2024
Chronic Venous Insufficiency and Management
Attaran R, Babapour G, Mena-Hurtado C, Ochoa Chaar C. Chronic Venous Insufficiency and Management. Interventional Cardiology Clinics 2024, 14: 283-296. PMID: 40049854, DOI: 10.1016/j.iccl.2024.11.013.Peer-Reviewed Original ResearchConceptsVenous insufficiencyHistory of deep vein thrombosisVaricose veinsPositive family historyDeep vein thrombosisIncompetent superficial veinsChronic venous insufficiencyChronic venous diseaseElimination of varicose veinsCatheter-based techniquesVein recanalizationAssociated with poor qualityVenous obstructionVein thrombosisPharmacological therapyFamily historyVenous diseaseRisk factorsLeg discomfortFemale genderSuperficial veinsLeg ulcersProlonged standingInsufficiencyVeinPain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design
Barron D, Saltoun K, Kiesow H, Fu M, Cohen-Tanugi J, Geha P, Scheinost D, Isaac Z, Silbersweig D, Bzdok D. Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design. BMC Medicine 2024, 22: 594. PMID: 39696368, PMCID: PMC11656997, DOI: 10.1186/s12916-024-03807-z.Peer-Reviewed Original ResearchConceptsChronic diseasesPain ProfileChronic conditionsPatient functionPain conditionsManagement of chronic diseasesChronic disease managementContinuum of careHealthcare delivery systemImprove quality of lifeQuality of lifePainful body partPain interferenceAssociated with clinical variablesUK BiobankWhole-body perspectiveHealth strategiesTreatment of individual patientsPain intensityClinically relevant differencesPatient wellbeingPain managementTreat painful conditionsICD codesMedical specialtiesHepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status
Re V, Newcomb C, Carbonari D, Mezochow A, Hennessy S, Rentsch C, Park L, Tate J, Bräu N, Bhattacharya D, Lim J, Mezzacappa C, Njei B, Roy J, Taddei T, Justice A, Torgersen J. Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status. Pharmacoepidemiology And Drug Safety 2024, 33: e70069. PMID: 39662972, PMCID: PMC11634562, DOI: 10.1002/pds.70069.Peer-Reviewed Original ResearchConceptsProton pump inhibitor initiationHazard ratioVeterans Health AdministrationSevere acute liver injuryProton pump inhibitorsChronic liver diseaseAcute liver injuryRates of hospitalizationSafety of medicationsPPI initiativesHealth AdministrationLiver disease statusMedication exposurePharmacoepidemiological studiesMedicationConfoundingScoresReports of hepatotoxicityDisease statusHepatotoxic medicationsDrug exposurePump inhibitorsHepatotoxic drugsOutpatient initiationHepatic safetySleep Deficiency A Symptoms Perspective: Exemplars from Chronic Heart Failure, Inflammatory Bowel Disease, and Breast Cancer
Redeker N, Conley S, Hwang Y. Sleep Deficiency A Symptoms Perspective: Exemplars from Chronic Heart Failure, Inflammatory Bowel Disease, and Breast Cancer. Sleep Medicine Clinics 2024, 19: 537-548. PMID: 39455175, DOI: 10.1016/j.jsmc.2024.07.003.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsChronic DiseaseFatigueFemaleHeart FailureHumansInflammatory Bowel DiseasesSleep Wake DisordersConceptsExcessive daytime sleepinessChronic heart failureInflammatory bowel diseaseBreast cancerHeart failureBowel diseaseContributions of sleep deficiencySleep disordersSleep deficiencyPrevalence of fatigueDaytime sleepinessDaytime symptomsChronic conditionsBreastCancerDeficiencySymptomsDiseaseSleepDisordersFatigueThe burden of cirrhosis and other chronic liver disease in the middle east and North Africa (MENA) region over three decades
Al Ta’ani O, Aleyadeh W, Al-Ajlouni Y, Alnimer L, Ismail A, Natour B, Njei B. The burden of cirrhosis and other chronic liver disease in the middle east and North Africa (MENA) region over three decades. BMC Public Health 2024, 24: 2979. PMID: 39468483, PMCID: PMC11514855, DOI: 10.1186/s12889-024-20445-5.Peer-Reviewed Original ResearchConceptsAge-standardized incidence rateAge-standardized death ratesDisability-adjusted life yearsBurden of cirrhosisGlobal Burden of DiseaseDisability burdenDeath rateAge-standardized disability-adjusted life yearsPublic health effortsBurden of diseaseSignificant health challengesGender-specific interventionsLiver disease incidenceChronic liver diseaseIncident casesMENA regionHealth effortsCountry-specific trendsHealthcare systemGlobal burdenHealth challengesIncreasing burdenIncidence rateLife yearsEpidemiological trendsA real-world study of persistence and adherence to prescription medications in patients with chronic idiopathic constipation in the United States.
