Select Publications
- Punctate Administration of Ficin as a human and animal model of non-histaminergic itch.Malewicz NM, Ieong HF, Oeck S, Kumowski N, Zhang Z, Shimada SG, LaMotte RH. J Eur Acad Dermatol Venereol. 2022 Aug; 2022 Apr 25. PMID: 35412669.
- Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain.Malewicz NM, Rattray Z, Oeck S, Jung S, Escamilla-Rivera V, Chen Z, Tang X, Zhou J, LaMotte RH. Int J Mol Sci. 2022 May 9; 2022 May 9. PMID: 35563669.
- Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates.Klein A, Solinski HJ, Malewicz NM, Ieong HF, Sypek EI, Shimada SG, Hartke TV, Wooten M, Wu G, Dong X, Hoon MA, LaMotte RH, Ringkamp M. Elife. 2021 Apr 23; 2021 Apr 23. PMID: 33891544.
- TMEM163 Regulates ATP-Gated P2X Receptor and Behavior.Salm EJ, Dunn PJ, Shan L, Yamasaki M, Malewicz NM, Miyazaki T, Park J, Sumioka A, Hamer RRL, He WW, Morimoto-Tomita M, LaMotte RH, Tomita S. Cell Rep. 2020 Jun 2. PMID: 32492420.
- Differences in itch and pain behaviors accompanying the irritant and allergic contact dermatitis produced by a contact allergen in mice.Zhang Z, Malewicz NM, Xu X, Pan J, Kumowski N, Zhu T, Shimada SG, Nie H, LaMotte RH. Pain Rep. 2019 Sep-Oct; 2019 Sep 11. PMID: 31875186.
- CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis.Jiang H, Cui H, Wang T, Shimada SG, Sun R, Tan Z, Ma C, LaMotte RH. Brain Behav Immun. 2019 Aug; 2019 Apr 11. PMID: 30981714.
- Identifying the pathways required for coping behaviours associated with sustained pain.Huang T, Lin SH, Malewicz NM, Zhang Y, Zhang Y, Goulding M, LaMotte RH, Ma Q. Nature. 2019 Jan; 2018 Dec 10. PMID: 30532001.
- Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.Wang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C, LaMotte RH. Neurosci Lett. 2018 Mar 6; 2018 Feb 3. PMID: 29355697.
- Molecular basis of tactile specialization in the duck bill.Schneider ER, Anderson EO, Mastrotto M, Matson JD, Schulz VP, Gallagher PG, LaMotte RH, Gracheva EO, Bagriantsev SN. Proc Natl Acad Sci U S A. 2017 Dec 5; 2017 Nov 6. PMID: 29109250.
- Cl(-) channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis.Qu L, Fu K, Shimada SG, LaMotte RH. J Neurophysiol. 2017 Jul 1; 2017 Apr 26. PMID: 28446581.
- Regulation of Cytokines in Cancer Pain.Song XJ, LaMotte RH, Xie Z. Mediators Inflamm. 2016; 2016 Mar 20. PMID: 27087747.
- Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse.LaMotte RH. Adv Exp Med Biol. 2016. PMID: 26900060.
- Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice.Wang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH. PLoS One. 2015; 2015 Sep 10. PMID: 26356638.
- CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis.Qu L, Fu K, Yang J, Shimada SG, LaMotte RH. Pain. 2015 Sep. PMID: 25932692.
- Psychophysical measurements of itch and nociceptive sensations in an experimental model of allergic contact dermatitis.Pall PS, Hurwitz OE, King BA, LaMotte RH. J Pain. 2015 Aug; 2015 May 19. PMID: 26002605.
- Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity.Fu K, Qu L, Shimada SG, Nie H, LaMotte RH. Neurosci Lett. 2014 Sep 5; 2014 Apr 3. PMID: 24704378.
- Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Brain. 2014 Apr; 2014 Feb 18. PMID: 24549959.
- Sensory neurons and circuits mediating itch.LaMotte RH, Dong X, Ringkamp M. Nat Rev Neurosci. 2014 Jan. PMID: 24356071.
