2025
Adaptation and validation of perceived HIV and TB stigma scales among persons with TB.
Ponticiello M, Nanziri L, Hennein R, Ochom E, Gupta A, Turimumahoro P, White M, Armstrong-Hough M, Katamba A, Davis J. Adaptation and validation of perceived HIV and TB stigma scales among persons with TB. The International Journal Of Tuberculosis And Lung Disease 2025, 29: 127-134. PMID: 40052658, DOI: 10.5588/ijtld.24.0497.Peer-Reviewed Original ResearchConceptsPerceived social supportSocial supportTB stigma scaleConvergent validityCommunity health workersAssess convergent validityEvaluate internal validityTB-affected householdsExperiences of personsCross-sectional studyInternal validityMultidisciplinary research teamMeasure stigmaOne-factor solutionTB stigmaStigma ScaleHIV ScaleHIV stigmaEvidence of convergent validityHealth workersFactor analysisExploratory factor analysisCognitive interviewsPsychometric propertiesMarginal model fit
2024
Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda
Nasuuna E, Tomlinson L, Kalyesubula R, Dziva Chikwari C, Castelnuovo B, Manabe Y, Nakanjako D, Weiss H. Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda. BMC Nephrology 2024, 25: 422. PMID: 39587464, PMCID: PMC11590532, DOI: 10.1186/s12882-024-03865-8.Peer-Reviewed Original ResearchConceptsAlbumin-creatinine ratioChronic kidney diseaseFactors associated with chronic kidney diseaseSerum creatinineAdjusted odds ratiosCystatin CKidney diseaseEarly diagnosisAssociated with chronic kidney diseasePrevalence of chronic kidney diseaseCompare serum creatinineCreatinine-based onesFactors of chronic kidney diseaseAssociated with high mortalityCases of chronic kidney diseaseDefinition of chronic kidney diseaseChronic kidney disease prevalenceCystatin C-based equationsCystatin C levelsEstimate adjusted odds ratiosMeasuring urinary albuminConfidence intervalsDiagnosis of chronic kidney diseaseMultivariate logistic regressionReduce disease progressionHigher prevalence of kidney function impairment among older people living with HIV in Uganda
Ssemasaazi A, Kalyesubula R, Manabe Y, Mbabazi P, Naikooba S, Ssekindi F, Nasuuna E, Byakika-Kibwika P, Castelnuovo B. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. BMC Nephrology 2024, 25: 321. PMID: 39334034, PMCID: PMC11428404, DOI: 10.1186/s12882-024-03761-1.Peer-Reviewed Original ResearchConceptsKidney function impairmentChronic kidney diseaseAntiretroviral therapyOlder PLWHFunctional impairmentKidney functionKidney diseaseHIV-related inflammationProgression of kidney diseasePrevalence of proteinuriaMultivariate logistic regression modelBurden of chronic kidney diseaseMeasures of kidney functionDiagnosis of hypertensionCross-sectional studyConclusionsHIV infectionHIV-related clinical characteristicsClinical characteristicsInstitution of measuresLogistic regression modelsDiabetes mellitusFemale sexHIVProteinuriaPLWHAn adapted scale to measure perceived TB and HIV stigma during household contact investigation.
Armstrong-Hough M, Shelby T, Ggita J, Nangendo J, Gupta A, Davis J, Katamba A. An adapted scale to measure perceived TB and HIV stigma during household contact investigation. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 433-438. PMID: 39187997, DOI: 10.5588/ijtld.23.0395.Peer-Reviewed Original ResearchConceptsHousehold contact investigationStigma ScaleTB-HIVNewly diagnosed TB patientsContact investigationCognitive interview dataHIV stigmaHealth behaviorsFactor analysisCognitive interviewsElimination of itemsInter-item covariationStandardised measuresPsychometric propertiesRandom sampleTB patientsInterview dataHIVIdentifying opportunitiesStigmaHousehold contactsItemsScoresHouseholdsCovariatesDiagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study
Nasuuna E, Kalyesubula R, Tomlinson L, Castelnuovo B, Okello E, Chikwari C, Weiss H. Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study. BMJ Open 2024, 14: e083221. PMID: 39153770, PMCID: PMC11331864, DOI: 10.1136/bmjopen-2023-083221.Peer-Reviewed Original ResearchConceptsPositive POC testCross-sectional studyChronic kidney diseaseDiagnostic performancePoint-of-care testingKidney diseaseHIV clinicPOC testingPOC testsBody mass index <Albumin-creatinine ratioPositive predictive valueUrinary excretion rateDiagnosis of chronic kidney diseaseYoung peopleYears of ageTherapy to adultsYPLHIVUrine dipstickCreatinine ratioDiagnosis of albuminuriaLogistic regressionPrimary outcomeAlbuminuriaHIVHealth-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda
Batte C, Semulimi A, Mukisa J, Nakabuye M, Nidoi J, Mukunya D, Ratanshi R, Castelnuovo B, Lamorde M, Meya D, Checkley W, Kalyesubula R, Siddharthan T, Babigumira J. Health-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda. PLOS ONE 2024, 19: e0306928. PMID: 39116145, PMCID: PMC11309503, DOI: 10.1371/journal.pone.0306928.Peer-Reviewed Original ResearchConceptsHealth-related quality of lifeHealth-related qualityQuality of lifeHRQoL scoresLong-term antiretroviral therapyAssociated with lower HRQoL scoresMedian health utility scorePhysical health scoresAntiretroviral therapyLower HRQOL scoresHealth utility scoresMedical Outcomes StudyEQ-5D-5LQuality-of-life assessmentManagement of PWHScores of peopleHealth scoresCompare HRQoLPlan early interventionsHRQoL dataHistory of smokingUrban clinicEQ-5DHRQoLUtility scoresMolecular detection of Coxiella burnetii in ticks collected from animals and the environment in Uganda
Eneku W, Erima B, Byaruhanga A, Cleary N, Atim G, Tugume T, Ukuli Q, Kibuuka H, Mworozi E, Tweyongyere R, Douglas C, Koehler J, von Fricken M, Wabwire‐Mangen F, Byarugaba D. Molecular detection of Coxiella burnetii in ticks collected from animals and the environment in Uganda. Zoonoses And Public Health 2024, 71: 869-875. PMID: 38982627, DOI: 10.1111/zph.13168.Peer-Reviewed Original ResearchConceptsC. burnetiiPresence of C. burnetiiTransmitting C. burnetiiDetection of Coxiella burnetiiHaemaphysalis ellipticaRhipicephalus decoloratusTick poolsRhipicephalus appendiculatusAmblyomma variegatumHighest infection rateVeterinary practiceTicksAnimal illnessCoxiella burnetiiRhipicephalusQ feverMolecular detectionAnimal hostsAnimal contactReal-time PCRPathogen detectionInfection rateAnimalsDecoloratusAmblyommaStrategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol.
Savinkina A, Muyindike W, Hahn J, Emenyonu N, Fatch R, Ngabirano C, Adong J, Jacobson K, Linas B. Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 335-342. PMID: 38961548, PMCID: PMC11875055, DOI: 10.5588/ijtld.23.0303.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyTB preventive therapyTuberculin skin testPreventive therapyReport alcohol useAlcohol useHIV-positive patientsTB disease incidenceLiver enzyme monitoringLatent TB infectionTB burden settingsSkin testTB infectionBurden settingsConsuming alcoholTB diseaseTB riskWHO guidanceTherapyEnzyme monitoringPLWHIsoniazidEvaluate hepatotoxicityHepatotoxicity concernsAST/ALTExamining HIV Knowledge and Sexually Risky Behaviors among Female Sex Workers in Kampala, Uganda
Ssenyonjo J, Mistler C, Adler T, Shrestha R, Kyambadde P, Copenhaver M. Examining HIV Knowledge and Sexually Risky Behaviors among Female Sex Workers in Kampala, Uganda. International Journal Of Environmental Research And Public Health 2024, 21: 163. PMID: 38397654, PMCID: PMC10888220, DOI: 10.3390/ijerph21020163.Peer-Reviewed Original ResearchConceptsFemale sex workersHealthcare providersHIV testingHIV preventionHistory of HIV testingRates of sexually transmitted infectionsCondom usageSex workersProvider-level barriersDevelopment of targeted interventionsPrimary HIV preventionHIV test resultsHealth education programsHIV transmission riskHIV prevention educationSexually transmitted infectionsHIV knowledgeHIV incidencePreventive interventionsFocus groupsTargeted interventionsReduce alcohol intakeHIV transmissionPrevention educationAlcohol intake
2023
Clinical Profile and Outcomes of Rheumatic Heart Disease Patients Undergoing Surgical Valve Procedures in Uganda
Rwebembera J, Chang A, Kitooleko S, Kaudha G, de Loizaga S, Nalule M, Ahabwe K, Zhang W, Okello E, Sinha P, Mwambu T, Sable C, Beaton A, Longenecker C. Clinical Profile and Outcomes of Rheumatic Heart Disease Patients Undergoing Surgical Valve Procedures in Uganda. Global Heart 2023, 18: 62. PMID: 38028964, PMCID: PMC10655755, DOI: 10.5334/gh.1260.Peer-Reviewed Original ResearchConceptsRheumatic heart diseaseAcute rheumatic feverComplication of acute rheumatic feverHeart diseaseValve surgery proceduresPost-operative survivalCohort of patientsProportion of patientsOutcome of operated patientsRetrospective cohort studyFifteen-year survivalValvular heart diseaseChronic valvular heart diseaseLong-term complicationsMortality of patientsValve surgeryValve repairValvular operationsValve proceduresPublic health problemRe-operationValve replacementSurgical managementUgandan patientsValvular interventionsChallenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework
Ingenhoff R, Robertson N, Munana R, Bodnar B, Weswa I, Sekitoleko I, Gaal J, Kirenga B, Kalyesubula R, Knauf F, Siddharthan T. Challenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework. International Journal Of Chronic Obstructive Pulmonary Disease 2023, 18: 2769-2783. PMID: 38046984, PMCID: PMC10693197, DOI: 10.2147/copd.s420137.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseImplementation Outcomes FrameworkCOPD screeningRural UgandaBurden of COPDReferral processCommunity health worker interventionHealth worker interventionObstructive pulmonary diseaseHealthcare providers' perceptionsCause of deathHigh patient volumeCommunity-based interventionsCHW supportCOPD awarenessCOPD careMiddle-income countriesPulmonary diseaseMedication accessBody of evidenceOutcomes FrameworkQualitative studyHealth outcomesProviders' perceptionsPatient volumeGenomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda
Saarman N, Son J, Zhao H, Cosme L, Kong Y, Li M, Wang S, Weiss B, Echodu R, Opiro R, Aksoy S, Caccone A. Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda. Infection Genetics And Evolution 2023, 114: 105501. PMID: 37709241, PMCID: PMC10593118, DOI: 10.1016/j.meegid.2023.105501.Peer-Reviewed Original ResearchConceptsGenome-wide association analysisNovel vector control strategiesAnimal African trypanosomiasisSex chromosome aneuploidyNatural populationsGenome assemblySex chromosomesGenomic regionsGenomic evidenceGenetic variationBp upstreamAutosomal SNPsSeq dataTrypanosome infectionTrypanosome parasitesAssociation analysisMolecular pathwaysAssembly metricsLinkage disequilibriumLecithin-cholesterol acyltransferaseAfrican trypanosomiasisMajor vectorGenomeSNPsPrimary vectorA user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial
Katamba A, Gupta A, Turimumahoro P, Ochom E, Ggita J, Nakasendwa S, Nanziri L, Musinguzi J, Hennein R, Sekadde M, Hanrahan C, Byaruhanga R, Yoeli E, Turyahabwe S, Cattamanchi A, Dowdy D, Haberer J, Armstrong-Hough M, Kiwanuka N, Davis J. A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial. BMC Public Health 2023, 23: 1568. PMID: 37592314, PMCID: PMC10436440, DOI: 10.1186/s12889-023-16510-0.Peer-Reviewed Original ResearchConceptsContact investigationClinical effectiveness outcomesPrimary implementation outcomeTB contact investigationTB preventative therapyTB treatment initiationTimely TB diagnosisTrial registrationThe trialTuberculosis contact investigationCluster-randomised trialHigh-burden settingsImplementation-effectiveness trialEvidence-based interventionsUganda National CouncilWorld Health OrganizationProportion of contactsTB evaluationPeer-reviewed journalsMiddle-income countriesTreatment initiationTB diagnosisPreventative therapyUndiagnosed personsInfectious deathSputum samplesWide distribution of Mediterranean and African spotted fever agents and the first identification of Israeli spotted fever agent in ticks in Uganda
Eneku W, Erima B, Byaruhanga A, Atim G, Tugume T, Ukuli Q, Kibuuka H, Mworozi E, Douglas C, Koehler J, Cleary N, von Fricken M, Tweyongyere R, Wabwire-Mangen F, Byarugaba D. Wide distribution of Mediterranean and African spotted fever agents and the first identification of Israeli spotted fever agent in ticks in Uganda. PLOS Neglected Tropical Diseases 2023, 17: e0011273. PMID: 37498943, PMCID: PMC10409254, DOI: 10.1371/journal.pntd.0011273.Peer-Reviewed Original ResearchConceptsTick poolsRickettsia sppTick speciesGeographical regions of UgandaPrevalence of RickettsiaOmpA geneRegion of UgandaGltA primersR. africaeRickettsia speciesTime of collectionTicksDiverse geographic regionsRickettsiaLife stagesR. conoriiHuman illnessCausative agentGltAReal-time PCRMediterranean regionPrimersSpeciesWide distributionIsraelensisMolecular characterisation of human adenoviruses associated with respiratory infections in Uganda
Ukuli Q, Erima B, Mubiru A, Atim G, Tugume T, Kibuuka H, Mworozi E, Ducatez M, Wabwire-Mangen F, Byarugaba D. Molecular characterisation of human adenoviruses associated with respiratory infections in Uganda. BMC Infectious Diseases 2023, 23: 435. PMID: 37370005, PMCID: PMC10294467, DOI: 10.1186/s12879-023-08403-9.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionSpecies of human adenovirusHuman adenovirusDiverse group of virusesMultiple genetic variantsInfluenza-like illnessAdenovirus-vectored vaccineGroup of virusesGenome sequenceGenetic diversityAdenovirus-positiveHAdV infectionGenomic characterizationSequenced isolatesSpecies HAdV-BGenetic variantsRespiratory infectionsChildren aged 5Hexon geneNasopharyngeal samplesGenotype B3Molecular characterisationTertiary hospitalUgandan populationCell linesSex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia
Abelman R, Fitzpatrick J, Zawedde J, Sanyu I, Byanyima P, Kaswabuli S, Musisi E, Hsieh J, Gardner K, Zhang M, Byanova K, Sessolo A, Hunt P, Lalitha R, Davis J, Crothers K, Worodria W, Huang L. Sex modifies the risk of HIV-associated obstructive lung disease in Ugandans postpneumonia. AIDS 2023, 37: 1683-1692. PMID: 37352494, PMCID: PMC10527596, DOI: 10.1097/qad.0000000000003626.Peer-Reviewed Original ResearchConceptsObstructive lung diseaseLung diseaseLung functionAbnormal lung functionMultivariable regression modelsWarrants further studyCommon comorbiditiesExpiratory volumeSpirometric abnormalitiesSmoking statusSpirometric testingTB statusVital capacitySex modifiesStratified analysisHIVWomenDiseaseComorbiditiesMenSexFurther studiesGreater degreeRiskTuberculosisPaenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study
