Research Interests and Approaches
Inflammation-mediated angiogenesis and lymphangiogenesis
Both angiogenesis and lymphangiogenesis are critical for tissue repair. We have identified the TNFR2-Bmx kinase (bone marrow tyrosine kinase in X chromosome)-VEGFR2/3 signaling pathway involved in EC proliferation, migration and tube formation. We are investigating how TNFR2-Bmx mediates angiogenesis, lymphangiogenesis and vascular tissue repair (see Figure 3).
Vascular development, endothelial cell progenitor differentiation and vascular malformation
Stress signaling pathways in EC
We have identified several critical upstream regulators of ASK1 (a member of MAP3K family) and have made several original discoveries in elucidating the mechanisms for ASK1 activation by various stresses (cytokine, oxidative stress, genotoxic stress and ER stress (see Figure 4, from a review article in 2009). We are determining how these mediators are specifically activated in response to stress.
Determine the mechanism of tumor progression and metastases
We have identified AIP1, a new member of Ras-GAP family protein (also known as DAB2IP), as a potential tumor suppressor gene. We are employing variety of tumor models to determine the role of AIP1 in tumor growth and metastasis.