Dar RD, Kieffer C. Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation. Proc Natl Acad Sci U S A 2024, 121: e2313823121. PMID: 38683980, DOI: 10.1073/pnas.2313823121.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Honors
honor Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)
04/03/2026National AwardNational Institute of Allergy and Infectious Diseases
News
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