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Our laboratory is interested in understanding how cells detect misfolded proteins and prevent protein aggregation in the cell. Since cells are continually exposed to various stress stimuli, proteins have a high probability of mislocalization, misfolding, aggregating, and causing cellular toxicity and human diseases. To tackle these problems, eukaryotic cells have evolved sophisticated molecular machinery for detecting and eliminating of misfolded proteins in the cell. Our goal is to identify and understand the components involved in various cellular quality control processes.