2025
Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa
Ntshiqa T, Velen K, Ginindza S, Nhlangulela L, Charalambous S, Hawn T, Churchyard G, Boom W, Chihota V, Wallis R. Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa. PLOS ONE 2025, 20: e0318819. PMID: 40343976, PMCID: PMC12063869, DOI: 10.1371/journal.pone.0318819.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyTuberculin skin testCD4 countQFT-PlusAssociated with lower CD4 countsTST responseQuantiFERON-TB Gold PlusBody mass index >Median CD4 countLow CD4 countExposure to TBRates of HIVLongitudinal cohort studyMedian ageTST/IGRAAntiretroviral treatmentMedian timePreventive therapySkin testFollow-upCohort studyLogistic regressionHIVMonthsAssay conversionHypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis
Adams T, Redlich C, Glazer C, Gulati M. Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis. PLOS ONE 2025, 20: e0323093. PMID: 40338891, PMCID: PMC12061107, DOI: 10.1371/journal.pone.0323093.Peer-Reviewed Original ResearchConceptsDiagnosis of HPHP patientsRetrospective cohort of patientsMold exposureTransplant free survivalCohort of patientsRetrospective cohort analysisMedical chart reviewDevelopment of HPHypersensitivity pneumonitis patientsHome moldFibrotic HPFree survivalAntigen exposureChart reviewConfident diagnosisRetrospective cohortPneumonic patientsInvasive proceduresHypersensitivity pneumonitisCohort analysisCulprit antigenPatientsImprove outcomesCohortGender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries
Balkan E, Babbs G, Meyers D, Kelly P, Yee K, Pletta D, Shireman T, Alpert A, Baker K, Hughto J. Gender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries. JAMA Network Open 2025, 8: e258072. PMID: 40310645, PMCID: PMC12046427, DOI: 10.1001/jamanetworkopen.2025.8072.Peer-Reviewed Original ResearchConceptsGender-affirming surgeryTransgender individualsRates of chronic conditionsTransgenderBeneficiaries' useProportion of residentsRegional differencesDual statusBeneficiariesChronic conditionsDiverse beneficiariesBeneficiary characteristicsMedicare beneficiariesGenderCross-sectional studyMedicare entitlementGender-affirming surgical proceduresPropensity score matchingNational Medicare dataMedicare programMedicaidProportion of Medicare beneficiariesSouthSurgical proceduresDescriptive analysisMedicaid Costs and Outcomes for Patients Treated in an Outpatient Telepsychiatry Clinic
Havlik J, Ghomi R, An N, Budhiraja P, Arzubi E. Medicaid Costs and Outcomes for Patients Treated in an Outpatient Telepsychiatry Clinic. JAMA Network Open 2025, 8: e258558. PMID: 40323598, DOI: 10.1001/jamanetworkopen.2025.8558.Peer-Reviewed Original ResearchConceptsTelepsychiatry clinicRate of admissionCross-sectional studyMedicaid costsEmergency departmentClinical servicesMedicaid patientsHospitalization ratesTelepsychiatry patientsEvidence of cost savingsReduce hospital admissionsInpatient hospitalization ratesClinic patientsAnnual hospitalization rateOutcomes associated with useTelepsychiatry carePropensity-matched controlsTimely carePsychiatric careMain OutcomesCare costsPMPM costsHospital readmissionInpatient hospitalizationTelepsychiatryConversion Therapy Exposure and Elevated Cardiovascular Disease Risk
Gibb J, Schrock J, Smith M, D’Aquila R, McDade T, Mustanski B. Conversion Therapy Exposure and Elevated Cardiovascular Disease Risk. JAMA Network Open 2025, 8: e258745. PMID: 40327341, DOI: 10.1001/jamanetworkopen.2025.8745.Peer-Reviewed Original ResearchConceptsHigh blood pressureSystolic blood pressureDiastolic blood pressureSelf-reported high blood pressureCohort studyCardiovascular health dataCardiovascular health indicatorsSelf-reported hypertensionSGM health disparitiesMental health impactsCardiovascular health consequencesCardiovascular disease riskBlood pressureElevated diastolic blood pressureHealth disparitiesCare approachElevated systolic blood pressureHealth indicatorsMain OutcomesIncreased DBPBehavioral covariatesHealth dataSGM individualsDisease riskHealth consequencesExamining the Factor Structure of the Acquired Capability for Suicide Scale (ACSS) in a Military Population: Initial Development and Validation of a Four-Factor Version of the ACSS