- A subpopulation of nociceptors specifically linked to itch.Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X. Nat Neurosci. 2013 Feb; 2012 Dec 23. PMID: 23263443.
- Two methods for full-length RNA sequencing for low quantities of cells and single cells.Pan X, Durrett RE, Zhu H, Tanaka Y, Li Y, Zi X, Marjani SL, Euskirchen G, Ma C, Lamotte RH, Park IH, Snyder MP, Mason CE, Weissman SM. Proc Natl Acad Sci U S A. 2013 Jan 8; 2012 Dec 24. PMID: 23267071.
- Mechanisms of itch evoked by β-alanine.Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, Dong X. J Neurosci. 2012 Oct 17. PMID: 23077038.
- Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons.Qu L, Li Y, Pan X, Zhang P, LaMotte RH, Ma C. J Neurosci. 2012 Jul 11. PMID: 22787041.
- In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans.Ma C, Nie H, Gu Q, Sikand P, Lamotte RH. J Neurophysiol. 2012 Jan; 2011 Oct 12. PMID: 21994268.
- Chronic compression of mouse dorsal root ganglion alters voltage-gated sodium and potassium currents in medium-sized dorsal root ganglion neurons.Fan N, Donnelly DF, LaMotte RH. J Neurophysiol. 2011 Dec; 2011 Sep 14. PMID: 21917996.
- Sensory responses to injection and punctate application of capsaicin and histamine to the skin.Sikand P, Shimada SG, Green BG, LaMotte RH. Pain. 2011 Nov; 2011 Jul 29. PMID: 21802851.
- A role for nociceptive, myelinated nerve fibers in itch sensation.Ringkamp M, Schepers RJ, Shimada SG, Johanek LM, Hartke TV, Borzan J, Shim B, LaMotte RH, Meyer RA. J Neurosci. 2011 Oct 19. PMID: 22016517.
- Mouse models of acute, chemical itch and pain in humans.LaMotte RH, Shimada SG, Sikand P. Exp Dermatol. 2011 Oct. PMID: 21929688.
- Neuronal Fc-gamma receptor I mediated excitatory effects of IgG immune complex on rat dorsal root ganglion neurons.Qu L, Zhang P, LaMotte RH, Ma C. Brain Behav Immun. 2011 Oct; 2011 Apr 18. PMID: 21521651.
- Increased Na+ and K+ currents in small mouse dorsal root ganglion neurons after ganglion compression.Fan N, Sikand P, Donnelly DF, Ma C, Lamotte RH. J Neurophysiol. 2011 Jul; 2011 Apr 27. PMID: 21525373.
- BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.Sikand P, Dong X, LaMotte RH. J Neurosci. 2011 May 18. PMID: 21593341.
- Expression of inwardly rectifying potassium channels by an inducible adenoviral vector reduced the neuronal hyperexcitability and hyperalgesia produced by chronic compression of the spinal ganglion.Ma C, Rosenzweig J, Zhang P, Johns DC, LaMotte RH. Mol Pain. 2010 Oct 6; 2010 Oct 6. PMID: 20923570.
- In vivo visualization and functional characterization of primary somatic neurons.Ma C, Donnelly DF, LaMotte RH. J Neurosci Methods. 2010 Aug 15; 2010 Jun 14. PMID: 20558205.
- Cathepsin S elicits itch and signals via protease-activated receptors.Reddy VB, Shimada SG, Sikand P, Lamotte RH, Lerner EA. J Invest Dermatol. 2010 May; 2010 Jan 14. PMID: 20072136.
- Altered functional properties of satellite glial cells in compressed spinal ganglia.Zhang H, Mei X, Zhang P, Ma C, White FA, Donnelly DF, Lamotte RH. Glia. 2009 Nov 15. PMID: 19330845.
- Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage.Sikand P, Shimada SG, Green BG, LaMotte RH. Pain. 2009 Jul; 2009 May 6. PMID: 19423224.
- Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.LaMotte RH, Shimada SG, Green BG, Zelterman D. J Neurophysiol. 2009 Mar; 2009 Jan 14. PMID: 19144738.
- Functional up-regulation of P2X 3 receptors in the chronically compressed dorsal root ganglion.Xiang Z, Xiong Y, Yan N, Li X, Mao Y, Ni X, He C, LaMotte RH, Burnstock G, Sun J. Pain. 2008 Nov 15; 2008 Aug 19. PMID: 18715715.
- Magnitude estimation of softness.Friedman RM, Hester KD, Green BG, LaMotte RH. Exp Brain Res. 2008 Nov; 2008 Aug 5. PMID: 18679665.
- Behavioral differentiation between itch and pain in mouse.Shimada SG, LaMotte RH. Pain. 2008 Oct 31; 2008 Sep 11. PMID: 18789837.
- Hyperexcitable neurons and altered non-neuronal cells in the compressed spinal ganglion.LaMotte RH, Ma C. Sheng Li Xue Bao. 2008 Oct 25. PMID: 18958366.
- A role for polymodal C-fiber afferents in nonhistaminergic itch.Johanek LM, Meyer RA, Friedman RM, Greenquist KW, Shim B, Borzan J, Hartke T, LaMotte RH, Ringkamp M. J Neurosci. 2008 Jul 23. PMID: 18650342.
- Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors.Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA. J Neurosci. 2008 Apr 23. PMID: 18434511.
- Multiple sites for generation of ectopic spontaneous activity in neurons of the chronically compressed dorsal root ganglion.Ma C, LaMotte RH. J Neurosci. 2007 Dec 19. PMID: 18094245.
- Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch.Johanek LM, Meyer RA, Hartke T, Hobelmann JG, Maine DN, LaMotte RH, Ringkamp M. J Neurosci. 2007 Jul 11. PMID: 17626210.
- Acutely dissociated sensory neurons: normal or neuropathic? Focus on: "Dissociation of dorsal root ganglion neurons induces hyperexcitability that is maintained by increased responsiveness to cAMP and cGMP".LaMotte RH. J Neurophysiol. 2007 Jan; 2006 Oct 11. PMID: 17035365.
- MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia.Sun JH, Yang B, Donnelly DF, Ma C, LaMotte RH. J Neurophysiol. 2006 Nov; 2006 Jun 14. PMID: 16775210.
- Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons.Ma C, Greenquist KW, Lamotte RH. J Neurophysiol. 2006 Apr; 2005 Dec 28. PMID: 16381809.
- Effects of a chronic compression of the dorsal root ganglion on voltage-gated Na+ and K+ currents in cutaneous afferent neurons.Tan ZY, Donnelly DF, LaMotte RH. J Neurophysiol. 2006 Feb. PMID: 16424456.
- Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion.White FA, Sun J, Waters SM, Ma C, Ren D, Ripsch M, Steflik J, Cortright DN, Lamotte RH, Miller RJ. Proc Natl Acad Sci U S A. 2005 Sep 27; 2005 Sep 20. PMID: 16174730.
- Enhanced excitability of dissociated primary sensory neurons after chronic compression of the dorsal root ganglion in the rat.Ma C, LaMotte RH. Pain. 2005 Jan. PMID: 15621370.
- Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.Simone DA, Zhang X, Li J, Zhang JM, Honda CN, LaMotte RH, Giesler GJ Jr. J Neurophysiol. 2004 Jan. PMID: 14715718.
- Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediators.Song XJ, Zhang JM, Hu SJ, LaMotte RH. Pain. 2003 Aug. PMID: 12927643.
- Upregulation of the hyperpolarization-activated cation current after chronic compression of the dorsal root ganglion.Yao H, Donnelly DF, Ma C, LaMotte RH. J Neurosci. 2003 Mar 15. PMID: 12657665.
- Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons.Ma C, Shu Y, Zheng Z, Chen Y, Yao H, Greenquist KW, White FA, LaMotte RH. J Neurophysiol. 2003 Mar; 2002 Nov 20. PMID: 12612024.
- Neural coding of the location and direction of a moving object by a spatially distributed population of mechanoreceptors.Friedman RM, Khalsa PS, Greenquist KW, LaMotte RH. J Neurosci. 2002 Nov 1. PMID: 12417680.
