2025
Cannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients
Mannes Z, Wall M, Alschuler D, Malte C, Olfson M, Livne O, Fink D, Keyhani S, Keyes K, Martins S, Cerdá M, Sacco D, Gutkind S, Maynard C, Sherman S, Saxon A, Hasin D. Cannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients. JAMA Health Forum 2025, 6: e251369. PMID: 40512510, PMCID: PMC12166489, DOI: 10.1001/jamahealthforum.2025.1369.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationVeterans Health Administration patientsMedical cannabis lawsOpioid use disorderPrevalence of opioid use disorderClassification of DiseasesRecreational cannabis lawsChronic painVeterans Health Administration electronic health recordClinical ModificationConsistent with overall findingsState medical cannabis lawsInternational Statistical Classification of DiseasesReceipt of prescription opioidsStatistical Classification of DiseasesElectronic health recordsInternational Classification of DiseasesNon-Hispanic whitesOpioid use disorder diagnosisOpioid use disorder prevalenceInternational Statistical ClassificationDifference-in-differences analysisCannabis lawsUse disorderBurden of opioid use disorderThe COVID-19 Pandemic and Goals-of-Care Conversations in Veterans Health Administration Clinics
Linsky A, Canter B, Glickman M, Qian S, Ryan S, Still M, Fried T, Wiener R. The COVID-19 Pandemic and Goals-of-Care Conversations in Veterans Health Administration Clinics. JAMA Network Open 2025, 8: e2515980. PMID: 40522660, DOI: 10.1001/jamanetworkopen.2025.15980.Peer-Reviewed Original ResearchConceptsAdvance care planningGoals-of-care conversationsHealth care deliveryCare planningCare deliveryRetrospective cohort studyUS Veterans Health Administration facilitiesImprove advance care planningVeterans Health Administration clinicsVeterans Health Administration facilitiesGoals-of-careFacility-level characteristicsCOVID-19 pandemicHealth care systemYear 3First-everCohort study of patientsRetrospective cohort study of patientsFacility levelStaffing shortagesCare systemOutpatient appointmentsMain OutcomesAdministration facilitiesSecondary analysisVirtual Patient-PCP-Hospitalist Care Transition Meeting Before Hospital Discharge
Li J, Reuter M, Schmidt J, Moore N, Forget N, Carron J, Ernest J, Williams M. Virtual Patient-PCP-Hospitalist Care Transition Meeting Before Hospital Discharge. JAMA Network Open 2025, 8: e2515848. PMID: 40512492, PMCID: PMC12166488, DOI: 10.1001/jamanetworkopen.2025.15848.Peer-Reviewed Original ResearchConceptsPrimary care practitionersAcceptability of Intervention MeasureIntervention appropriateness measureQuality improvement studyImprovement studyPerceptions of care coordinationCenters for Medicare & Medicaid ServicesHospital dischargeHealth care systemIncrease patient confidenceOpen-ended questionsFamily caregiversCare coordinationRelational EmpathyDischarge planningPatient feedbackCare practitionersCare questionsCare systemPatients' perceptionsMedicaid ServicesPatient confidenceHospital settingHospitalistsMain OutcomesResistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa
Ntshiqa T, Velen K, Ginindza S, Nhlangulela L, Charalambous S, Hawn T, Churchyard G, Boom W, Chihota V, Wallis R. Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa. PLOS ONE 2025, 20: e0318819. PMID: 40343976, PMCID: PMC12063869, DOI: 10.1371/journal.pone.0318819.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyTuberculin skin testCD4 countQFT-PlusAssociated with lower CD4 countsTST responseQuantiFERON-TB Gold PlusBody mass index >Median CD4 countLow CD4 countExposure to TBRates of HIVLongitudinal cohort studyMedian ageTST/IGRAAntiretroviral treatmentMedian timePreventive therapySkin testFollow-upCohort studyLogistic regressionHIVMonthsAssay conversionHypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis
Adams T, Redlich C, Glazer C, Gulati M. Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis. PLOS ONE 2025, 20: e0323093. PMID: 40338891, PMCID: PMC12061107, DOI: 10.1371/journal.pone.0323093.Peer-Reviewed Original ResearchConceptsDiagnosis of HPHP patientsRetrospective cohort of patientsMold exposureTransplant free survivalCohort of patientsRetrospective cohort analysisMedical chart reviewDevelopment of HPHypersensitivity pneumonitis patientsHome moldFibrotic HPFree survivalAntigen exposureChart reviewConfident diagnosisRetrospective cohortPneumonic patientsInvasive proceduresHypersensitivity pneumonitisCohort analysisCulprit antigenPatientsImprove outcomesCohortValidity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes
Ferrante N, Hubbard R, Weinfurtner K, Mezina A, Newcomb C, Furth E, Bhattacharya D, Njei B, Taddei T, Singal A, Hoteit M, Park L, Kaplan D, Re V. Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes. Pharmacoepidemiology And Drug Safety 2025, 34: e70154. PMID: 40328444, PMCID: PMC12055315, DOI: 10.1002/pds.70154.Peer-Reviewed Original ResearchConceptsPositive predictive valueVeterans Health AdministrationExtrahepatic cholangiocarcinomaValidity of diagnostic codesInternational Classification of Diseases for OncologyUS Veterans Health AdministrationConfidence intervalsPharmacoepidemiological studiesICD-O-3Days of diagnosisVA dataHealth AdministrationIntrahepatic cholangiocarcinomaDiagnostic codesHistology codesCholangiocarcinomaUnique patientsInclusion criteriaCholangiocarcinoma subtypesTopography codesPredictive valuePatientsEvaluate medicationsSubtypesEvaluate determinantsPrognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease
Qiu Y, Jacobs D, Messer K, Salmon D, Wellington C, Stukas S, Revta C, Brewer J, Léger G, Askew B, Donahue L, Kaplita S, Coric V, Qureshi I, Feldman H. Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease. Alzheimer's Research & Therapy 2025, 17: 97. PMID: 40317057, PMCID: PMC12046789, DOI: 10.1186/s13195-025-01745-3.Peer-Reviewed Original ResearchConceptsMild to moderate ADADAS-cog11CDR-SBBaseline plasma NfLAlzheimer's diseasePlasma biomarkersMild-to-moderate Alzheimer's diseasePrognostic valueClinical trialsBaseline NfLPlasma NfLPlacebo-controlled trialCortical volumeConcentrations of plasma biomarkersMethodsPost hoc analysisDesign of clinical trialsClinical outcome dataIncreased ventricular volumeTrial participantsVolumetric MRIBaseline concentrationsEarly disease stagesClinical trial designTrial entry criteriaAD trialsGender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries
Balkan E, Babbs G, Meyers D, Kelly P, Yee K, Pletta D, Shireman T, Alpert A, Baker K, Hughto J. Gender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries. JAMA Network Open 2025, 8: e258072. PMID: 40310645, PMCID: PMC12046427, DOI: 10.1001/jamanetworkopen.2025.8072.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCross-Sectional StudiesFemaleHumansMaleMedicareMiddle AgedTransgender PersonsUnited StatesConceptsGender-affirming surgeryTransgender individualsRates of chronic conditionsTransgenderBeneficiaries' useProportion of residentsRegional differencesDual statusBeneficiariesChronic conditionsDiverse beneficiariesBeneficiary characteristicsMedicare beneficiariesGenderCross-sectional studyMedicare entitlementGender-affirming surgical proceduresPropensity score matchingNational Medicare dataMedicare programMedicaidProportion of Medicare beneficiariesSouthSurgical proceduresDescriptive analysisHospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Mathis M, Mentz G, Cao J, Balczewski E, Janda A, Likosky D, Schonberger R, Hawkins R, Heung M, Ailawadi G, Ladhania R, Sjoding M, Kheterpal S, Singh K, Sundt T, Fitzsimons M, Shann K, Kumar V, Yarboro L, Naik B, Tibayan F, Aziz M, Mulligan M, Jelacic S, Kaneko T, Graetz T, Assi R, Mallidi H, Querejeta-Roca G, Shook D, Tsai C, Jewell E, Wanderer J, Freundlich R, Rock P, Douville N, Fisher C, Pace N, Domino K, Wagener G, King C, O'Reilly-Shah V, Bardia A, Clark D. Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury. JAMA Network Open 2025, 8: e258342. PMID: 40314957, PMCID: PMC12048843, DOI: 10.1001/jamanetworkopen.2025.8342.Peer-Reviewed Original ResearchConceptsAcute kidney injuryClinician-level variationAssociated with acute kidney injuryAcute kidney injury ratesCardiac surgeryIntraclass correlation coefficientAdult patientsKidney injuryCohort studyCohort study of adult patientsResuscitation practicesPostoperative acute kidney injuryOperating room practiceStudy of adult patientsAssociated with increased morbidityCardiac surgical proceduresCardiac surgical databasePractice variationRBC transfusion ratesFluid volume administrationHospital-level variationMultilevel mixed-effects modelsPatient-level characteristicsRisk-adjustment modelsHealth care costsMedicaid Costs and Outcomes for Patients Treated in an Outpatient Telepsychiatry Clinic
Havlik J, Ghomi R, An N, Budhiraja P, Arzubi E. Medicaid Costs and Outcomes for Patients Treated in an Outpatient Telepsychiatry Clinic. JAMA Network Open 2025, 8: e258558. PMID: 40323598, DOI: 10.1001/jamanetworkopen.2025.8558.Peer-Reviewed Original ResearchConceptsTelepsychiatry clinicRate of admissionCross-sectional studyMedicaid costsEmergency departmentClinical servicesMedicaid patientsHospitalization ratesTelepsychiatry patientsEvidence of cost savingsReduce hospital admissionsInpatient hospitalization ratesClinic patientsAnnual hospitalization rateOutcomes associated with useTelepsychiatry carePropensity-matched controlsTimely carePsychiatric careMain OutcomesCare costsPMPM costsHospital readmissionInpatient hospitalizationTelepsychiatryExamining the Factor Structure of the Acquired Capability for Suicide Scale (ACSS) in a Military Population: Initial Development and Validation of a Four-Factor Version of the ACSS
Thomas K, Hoyt W, Goldberg S, Abbas M, Schultz M, Hiserodt M, Wyman M. Examining the Factor Structure of the Acquired Capability for Suicide Scale (ACSS) in a Military Population: Initial Development and Validation of a Four-Factor Version of the ACSS. Psychological Services 2025, 22: 312-323. PMID: 39636588, PMCID: PMC12011536, DOI: 10.1037/ser0000917.Peer-Reviewed Original ResearchConceptsInterpersonal theory of suicideTheory of suicideFour-factor versionInterpersonal theorySuicide ScaleAcquired CapabilityFactor structureMilitary populationNational Guard service membersReturn from deploymentConfirmatory factor analysisMonths postdeploymentMilitary sampleSuicidal behaviorPreliminary supportPredictive validityPostdeployment dataAssessment pointsSuicideService membersTheory-relevantVeteran populationLife experiencesFour-factorAdequate validityRadiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study
Justet A, Jackson L, Bardon M, Lerouge D, Césaire M, Loiseau C, Bergot E, Christy F, Thariat J. Radiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study. Cancer/Radiothérapie 2025, 29: 104622. PMID: 40311519, DOI: 10.1016/j.canrad.2025.104622.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseNon-small cell lung cancerProgression-free survivalCell lung cancerOverall survivalLung diseaseCase-control studyLung cancerCentral reviewOligometastatic non-small cell lung cancerMedian progression-free survivalCase-control study of patientsPrevalence of interstitial lung diseaseConsecutive lung cancer patientsIntensity-modulated radiotherapyStereotactic body radiotherapyMedian overall survivalThree-dimensional radiotherapyScore of fibrosisPrognosis of patientsGround-glass patternInterstitial pulmonary fibrosisStudy of patientsLung cancer patientsCancer treatment characteristicsAortic valve calcium as a novel risk marker for kidney function deterioration: The MESA study