Thomas K, Hoyt W, Goldberg S, Abbas M, Schultz M, Hiserodt M, Wyman M. Examining the Factor Structure of the Acquired Capability for Suicide Scale (ACSS) in a Military Population: Initial Development and Validation of a Four-Factor Version of the ACSS. Psychological Services 2025, 22: 312-323. PMID: 39636588, PMCID: PMC12011536, DOI: 10.1037/ser0000917.Peer-Reviewed Original ResearchConceptsInterpersonal theory of suicideTheory of suicideFour-factor versionInterpersonal theorySuicide ScaleAcquired CapabilityFactor structureMilitary populationNational Guard service membersReturn from deploymentConfirmatory factor analysisMonths postdeploymentMilitary sampleSuicidal behaviorPreliminary supportPredictive validityPostdeployment dataAssessment pointsSuicideService membersTheory-relevantVeteran populationLife experiencesFour-factorAdequate validityRadiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study
Justet A, Jackson L, Bardon M, Lerouge D, Césaire M, Loiseau C, Bergot E, Christy F, Thariat J. Radiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study. Cancer/Radiothérapie 2025, 29: 104622. PMID: 40311519, DOI: 10.1016/j.canrad.2025.104622.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseNon-small cell lung cancerProgression-free survivalCell lung cancerOverall survivalLung diseaseCase-control studyLung cancerCentral reviewOligometastatic non-small cell lung cancerMedian progression-free survivalCase-control study of patientsPrevalence of interstitial lung diseaseConsecutive lung cancer patientsIntensity-modulated radiotherapyStereotactic body radiotherapyMedian overall survivalThree-dimensional radiotherapyScore of fibrosisPrognosis of patientsGround-glass patternInterstitial pulmonary fibrosisStudy of patientsLung cancer patientsCancer treatment characteristicsFactors affecting family planning among general surgery trainees
Zheng C, Bussies P, Wo L, Eidelson S, Zhang C, Mouhanna J, Möller M. Factors affecting family planning among general surgery trainees. BMC Medical Education 2025, 25: 615. PMID: 40287697, PMCID: PMC12032787, DOI: 10.1186/s12909-024-06435-6.Peer-Reviewed Original ResearchConceptsGeneral surgeryFamily planningFisher's exact testPearson chi-square testFamily planning needsGeneral surgery traineesFellowship program directorsChi-square testFertility preservationExact testBarriers to family planningSurgery traineesFemale genderOutcome measuresSurgical traineesFemale surgeonsProgram directorsTrainee experienceSurgeryNovel heterozygous SPI1c.538C>T p.(Leu180Phe) variant causes PU.1 haploinsufficiency leading to agammaglobulinemia
Daddali R, Kettunen K, Turunen T, Knox A, Laine P, Chowdhury I, Vänttinen M, Mamia N, Stiegler A, Boggon T, Kere J, Romberg N, Seppänen M, Varjosalo M, Martelius T, Grönholm J. Novel heterozygous SPI1c.538C>T p.(Leu180Phe) variant causes PU.1 haploinsufficiency leading to agammaglobulinemia. Clinical Immunology 2025, 277: 110503. PMID: 40294836, DOI: 10.1016/j.clim.2025.110503.Peer-Reviewed Original ResearchConceptsDendritic cell countHeterozygous loss-of-function variantsLoss-of-function variantsCentrosome-associated proteinsFamily transcription factorsEts family transcription factorGene expression patternsAssociated with B cell developmentHematopoietic cell fatePDC countsB cell developmentCell countDisrupts gene expression patternsB-cell countsCell fateCarrier sisterSevere bacterial infectionsTranscription factorsIsolated IgA deficiencyFinnish familiesExpression patternsIn vitro studiesIgA deficiencyVariable penetranceIndex patientClinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome
Zhang Z, Hu X, Du Q, Mo P, Chen X, Luo M, Jiang Q, Deng L, Xiong Y. Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome. BMC Infectious Diseases 2025, 25: 508. PMID: 40217170, DOI: 10.1186/s12879-025-10900-y.Peer-Reviewed Original ResearchConceptsDisseminated intravascular coagulationOutcomes of disseminated intravascular coagulationPresence of disseminated intravascular coagulationNon-DIC groupIndependent risk factorIntravascular coagulationClinical characteristicsRisk factorsDisseminated intravascular coagulation groupThrombocytopenia syndromeMultivariate logistic regression analysisAssociated with high mortalityIn-hospital mortality of patientsCumulative survival rateZhongnan Hospital of Wuhan UniversityMortality of patientsIn-hospital mortalitySevere feverLogistic regression analysisConsecutive patientsFerritin levelsD-dimerViral loadClinical dataCystatin CDaily Minority Stressors, Threat Appraisal, and Identity Concealment Among Trauma-Exposed Sexual Minority Women and Transgender and Gender-Diverse People
Scheer J, Jackson S, Cascalheira C, Behari K, Helminen E, Batchelder A, Sullivan T. Daily Minority Stressors, Threat Appraisal, and Identity Concealment Among Trauma-Exposed Sexual Minority Women and Transgender and Gender-Diverse People. Journal Of Counseling Psychology 2025, 72: 211-222. PMID: 39928459, DOI: 10.1037/cou0000782.Peer-Reviewed Original ResearchConceptsSexual minority womenTGD peopleMinority stressorsIdentity concealmentGender minority peopleGender diverse peopleAvoidant copingThreat appraisalMinority stressMinority WomenMinority peopleWhite dominationAssociated with concealmentStigma exposureWestern narrativesLower avoidance copingBetween-person levelGender diversityTransgenderIntensive longitudinal studyTGDMinorityIndividual characteristicsSpecific contextsCounseling psychologistsDelineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis
Bronstein M, Kummerfeld E, Bearden C, Cornblatt B, Walker E, Woods S, Mathalon D, Perkins D, Cadenhead K, Addington J, Cannon T, Vinogradov S. Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis. Journal Of Psychopathology And Clinical Science 2025, 134: 239-250. PMID: 39913476, DOI: 10.1037/abn0000969.Peer-Reviewed Original ResearchConceptsClinical high riskNorth American Prodrome Longitudinal StudyClinical high-risk samplesAttenuated psychosis symptomsPathways to suicideSuicide risk reductionPsychosis symptomsCausal pathwaysDepressed moodPsychosisIntervention effortsSelf-deprecationSuicideLongitudinal studyMeasurement time pointsStudy timepointsHigh riskSymptomsInterventionHopelessnessMoodTime pointsDepressionIndividualsDirect causesSocioeconomic and demographic disparities in the impact of digestive diseases in the middle East and North Africa (MENA) region
Al Ta’ani O, Al-Ajlouni Y, Lahoud C, Almasaid S, Alhalalmeh Y, Oweis Z, Danpanichkul P, Baidoun A, Alsakarneh S, Dahiya D, Njei B. Socioeconomic and demographic disparities in the impact of digestive diseases in the middle East and North Africa (MENA) region. International Journal For Equity In Health 2025, 24: 85. PMID: 40148874, PMCID: PMC11951616, DOI: 10.1186/s12939-025-02448-9.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsEstimated annual percentage changeSocio-demographic indexAge-standardized incidence rateDisability-adjusted life year ratesGlobal Burden of DiseaseMiddle East and North AfricaGender Inequality IndexHuman Development IndexMiddle East and North Africa regionImpact of socioeconomic disparitiesIncidence rateAge-standardized mortalityAge-standardized ratesAnnual percentage changePercentage changeInfluence disease burdenBurden of DDBurden of diseasePublic health challengeHighest incidence rateSocioeconomic disparitiesDD incidenceTargeted interventionsNorth AfricaMultilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study
Whittemore R, Jeon S, Akyirem S, Chen H, Lipson J, Minchala M, Wagner J. Multilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study. JMIR Formative Research 2025, 9: e67293. PMID: 40131327, DOI: 10.2196/67293.Peer-Reviewed Original ResearchConceptsCommunity health centersPatient portal useDigital health literacyPortal useHealth literacyMultilevel interventionsType 2 diabetesSocial determinants of healthDiabetes self-management educationCommunity health workersImprove health equityDeterminants of healthSelf-management educationDiabetes self-efficacyHealth-related outcomesBarriers to clinical integrationPre-post designHemoglobin A<sub>1c</sub> levelDiabetes distressHealth equityPatient portalsSocial determinantsDeliver carePortal accountHealth appsUnintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial.
Hooten W, Erickson D, Chawarski M, Scholz N, Waljee J, Brummett C, Jeffery M. Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial. JMIR Research Protocols 2025, 14: e72032. PMID: 39992690, DOI: 10.2196/72032.Peer-Reviewed Original ResearchConceptsINTERNATIONAL REGISTERED REPORT IDENTIFIERElectronic health record systemsPatient recruitmentPractice environment characteristicsPrescribing opioids to patientsOpioid prescriptionsHealth record systemsPatient characteristicsContinuation of opioid therapyIndividual practice environmentsOpioids to patientsOpioid-naive adultsOpioid-naive patientsProlonged opioid useSelf-report surveyNational administrative claims databaseMisuse of prescription opioidsCOVID-19 pandemicPublic health problemClinician recruitmentCase-control trialShort-term useAdministrative claims databaseMayo Clinic sitesCTSA programThe association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach
Mestre-Bach G, Paiva U, San Martín Iniguez L, Beranuy M, Martín-Vivar M, Mallorquí-Bagué N, Normand E, Chicote M, Potenza M, Arrondo G. The association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach. Psychological Medicine 2025, 55: e77. PMID: 40071718, DOI: 10.1017/s0033291725000376.Peer-Reviewed Original ResearchConceptsInternet-use disordersSystematic reviewMeta-analysisInternet-useInternet use disorderRandom-effects modelWeb of ScienceDegree of lonelinessUCLA Loneliness ScaleStatistical poolingQuantify associationsOdds ratioCohen's dDisorder symptomsGreater lonelinessMeta-regressionPooled differenceEffect sizePre-registeredUCLA-LonelinessLonelinessEffects of ageCategorical approachSymptomsGroup of individualsModerate alcohol-associated hepatitis: A real-world multicenter study
Idalsoaga F, Díaz L, Dunn W, Mehta H, Muñoz K, Caldentey V, Arnold J, Ayares G, Mortuza R, Sarin S, Maiwall R, Zhang W, Qian S, Simonetto D, Singal A, Elfeki M, Ramirez-Cadiz C, Malhi G, Ahmed A, Homsi H, Abid Z, Cabezas J, Echavarría V, Poca M, Soriano G, Cuyas B, Cots M, La Tijera M, Ayala-Valverde M, Perez D, Gomez J, Abraldes J, Al-Karaghouli M, Jalal P, Ibrahim M, García-Tsao G, Goyes D, Skladaný L, Havaj D, Sulejova K, Selcanova S, Rincón D, Chacko K, Restrepo J, Yaquich P, Toro L, Shah V, Arrese M, Kamath P, Bataller R, Arab J. Moderate alcohol-associated hepatitis: A real-world multicenter study. Hepatology Communications 2025, 9: e0673. PMID: 40131003, PMCID: PMC11936654, DOI: 10.1097/hc9.0000000000000673.Peer-Reviewed Original ResearchConceptsSevere alcohol-associated hepatitisNeutrophil-to-lymphocyte ratioMaddrey's discriminant functionModerate AHMultiple organ failureOrgan failureMulticenter retrospective cohort studyAlcohol-associated hepatitisCumulative survival rateRetrospective cohort studyReceiver operating characteristic curveLong-term outcomesShort-term mortalityMortality scoring systemsPrognostic factorsSerum bilirubinMELD scoreWell-characterized diseaseClinical profileMedian MELDCohort studyCox regressionMultivariate analysisTherapeutic strategiesSurvival rateGenomic Landscape of Late-Stage Gastric Cancer: Analysis From KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Studies
