Notch Lineages in the CNS
The Notch signaling pathway is an evolutionarily conserved cell interaction mechanism that is active in a wide range of organisms and tissues, is associated with early lineage decisions, and affects CNS development at many different levels, including neuronal progenitor maintenance, cell fate decisions between neuronal and glial lineages, terminally differentiated neuron behavior, as well as patterning of cellular fields. We are investigating cellular lineages that depend on Notch activity in the developing and adult brain by utilizing a unique set of transgenic mice generated in the Artavanis-Tsakonas laboratory.
- The Notch pathway in CNS homeostasis and neurodegeneration.Ho DM, Artavanis-Tsakonas S, Louvi A. Wiley Interdiscip Rev Dev Biol. 2020 Jan; 2019 Sep 10. PMID: 31502763.
- Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus.Zhang R, Boareto M, Engler A, Louvi A, Giachino C, Iber D, Taylor V. Cell Rep. 2019 Aug 6. PMID: 31390563.
- Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone.Engler A, Rolando C, Giachino C, Saotome I, Erni A, Brien C, Zhang R, Zimber-Strobl U, Radtke F, Artavanis-Tsakonas S, Louvi A, Taylor V. Cell Rep. 2018 Jan 23; 2018 Jan 28. PMID: 29386140.
- Notch signalling in vertebrate neural development.Louvi A, Artavanis-Tsakonas S. Nat Rev Neurosci. 2006 Feb. PMID: 16429119.