2025
Medicare Parity and Outpatient Mental Health Service Use and Costs Among Beneficiaries With Depression
Tetlow S, Phillips V, Hockenberry J. Medicare Parity and Outpatient Mental Health Service Use and Costs Among Beneficiaries With Depression. JAMA Network Open 2025, 8: e258491. PMID: 40314953, PMCID: PMC12048850, DOI: 10.1001/jamanetworkopen.2025.8491.Peer-Reviewed Original ResearchConceptsMental health service useOutpatient mental health service useHealth service useOut-of-pocket expenditureMental health servicesOutpatient mental health servicesService useMedicare beneficiariesHealth servicesDepression screeningUS Preventive Services Task Force recommendationsAccessibility of mental health servicesMedical Expenditure Panel Survey Household ComponentInterrupted time series designOutpatient mental healthMental health careCost-sharingMental health conditionsEconomic evaluationProportion of beneficiariesTask Force recommendationsBarriers to treatmentNationally representative sampleTime series designOlder with depressionDelineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis
Bronstein M, Kummerfeld E, Bearden C, Cornblatt B, Walker E, Woods S, Mathalon D, Perkins D, Cadenhead K, Addington J, Cannon T, Vinogradov S. Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis. Journal Of Psychopathology And Clinical Science 2025, 134: 239-250. PMID: 39913476, DOI: 10.1037/abn0000969.Peer-Reviewed Original ResearchConceptsClinical high riskNorth American Prodrome Longitudinal StudyClinical high-risk samplesAttenuated psychosis symptomsPathways to suicideSuicide risk reductionPsychosis symptomsCausal pathwaysDepressed moodPsychosisIntervention effortsSelf-deprecationSuicideLongitudinal studyMeasurement time pointsStudy timepointsHigh riskSymptomsInterventionHopelessnessMoodTime pointsDepressionIndividualsDirect causesRandomised controlled trial of LGBTQ-affirmative cognitive-behavioural therapy for sexual minority women’s minority stress, mental health and hazardous drinking: Project EQuIP protocol
Pachankis J, Chiaramonte D, Scheer J, Ankrum H, Eisenstadt B, Hobbs R, Baldwin H, Kidd J, Witkiewitz K, Esserman D, Plourde K, Drabble L, Hughes T. Randomised controlled trial of LGBTQ-affirmative cognitive-behavioural therapy for sexual minority women’s minority stress, mental health and hazardous drinking: Project EQuIP protocol. BMJ Open 2025, 15: e086738. PMID: 40032395, PMCID: PMC11877267, DOI: 10.1136/bmjopen-2024-086738.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapy interventionSexual minority womenMinority womenHazardous drinkingMinority stressRandomised controlled trialsProportion of heavy drinking daysSessions of supportive counselingComorbid mental health problemsRisk of hazardous drinkingCognitive-behavioral therapyHeavy drinking daysHazardous alcohol useHuman Subjects CommitteeMental health comorbiditiesMental health problemsAnxiety disordersAnxious symptomsDrinking daysEvidence-based interventionsSupportive counselingControlled trialsStress copingComorbid depression/anxietyDisproportionate riskPrenatal Cannabis Use and Depressive Symptoms
Pitt T, Allshouse A, Kim P, McMillin G, Silver R, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Metz T. Prenatal Cannabis Use and Depressive Symptoms. Obstetrics And Gynecology 2025, 145: 417-425. PMID: 40014863, PMCID: PMC11925678, DOI: 10.1097/aog.0000000000005860.Peer-Reviewed Original ResearchConceptsAssociated with later depressive symptomsCannabis exposureDepressive symptomsCannabis useTHC-COOHAssociated with increased depressive symptomsAssociated with greater oddsAssociated with depressive symptomsFirst-trimesterExposed to cannabisPregnancy outcome dataWeeks of gestationFirst-trimester exposureGreater oddsCannabis metabolitesSecondary analysisCannabisAssociated with increased oddsExploratory analysisUrine immunoassayTrimesterHigher levelsPrimary outcomePregnancyAcademic centersBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological healthUnderstanding depression in autism: the role of subjective perception and anterior cingulate cortex volume