Janjigian Y, Cecchini M, Shitara K, Enzinger P, Wainberg Z, Chau I, Satoh T, Lee J, Nebozhyn M, Loboda A, Kobie J, Vajdi A, Shih C, Cristescu R, Cao Z. Genomic Landscape of Late-Stage Gastric Cancer: Analysis From KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Studies. JCO Precision Oncology 2025, 9: e2400456. PMID: 40117530, PMCID: PMC11949223, DOI: 10.1200/po-24-00456.Peer-Reviewed Original ResearchConceptsTumor mutational burdenHomologous recombination deficiencyMicrosatellite instability-highGenomic characteristicsChromosomal instabilityKEYNOTE-062Late-stage GCKEYNOTE-059KEYNOTE-061Molecular subtypesAsian originWhole-exome sequencingGastric cancerSubtype prevalenceEpstein-Barr virus-positiveHomologous recombination deficiency scoresPretreatment tumor samplesWES dataGene expression signaturesCancer Genome AtlasMicrosatellite instability-high subtypeRNA sequencingGenomic landscapeEarly-stage GCGenomic alterationsGambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome?
Mestre-Bach G, Potenza M, Granero R, Håkansson A, Gómez-Peña M, Perales I, Vicó À, Uríszar J, Fernández-Aranda F, Sánchez I, Jiménez-Murcia S. Gambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome? Journal Of Behavioral Addictions 2025, 14: 465-479. PMID: 40116860, DOI: 10.1556/2006.2025.00023.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyGambling disorderPornography useEmotion regulationGD severityTreatment outcomesCognitive-behavioral therapy approachCognitive-behavioral therapy sessionsTreatment outcomes of individualsCo-occurrence of GDCo-occurrenceMental health concernsImprove treatment adherenceBehavioral addictionsTreatment dropoutOutcomes of individualsWeekly sessionsTreatment adherencePsychopathologyGamblingSessionsDisordersAssociated with higher likelihoodRelapseImpulseLipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana
Amegashie E, Kwayisi‐Darkwah C, Adusei‐Poku M, Sikeola R, Ativi L, Ahene A, Atampugbire G, Tagoe E, Paintsil E, Torpey K, Quaye O. Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana. Journal Of Medical Virology 2025, 97: e70301. PMID: 40110873, DOI: 10.1002/jmv.70301.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoinfectionCoronavirus InfectionsCross-Sectional StudiesCyclopropanesDideoxyadenosineDideoxynucleosidesFemaleGhanaGlutathioneHeterocyclic Compounds, 3-RingHIV InfectionsHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxazinesOxidative StressPiperazinesProspective StudiesPyridonesYoung AdultConceptsHuman immunodeficiency virusHuman immunodeficiency virus co-infectionCo-infectionGSH levelsART-experienced individualsPLWH co-infectedHuman coronavirusesHIV co-infectionHIV-negative individualsMalondialdehyde levelsOxidative stressOxidative stress markersIncreased MDA levelsCross-sectional studyOro-pharyngeal swabsImmunodeficiency virusGhanaian patientsMono-infectionReduced GSH levelsTreatment strategiesPlasma samplesDisease severityMDA levelsStress markersTailored monitoring
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