Cash B, Lu M, Lembo A, Feuerstadt P, Nguyen L, Terasawa E, Ayyagari R, Du S, Pi S, Westermeyer B, Terreri B, Boules M, Moshiree B. A real-world study of persistence and adherence to prescription medications in patients with chronic idiopathic constipation in the United States. Journal Of Managed Care & Specialty Pharmacy 2024, 30: 1136-1148. PMID: 39321115, PMCID: PMC11424913, DOI: 10.18553/jmcp.2024.30.10.1136.Peer-Reviewed Original ResearchConceptsChronic idiopathic constipationHazard ratioIdiopathic constipationTreatment of chronic idiopathic constipationHigher treatment persistencePrescription medicationsComparator medicationUS Food and Drug AdministrationProportion of patientsIBM MarketScan Commercial ClaimsObservational cohort studyFood and Drug AdministrationAdjusted hazard ratiosMarketScan Commercial ClaimsProportion of daysAssociated with lower oddsTreatment persistencePrucaloprideCohort studyOdds ratioPrescription fillsPrescription therapyDrug AdministrationCompare persistenceInclusion criteriaCardiomyopathy‐Associated Chronic Heart Failure in Infants Aged <1 Year: A Prospective Observational Cohort Over 5 Years in Northern China
Ding W, Wang B, Hong J, Lu L, Xiao Y, Shan G, Myers C, Yu Q, Spurney C, Li Z, Han L. Cardiomyopathy‐Associated Chronic Heart Failure in Infants Aged <1 Year: A Prospective Observational Cohort Over 5 Years in Northern China. Journal Of The American Heart Association 2024, 13: e029121. PMID: 39344650, PMCID: PMC11681489, DOI: 10.1161/jaha.122.029121.Peer-Reviewed Original ResearchConceptsBundle-branch blockHeart failureVentricular noncompactionReduced left ventricular ejection fractionInfants aged <1 yearPatients up to 5Infants aged <1Pediatric heart centersOutcomes of infantsPresence of left bundle-branch blockVentricular ejection fractionLeft ventricular noncompactionEjection fraction groupChronic heart failureProspective observational studyYear of diagnosisChinese pediatric populationSecondary to cardiomyopathyProspective observational cohortIncreased heart sizeFavorable predictorsBaseline LVEFEjection fractionNo significant differenceMedical therapyChanges in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection
Hu Z, Cinque P, Dravid A, Hagberg L, Yilmaz A, Zetterberg H, Fuchs D, Gostner J, Blennow K, Spudich S, Kincer L, Zhou S, Joseph S, Swanstrom R, Price R, Gisslén M. Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection. PLOS Pathogens 2024, 20: e1012470. PMID: 39316609, PMCID: PMC11469498, DOI: 10.1371/journal.ppat.1012470.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS Dementia ComplexBiomarkersCerebrospinal Fluid ProteinsChronic DiseaseFemaleHIV InfectionsHIV-1HumansMaleMiddle AgedConceptsHIV-1 infectionHIV-associated dementiaCerebrospinal fluidCerebrospinal fluid proteinCerebrospinal fluid HIV-1 RNAImpact of HIV-1 infectionTreating chronic HIV-1 infectionChronic HIV-1 infectionHIV-1 RNAHIV-1 progressionTreat chronic infectionsInflammatory cell lineagesNeurofilament light chain proteinCSF escapeChronic infectionHIV-1Light chain proteinProtein changesClinical centersCNS injuryCSF proteinClinical informationCell lineagesInfectionCerebrospinal fluid proteomeThe extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries
Dorr D, Markwardt S, Bobo M, Allore H, Botoseneanu A, Newsom J, Nagel C, Quiñones A. The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries. BMC Geriatrics 2024, 24: 777. PMID: 39304796, PMCID: PMC11414248, DOI: 10.1186/s12877-024-05329-y.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChronic DiseaseCost of IllnessFemaleHumansLongitudinal StudiesMaleMedicareMultimorbidityUnited StatesConceptsHigh multimorbidityMultimorbidity levelOlder adultsHigher levels of multimorbidityHealth and Retirement Study dataAssociated with sociodemographic characteristicsWell-being of older adultsLevels of multimorbidityProgression of multimorbidityImpact of multimorbidityBurden of multimorbidityHigher healthcare utilizationRetirement Study dataYounger birth cohortsMultimorbidity groupsHealthcare utilizationLower educationNon-HispanicMultimorbiditySociodemographic characteristicsMedicare beneficiariesSocioeconomic statusHealth indicatorsBirth cohortChronic diseasesMultimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis
Liu R, Nagel C, Chen S, Newsom J, Allore H, Quiñones A. Multimorbidity and associated informal care receiving characteristics for US older adults: a latent class analysis. BMC Geriatrics 2024, 24: 571. PMID: 38956501, PMCID: PMC11221032, DOI: 10.1186/s12877-024-05158-z.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCaregiversChronic DiseaseFemaleHumansLatent Class AnalysisMaleMultimorbidityPatient CareUnited StatesConceptsNational Health and Aging Trends StudyMultimorbidity patternsCare needsOlder adultsSelf-careInformal careLatent class analysisCare receiver characteristicsCombinations of multimorbidityPerson-centered carePatterns of multimorbidityDifferential care needsUS older adultsAssociated with lower oddsAssociated with higher oddsGroup of older adultsMultinomial logistic regression modelModerate cognitive impairmentClass analysisLogistic regression modelsInformal caregiversBackgroundOlder adultsCare recipientsMultimorbidity groupsChronic conditionsCombating Chronic Disease with Barbershop Health Interventions: A Review of Current Knowledge and Potential for Big Data
Khosla P, Amin K, Doshi R. Combating Chronic Disease with Barbershop Health Interventions: A Review of Current Knowledge and Potential for Big Data. The Yale Journal Of Biology And Medicine 2024, 97: 239-245. PMID: 38947107, PMCID: PMC11202109, DOI: 10.59249/otfp5065.Peer-Reviewed Original ResearchMeSH KeywordsBarberingBig DataChronic DiseaseCommunity-Based Participatory ResearchCOVID-19Health PromotionHumansSARS-CoV-2ConceptsCommunity-based participatory researchPromote health equityHealth equityHealth disparitiesIncreasing awareness of cancer riskAwareness of cancer riskChronic diseasesPromote cancer screeningCultural appropriateness of interventionsMental health promotionChronic disease managementImprove diabetes awarenessIncrease testing ratesPromote preventive behaviorsCombat chronic diseasesAppropriateness of interventionsHealth promotionDiabetes awarenessScreening servicesCancer screeningHealth interventionsSelf-managementCancer riskCommunity settingsHealth educationSeksuell helse hos eldre.
Sunde A, Sivertsen Ø, Skjellegrind H, Svendsen K, Berge S, Alsnes I. Seksuell helse hos eldre. Tidsskrift For Den Norske Legeforening 2024, 144 PMID: 38832621, DOI: 10.4045/tidsskr.23.0809.Peer-Reviewed Original ResearchMeSH KeywordsAgedAgingChronic DiseaseFemaleHumansMaleQuality of LifeSexual BehaviorSexual Dysfunction, PhysiologicalSexual HealthSexualityConceptsOlder adultsSexual healthImprove sexual healthQuality of lifeClinical review articleAdverse effects of medicationsOlder adult sexualityEffects of medicationHealthcare personnelCoping skillsChronic diseasesSexual challengesCognitive failuresHealthAdult sexualityAdultsConjugal relationshipHealthcareCopingMedicationReview articleBarriers to Pulmonary Rehabilitation.
Rochester C. Barriers to Pulmonary Rehabilitation. Respiratory Care 2024, 69: 713-723. PMID: 38806224, PMCID: PMC11147625, DOI: 10.4187/respcare.11656.Peer-Reviewed Original ResearchMeSH KeywordsChronic DiseaseHealth Services AccessibilityHealthcare DisparitiesHumansLung DiseasesSocioeconomic FactorsUnited StatesConceptsBarriers to PRHealth care professionalsPulmonary rehabilitationPR programChronic respiratory diseasesMultidisciplinary health care professionalsHealth care provider visitsHealth care disparitiesInfluence patients' likelihoodKnowledge of PRAvailability of PRLack of insurance coverageBurden of treatmentCare disparitiesProvider visitsCare professionalsReferral processProvider recommendationRespiratory diseaseTransportation difficultiesRacial disparitiesPatient accessPatient's residenceLack of knowledgeLow knowledgeBarriers to care and health-related quality of life among US adults with several common chronic inflammatory skin diseases: a cross-sectional analysis of the NIH All of Us Research Program
Nock M, Barbieri J, Cohen J. Barriers to care and health-related quality of life among US adults with several common chronic inflammatory skin diseases: a cross-sectional analysis of the NIH All of Us Research Program. Archives Of Dermatological Research 2024, 316: 201. PMID: 38775812, PMCID: PMC12085989, DOI: 10.1007/s00403-024-02954-w.Peer-Reviewed Original ResearchConceptsHealth-related quality of lifeHealth-related qualityUS adultsQuality of lifeSocial determinants of healthDeterminants of healthUs Research ProgramCross-sectional analysisNational Institutes of HealthSocial determinantsPhysician careInstitutes of HealthImpact of barriersCost barriersHRQoLAdultsNational InstituteHealthChronic inflammatory skin diseaseBarriersAoURPCarePhysiciansLifeInflammatory skin diseaseAssociations Between Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments
Wallach J, Yoon S, Doernberg H, Glick L, Ciani O, Taylor R, Mooghali M, Ramachandran R, Ross J. Associations Between Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments. JAMA 2024, 331: 1646-1654. PMID: 38648042, PMCID: PMC11036312, DOI: 10.1001/jama.2024.4175.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersChronic DiseaseClinical Trials as TopicHumansMeta-Analysis as TopicTreatment OutcomeConceptsMeta-analysesChronic diseasesFood and Drug AdministrationMeta-regression analysisMeta-analyses of observational studiesSurrogate markerClinical outcomesClinical trialsMeta-analysisEvidence of associationPublished meta-analysesStrength of associationMeta-analyses of clinical trialsChronic disease treatmentFood and Drug Administration tableResults of meta-regression analysisOutcome pairsFood and Drug Administration approvalMain OutcomesData extractionSystematic reviewStatistically significant resultsObservational studyPooled analysisDrug AdministrationThe nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study
Heigl T, Kaes J, Aelbrecht C, Serré J, Yamada Y, Geudens V, Van Herck A, Vanstapel A, Sacreas A, Ordies S, Frick A, Gimenez B, Van Slambrouck J, Beeckmans H, Oztürk N, Orlitova M, Vaneylen A, Claes S, Schols D, Velde G, Schupp J, Kaminski N, Boesch M, Korf H, van der Merwe S, Dupont L, Vanoirbeek J, Godinas L, Van Raemdonck D, Janssens W, Gayan-Ramirez G, Ceulemans L, McDonough J, Verbeken E, Vos R, Vanaudenaerde B. The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study. Frontiers In Immunology 2024, 15: 1369536. PMID: 38736881, PMCID: PMC11084670, DOI: 10.3389/fimmu.2024.1369536.Peer-Reviewed Original ResearchConceptsChronic lung allograft dysfunctionChronic rejectionLung transplantationSingle cell RNASingle cell RNA profilingOrthotopic left lung transplantationComplications post-transplantationLung allograft dysfunctionMouse lung transplantationLeft lung transplantationLung transplantation studiesAllograft dysfunctionPleural infiltrationPost-transplantationBronchiolitis obliteransInnate inflammationChronic complicationsPrimary onsetEndothelial destructionTransplantationDay 7Immunological perspectiveArterial responseTransplantation studiesLungNeuroimaging alterations and relapse in early-stage psychosis
Mihaljevic M, Nagpal A, Etyemez S, Narita Z, Ross A, Schaub R, Cascella N, Coughlin J, Nestadt G, Nucifora F, Sedlak T, Calhoun V, Faria A, Yang K, Sawa A. Neuroimaging alterations and relapse in early-stage psychosis. Journal Of Psychiatry And Neuroscience 2024, 49: e135-e142. PMID: 38569725, PMCID: PMC10980532, DOI: 10.1503/jpn.230115.Peer-Reviewed Original ResearchMeSH KeywordsBrainChronic DiseaseHumansMagnetic Resonance ImagingNeuroimagingPsychotic DisordersRecurrenceSchizophreniaConceptsEarly-stage psychosisNeuroimaging alterationsResting-state functional MRI dataNo-relapse groupFunctional connectivity changesFunctional MRI dataHealthy controlsMagnetic resonance imagingRelapse groupPsychotic disordersFunctional connectivity estimatesBrain changesPsychotic eventsPsychosisConnectivity changesSymptom exacerbationConnectivity estimatesComparison correctionNo relapseLongitudinal studyThalamusNeuroimagingMRI dataClinical confounding factorsControl groupSelection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Lennon N, Kottyan L, Kachulis C, Abul-Husn N, Arias J, Belbin G, Below J, Berndt S, Chung W, Cimino J, Clayton E, Connolly J, Crosslin D, Dikilitas O, Velez Edwards D, Feng Q, Fisher M, Freimuth R, Ge T, Glessner J, Gordon A, Patterson C, Hakonarson H, Harden M, Harr M, Hirschhorn J, Hoggart C, Hsu L, Irvin M, Jarvik G, Karlson E, Khan A, Khera A, Kiryluk K, Kullo I, Larkin K, Limdi N, Linder J, Loos R, Luo Y, Malolepsza E, Manolio T, Martin L, McCarthy L, McNally E, Meigs J, Mersha T, Mosley J, Musick A, Namjou B, Pai N, Pesce L, Peters U, Peterson J, Prows C, Puckelwartz M, Rehm H, Roden D, Rosenthal E, Rowley R, Sawicki K, Schaid D, Smit R, Smith J, Smoller J, Thomas M, Tiwari H, Toledo D, Vaitinadin N, Veenstra D, Walunas T, Wang Z, Wei W, Weng C, Wiesner G, Yin X, Kenny E. Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations. Nature Medicine 2024, 30: 480-487. PMID: 38374346, PMCID: PMC10878968, DOI: 10.1038/s41591-024-02796-z.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresPredictive performance of polygenic risk scoresPerformance of polygenic risk scoresPolygenic risk score performanceRisk scoreGenetic diversity dataElectronic medical recordsDiverse US populationStrength of evidenceDiverse clinical settingsDiverse adultsUS populationHispanic populationCardiometabolic diseasesGenetic ancestryProgram cohortGenetic resultsMedical recordsDiverse populationsMedical actionClinical settingProvidersRisk assessmentScoresDiverse data
2023
Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
Kokkinidis D, Schizas D, Pargaonkar S, Karamanis D, Mylonas K, Hasemaki N, Palaiodimos L, Varrias D, Tzavellas G, Siasos G, Klonaris C, Kharawala A, Chlorogiannis D, Georgopoulos S, Bakoyiannis C. Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions. Medicina 2023, 59: 2029. PMID: 38004078, PMCID: PMC10673017, DOI: 10.3390/medicina59112029.Peer-Reviewed Original ResearchConceptsChronic total occlusionHistory of malignancyCTO groupRevascularization proceduresSuccessful revascularizationLower extremity chronic total occlusionChronic limb-threatening ischemiaEnd-stage renal diseaseSuccessful endovascular interventionUse of aspirinBaseline clinical variablesLimb-threatening ischemiaPeripheral artery diseaseNegative predictorHigh disease burdenInterventional characteristicsAngiographic characteristicsAspirin useCTO patientsEndovascular revascularizationPositive predictorArtery diseaseStenosis patientsRenal diseaseVascular centersThe Clinical Utility of Antroduodenal Manometry in the Evaluation of Children with Upper Gastrointestinal Symptoms
Arbizu R, Trauernicht S, Pinillos S, Nurko S, Rodriguez L. The Clinical Utility of Antroduodenal Manometry in the Evaluation of Children with Upper Gastrointestinal Symptoms. Journal Of Pediatric Gastroenterology And Nutrition 2023, 77: 734-740. PMID: 37756372, DOI: 10.1097/mpg.0000000000003956.Peer-Reviewed Original ResearchConceptsGroup B symptomsUpper gastrointestinal symptomsIdiopathic etiologyB symptomsGastrointestinal symptomsPhase IIITreatment responseInitial successful responseIntestinal phase IIIOverall treatment responseSuccessful treatment responseSmall bowel motilityEvaluation of childrenSuccessful responseManometry measuresUGI symptomsAbdominal distentionAntroduodenal manometryPredominant symptomBowel motilityRetrospective reviewClinical findingsClinical utilitySymptomsEtiology
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