- Comparison of responses to tensile and compressive stimuli in C-mechanosensitive nociceptors in rat hairy skin.Zheng Z, Lamotte RH, Grigg P. Somatosens Mot Res. 2002. PMID: 12088384.
- Fine-scale organization of SI (area 3b) in the squirrel monkey revealed with intrinsic optical imaging.Chen LM, Friedman RM, Ramsden BM, LaMotte RH, Roe AW. J Neurophysiol. 2001 Dec. PMID: 11731557.
- Protein kinase A modulates spontaneous activity in chronically compressed dorsal root ganglion neurons in the rat.Hu SJ, Song XJ, Greenquist KW, Zhang JM, LaMotte RH. Pain. 2001 Oct. PMID: 11576743.
- Softness discrimination with a tool.LaMotte RH. J Neurophysiol. 2000 Apr. PMID: 10758090.
- Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion.Zhang JM, Song XJ, LaMotte RH. J Neurophysiol. 1999 Dec. PMID: 10601467.
- Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia.Song XJ, Hu SJ, Greenquist KW, Zhang JM, LaMotte RH. J Neurophysiol. 1999 Dec. PMID: 10601466.
- Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.Brull SJ, Atanassoff PG, Silverman DG, Zhang J, Lamotte RH. Somatosens Mot Res. 1999. PMID: 10632027.
- Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.Atanassoff PG, Brull SJ, Zhang J, Greenquist K, Silverman DG, Lamotte RH. Somatosens Mot Res. 1999. PMID: 10632026.
- Raised object on a planar surface stroked across the fingerpad: responses of cutaneous mechanoreceptors to shape and orientation.LaMotte RH, Friedman RM, Lu C, Khalsa PS, Srinivasan MA. J Neurophysiol. 1998 Nov. PMID: 9819255.
- Encoding of shape and orientation of objects indented into the monkey fingerpad by populations of slowly and rapidly adapting mechanoreceptors.Khalsa PS, Friedman RM, Srinivasan MA, Lamotte RH. J Neurophysiol. 1998 Jun. PMID: 9636122.
- Patch clamp recording from the intact dorsal root ganglion.Zhang JM, Donnelly DF, LaMotte RH. J Neurosci Methods. 1998 Jan 31. PMID: 9531465.
- Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons.Zhang JM, Donnelly DF, Song XJ, Lamotte RH. J Neurophysiol. 1997 Nov. PMID: 9356426.
- An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion.Zhang JM, Song XJ, LaMotte RH. Pain. 1997 Aug. PMID: 9272787.
- Tensile and compressive responses of nociceptors in rat hairy skin.Khalsa PS, LaMotte RH, Grigg P. J Neurophysiol. 1997 Jul. PMID: 9242296.
- Neural encoding of shape: responses of cutaneous mechanoreceptors to a wavy surface stroked across the monkey fingerpad.LaMotte RH, Srinivasan MA. J Neurophysiol. 1996 Dec. PMID: 8985876.
- Multiple capsaicin-evoked currents in isolated rat sensory neurons.Petersen M, Lamotte RH, Klusch A, Kniffki KD. Neuroscience. 1996 Nov. PMID: 8931013.
- Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction.Petersen M, Zhang J, Zhang JM, LaMotte RH. Pain. 1996 Oct. PMID: 8951934.
- Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat.LaMotte RH, Zhang JM, Petersen M. Prog Brain Res. 1996. PMID: 9000719.
- Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat.Xie Y, Zhang J, Petersen M, LaMotte RH. J Neurophysiol. 1995 May. PMID: 7623082.
- Tactual discrimination of softness.Srinivasan MA, LaMotte RH. J Neurophysiol. 1995 Jan. PMID: 7714593.
- Cutaneous neural codes for shape.LaMotte RH, Srinivasan MA, Lu C, Klusch-Petersen A. Can J Physiol Pharmacol. 1994 May. PMID: 7954079.
- Responses of cutaneous mechanoreceptors to the shape of objects applied to the primate fingerpad.LaMotte RH, Srinivasan MA. Acta Psychol (Amst). 1993 Oct. PMID: 8237455.
- Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells.Petersen M, LaMotte RH. Pain. 1993 Jul. PMID: 7690929.
- Cutaneous mechanoreceptors of the hand: experimental studies and their implications for clinical testing of tactile sensation.Greenspan JD, LaMotte RH. J Hand Ther. 1993 Apr-Jun. PMID: 8343885.
- Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans.Torebjörk HE, Lundberg LE, LaMotte RH. J Physiol. 1992 Mar. PMID: 1593489.
- Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.LaMotte RH, Lundberg LE, Torebjörk HE. J Physiol. 1992 Mar. PMID: 1593488.
- Relationships between capsaicin sensitivity of mammalian sensory neurons, cell size and type of voltage gated Ca-currents.Petersen M, LaMotte RH. Brain Res. 1991 Oct 4. PMID: 1665752.
- Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons.Simone DA, Sorkin LS, Oh U, Chung JM, Owens C, LaMotte RH, Willis WD. J Neurophysiol. 1991 Jul. PMID: 1919669.
- Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia.Baumann TK, Simone DA, Shain CN, LaMotte RH. J Neurophysiol. 1991 Jul. PMID: 1919668.
- Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms.LaMotte RH, Shain CN, Simone DA, Tsai EF. J Neurophysiol. 1991 Jul. PMID: 1919666.
- Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine.Simone DA, Alreja M, LaMotte RH. Somatosens Mot Res. 1991. PMID: 1767623.
- A model of peripheral mononeuropathy in the rat.Hirata H, Pataky A, Kajander K, LaMotte RH, Collins JG. Pain. 1990 Aug. PMID: 2174143.
- Tactile detection of slip: surface microgeometry and peripheral neural codes.Srinivasan MA, Whitehouse JM, LaMotte RH. J Neurophysiol. 1990 Jun. PMID: 2358880.
- Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin.Simone DA, Baumann TK, LaMotte RH. Pain. 1989 Jul. PMID: 2780068.
- Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin.Simone DA, Baumann TK, Collins JG, LaMotte RH. Brain Res. 1989 May 1. PMID: 2720428.
- Psychophysical and neurophysiological studies of chemically induced cutaneous pain and itch. The case of the missing nociceptor.Lamotte RH. Prog Brain Res. 1988. PMID: 3187041.
- Hyperalgesia to heat after intradermal injection of capsaicin.Simone DA, Ngeow JY, Putterman GJ, LaMotte RH. Brain Res. 1987 Aug 18. PMID: 3664271.
- Tactile discrimination of shape: responses of slowly and rapidly adapting mechanoreceptive afferents to a step indented into the monkey fingerpad.Srinivasan MA, LaMotte RH. J Neurosci. 1987 Jun. PMID: 3598642.
- Tactile discrimination of shape: responses of rapidly adapting mechanoreceptive afferents to a step stroked across the monkey fingerpad.LaMotte RH, Srinivasan MA. J Neurosci. 1987 Jun. PMID: 3598641.
- Tactile discrimination of shape: responses of slowly adapting mechanoreceptor afferents to a step stroked across the monkey fingerpad.LaMotte RH, Srinivasan MA. J Neurosci. 1987 Jun. PMID: 3598640.
- The magnitude and duration of itch produced by intracutaneous injections of histamine.Simone DA, Ngeow JY, Whitehouse J, Becerra-Cabal L, Putterman GJ, LaMotte RH. Somatosens Res. 1987. PMID: 3423533.
- James Daniel Hardy (1904-1985). Tribute to a pioneer in pain psychophysics.LaMotte RH. Pain. 1986 Oct. PMID: 3537920.
- Tactile detection of a dot on a smooth surface: peripheral neural events.LaMotte RH, Whitehouse J. J Neurophysiol. 1986 Oct. PMID: 3097273.
- Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human.LaMotte RH, Torebjörk HE, Robinson CJ, Thalhammer JG. J Neurophysiol. 1984 Jun. PMID: 6737035.
- Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers.Torebjörk HE, LaMotte RH, Robinson CJ. J Neurophysiol. 1984 Feb. PMID: 6707724.