Hao Y, Banker S, Trayvick J, Barkley S, Peters A, Thinakaran A, McLaughlin C, Gu X, Schiller D, Foss-Feig J. Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume. Molecular Autism 2025, 16: 9. PMID: 39930465, PMCID: PMC11812218, DOI: 10.1186/s13229-025-00638-4.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexAutism spectrum disorderSelf-reported depressionAnterior cingulate cortex volumeCo-occurring depressionAmygdala volumeAutism symptomsSocial functioningCingulate cortex volumeSocial interaction taskSocial interactionSocial interaction behaviorClinically diagnosed depressionHeterogeneity of autism spectrum disorderSubjective perceptionHeightened self-awarenessAutistic young adultsASD adultsDepressive phenotypeSocial deficitsCingulate cortexCross-sectional natureSocial impairmentPrevalence of depressionASD individualsAssociation of workforce participation with depression among US older adults: results from NHANES 2005–2018
Sun Z, Wang Y, Chen X, Qian D. Association of workforce participation with depression among US older adults: results from NHANES 2005–2018. BMC Geriatrics 2025, 25: 77. PMID: 39905307, PMCID: PMC11792604, DOI: 10.1186/s12877-025-05712-3.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyUS older adultsPHQ-9 scoresOlder adultsDepression riskLogistic regression modelsWorkforce participationPatient Health Questionnaire-9 itemsWork statusHealth and Nutrition Examination SurveyAnalysis of subgroupsRegular daytimeMethodsThis cross-sectional studyNutrition Examination SurveyPrevalence of depressionDecrease depression riskPotential reverse causationRegression modelsCross-sectional studyNon-linear associationInstrumental variablesPHQ-9Propensity score matchingExamination SurveyReverse causationBidirectional relationship between epigenetic age and stroke, dementia, and late-life depression
Rivier C, Szejko N, Renedo D, Clocchiatti-Tuozzo S, Huo S, de Havenon A, Zhao H, Gill T, Sheth K, Falcone G. Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression. Nature Communications 2025, 16: 1261. PMID: 39893209, PMCID: PMC11787333, DOI: 10.1038/s41467-024-54721-0.Peer-Reviewed Original ResearchThis study shows a bidirectional link between accelerated epigenetic aging and brain health events like stroke, dementia, and depression, supporting new prevention strategies for aging-related conditions.Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D’Onofrio G, Pilote L, Lichtman J. Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction. 2025, 87: 129-137. PMID: 39909011, DOI: 10.1097/psy.0000000000001363.Peer-Reviewed Original ResearchConceptsLow social supportCardiac-specific quality of lifeNatural direct effectSocial supportMonths post-AMIQuality of lifeAcute myocardial infarctionMarital stressComprehensive secondary preventive strategySignificant depressive symptomsPost-AMISecondary prevention strategiesYoung adultsMyocardial infarctionSociodemographic factorsDepressive symptomsAMI survivorsCovariate adjustmentPrevention strategiesSelf-reportContinuous scoresQoLBaseline QoLCategorical depressionDepressionBridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia
Guo H, Xiao Y, Dong S, Yang J, Zhao P, Zhao T, Cai A, Tang L, Liu J, Wang H, Hua R, Liu R, Wei Y, Sun D, Liu Z, Xia M, He Y, Wu Y, Si T, Womer F, Xu F, Tang Y, Wang J, Zhang W, Zhang X, Wang F. Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia. BMC Medicine 2025, 23: 38. PMID: 39849528, PMCID: PMC11755933, DOI: 10.1186/s12916-025-03850-4.Peer-Reviewed Original ResearchConceptsIntermediate phenotypesCore symptoms of depressionAmplitude of low-frequency fluctuationNeuroimaging patternsSubtypes of depressionCore depressive symptomsExpression of risk genesDiverse clinical populationsSymptoms of depressionRodent modelsAssociated with depressionLow-frequency fluctuationsStress-related changesDepression subtypesCore symptomsCross-species validationPsychiatric disordersNeuropsychiatric disordersDepressive symptomsBehavioral manifestationsStress modelDepression cohortClinical populationsSensorimotor regionsAnhedoniaAssociation between prenatal depressive symptoms and receipt of recommended maternal and infant care postpartum