Abdollahi A, Sani M, Shabani M, Matuck B, Blaha M, Wu C, Ambale-Venkatesh B, Budoff M, Strom J, Rotter J, Post W, Blumenthal R, Bluemke D, Ghahramani N, Lima J, Whelton S. Aortic valve calcium as a novel risk marker for kidney function deterioration: The MESA study. European Journal Of Internal Medicine 2025, 136: 49-55. PMID: 40263084, DOI: 10.1016/j.ejim.2025.03.037.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisRisk of incident chronic kidney diseaseIncident chronic kidney diseaseAortic valve calciumInternational Classification of DiseasesChronic kidney diseaseCardiac CT scansAdjusted Cox proportional hazards regression modelsMultivariable adjusted Cox proportional hazards regression modelsParticipants free of chronic kidney diseaseCardiovascular diseaseMulti-Ethnic Study of Atherosclerosis studyValve calciumCT scanCVD risk factorsHistory of cardiovascular diseaseCategorized as 0Higher risk of incident CKDFree of chronic kidney diseaseAssociated with increased risk of mortalityMulti-Ethnic StudyAtherosclerotic CVD risk factorsMulti-ethnic cohortAPOE-e4 genotypeClassification of DiseasesClinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome
Zhang Z, Hu X, Du Q, Mo P, Chen X, Luo M, Jiang Q, Deng L, Xiong Y. Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome. BMC Infectious Diseases 2025, 25: 508. PMID: 40217170, DOI: 10.1186/s12879-025-10900-y.Peer-Reviewed Original ResearchConceptsDisseminated intravascular coagulationOutcomes of disseminated intravascular coagulationPresence of disseminated intravascular coagulationNon-DIC groupIndependent risk factorIntravascular coagulationClinical characteristicsRisk factorsDisseminated intravascular coagulation groupThrombocytopenia syndromeMultivariate logistic regression analysisAssociated with high mortalityIn-hospital mortality of patientsCumulative survival rateZhongnan Hospital of Wuhan UniversityMortality of patientsIn-hospital mortalitySevere feverLogistic regression analysisConsecutive patientsFerritin levelsD-dimerViral loadClinical dataCystatin CGeographic patterns in wildland fire exposures and county-level lung cancer mortality in the United States
Remigio R, Buller I, Bogle M, Kamenetsky M, Ammons S, Bell J, Fisher J, Freedman N, Jones R. Geographic patterns in wildland fire exposures and county-level lung cancer mortality in the United States. International Journal Of Health Geographics 2025, 24: 8. PMID: 40217528, DOI: 10.1186/s12942-025-00394-x.Peer-Reviewed Original ResearchMeSH KeywordsEnvironmental ExposureFemaleHumansLung NeoplasmsMaleMiddle AgedMortalityUnited StatesWildfiresConceptsLung cancer mortality ratesLung cancer mortalityCigarette smoking prevalenceCancer mortalityWestern USSmoking prevalenceBurned land areasNational Center for Health StatisticsCenter for Health StatisticsLand areaExposure-response assessmentLee's L statisticGeographic patternsMid‐Appalachian regionCombustion by-productsConterminous United StatesSex-specificUnited StatesHealth StatisticsEvaluate geographic patternsWildland firesPoisson regressionMultiple comparisonsUS countiesBivariate associationsDaily Minority Stressors, Threat Appraisal, and Identity Concealment Among Trauma-Exposed Sexual Minority Women and Transgender and Gender-Diverse People
Scheer J, Jackson S, Cascalheira C, Behari K, Helminen E, Batchelder A, Sullivan T. Daily Minority Stressors, Threat Appraisal, and Identity Concealment Among Trauma-Exposed Sexual Minority Women and Transgender and Gender-Diverse People. Journal Of Counseling Psychology 2025, 72: 211-222. PMID: 39928459, DOI: 10.1037/cou0000782.Peer-Reviewed Original ResearchConceptsSexual minority womenTGD peopleMinority stressorsIdentity concealmentGender minority peopleGender diverse peopleAvoidant copingThreat appraisalMinority stressMinority WomenMinority peopleWhite dominationAssociated with concealmentStigma exposureWestern narrativesLower avoidance copingBetween-person levelGender diversityTransgenderIntensive longitudinal studyTGDMinorityIndividual characteristicsSpecific contextsCounseling psychologistsEnsemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images PRESENT SHD
Dhingra L, Aminorroaya A, Sangha V, Pedroso A, Shankar S, Coppi A, Foppa M, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images PRESENT SHD. Journal Of The American College Of Cardiology 2025, 85: 1302-1313. PMID: 40139886, DOI: 10.1016/j.jacc.2025.01.030.Peer-Reviewed Original ResearchConceptsStructural heart diseaseYale-New Haven HospitalTransthoracic echocardiogramRisk stratificationHeart failureLeft-sided valvular diseaseSevere left ventricular hypertrophyLeft ventricular ejection fractionReceiver-operating characteristic curveVentricular ejection fractionLeft ventricular hypertrophyHeart disease screeningELSA-BrasilEnsemble deep learning algorithmRisk of deathConvolutional neural network modelEjection fractionEnsemble deep learning approachVentricular hypertrophyDeep learning algorithmsNew Haven HospitalDeep learning approachValvular diseaseNeural network modelClinical cohortSocioeconomic and demographic disparities in the impact of digestive diseases in the middle East and North Africa (MENA) region
Al Ta’ani O, Al-Ajlouni Y, Lahoud C, Almasaid S, Alhalalmeh Y, Oweis Z, Danpanichkul P, Baidoun A, Alsakarneh S, Dahiya D, Njei B. Socioeconomic and demographic disparities in the impact of digestive diseases in the middle East and North Africa (MENA) region. International Journal For Equity In Health 2025, 24: 85. PMID: 40148874, PMCID: PMC11951616, DOI: 10.1186/s12939-025-02448-9.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsEstimated annual percentage changeSocio-demographic indexAge-standardized incidence rateDisability-adjusted life year ratesGlobal Burden of DiseaseMiddle East and North AfricaGender Inequality IndexHuman Development IndexMiddle East and North Africa regionImpact of socioeconomic disparitiesIncidence rateAge-standardized mortalityAge-standardized ratesAnnual percentage changePercentage changeInfluence disease burdenBurden of DDBurden of diseasePublic health challengeHighest incidence rateSocioeconomic disparitiesDD incidenceTargeted interventionsNorth AfricaMultilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study
Whittemore R, Jeon S, Akyirem S, Chen H, Lipson J, Minchala M, Wagner J. Multilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study. JMIR Formative Research 2025, 9: e67293. PMID: 40131327, DOI: 10.2196/67293.Peer-Reviewed Original ResearchConceptsCommunity health centersPatient portal useDigital health literacyPortal useHealth literacyMultilevel interventionsType 2 diabetesSocial determinants of healthDiabetes self-management educationCommunity health workersImprove health equityDeterminants of healthSelf-management educationDiabetes self-efficacyHealth-related outcomesBarriers to clinical integrationPre-post designHemoglobin A<sub>1c</sub> levelDiabetes distressHealth equityPatient portalsSocial determinantsDeliver carePortal accountHealth appsModerate alcohol-associated hepatitis: A real-world multicenter study
Idalsoaga F, Díaz L, Dunn W, Mehta H, Muñoz K, Caldentey V, Arnold J, Ayares G, Mortuza R, Sarin S, Maiwall R, Zhang W, Qian S, Simonetto D, Singal A, Elfeki M, Ramirez-Cadiz C, Malhi G, Ahmed A, Homsi H, Abid Z, Cabezas J, Echavarría V, Poca M, Soriano G, Cuyas B, Cots M, La Tijera M, Ayala-Valverde M, Perez D, Gomez J, Abraldes J, Al-Karaghouli M, Jalal P, Ibrahim M, García-Tsao G, Goyes D, Skladaný L, Havaj D, Sulejova K, Selcanova S, Rincón D, Chacko K, Restrepo J, Yaquich P, Toro L, Shah V, Arrese M, Kamath P, Bataller R, Arab J. Moderate alcohol-associated hepatitis: A real-world multicenter study. Hepatology Communications 2025, 9: e0673. PMID: 40131003, PMCID: PMC11936654, DOI: 10.1097/hc9.0000000000000673.Peer-Reviewed Original ResearchConceptsSevere alcohol-associated hepatitisNeutrophil-to-lymphocyte ratioMaddrey's discriminant functionModerate AHMultiple organ failureOrgan failureMulticenter retrospective cohort studyAlcohol-associated hepatitisCumulative survival rateRetrospective cohort studyReceiver operating characteristic curveLong-term outcomesShort-term mortalityMortality scoring systemsPrognostic factorsSerum bilirubinMELD scoreWell-characterized diseaseClinical profileMedian MELDCohort studyCox regressionMultivariate analysisTherapeutic strategiesSurvival rate
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply