2024
Childhood Sexual Abuse, Alcohol Problem Scores, and Race Are Associated With Syphilis Incidence in a Prospective Cohort of Young Sexual and Gender Minority Adults Assigned Male at Birth
Hall C, Ryan D, Hayford C, Morgan E, D'Aquila R, Mustanski B. Childhood Sexual Abuse, Alcohol Problem Scores, and Race Are Associated With Syphilis Incidence in a Prospective Cohort of Young Sexual and Gender Minority Adults Assigned Male at Birth. Sexually Transmitted Diseases 2024, 52: 266-271. PMID: 39681071, DOI: 10.1097/olq.0000000000002120.Peer-Reviewed Original ResearchConceptsChildhood sexual abuseSexual abuseSyndemic conditionsAlcohol problemsExperience childhood sexual abuseIndicators of sexual riskUnited StatesGender minoritiesViolence victimizationYoung sexualitiesTransgender womenAlcohol problem scoresComorbid healthBlack identitySexual riskSubstance useSyphilis risk factorsSyndemic frameworkAbuseYoung menMental healthSyphilis ratesGenderSyphilis incidenceRisk factorsExploring the syndemic interaction between social, environmental and structural contexts of HIV infection in peri-mining areas in South Africa: a qualitative study
Chimoyi L, Ndini P, Oladimeji M, Seatlholo N, Mawokomatanda K, Charalambous S, Setswe G. Exploring the syndemic interaction between social, environmental and structural contexts of HIV infection in peri-mining areas in South Africa: a qualitative study. BMJ Open 2024, 14: e076198. PMID: 38521520, PMCID: PMC10961556, DOI: 10.1136/bmjopen-2023-076198.Peer-Reviewed Original ResearchConceptsFemale sex workersFocus group discussionsIn-depth interviewsInjection drug usersUptake of HIV prevention servicesHealthcare workersHIV prevention servicesHIV infectionHIV prevention programmesPre-exposure prophylaxisAssociated with HIV acquisitionAccessibility to alcoholSocio-behavioral factorsCommunity-based organisationsPreventive servicesHIV prevalencePrevention programmesAreas of South AfricaSyndemic factorsQualitative studyHIV transmissionHIV acquisitionInclusion criteriaFactors affecting peopleSex workers
2022
A New Syndemic: Complications of Opioid Use Disorder During a Heat Wave.
Ryus C, Bernstein SL. A New Syndemic: Complications of Opioid Use Disorder During a Heat Wave. Journal Of Health Care For The Poor And Underserved 2022, 33: 1671-1677. PMID: 36245188, DOI: 10.1353/hpu.2022.0092.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersOpioid crisisHealth care providersHeat-related illnessOpioid useAccidental overdosesCase seriesCare providersCare practicesRisk of useGreater riskHarm reduction initiativesDisordersComplicationsDeathIllnessInadequate accessRiskParticular vulnerabilityExcess burdenFurther researchPatientsProvidersOverdoses
2021
Armed conflict, HIV, and syndemic risk markers of mental distress, alcohol misuse, and intimate partner violence among couples in Uganda
Mootz JJ, Basaraba CN, Corbeil T, Johnson K, Kubanga KP, Wainberg ML, Khoshnood K. Armed conflict, HIV, and syndemic risk markers of mental distress, alcohol misuse, and intimate partner violence among couples in Uganda. Journal Of Traumatic Stress 2021, 34: 1016-1026. PMID: 34647647, PMCID: PMC8530966, DOI: 10.1002/jts.22740.Peer-Reviewed Original ResearchConceptsSyndemic problemsHIV statusRisk markersIntimate partner violenceSyndemic scoreAlcohol misuseMale partnersMental distressUnknown HIV statusPopulation-based studyRisk of maleHIV/AIDSFemale intimate partner violencePartner violencePsychosocial interventionsHIVSignificant total effectWomenProblem scoresHigh rateNortheastern UgandaMen's exposureExposureConflict exposureTotal effectSyndemic Framework Evaluation of Severe COVID-19 Outcomes in the United States: Factors Associated With Race and Ethnicity
Williams C, Vermund SH. Syndemic Framework Evaluation of Severe COVID-19 Outcomes in the United States: Factors Associated With Race and Ethnicity. Frontiers In Public Health 2021, 9: 720264. PMID: 34616705, PMCID: PMC8488144, DOI: 10.3389/fpubh.2021.720264.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infection riskSevere COVID-19 outcomesSevere clinical outcomesCOVID-19 outcomesSeverity of diseaseAssociated disease burdenCOVID-19Ethnic health inequalitiesIndividual clinical dataClinical care environmentLong-term careCoronavirus disease (COVID-19) pandemicClinical outcomesSyndemic factorsDisease burdenClinical dataHealthcare barriersHealth outcomesInfection riskHealth inequalitiesDisease pandemicSyndemic theoryVulnerable populationsCare environmentFuture pandemicsAssociation of Syndemic Unhealthy Alcohol Use, Smoking, and Depressive Symptoms on Incident Cardiovascular Disease among Veterans With and Without HIV-Infection
Chichetto NE, Kundu S, Freiberg MS, Koethe JR, Butt AA, Crystal S, So-Armah KA, Cook RL, Braithwaite RS, Justice AC, Fiellin DA, Khan M, Bryant KJ, Gaither JR, Barve SS, Crothers K, Bedimo RJ, Warner A, Tindle HA. Association of Syndemic Unhealthy Alcohol Use, Smoking, and Depressive Symptoms on Incident Cardiovascular Disease among Veterans With and Without HIV-Infection. AIDS And Behavior 2021, 25: 2852-2862. PMID: 34101074, PMCID: PMC8376776, DOI: 10.1007/s10461-021-03327-4.Peer-Reviewed Original ResearchConceptsIncident cardiovascular diseaseUnhealthy alcohol useCardiovascular diseaseDepressive symptomsCVD riskHIV statusAlcohol useMultivariable Cox proportional hazards regressionCases of CVDCox proportional hazards regressionCVD-free participantsHIV-negative veteransProportional hazards regressionHIV-negativeHIV infectionHazards regressionSyndemic conditionsExcess riskRisk factorsDiagnostic codesHigh prevalenceObservational studyBaseline numberGreater riskSmokingSyndemic Profiles and Sexual Minority Men’s HIV-Risk Behavior: A Latent Class Analysis
Scheer J, Clark K, Maiolatesi A, Pachankis J. Syndemic Profiles and Sexual Minority Men’s HIV-Risk Behavior: A Latent Class Analysis. Archives Of Sexual Behavior 2021, 50: 2825-2841. PMID: 33483851, PMCID: PMC8295412, DOI: 10.1007/s10508-020-01850-4.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsSyndemic conditionsSexual minority menLatent class analysisAlcohol misusePolydrug useMinority menHIV acquisitionHIV syndemicClass analysisTransmission riskVulnerable subpopulationsReference groupSocioeconomic distressSyndemic theorySyndemicGroup differencesMenStatus characteristicsSocial status characteristicsLatent classesClass membershipMisuse
2020
Latent Profile Analysis of a Syndemic of Vulnerability Factors on Incident Sexually Transmitted Infection in a Cohort of Black Men Who Have Sex With Men Only and Black Men Who Have Sex With Men and Women in the HIV Prevention Trials Network 061 Study.
Dyer TV, Turpin RE, Stall R, Khan MR, Nelson L, Brewer R, Friedman MR, Mimiaga MJ, Cook RL, O'Cleirigh C, Mayer KH. Latent Profile Analysis of a Syndemic of Vulnerability Factors on Incident Sexually Transmitted Infection in a Cohort of Black Men Who Have Sex With Men Only and Black Men Who Have Sex With Men and Women in the HIV Prevention Trials Network 061 Study. Sexually Transmitted Diseases 2020, 47: 571-579. PMID: 32496390, PMCID: PMC7442627, DOI: 10.1097/olq.0000000000001208.Peer-Reviewed Original ResearchConceptsHIV Prevention Trials Network 061 studySexual risk profilesSyndemic factorsRisk profileBlack menImportant public health concernHIV/STI riskHigh-risk sexual behaviorPublic health concernExperience elevated levelsIncident STIsRisk factorsSTI riskVulnerability factorsSexual riskHealth concernElevated levelsBMSMWInfectionSyndemicIntimate partner violenceMenSexSexual behaviorRiskThe OATH Syndemic: opioids and other substances, aging, alcohol, tobacco, and HIV.
Womack JA, Justice AC. The OATH Syndemic: opioids and other substances, aging, alcohol, tobacco, and HIV. Current Opinion In HIV And AIDS 2020, 15: 218-225. PMID: 32487817, PMCID: PMC7422477, DOI: 10.1097/coh.0000000000000635.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnalgesics, OpioidHIV InfectionsHumansNicotianaSubstance-Related DisordersSyndemicConceptsSubstance useTreatment of frailtyManagement of HIVAdverse drug interactionsAge-related outcomesPrescribed medicationsHIVHealth statusHealthcare teamFrailtyAdverse effectsSyndemicStigma contributesTreatmentSerious consequencesSubstance interactionsIndividual manifestationsPLWHPolypharmacyOpioidsMedicationsMultimorbidityImportant pathwaySex biasSubstancesIdentifying and managing infectious disease syndemics in patients with HIV.
Bromberg DJ, Mayer KH, Altice FL. Identifying and managing infectious disease syndemics in patients with HIV. Current Opinion In HIV And AIDS 2020, 15: 232-242. PMID: 32487816, PMCID: PMC7376494, DOI: 10.1097/coh.0000000000000631.Peer-Reviewed Original ResearchConceptsInfectious diseasesDisease progressionHIV disease progressionInfluence of HIVEvidence-based interventionsAntiretroviral therapyHIV acquisitionPsychiatric comorbidityRisky sex behaviorsHIVRisk behaviorsDiseaseSubstance useInfectionSex behaviorDisease synergismSyndemicSynergistic interactionIntervention strategiesBehavioral determinantsPatientsMultipronged approachProgressionStructural determinantsPast yearRacial and ethnic differences in women’s HIV risk and attitudes towards pre-exposure prophylaxis (PrEP) in the context of the substance use, violence, and depression syndemic
Willie TC, Kershaw TS, Blackstock O, Galvao RW, Safon CB, Tekeste M, Ogburn DF, Wilbourn B, Modrakovic D, Taggart T, Kaplan C, Caldwell A, Calabrese SK. Racial and ethnic differences in women’s HIV risk and attitudes towards pre-exposure prophylaxis (PrEP) in the context of the substance use, violence, and depression syndemic. AIDS Care 2020, 33: 219-228. PMID: 32408837, PMCID: PMC7666028, DOI: 10.1080/09540121.2020.1762067.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisSyndemic conditionsPrEP attitudesNon-Hispanic blacksHIV riskHispanic womenMultiple male sexual partnersEffect of racePrEP-eligible womenMale sexual partnersHIV sexual riskMore syndemic conditionsWomen's HIV riskNon-Hispanic whitesCo-occurring epidemicsHIV acquisitionPrEP uptakeHigher oddsElevated riskSexual partnersSexual riskWhite womenSubstance useWomenEthnic differences
2019
Psychosocial Syndemic Risks Surrounding Physical Health Conditions Among Sexual and Gender Minority Individuals
Scheer JR, Pachankis JE. Psychosocial Syndemic Risks Surrounding Physical Health Conditions Among Sexual and Gender Minority Individuals. LGBT Health 2019, 6: 377-385. PMID: 31644383, PMCID: PMC6918840, DOI: 10.1089/lgbt.2019.0025.Peer-Reviewed Original ResearchConceptsPhysical health conditionsPhysical health outcomesGender minority individualsSyndemic riskPhysical healthHealth conditionsMinority individualsIndividual's physical healthPosttraumatic stress disorderHealth outcomesSGM adultsOverall health burdenStress disorderPsychosocial risksSexual assaultDisparate exposuresSGM identitiesSubstance useSyndemic conditionsHealth burdenHigh prevalenceSyndemic frameworkComprehensive interventionHealth disparitiesOnline surveyPreparing for emerging infections means expecting new syndemics
Carlson C, Mendenhall E. Preparing for emerging infections means expecting new syndemics. The Lancet 2019, 394: 297. PMID: 31354135, DOI: 10.1016/s0140-6736(19)31237-1.Peer-Reviewed Original Research
2018
Validating the Syndemic Threat Surrounding Sexual Minority Men's Health in a Population-Based Study With National Registry Linkage and a Heterosexual Comparison
Bränström R, Pachankis JE. Validating the Syndemic Threat Surrounding Sexual Minority Men's Health in a Population-Based Study With National Registry Linkage and a Heterosexual Comparison. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 78: 376-382. PMID: 29940602, DOI: 10.1097/qai.0000000000001697.Peer-Reviewed Original ResearchConceptsHIV infectionSyndemic conditionsElevated riskSexual minority menStockholm Public Health CohortBisexual menPsychosocial health disparitiesHealth threatHealth registry dataTimes higher riskNational health registry dataPopulation-based examinationHIV prevention interventionsHeterosexual menMinority menMinority men's healthRegistry linkageHealth cohortRegistry dataHigh riskAdult menHealth disparitiesMen's healthInfectionMenLongitudinal Evaluation of Syndemic Risk Dyads in a Cohort of Young Pregnant Couples
Martinez I, Ickovics JR, Keene DE, Perez-Escamilla R, Kershaw TS. Longitudinal Evaluation of Syndemic Risk Dyads in a Cohort of Young Pregnant Couples. Journal Of Adolescent Health 2018, 63: 189-196. PMID: 29970332, PMCID: PMC6113066, DOI: 10.1016/j.jadohealth.2018.02.011.Peer-Reviewed Original ResearchConceptsSyndemic riskSyndemic scoreTime pointsPregnant couplesHigh-risk individualsLater time pointsSyndemic burdenYoung pregnant couplesRisk dyadsPostpartum periodRisk factorsPrevention programsLongitudinal evaluationPregnancySeverityWomenSignificant differencesMenScoresRiskSubsequent scoresSyndemicBurdenActor effectsResilience as a moderator between syndemics and depression in mothers living with HIV
Thurston IB, Howell KH, Kamody RC, Maclin-Akinyemi C, Mandell J. Resilience as a moderator between syndemics and depression in mothers living with HIV. AIDS Care 2018, 30: 1257-1264. PMID: 29499626, DOI: 10.1080/09540121.2018.1446071.Peer-Reviewed Original ResearchConceptsDepressive symptomsMental healthLife stressorsHigher depressive symptomsGreater depressive symptomsLower depressive symptomsProblematic mental health outcomesMental health outcomesChild mental healthAIDS/HIVStrengths-based treatmentMaternal adversityKey protective factorHIVCo-occurring adversitiesHealth outcomesEmotional adversitySymptomsSubstance abuseProtective factorsEffect of resilienceRole of resilienceMothersDepressionCommunity agencies
2017
Acculturation and Syndemic Risk: Longitudinal Evaluation of Risk Factors Among Pregnant Latina Adolescents in New York City
Martinez I, Kershaw TS, Keene D, Perez-Escamilla R, Lewis JB, Tobin JN, Ickovics JR. Acculturation and Syndemic Risk: Longitudinal Evaluation of Risk Factors Among Pregnant Latina Adolescents in New York City. Annals Of Behavioral Medicine 2017, 52: 42-52. PMID: 28707175, PMCID: PMC6367896, DOI: 10.1007/s12160-017-9924-y.Peer-Reviewed Original ResearchConceptsPregnant Latina adolescentsYear postpartumRisk factorsSyndemic riskSyndemic scoreLongitudinal mixed-effects modelingSubstance useIntimate partner violenceLatina adolescentsCo-occurring epidemicsHigh-risk adolescentsMixed-effects modelingPostpartum periodPartner violenceHealth outcomesPregnancyLongitudinal evaluationLongitudinal changesNew York CitySyndemicSeverityAdolescentsPostpartumRisk reductionYork City
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