2025
Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa
Ntshiqa T, Velen K, Ginindza S, Nhlangulela L, Charalambous S, Hawn T, Churchyard G, Boom W, Chihota V, Wallis R. Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa. PLOS ONE 2025, 20: e0318819. PMID: 40343976, PMCID: PMC12063869, DOI: 10.1371/journal.pone.0318819.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHIV InfectionsHumansInterferon-gamma Release TestsMaleMiddle AgedMinersSouth AfricaTuberculin TestTuberculosisConceptsIsoniazid preventive therapyTuberculin skin testCD4 countQFT-PlusAssociated with lower CD4 countsTST responseQuantiFERON-TB Gold PlusBody mass index >Median CD4 countLow CD4 countExposure to TBRates of HIVLongitudinal cohort studyMedian ageTST/IGRAAntiretroviral treatmentMedian timePreventive therapySkin testFollow-upCohort studyLogistic regressionHIVMonthsAssay conversionLipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana
Amegashie E, Kwayisi‐Darkwah C, Adusei‐Poku M, Sikeola R, Ativi L, Ahene A, Atampugbire G, Tagoe E, Paintsil E, Torpey K, Quaye O. Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana. Journal Of Medical Virology 2025, 97: e70301. PMID: 40110873, DOI: 10.1002/jmv.70301.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoinfectionCoronavirus InfectionsCross-Sectional StudiesCyclopropanesDideoxyadenosineDideoxynucleosidesFemaleGhanaGlutathioneHeterocyclic Compounds, 3-RingHIV InfectionsHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxazinesOxidative StressPiperazinesProspective StudiesPyridonesYoung AdultConceptsHuman immunodeficiency virusHuman immunodeficiency virus co-infectionCo-infectionGSH levelsART-experienced individualsPLWH co-infectedHuman coronavirusesHIV co-infectionHIV-negative individualsMalondialdehyde levelsOxidative stressOxidative stress markersIncreased MDA levelsCross-sectional studyOro-pharyngeal swabsImmunodeficiency virusGhanaian patientsMono-infectionReduced GSH levelsTreatment strategiesPlasma samplesDisease severityMDA levelsStress markersTailored monitoringIdentifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana
Mensah B, Mensah-Brown H, Partey F, Addo C, Buah G, Afudego G, Okyere D, Tetteh M, Boateng E, Wilson M, Paintsil E. Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana. BMC Public Health 2025, 25: 1042. PMID: 40102895, PMCID: PMC11917097, DOI: 10.1186/s12889-025-22254-w.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleGhanaHIV InfectionsHumansLost to Follow-UpMaleMiddle AgedRetrospective StudiesRisk FactorsYoung AdultConceptsFactors associated with LTFUHigh-burden districtsIdentified risk factorsRisk factorsAssociated with loss to follow-upPromote health literacyCare of personsBackgroundLoss to follow-upLoss to follow-upGlobal health initiativesAssociated with LTFULogistic regression modelsAntiretroviral therapyHealth literacyHIV careHealth initiativesFollow-upNo educationHIV clinicEffective interventionsEffectiveness of treatment strategiesLTFUHospital visitsCareMethodsA retrospective analysisTranscriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review
Valizadeh A, Veenhuis R, Bradley B, Xu K. Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review. International Journal Of Molecular Sciences 2025, 26: 2598. PMID: 40141240, PMCID: PMC11942185, DOI: 10.3390/ijms26062598.Peer-Reviewed Original ResearchConceptsSimian immunodeficiency virus (SIV)-infected macaquesPrevalence of cannabis useSIV-infected macaquesChronic immune activationHIV-infected human cellsEpithelial cell proliferationModulate immune responsesSystematic reviewSIV/HIV infectionHIV infectionPreclinical evidencePathways related to inflammationImmune activationCannabis useMicro-RNA expressionImmunomodulatory roleImmunomodulatory effectsReduce inflammationImmune responseTetrahydrocannabinolComprehensive searchCell proliferationTranscriptomic alterationsMethodological qualityPWHAberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV
Xu K, Zhang X, Asam K, Quach B, Page G, Konkle‐Parker D, Martinez C, Lahiri C, Topper E, Cohen M, Kassaye S, DeHovitz J, Kuniholm M, Archin N, Valizadeh A, Tien P, Marconi V, Hancock D, Johnson E, Aouizerat B. Aberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV. Clinical And Translational Medicine 2025, 15: e70267. PMID: 40070009, PMCID: PMC11896887, DOI: 10.1002/ctm2.70267.Peer-Reviewed Original ResearchMeSH KeywordsAdultCD4-Positive T-LymphocytesDNA MethylationFemaleHIV InfectionsHIV-1HumansMiddle AgedVirus ReplicationConceptsCD4+ T cellsHIV-1 reservoirHIV-1 latencyT cellsHIV-1Aberrant DNA methylationMechanisms of HIV-1 latencyViral replicationVirally suppressed womenDNA methylationHIV-1 integration sitesHIV-1 replicationMolecular targetsDifferentially methylated CpG sitesImmune defenceDNA methylation sequencingHost epigenetic landscapeDNA methylation sitesHIV-1 DNA integrationDifferentially methylated sitesHost genome integrityInterferon signaling genesCure HIVHost-virus interactionsCD4Evaluating community knowledge of tuberculosis preventive therapy in rural South Africa
Foppiano Palacios C, Moll A, Shrestha R, Kompala T, Davis J, Charalambous S, Chimoyi L, Chihota V, Andrews L, Shenoi S. Evaluating community knowledge of tuberculosis preventive therapy in rural South Africa. BMC Public Health 2025, 25: 918. PMID: 40055618, DOI: 10.1186/s12889-025-21719-2.Peer-Reviewed Original ResearchConceptsKnowledge of TBTB knowledgeExploratory factor analysisCommunity membersPublic health educationRural South AfricaCross-sectional studyPreventive therapyTuberculosis preventive therapyMultivariate linear regressionLinear regressionHealth educationChi-square testMedian scoreCounseling effortsCommunity eventsDescriptive statisticsEvaluate knowledgeTesting initiativesCultural beliefsTB incidenceCommunity knowledgeKwaZulu NatalSouth AfricaFactor analysisAdaptation and validation of perceived HIV and TB stigma scales among persons with TB.
Ponticiello M, Nanziri L, Hennein R, Ochom E, Gupta A, Turimumahoro P, White M, Armstrong-Hough M, Katamba A, Davis J. Adaptation and validation of perceived HIV and TB stigma scales among persons with TB. The International Journal Of Tuberculosis And Lung Disease 2025, 29: 127-134. PMID: 40052658, DOI: 10.5588/ijtld.24.0497.Peer-Reviewed Original ResearchConceptsPerceived social supportSocial supportTB stigma scaleConvergent validityCommunity health workersAssess convergent validityEvaluate internal validityTB-affected householdsExperiences of personsCross-sectional studyInternal validityMultidisciplinary research teamMeasure stigmaOne-factor solutionTB stigmaStigma ScaleHIV ScaleHIV stigmaEvidence of convergent validityHealth workersFactor analysisExploratory factor analysisCognitive interviewsPsychometric propertiesMarginal model fitAcceptability of long-acting antiretroviral therapy among people living with HIV who use drugs in Vancouver, Canada: A qualitative study
Chayama K, Ng C, Brohman I, Mansoor M, Small W, Philbin M, Collins A, McNeil R. Acceptability of long-acting antiretroviral therapy among people living with HIV who use drugs in Vancouver, Canada: A qualitative study. PLOS ONE 2025, 20: e0319010. PMID: 40019916, PMCID: PMC11870339, DOI: 10.1371/journal.pone.0319010.Peer-Reviewed Original ResearchConceptsAdherence to antiretroviral therapyLong-acting antiretroviral therapyLA-ARTAntiretroviral therapySuboptimal adherence to antiretroviral therapyAdherence barriersProspective cohort studySuboptimal ART adherenceAdverse side effectsPill burdenTreatment optionsSubstance useCohort studyART adherenceTreatment advancesSide effectsTreatment changesPLHIVTreatment approachesTherapyCredible sources of informationPopulation-level benefitsDrugHIVSocial-structural inequitiesRacism-related stress, health outcomes, substance use, and PrEP attitudes among Asian sexual minority men
Chin L, Kershaw T, Hernandez-Ramirez R, Ramos S. Racism-related stress, health outcomes, substance use, and PrEP attitudes among Asian sexual minority men. Scientific Reports 2025, 15: 6994. PMID: 40016341, PMCID: PMC11868514, DOI: 10.1038/s41598-025-91794-3.Peer-Reviewed Original ResearchConceptsAsian American Racism-Related Stress InventoryRacism-related stressSexual minority menHealth outcomesIncreased substance useMinority menSubstance useBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemSexual minority identitySecondary analysis of dataHIV self-testingNational Survey on Drug Use and HealthDecreased psychological well-beingDrug Use and HealthPsychological well-beingMinority identityPrEP attitudesRacial inequalityIntersecting factorsPhysical healthSocietal discriminationPolitical climateStress InventoryRacial discriminationLongitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection
Chan P, Li X, Li F, Emu B, Price R, Spudich S. Longitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection. Frontiers In Immunology 2025, 16: 1531828. PMID: 40070827, PMCID: PMC11893981, DOI: 10.3389/fimmu.2025.1531828.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid HIV RNAPrimary HIV infectionT cell activationCD8+ T cell activationAntiretroviral therapyHIV RNACD4+HIV infectionCerebrospinal fluidT cellsMonocyte activationNeuronal injuryCD4+ T cell activationCD8<sup>+</sup> T cellsCD8+ T cellsFrequencies of activated CD4+ART-naive peopleChronic HIV infectionTrafficking of immune cellsAntiretroviral therapy initiationChemokine receptor expressionMultiparameter flow cytometryImmune cell activationSurface marker expressionCentral nervous systemNeuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand
Ocampo F, Sacdalan C, Pinyakorn S, Paudel M, Wansom T, Poltubtim N, Sriplienchan S, Phanuphak N, Paul R, Hsu D, Colby D, Trautmann L, Spudich S, Chan P. Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand. AIDS Research And Therapy 2025, 22: 20. PMID: 39972347, PMCID: PMC11841302, DOI: 10.1186/s12981-025-00707-x.Peer-Reviewed Original ResearchConceptsWeeks of antiretroviral therapyAcute HIV infectionT-cell countsT cell ratioAntiretroviral therapyPatient Health Questionnaire-9HCV seroconversionDAA treatmentCD4 + and CD8 + T cell countsCD4+ /CD8+ T-cell ratioCD8+ T cell countsDirect-acting antiviral (DAA) therapyAlanine transaminaseCD4+ /CD8+ ratioAspartate transferaseIntravenous drug useEarly HCV infectionSexually transmitted infectionsFollow-up visitPatient Health Questionnaire-9 scoresBackgroundHepatitis C virusHepatitis C treatmentHIV RNAVirological responseDAA therapyPrescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial
Mobley A, Wegman M, Bazazi A, Shenoi S, Bromberg D, Ahmad A, Kamarulzaman A, Altice F. Prescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial. International Journal Of Drug Policy 2025, 137: 104733. PMID: 39923270, PMCID: PMC11875876, DOI: 10.1016/j.drugpo.2025.104733.Peer-Reviewed Original ResearchConceptsLinkage to HIV careHIV careIncrease linkage to HIV careTreatment-as-prevention strategiesHIV treatment cascadeHIV treatment outcomesOpen-label trialCox proportional hazards modelsPatient preference trialOpioid use disorderMalaysia’s largest prison.Impact of methadoneProportional hazards modelTreatment cascadeInverse probability weighted Cox proportional hazards modelAnalytic sampleStudy participantsCareTreatment outcomesPrescribed methadoneOpioidConfounding variablesHIVUse disorderHazards modelHIV, smoking, and the brain: a convergence of neurotoxicities
Orlinick B, Farhadian S. HIV, smoking, and the brain: a convergence of neurotoxicities. AIDS Research And Therapy 2025, 22: 13. PMID: 39915881, PMCID: PMC11804093, DOI: 10.1186/s12981-025-00714-y.Peer-Reviewed Original ResearchMeSH Keywordsalpha7 Nicotinic Acetylcholine ReceptorBrainHIV InfectionsHumansMicrogliaNeurotoxicity SyndromesOxidative StressSmokingConceptsHuman immunodeficiency virusCholinergic anti-inflammatory pathwayAnti-inflammatory pathwayNeurocognitive impairmentTobacco smokeEffect of human immunodeficiency virusEffects of tobacco smokingNeurotoxic effectsBrain volume changesClinically significant impactIncreased oxidative stressImmunodeficiency virusAlpha7 nicotinic acetylcholine receptorPWHBrain regionsMicroglial activationCognitive functionBrain healthIncreased neuroinflammationNeuronal apoptosisTherapeutic targetAcetylcholine receptorsGeneral populationNeurotoxicitySmokingHIV Trends in Metropolitan US Cities From 2014 to 2021: Baseline Data for the Ending the HIV Epidemic Initiative.
Gupta R, Vermund S. HIV Trends in Metropolitan US Cities From 2014 to 2021: Baseline Data for the Ending the HIV Epidemic Initiative. American Journal Of Public Health 2025, 115: 217-220. PMID: 39778137, PMCID: PMC11715565, DOI: 10.2105/ajph.2024.307890.Peer-Reviewed Original ResearchConceptsDifference-in-differences analysisMetropolitan statistical areasHIV Epidemic initiativeMetropolitan US cityReduce HIV incidenceHIV diagnosisHIV incidenceHIV trendsEpidemic initiativeHIV casesHIV epidemicProgrammatic evaluationIncident infectionsProgrammatic effectivenessHIVStatistical areasDiagnostic rateUS citiesBaseline trendsRate trendsBaselineEHEBaseline datasUnited StatesIncidenceThe sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection
Yang R, Chen Q, Jiao F, Yu X, Xiong Y. The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection. Scientific Reports 2025, 15: 4018. PMID: 39893294, PMCID: PMC11787304, DOI: 10.1038/s41598-025-88530-2.Peer-Reviewed Original ResearchConceptsCD4+ T-lymphocyte countT lymphocyte countsEnd-stage-liver diseaseFIB-4 scoreHBV coinfectionFIB-4HBV DNADecline of HBV DNA levelsDisease progressionLong-term surveillance periodRisk factorsPrevalence of liver cirrhosisHBV co-infectionMultivariate logistic regression analysisHBV DNA levelsProgression of liver diseaseIndependent risk factorLiver disease progressionLiver fibrosis levelsAll-cause mortalityMultivariate logistic regressionLogistic regression analysisMale groupSex differencesFemale groupTrauma-informed HIV prevention for forcibly displaced adolescents and young adults
Chantre C, Kershaw T, Lowe S, Davis J, Suleman A, Vermund S, Mootz J. Trauma-informed HIV prevention for forcibly displaced adolescents and young adults. The Lancet HIV 2025, 12: e234-e238. PMID: 39884299, DOI: 10.1016/s2352-3018(24)00313-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentFemaleHIV InfectionsHumansMaleMental HealthRefugeesVulnerable PopulationsYoung AdultConceptsBurden of mental ill healthMental ill-healthHIV preventionIll healthYoung adultsConflict-affected populationsHIV careHIV interventionsMental healthPoor engagementHIV acquisitionHIV epidemicHIV riskTrauma exposureVulnerable populationsLevel of vulnerabilityHIVHealthSocioenvironmental contextAdolescent girlsDevelopmental periodMigration stressAdultsDocumented associationAdolescentsObservational pilot using a Data to Care intervention strategy to promote HCV re-engagement and cure for persons with HIV/HCV co-infection who are out of care
Wegener M, Gosselin D, Brooks R, Speers S, Villanueva M. Observational pilot using a Data to Care intervention strategy to promote HCV re-engagement and cure for persons with HIV/HCV co-infection who are out of care. BMC Health Services Research 2025, 25: 140. PMID: 39856760, PMCID: PMC11763122, DOI: 10.1186/s12913-025-12307-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiviral AgentsCoinfectionConnecticutFemaleHepatitis CHIV InfectionsHumansMaleMiddle AgedPilot ProjectsConceptsDepartment of Public HealthHepatitis C virus treatment initiationHIV/HCV co-infectionHepatitis C virusPublic health strategiesConnecticut Department of Public HealthRe-engagementMethodsIn partnershipOutreach outcomesCare engagementCo-infectionHealth strategiesTreatment initiationHIV/HCV co-infected personsHepatitis C virus cureFollow-up approachHepatitis C virus treatmentCo-infected personsDirect-acting antiviralsIntervention strategiesPublic healthOutreach effortsPersons co-infectedHIVObservational pilotRationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study
Meyer J, Brunson S, Price C, Mulrain M, Nguyen J, Altice F, Kyriakides T, Cropsey K, Eaton E. Rationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study. Addiction Science & Clinical Practice 2025, 20: 4. PMID: 39825419, PMCID: PMC11742507, DOI: 10.1186/s13722-024-00534-x.Peer-Reviewed Original ResearchConceptsCriminal legal systemOpioid use disorderLegal systemStandard of careStructural barriersUse disorderEnhanced standard of careRates of opioid use disorderDelivery of PrEPPre-exposure prophylaxisWomen's abilityRandomized clinical trialsLife-saving interventionsRandomized controlled trialsHealth disparitiesImplementation outcomesPrEP initiationPreventive servicesClinical outcomesIntegrated deliveryFollow-upDelivery modelsClinical trialsDecision aidPrEP“Men Take Care of Each Other”: Evaluation of a Community-Based Model for Pre-exposure Prophylaxis Services Among Male Bar Patrons in Rural South Africa
Chen P, Nkosi S, Moll A, Braithwaite R, Ngubane S, Shenoi S. “Men Take Care of Each Other”: Evaluation of a Community-Based Model for Pre-exposure Prophylaxis Services Among Male Bar Patrons in Rural South Africa. AIDS Patient Care And STDs 2025, 39: 3-11. PMID: 39761130, PMCID: PMC11839517, DOI: 10.1089/apc.2024.0154.Peer-Reviewed Original ResearchConceptsMale nursesAlcohol-serving venuesPrEP servicesHIV servicesHIV testingSocial supportHIV service delivery modelsAlcohol useNurse follow-upAlcohol-associated riskAvoidance of stigmaCommunity-based modelRural South AfricaService delivery modelsPre-exposure prophylaxisMale bar patronsPatient ambassadorsCommunity nursesNursing assistantsPrEP disclosurePrEP initiationHome visitsSouth AfricaPost-pilotClinic attendancePerspectives and experiences regarding pre-exposure prophylaxis (PrEP) in a community sample of Veterans with unhealthy alcohol use: overall and across sexual orientation and gender identity
Fletcher O, Beaver K, Austin E, van Draanen J, Edelman E, Williams E. Perspectives and experiences regarding pre-exposure prophylaxis (PrEP) in a community sample of Veterans with unhealthy alcohol use: overall and across sexual orientation and gender identity. Addiction Science & Clinical Practice 2025, 20: 5. PMID: 39876005, PMCID: PMC11773927, DOI: 10.1186/s13722-024-00533-y.Peer-Reviewed Original ResearchConceptsSexual orientationHeavy episodic drinkingPre-exposure prophylaxisGender identityUnhealthy alcohol useAlcohol useEpisodic drinkingSelf-reported sexual orientationHIV preventionSexual orientation/gender identityGender identity groupsFrequent heavy episodic drinkingSurvey of VeteransBackgroundUnhealthy alcohol useCommunity sampleNational online surveyPrEP awarenessCommunity organizationsIdentity groupsPrEP outcomesSevere unhealthy alcohol useHIV risk factorsMinoritized groupsMethodsUsing dataRisk factors
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