Masters C, Carandang R, Rojina J, Lewis J, Ickovics J, Cunningham S, Hagaman A. Association between prenatal depressive symptoms and receipt of recommended maternal and infant care postpartum. Journal Of Affective Disorders 2025, 375: 174-179. PMID: 39862978, DOI: 10.1016/j.jad.2025.01.111.Peer-Reviewed Original ResearchConceptsPrenatal depressive symptomsPostpartum check-upPrenatal depressionDepressive symptomsImpact health care accessImpact of maternal depressionCheck-upGroup prenatal careMaternal mental healthInfant receiptHealth care accessMental health interventionsReceipt of recommended vaccinationsReceipt of vaccinationPostpartum healthcareCare accessNo significant associationHealth interventionsPostpartum individualsMaternal depressionPrenatal careYear postpartumMental healthMonths postpartumPotential confoundersPolygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults. Journal Of Psychiatry And Neuroscience 2025, 50: e31-e44. PMID: 39809531, PMCID: PMC11737878, DOI: 10.1503/jpn.240087.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPolygenic risk scoresSubgenual anterior cingulate cortexAnterior cingulate cortexDepression severityCingulate cortexSubclinical depressionHealthy young adultsSomatic complaintsYoung adultsPolygenic riskAssociated with depression severitySeverity of somatic complaintsSeverity of depressive symptomsAssociated with polygenic riskWhole-brain regressionAlcohol use severityMarkers of depressionManifestations of depressionHuman Connectome ProjectDepressive disorderSubclinical populationsMode networkDepressive symptomsBrain structuresInsight and suicidality in first-episode psychosis: The mediating role of depression
Tayfur S, Song Z, Li F, Hazan H, Gibbs-Dean T, Purushothaman D, Karmani S, Terashima J, Tek C, Srihari V. Insight and suicidality in first-episode psychosis: The mediating role of depression. Schizophrenia Research 2025, 275: 189-195. PMID: 39754935, DOI: 10.1016/j.schres.2024.12.013.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisPredictors of suicideCoordinated specialty careTreatment of depressionPersistence of depressionEffects of depressionSuicide attemptsMediation analysisPrevent suicideDepressionSuicideImpact suicidePsychosisTargeted interventionsLongitudinal cohort studyEarly treatment stageParticipantsSignificant predictorsImproving clinical outcomesRegression analysisSpecialty careClinical outcomesCohort studyRelationshipMonths
2024
Happiness in US military veterans: Results from a nationally representative study
Kang H, Fischer I, Na P, Pietrzak R. Happiness in US military veterans: Results from a nationally representative study. PLOS ONE 2024, 19: e0313609. PMID: 39661580, PMCID: PMC11633995, DOI: 10.1371/journal.pone.0313609.Peer-Reviewed Original ResearchConceptsUS military veteransMilitary veteransNational Health and ResilienceWhole Health approachEmotional stabilityMean happiness scoreWell-beingPerception of well-beingSeverity of depressive symptomsNationally representative sampleCorrelates of happinessMeasures of optimismVeterans' perceptionsPsychosocial characteristicsVeterans StudySubjective well-beingDepressive symptomsHealth approachRepresentative sampleHigher optimismVeteransHappiness scoresGreater happinessAnalyzed dataUS DepartmentDepression and anxiety management in cirrhosis
Zimbrean P, Jakab S. Depression and anxiety management in cirrhosis. Hepatology Communications 2024, 9: e0600. PMID: 39670879, PMCID: PMC11637748, DOI: 10.1097/hc9.0000000000000600.Peer-Reviewed Original ResearchConceptsAnxiety disordersAnxiety symptomsPrevalence of generalized anxiety disorderDiagnosis of depressionPrevalence of depressionGeneral populationAnxietyScreening instrumentAnxiety managementTreatment interventionsDepressionPsychotherapyDisordersHealth-related quality of lifeLiver diseaseIntegrated care approachSymptomsHealth-related qualitySevere symptomsPharmacological agentsStand-alone therapyQuality of lifeCare approachAntidepressantsDose adjustmentAntidepressant use in spatial social networks
Lengyel B, Tóth G, Christakis N, Bíró A. Antidepressant use in spatial social networks. Science Advances 2024, 10: eadr0302. PMID: 39642229, PMCID: PMC11623294, DOI: 10.1126/sciadv.adr0302.Peer-Reviewed Original ResearchConceptsAntidepressant useSpatial social networksSocial networksAssociated with depression treatmentSmall-town residentsCohesiveness of social networksDiversity of social networksCohesive social networksMental health careDepression treatmentMental well-beingLocal communitiesMental healthEmpirical workWell-beingDistant communitiesDiverse networksHealth careLocal accessDistant placesCommunityIndividualsAntidepressantsYoung individualsTiesPsilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic
Back A, Freeman-Young T, Morgan L, Sethi T, Baker K, Myers S, McGregor B, Harvey K, Tai M, Kollefrath A, Thomas B, Sorta D, Kaelen M, Kelmendi B, Gooley T. Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2449026. PMID: 39636638, PMCID: PMC11621983, DOI: 10.1001/jamanetworkopen.2024.49026.Peer-Reviewed Original ResearchConceptsAdvanced practice practitionersSymptoms of depressionMontgomery-Asberg Depression Rating ScalePosttraumatic stress disorderSymptoms of burnoutMontgomery-Asberg Depression Rating Scale scoreSymptoms of posttraumatic stress disorderFrontline carePsilocybin therapyRandomized clinical trialsSevere symptoms of depressionMental health diagnosesScore changesImprove symptoms of depressionCOVID-19 pandemicPCL-5Intention-to-treat principleMedication sessionsDepression Rating ScalePCL-5 scoresPsychological morbidityHealth diagnosisMain OutcomesPractice practitionersUS cliniciansMentalization-Based Treatment for Adolescent Depression.
Luyten P, Malcorps S, Fonagy P. Mentalization-Based Treatment for Adolescent Depression. Psychodynamic Psychiatry 2024, 52: 490-511. PMID: 39679698, DOI: 10.1521/pdps.2024.52.4.490.Peer-Reviewed Original ResearchConceptsMentalization-based treatmentHistory of attachment traumaSeverity of depressionTreatment of depressionTreatment of adolescentsMental health problemsLong-term impairmentAttachment traumaAdolescent depressionPsychological interventionsMental perspectiveDepressionAdolescentsMental approachSpectrum of severityMentalMeta-analysesSevere endHealth problemsRelated problemsEmpirical evidenceImpairmentPersonsThoughtsTreatmentHealth-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk
Marini S, Kimball T, Mayerhofer E, Tack R, Senff J, Prapiadou S, Rivier C, Duskin J, Kourkoulis C, Falcone G, Yechoor N, Tanzi R, Rosand J, Singh S, Parodi L, Anderson C. Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk. Neurology 2024, 103: e210014. PMID: 39504504, DOI: 10.1212/wnl.0000000000210014.Peer-Reviewed Original ResearchConceptsLate-life depressionGenetic riskDementia riskUK Biobank (UKBEffects of healthy lifestylesHealth-related behaviorsGenetic predispositionElevated genetic riskProspective cohort studyHazard of strokeCox proportional hazards modelsAge-related brain diseasesLifestyle behaviorsCare scoresUKB participantsProportional hazards modelHealthy lifestyleIncidence of strokeMultivariate Cox proportional hazards modelPolygenic scoresTargeted interventionsLifestyle adjustmentsAggregate risk estimatesRisk estimatesCohort studyLife's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participants
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