2025
Visualizing nuclear pore complex plasticity with pan-expansion microscopy
Morgan K, Carley E, Coyne A, Rothstein J, Lusk C, King M. Visualizing nuclear pore complex plasticity with pan-expansion microscopy. Journal Of Cell Biology 2025, 224: e202409120. PMID: 40504117, PMCID: PMC12162248, DOI: 10.1083/jcb.202409120.Peer-Reviewed Original ResearchOrchestrating Neural Development Through mRNA Translation Regulation
Rodrigue B, Sajish M, Salmaso N, Aguilar‐Valles A. Orchestrating Neural Development Through mRNA Translation Regulation. Journal Of Neurochemistry 2025, 169: e70128. PMID: 40509688, PMCID: PMC12163303, DOI: 10.1111/jnc.70128.Peer-Reviewed Original ResearchConceptsMRNA translation regulationRegulation of mRNA translationMammalian/mechanistic target of rapamycin complex 1MRNA translationTranslational regulationFragile X Messenger Ribonucleoprotein 1Neural developmentGene expressionRegulation of gene expressionCell fate decisionsControlling gene expressionControl of brain developmentTarget of rapamycin complex 1Integrated stress responseNeuronal growth conesDysregulation of mRNA translationRapamycin complex 1Fate decisionsSubcellular compartmentsTranscriptional controlSignaling cascadesFragile X syndromeAxon guidanceMammalian/mechanistic targetStem cell proliferationCannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients
Mannes Z, Wall M, Alschuler D, Malte C, Olfson M, Livne O, Fink D, Keyhani S, Keyes K, Martins S, Cerdá M, Sacco D, Gutkind S, Maynard C, Sherman S, Saxon A, Hasin D. Cannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients. JAMA Health Forum 2025, 6: e251369. PMID: 40512510, PMCID: PMC12166489, DOI: 10.1001/jamahealthforum.2025.1369.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationVeterans Health Administration patientsMedical cannabis lawsOpioid use disorderPrevalence of opioid use disorderClassification of DiseasesRecreational cannabis lawsChronic painVeterans Health Administration electronic health recordClinical ModificationConsistent with overall findingsState medical cannabis lawsInternational Statistical Classification of DiseasesReceipt of prescription opioidsStatistical Classification of DiseasesElectronic health recordsInternational Classification of DiseasesNon-Hispanic whitesOpioid use disorder diagnosisOpioid use disorder prevalenceInternational Statistical ClassificationDifference-in-differences analysisCannabis lawsUse disorderBurden of opioid use disorderThe COVID-19 Pandemic and Goals-of-Care Conversations in Veterans Health Administration Clinics
Linsky A, Canter B, Glickman M, Qian S, Ryan S, Still M, Fried T, Wiener R. The COVID-19 Pandemic and Goals-of-Care Conversations in Veterans Health Administration Clinics. JAMA Network Open 2025, 8: e2515980. PMID: 40522660, DOI: 10.1001/jamanetworkopen.2025.15980.Peer-Reviewed Original ResearchConceptsAdvance care planningGoals-of-care conversationsHealth care deliveryCare planningCare deliveryRetrospective cohort studyUS Veterans Health Administration facilitiesImprove advance care planningVeterans Health Administration clinicsVeterans Health Administration facilitiesGoals-of-careFacility-level characteristicsCOVID-19 pandemicHealth care systemYear 3First-everCohort study of patientsRetrospective cohort study of patientsFacility levelStaffing shortagesCare systemOutpatient appointmentsMain OutcomesAdministration facilitiesSecondary analysisVirtual Patient-PCP-Hospitalist Care Transition Meeting Before Hospital Discharge
Li J, Reuter M, Schmidt J, Moore N, Forget N, Carron J, Ernest J, Williams M. Virtual Patient-PCP-Hospitalist Care Transition Meeting Before Hospital Discharge. JAMA Network Open 2025, 8: e2515848. PMID: 40512492, PMCID: PMC12166488, DOI: 10.1001/jamanetworkopen.2025.15848.Peer-Reviewed Original ResearchConceptsPrimary care practitionersAcceptability of Intervention MeasureIntervention appropriateness measureQuality improvement studyImprovement studyPerceptions of care coordinationCenters for Medicare & Medicaid ServicesHospital dischargeHealth care systemIncrease patient confidenceOpen-ended questionsFamily caregiversCare coordinationRelational EmpathyDischarge planningPatient feedbackCare practitionersCare questionsCare systemPatients' perceptionsMedicaid ServicesPatient confidenceHospital settingHospitalistsMain OutcomesMapping pesticide-induced metabolic alterations in human gut bacteria
Chen L, Yan H, Di S, Guo C, Zhang H, Zhang S, Gold A, Wang Y, Hu M, Wu D, Johnson C, Wang X, Zhu J. Mapping pesticide-induced metabolic alterations in human gut bacteria. Nature Communications 2025, 16: 4355. PMID: 40348778, PMCID: PMC12065874, DOI: 10.1038/s41467-025-59747-6.Peer-Reviewed Original ResearchConceptsModulating gut microbiota compositionGut bacteria speciesGut microbial speciesHuman gut bacteriaGut microbiota compositionGut bacterial metabolismPesticide exposureHost healthGut bacteriaMicrobiota compositionMicrobial speciesBacterial metabolismBacteria speciesMolecular mechanismsComprehensive atlasLipid metabolismGutIn vivo mouse modelPesticidesHostMetabolismSpeciesInteractive atlasMouse modelMetabolic changesAn exploration of trauma-informed care curricula in chiropractic programs: A scoping document analysis protocol
Bensel V, Cupler Z, Poppen O, Joyce J, Allgeier M, Wiles M, Driscoll M, Carbonelli-Cloutier K, Coleman B. An exploration of trauma-informed care curricula in chiropractic programs: A scoping document analysis protocol. PLOS ONE 2025, 20: e0321498. PMID: 40343894, PMCID: PMC12063856, DOI: 10.1371/journal.pone.0321498.Peer-Reviewed Original ResearchConceptsDoctor of chiropractic programTrauma-informed careChiropractic educationChiropractic programsTrauma-informed care trainingTrauma-informed care curriculumRisk of re-traumatizationSubstance Abuse and Mental Health Services AdministrationMental Health Services AdministrationSignificant public health issueHealth Services AdministrationPublic health issueChiropractic careChiropractic trainingImprove patient outcomesEnhance careCare curriculumHealthcare deliveryHealthcare settingsPhysical healthTrauma-exposed patientsServices AdministrationHealth issuesData extractionUnited StatesResistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa
Ntshiqa T, Velen K, Ginindza S, Nhlangulela L, Charalambous S, Hawn T, Churchyard G, Boom W, Chihota V, Wallis R. Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa. PLOS ONE 2025, 20: e0318819. PMID: 40343976, PMCID: PMC12063869, DOI: 10.1371/journal.pone.0318819.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyTuberculin skin testCD4 countQFT-PlusAssociated with lower CD4 countsTST responseQuantiFERON-TB Gold PlusBody mass index >Median CD4 countLow CD4 countExposure to TBRates of HIVLongitudinal cohort studyMedian ageTST/IGRAAntiretroviral treatmentMedian timePreventive therapySkin testFollow-upCohort studyLogistic regressionHIVMonthsAssay conversionPredicting adenine base editing efficiencies in different cellular contexts by deep learning
Kissling L, Mollaysa A, Janjuha S, Mathis N, Marquart K, Weber Y, Moon W, Lin P, Fan S, Muramatsu H, Vadovics M, Allam A, Pardi N, Tam Y, Krauthammer M, Schwank G. Predicting adenine base editing efficiencies in different cellular contexts by deep learning. Genome Biology 2025, 26: 115. PMID: 40340964, PMCID: PMC12060317, DOI: 10.1186/s13059-025-03586-7.Peer-Reviewed Original ResearchConceptsBase editing efficiencyEditing efficiencyCell linesPathogenic mutationsBase editingPrimary cells in vivoBase editing screensBase editing outcomesCells in vivoHEK293T cellsAdenine base editingIn vivo settingTarget lociT cellsLipid nanoparticlesCellular contextTarget sequenceMRNA deliveryBase pairsOn-target editingBystander effectEditing outcomesBase editorsIn vitro datasetsMurine liverHypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis
Adams T, Redlich C, Glazer C, Gulati M. Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis. PLOS ONE 2025, 20: e0323093. PMID: 40338891, PMCID: PMC12061107, DOI: 10.1371/journal.pone.0323093.Peer-Reviewed Original ResearchConceptsDiagnosis of HPHP patientsRetrospective cohort of patientsMold exposureTransplant free survivalCohort of patientsRetrospective cohort analysisMedical chart reviewDevelopment of HPHypersensitivity pneumonitis patientsHome moldFibrotic HPFree survivalAntigen exposureChart reviewConfident diagnosisRetrospective cohortPneumonic patientsInvasive proceduresHypersensitivity pneumonitisCohort analysisCulprit antigenPatientsImprove outcomesCohortValidity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes
Ferrante N, Hubbard R, Weinfurtner K, Mezina A, Newcomb C, Furth E, Bhattacharya D, Njei B, Taddei T, Singal A, Hoteit M, Park L, Kaplan D, Re V. Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes. Pharmacoepidemiology And Drug Safety 2025, 34: e70154. PMID: 40328444, PMCID: PMC12055315, DOI: 10.1002/pds.70154.Peer-Reviewed Original ResearchConceptsPositive predictive valueVeterans Health AdministrationExtrahepatic cholangiocarcinomaValidity of diagnostic codesInternational Classification of Diseases for OncologyUS Veterans Health AdministrationConfidence intervalsPharmacoepidemiological studiesICD-O-3Days of diagnosisVA dataHealth AdministrationIntrahepatic cholangiocarcinomaDiagnostic codesHistology codesCholangiocarcinomaUnique patientsInclusion criteriaCholangiocarcinoma subtypesTopography codesPredictive valuePatientsEvaluate medicationsSubtypesEvaluate determinantsLiver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis
Sakuma I, Gaspar R, Nasiri A, Dufour S, Kahn M, Zheng J, LaMoia T, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Huttasch M, Knebel B, Kahl S, Roden M, Samuel V, Tanaka T, Shulman G. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502978122. PMID: 40310463, DOI: 10.1073/pnas.2502978122.Peer-Reviewed Original ResearchConceptsCholine-deficient l-amino acid-defined high-fat dietBempedoic acidLiver fibrosisLiver diseaseL-amino acid-defined high-fat dietAdvanced liver diseaseCholesterol contentHSD17B13 variantsHigh-fat dietTotal liver cholesterol contentTreated miceActivate signaling pathwaysVariant rs738409Liver cholesterol contentLiver lipidsFibrotic responsePromote inflammationTherapeutic approachesSteatotic liver diseaseDietary cholesterol supplementationFibrosisHuman liver samplesI148MAntisense oligonucleotidesProgressive formBehavior engineering using quantitative reinforcement learning models
Dan O, Plonsky O, Loewenstein Y. Behavior engineering using quantitative reinforcement learning models. Nature Communications 2025, 16: 4109. PMID: 40316521, PMCID: PMC12048583, DOI: 10.1038/s41467-025-58888-y.Peer-Reviewed Original ResearchConceptsTwo-alternative taskReinforcement learning modelModel of choiceReward schedulePsychological principlesMethods of model comparisonEffects of engineeringCognitive scienceExperimental participantsShape behaviorQuantitative modelTheoretical importanceAnimal behaviorLearning modelsEngine behaviorBehavioral engineeringEngineeringEngineering approachModel comparisonTaskAcademic competitionQualitative principlesPrognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease
Qiu Y, Jacobs D, Messer K, Salmon D, Wellington C, Stukas S, Revta C, Brewer J, Léger G, Askew B, Donahue L, Kaplita S, Coric V, Qureshi I, Feldman H. Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease. Alzheimer's Research & Therapy 2025, 17: 97. PMID: 40317057, PMCID: PMC12046789, DOI: 10.1186/s13195-025-01745-3.Peer-Reviewed Original ResearchConceptsMild to moderate ADADAS-cog11CDR-SBBaseline plasma NfLAlzheimer's diseasePlasma biomarkersMild-to-moderate Alzheimer's diseasePrognostic valueClinical trialsBaseline NfLPlasma NfLPlacebo-controlled trialCortical volumeConcentrations of plasma biomarkersMethodsPost hoc analysisDesign of clinical trialsClinical outcome dataIncreased ventricular volumeTrial participantsVolumetric MRIBaseline concentrationsEarly disease stagesClinical trial designTrial entry criteriaAD trialsMedicare Parity and Outpatient Mental Health Service Use and Costs Among Beneficiaries With Depression
Tetlow S, Phillips V, Hockenberry J. Medicare Parity and Outpatient Mental Health Service Use and Costs Among Beneficiaries With Depression. JAMA Network Open 2025, 8: e258491. PMID: 40314953, PMCID: PMC12048850, DOI: 10.1001/jamanetworkopen.2025.8491.Peer-Reviewed Original ResearchConceptsMental health service useOutpatient mental health service useHealth service useOut-of-pocket expenditureMental health servicesOutpatient mental health servicesService useMedicare beneficiariesHealth servicesDepression screeningUS Preventive Services Task Force recommendationsAccessibility of mental health servicesMedical Expenditure Panel Survey Household ComponentInterrupted time series designOutpatient mental healthMental health careCost-sharingMental health conditionsEconomic evaluationProportion of beneficiariesTask Force recommendationsBarriers to treatmentNationally representative sampleTime series designOlder with depressionGender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries
Balkan E, Babbs G, Meyers D, Kelly P, Yee K, Pletta D, Shireman T, Alpert A, Baker K, Hughto J. Gender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries. JAMA Network Open 2025, 8: e258072. PMID: 40310645, PMCID: PMC12046427, DOI: 10.1001/jamanetworkopen.2025.8072.Peer-Reviewed Original ResearchConceptsGender-affirming surgeryTransgender individualsRates of chronic conditionsTransgenderBeneficiaries' useProportion of residentsRegional differencesDual statusBeneficiariesChronic conditionsDiverse beneficiariesBeneficiary characteristicsMedicare beneficiariesGenderCross-sectional studyMedicare entitlementGender-affirming surgical proceduresPropensity score matchingNational Medicare dataMedicare programMedicaidProportion of Medicare beneficiariesSouthSurgical proceduresDescriptive analysisHospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Mathis M, Mentz G, Cao J, Balczewski E, Janda A, Likosky D, Schonberger R, Hawkins R, Heung M, Ailawadi G, Ladhania R, Sjoding M, Kheterpal S, Singh K, Sundt T, Fitzsimons M, Shann K, Kumar V, Yarboro L, Naik B, Tibayan F, Aziz M, Mulligan M, Jelacic S, Kaneko T, Graetz T, Assi R, Mallidi H, Querejeta-Roca G, Shook D, Tsai C, Jewell E, Wanderer J, Freundlich R, Rock P, Douville N, Fisher C, Pace N, Domino K, Wagener G, King C, O'Reilly-Shah V, Bardia A, Clark D. Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury. JAMA Network Open 2025, 8: e258342. PMID: 40314957, PMCID: PMC12048843, DOI: 10.1001/jamanetworkopen.2025.8342.Peer-Reviewed Original ResearchConceptsAcute kidney injuryClinician-level variationAssociated with acute kidney injuryAcute kidney injury ratesCardiac surgeryIntraclass correlation coefficientAdult patientsKidney injuryCohort studyCohort study of adult patientsResuscitation practicesPostoperative acute kidney injuryOperating room practiceStudy of adult patientsAssociated with increased morbidityCardiac surgical proceduresCardiac surgical databasePractice variationRBC transfusion ratesFluid volume administrationHospital-level variationMultilevel mixed-effects modelsPatient-level characteristicsRisk-adjustment modelsHealth care costsMedicaid Costs and Outcomes for Patients Treated in an Outpatient Telepsychiatry Clinic
Havlik J, Ghomi R, An N, Budhiraja P, Arzubi E. Medicaid Costs and Outcomes for Patients Treated in an Outpatient Telepsychiatry Clinic. JAMA Network Open 2025, 8: e258558. PMID: 40323598, DOI: 10.1001/jamanetworkopen.2025.8558.Peer-Reviewed Original ResearchConceptsTelepsychiatry clinicRate of admissionCross-sectional studyMedicaid costsEmergency departmentClinical servicesMedicaid patientsHospitalization ratesTelepsychiatry patientsEvidence of cost savingsReduce hospital admissionsInpatient hospitalization ratesClinic patientsAnnual hospitalization rateOutcomes associated with useTelepsychiatry carePropensity-matched controlsTimely carePsychiatric careMain OutcomesCare costsPMPM costsHospital readmissionInpatient hospitalizationTelepsychiatryConversion Therapy Exposure and Elevated Cardiovascular Disease Risk
Gibb J, Schrock J, Smith M, D’Aquila R, McDade T, Mustanski B. Conversion Therapy Exposure and Elevated Cardiovascular Disease Risk. JAMA Network Open 2025, 8: e258745. PMID: 40327341, DOI: 10.1001/jamanetworkopen.2025.8745.Peer-Reviewed Original ResearchConceptsHigh blood pressureSystolic blood pressureDiastolic blood pressureSelf-reported high blood pressureCohort studyCardiovascular health dataCardiovascular health indicatorsSelf-reported hypertensionSGM health disparitiesMental health impactsCardiovascular health consequencesCardiovascular disease riskBlood pressureElevated diastolic blood pressureHealth disparitiesCare approachElevated systolic blood pressureHealth indicatorsMain OutcomesIncreased DBPBehavioral covariatesHealth dataSGM individualsDisease riskHealth consequencesPreclinical Activity of Datopotamab Deruxtecan, an Antibody-Drug Conjugate Targeting Trophoblast Cell-Surface Antigen 2, in Uterine Serous Carcinoma.
Greenman M, Demirkiran C, Bellone S, Hartwich T, McNamara B, Ettorre V, Santin N, Sethi N, Yang-Hartwich Y, Papatla K, Ratner E, Santin A. Preclinical Activity of Datopotamab Deruxtecan, an Antibody-Drug Conjugate Targeting Trophoblast Cell-Surface Antigen 2, in Uterine Serous Carcinoma. Cancer Research Communications 2025, 5: 774-782. PMID: 40299780, PMCID: PMC12062949, DOI: 10.1158/2767-9764.crc-25-0057.Peer-Reviewed Original ResearchConceptsTrophoblast cell surface antigen 2Uterine serous carcinomaAntibody-dependent cell-mediated cytotoxicityAntibody-drug conjugatesCell-mediated cytotoxicitySerous carcinomaPreclinical activityCell linesTargets trophoblast cell-surface antigen-2Presence of peripheral blood lymphocytesTreatment of uterine serous carcinomaInduce antibody-dependent cell-mediated cytotoxicityPrimary USC cell linesRecurrent uterine serous carcinomaUSC xenograftsUterine serous carcinoma cell linesAntigen 2In vivoPrimary tumor cell linesTROP2 overexpressionBiomarker-targeted therapiesControl ADCChromium release assayHigher recurrence rateTumor growth suppression
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