Morton S, Hehnly C, Burgoine K, Ssentongo P, Ericson J, Kumar M, Hagmann C, Fronterre C, Smith J, Movassagh M, Streck N, Bebell L, Bazira J, Kumbakumba E, Bajunirwe F, Mulondo R, Mbabazi-Kabachelor E, Nsubuga B, Natukwatsa D, Nalule E, Magombe J, Erickson T, Ngonzi J, Ochora M, Olupot-Olupot P, Onen J, Ssenyonga P, Mugamba J, Warf B, Kulkarni A, Lane J, Whalen A, Zhang L, Sheldon K, Meier F, Kiwanuka J, Broach J, Paulson J, Schiff S. Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study. The Lancet Microbe 2023, 4: e601-e611. PMID: 37348522, PMCID: PMC10529524, DOI: 10.1016/s2666-5247(23)00106-4.Peer-Reviewed Original ResearchConceptsMother-newborn pairsPostinfectious hydrocephalusCerebrospinal fluidNeonatal sepsisSpp infectionUgandan infantsMaternal bloodObservational case-control studyHospital OfficeInfant's cerebrospinal fluidBurden of morbidityCase-control studyRoute of infectionSubset of participantsMaternal feverCranial ultrasoundNeonatal infectionSepsis cohortOptimise treatmentTransplacental transmissionCord bloodObservational studyPlacental samplesSepsisHydrocephalusFrequency of HIV serodifferent couples within TB-affected households in a setting with a high burden of HIV-associated TB
Anguzu G, Gupta A, Ochom E, Tseng A, Zhang M, Barnabas R, Flaxman A, Katamba A, Davis J, Ross J. Frequency of HIV serodifferent couples within TB-affected households in a setting with a high burden of HIV-associated TB. BMC Infectious Diseases 2023, 23: 388. PMID: 37296396, PMCID: PMC10251627, DOI: 10.1186/s12879-023-08365-y.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusUganda AIDS Indicator SurveyHIV prevention servicesIndex participantsContact investigationGeneral populationPrevention servicesFrequency of HIVProportion of HIVRisk of HIVSelf-reported HIV statusHIV testing resultsHIV-serodifferent couplesHousehold contact investigationTB contact investigationAIDS Indicator SurveyCross-sectional trialCommunity health workersIndex partnerSerodifferent couplesTB evaluationHousehold contactsHomes of participantsHIV statusImmunodeficiency virusNeonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda
Ericson J, Burgoine K, Kumbakumba E, Ochora M, Hehnly C, Bajunirwe F, Bazira J, Fronterre C, Hagmann C, Kulkarni A, Kumar M, Magombe J, Mbabazi-Kabachelor E, Morton S, Movassagh M, Mugamba J, Mulondo R, Natukwatsa D, Kaaya B, Olupot-Olupot P, Onen J, Sheldon K, Smith J, Ssentongo P, Ssenyonga P, Warf B, Wegoye E, Zhang L, Kiwanuka J, Paulson J, Broach J, Schiff S. Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda. Clinical Infectious Diseases 2023, 77: 768-775. PMID: 37279589, PMCID: PMC10495130, DOI: 10.1093/cid/ciad337.Peer-Reviewed Original ResearchConceptsNeonatal sepsisPostinfectious hydrocephalusCerebrospinal fluidSigns of sepsisFull-term neonatesOptimal antibiotic treatmentUgandan referral hospitalQuantitative polymerase chain reactionNeonatal characteristicsClinical sepsisTerm neonatesUnderdiagnosed causeAntibiotic choiceMedian ageReferral hospitalUgandan hospitalNeurodevelopmental impairmentAdverse outcomesSpecimen typesAntibiotic treatmentPolymerase chain reactionClinical signsUnusual pathogensSepsisHigh riskDiabetes mellitus care cascade among a cohort of persons living with HIV and hypertension in Uganda: A retrospective cohort study
Ambangira F, Sharman J, Muddu M, Kimera I, Namara D, Musimbaggo D, Namugenyi C, Ssenyonjo R, Mbuliro M, Katwesigye R, Schwartz J, Semitala F, Ssinabulya I. Diabetes mellitus care cascade among a cohort of persons living with HIV and hypertension in Uganda: A retrospective cohort study. International Journal Of STD & AIDS 2023, 34: 728-734. PMID: 37269360, DOI: 10.1177/09564624231179497.Peer-Reviewed Original ResearchConceptsDiabetes mellitusLarge urban HIV clinicNon-suppressed viral loadNon-communicable disease burdenUrban HIV clinicHIV care programsRetrospective cohort studyCohort of personsAppropriate diabetes careDiabetes mellitus careNon-communicable diseasesDual HIVCare cascadeHIV clinicCohort studyGlycaemic controlMedian ageViral loadRetrospective studyDiabetes careDisease burdenMellitus careCare programHIVHypertension
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply