2023
Health Care Disparities in Patients Undergoing Hysterectomy for Benign Indications
Wieslander C, Grimes C, Balk E, Hobson D, Ringel N, Sanses T, Singh R, Richardson M, Lipetskaia L, Gupta A, White A, Orejuela F, Meriwether K, Antosh D. Health Care Disparities in Patients Undergoing Hysterectomy for Benign Indications. Obstetrics And Gynecology 2023, 142: 1044-1054. PMID: 37826848, DOI: 10.1097/aog.0000000000005389.Peer-Reviewed Original ResearchConceptsHealth care disparitiesBenign indicationsCare disparitiesVaginal hysterectomyMedicare insuranceHysterectomy complicationsPatient-level outcomesMultivariable regression analysisInvasive hysterectomy proceduresHealth care systemPrior hysterectomyStrength of associationLaparoscopic hysterectomyBlack patientsMultivariable analysisSurgical outcomesPoor outcomeInsurance statusRisk markersIndependent associationEligible studiesSTUDY SELECTIONHysterectomy proceduresHysterectomyHispanic ethnicityFood Insecurity and Suicidal Ideation: Results from a National Longitudinal Study of Military Veterans
Elbogen E, Graziano R, LaRue G, Cohen A, Hooshyar D, Wagner H, Tsai J. Food Insecurity and Suicidal Ideation: Results from a National Longitudinal Study of Military Veterans. Archives Of Suicide Research 2023, 28: 644-659. PMID: 37165670, PMCID: PMC10636240, DOI: 10.1080/13811118.2023.2200795.Peer-Reviewed Original ResearchMental health disordersSubsequent suicidal ideationHealth disordersSuicidal ideationOne-yearMilitary veteransSuicide riskIndependent risk markerSubsequent suicide riskU.S. military service membersPost-9/11 veteransMilitary service membersFood insecurityMultivariable analysisOdds of suicideRisk markersClinical covariatesHigher oddsElevated riskMental disordersSocial determinantsRepresentative longitudinal surveyDisordersService membersNational Longitudinal Study
2022
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study
Galderisi A, Tordin M, Suppiej A, Cainelli E, Baraldi E, Trevisanuto D. Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European Journal Of Pediatrics 2022, 182: 837-844. PMID: 36484862, PMCID: PMC9899169, DOI: 10.1007/s00431-022-04694-3.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyTherapeutic hypothermiaNeurodevelopmental outcomesLactate ratioDay 1Severe hypoxic-ischemic encephalopathyNew risk markerSevere hypoNeonatal hypoglycemiaMetabolic outcomesRisk markersObservational studyMetabolic variablesDay 2InfantsLactate concentrationEncephalopathyLactate kineticsNeurodevelopmentMetabolic fuelsNeonatesStrongest predictorHypothermiaOutcomesGlucoseTranslating Big Data to Clinical Outcomes in Anxiety: Potential for Multimodal Integration
Khosravi P, Zugman A, Amelio P, Winkler A, Pine D. Translating Big Data to Clinical Outcomes in Anxiety: Potential for Multimodal Integration. Current Psychiatry Reports 2022, 24: 841-851. PMID: 36469202, PMCID: PMC9931491, DOI: 10.1007/s11920-022-01385-6.Peer-Reviewed Original ResearchConceptsAnxiety disordersError Related NegativityPediatric anxiety disordersMost anxiety disordersDisorder treatment outcomesAnxious individualsNeural correlatesMultimodal integrationNeural markersGroup differencesResponse/outcomesAnxietyMultimodal dataCorrelatesTreatment responseTreatment outcomesDiverse relationsDisordersReviewThis reviewNegativityRecent FindingsRecent literatureRisk markersAdulthoodSuch workOutcomesResidual stroke risk despite oral anticoagulation in patients with atrial fibrillation
Carlisle M, Shrader P, Fudim M, Pieper K, Blanco R, Fonarow G, Naccarelli G, Gersh B, Reiffel J, Kowey P, Steinberg B, Freeman J, Ezekowitz M, Singer D, Allen L, Chan P, Pokorney S, Peterson E, Piccini J, Patients and Investigators O. Residual stroke risk despite oral anticoagulation in patients with atrial fibrillation. Heart Rhythm O2 2022, 3: 621-628. PMID: 36589908, PMCID: PMC9795305, DOI: 10.1016/j.hroo.2022.09.018.Peer-Reviewed Original ResearchTransient ischemic attackPermanent atrial fibrillationOral anticoagulationAtrial fibrillationVASc scoreIschemic attackThromboembolic eventsFemale sexPrevious stroke/transient ischemic attackStroke/transient ischemic attackTransient ischemic attack eventsCox proportional hazard modelingResidual riskResidual stroke riskBetter Informed TreatmentRisk of thromboembolismProportional hazard modelingSystemic embolismPrevious strokeStroke riskOutcomes RegistryMean ageRisk markersOutcome eventsThromboembolismThe obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study
Levitsky LL, Drews KL, Haymond M, Glubitosi-Klug RA, Katz L, Mititelu M, Tamborlane W, Tryggestad JB, Weinstock RS, Group T. The obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study. Journal Of Diabetes And Its Complications 2022, 36: 108259. PMID: 36150365, DOI: 10.1016/j.jdiacomp.2022.108259.Peer-Reviewed Original ResearchConceptsNon-proliferative diabetic retinopathyType 2 diabetesHigh-sensitivity C-reactive proteinObesity paradoxInflammatory biomarkersHDL cholesterolLDL cholesterolInsulin-like growth factor binding protein 1Sensitivity C-reactive proteinGrowth factor binding protein 1Today StudyPresence of retinopathyRelationship of obesityC-reactive proteinPlasminogen activator inhibitor-1Tumor necrosis factor receptor 1Digital fundus photographsNecrosis factor receptor 1Activator inhibitor-1Factor receptor 1Higher BMIObese participantsRisk markersDiabetic retinopathyInterleukin-6Next Generation Risk Markers in Preventive Cardio-oncology
Lamberg M, Rossman A, Bennett A, Painter S, Goodman R, MacLeod J, Maddula R, Rayan D, Doshi K, Bick A, Bailey S, Brown S. Next Generation Risk Markers in Preventive Cardio-oncology. Current Atherosclerosis Reports 2022, 24: 443-456. PMID: 35441347, PMCID: PMC10026729, DOI: 10.1007/s11883-022-01021-x.Peer-Reviewed Original ResearchConceptsClonal hematopoiesis of indeterminate potentialBreast arterial calcificationCoronary artery calcificationPurpose of reviewCardiovascular diseaseCoronary artery diseaseRisk stratificationRisk markersCVD risk assessmentCancer treatmentArtery calcificationImprove CV risk stratificationPresence of clonal hematopoiesis of indeterminate potentialAtherosclerotic CVDIndependent of traditional CV risk factorsLong-term CVD outcomesIncreased risk of CVDTraditional CV risk factorsCV risk markersPrediction of coronary artery diseaseCardio-oncology practiceLung cancer screeningCV risk factorsCVD risk calculatorsCV risk stratificationCoronary artery stenosisAn Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy
Fahmy A, Csecs I, Arafati A, Assana S, Yankama T, Al-Otaibi T, Rodriguez J, Chen Y, Ngo L, Manning W, Kwong R, Nezafat R. An Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy. JACC Cardiovascular Imaging 2022, 15: 766-779. PMID: 35033500, DOI: 10.1016/j.jcmg.2021.11.029.Peer-Reviewed Original ResearchConceptsNonischemic dilated cardiomyopathyBeth Israel Deaconess Medical CenterComposite endpointRight ventricular (RV) dysfunctionCardiovascular hospitalizationRisk prediction modelAdverse outcomesRisk markersMarker of adverse outcomeCardiac magnetic resonance markersRisk stratification of patientsRight ventricular dysfunctionRV ejection fractionMedical CenterFollow-up durationCardiac magnetic resonanceEnd-diastolic volumeStratification of patientsArea under the curveAll-cause deathHigh-risk thresholdVentricular dysfunctionEjection fractionNonischemic cardiomyopathyPrognostic significance
2021
Armed conflict, HIV, and syndemic risk markers of mental distress, alcohol misuse, and intimate partner violence among couples in Uganda
Mootz JJ, Basaraba CN, Corbeil T, Johnson K, Kubanga KP, Wainberg ML, Khoshnood K. Armed conflict, HIV, and syndemic risk markers of mental distress, alcohol misuse, and intimate partner violence among couples in Uganda. Journal Of Traumatic Stress 2021, 34: 1016-1026. PMID: 34647647, PMCID: PMC8530966, DOI: 10.1002/jts.22740.Peer-Reviewed Original ResearchConceptsSyndemic problemsHIV statusRisk markersIntimate partner violenceSyndemic scoreAlcohol misuseMale partnersMental distressUnknown HIV statusPopulation-based studyRisk of maleHIV/AIDSFemale intimate partner violencePartner violencePsychosocial interventionsHIVSignificant total effectWomenProblem scoresHigh rateNortheastern UgandaMen's exposureExposureConflict exposureTotal effectRisky sexual behaviour among Russian adolescents: association with internalizing and externalizing symptoms
Isaksson J, Westermark C, Koposov R, Stickley A, Ruchkin V. Risky sexual behaviour among Russian adolescents: association with internalizing and externalizing symptoms. Child And Adolescent Psychiatry And Mental Health 2021, 15: 40. PMID: 34372880, PMCID: PMC8353740, DOI: 10.1186/s13034-021-00393-3.Peer-Reviewed Original ResearchMultiple binary logistic regression analysisExternalizing symptomsBinary logistic regression analysisMajor health problemLogistic regression analysisSexual behaviorSymptoms of anxietyHIV infectionRisky sexual behaviorRisk markersHealth problemsSymptomsTeenage pregnancyProtective factorsMental wellbeingRegression analysisHigh rateAdolescentsInternalizing symptomsAssociationBoysPregnancyInfectionInternalizingResultsBoysC‐reactive protein in adult Samoans: Population variation and physiological correlates
Rivara AC, Corley M, Choy CC, Duckham RL, Pomer A, Reupena MS, Viali S, Naseri T, Kershaw EE, Crouter SE, McGarvey ST, Bribiescas RG, Valeggia C, Hawley NL. C‐reactive protein in adult Samoans: Population variation and physiological correlates. American Journal Of Human Biology 2021, 34: e23646. PMID: 34260111, PMCID: PMC8758804, DOI: 10.1002/ajhb.23646.Peer-Reviewed Original ResearchConceptsC-reactive proteinBody mass indexCardiometabolic disease riskMeasures of adiposityAdult SamoansCRP correlateDisease riskSerum C-reactive proteinMeasures of BMICardiometabolic risk markersPercent body fatSex-dependent associationsCardiometabolic markersCardiometabolic riskCRP quartileMass indexUnadjusted analysesRisk markersBody fatKruskal-Wallis testAdiposityPacific Islander populationsSpearman rank correlationFirst examinationRank correlation
2019
Association Between Mobility Measured During Hospitalization and Functional Outcomes in Older Adults With Acute Myocardial Infarction in the SILVER-AMI Study
Hajduk AM, Murphy TE, Geda ME, Dodson JA, Tsang S, Haghighat L, Tinetti ME, Gill TM, Chaudhry SI. Association Between Mobility Measured During Hospitalization and Functional Outcomes in Older Adults With Acute Myocardial Infarction in the SILVER-AMI Study. JAMA Internal Medicine 2019, 179: 1669-1677. PMID: 31589285, PMCID: PMC6784755, DOI: 10.1001/jamainternmed.2019.4114.Peer-Reviewed Original ResearchAcute myocardial infarctionFunctional declineModerate impairmentMild impairmentSevere impairmentOlder patientsADL declineMyocardial infarctionRisk markersMobility impairmentsOlder survivorsAMI hospitalizationMultivariable-adjusted logistic regressionImportant patient-centered outcomesOlder adultsProspective cohort studyPatient-centered outcomesSelf-reported functionSILVER-AMI StudyPotent risk markerPercent of participantsCohort studyPrimary outcomeMean ageFunctional outcomeWhite Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?
Schepers E, Lousberg R, Guloksuz S, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, Rutten B, van Os J. White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder? Frontiers In Psychiatry 2019, 10: 676. PMID: 31607966, PMCID: PMC6774265, DOI: 10.3389/fpsyt.2019.00676.Peer-Reviewed Original ResearchAnemia at Discharge From the PICU: A Bicenter Descriptive Study.
Demaret P, Valla FV, Behal H, Mimouni Y, Baudelet JB, Karam O, Recher M, Duhamel A, Tucci M, Javouhey E, Leteurtre S. Anemia at Discharge From the PICU: A Bicenter Descriptive Study. Pediatric Critical Care Medicine 2019, 20: e400-e409. PMID: 31246740, DOI: 10.1097/pcc.0000000000002015.Peer-Reviewed Original ResearchConceptsPediatric critical illnessPICU admissionPICU dischargeRisk of anemiaCritical illnessRisk markersHigher C-reactive protein levelsInotropic/vasopressor supportC-reactive protein levelsWorld Health Organization criteriaMedian hemoglobin levelRetrospective cohort studyElectronic medical recordsVasopressor supportPlasma transfusionCohort studyCreatinine levelsMultivariate adjustmentAnemic childrenHemoglobin levelsMechanical ventilationAnemia statusOrganization criteriaMedical recordsIll childrenInitial Results From An Opioid Dependence Whole Exome Sequencing Study
Gelernter J, Sherva R, Zhao H, Kranzler H, Farrer L. Initial Results From An Opioid Dependence Whole Exome Sequencing Study. European Neuropsychopharmacology 2019, 29: s732. DOI: 10.1016/j.euroneuro.2017.06.056.Peer-Reviewed Original ResearchOpioid dependenceWhole-exome sequencesAfrican AmericansCase/control studySubstance use disordersSensory neuron developmentRisk markersPain perceptionSynaptic responsesWhole-exome sequencing studiesOD diagnosisUse disordersControl studySynaptic plasticityNeuron developmentExome sequencing studiesSynapse functionEuropean AmericansPrdm12Myotonic dystrophyGene-based testsBonferroni correctionCommon risk variantsOD riskRisk variants
2018
Understanding the Link between Anxiety and a Neural Marker of Anxiety (The Error-Related Negativity) in 5 to 7 Year-Old Children
Chong L, Meyer A. Understanding the Link between Anxiety and a Neural Marker of Anxiety (The Error-Related Negativity) in 5 to 7 Year-Old Children. Developmental Neuropsychology 2018, 44: 71-87. PMID: 30407088, DOI: 10.1080/87565641.2018.1528264.Peer-Reviewed Original ResearchConceptsChild anxiety symptomsError-related negativitySelf-report scalesGood internal reliabilityChildren ages 5Psychological constructsAnxiety symptomsNeural markersYear old childrenConvergent validityInternal reliabilityAge 5AnxietySensitivity indexError sensitivityChildrenNegativityConstructsValidityScoresRelationshipSymptomsRisk markers
2017
Anemia at pediatric intensive care unit discharge: prevalence and risk markers
Demaret P, Karam O, Tucci M, Lacroix J, Behal H, Duhamel A, Lebrun F, Mulder A, Leteurtre S. Anemia at pediatric intensive care unit discharge: prevalence and risk markers. Annals Of Intensive Care 2017, 7: 107. PMID: 29067568, PMCID: PMC5655401, DOI: 10.1186/s13613-017-0328-8.Peer-Reviewed Original ResearchPICU dischargePICU admissionRisk markersOdds ratioPediatric intensive care unit admissionPediatric intensive care unit dischargeIntensive care unit admissionTertiary care children's hospitalIntensive care unit dischargeCare unit admissionNon-cardiac surgeryPrevalence of anemiaProspective observational studyRisk of anemiaConsequences of anemiaMedian Hb levelStrong risk markerUnit admissionAge-based definitionCritical illnessHospital dischargeMultivariate adjustmentAnemic childrenMedical chartsHemoglobin levelsBiochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification
Akintoye E, Briasoulis A, Afonso L. Biochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification. American Heart Journal 2017, 193: 95-103. PMID: 29129262, DOI: 10.1016/j.ahj.2017.08.002.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsNet reclassification indexBiochemical risk markersBiomarker scoreCohort EquationsC-statisticRisk markersTreatment decisionsPrimary atherosclerotic cardiovascular disease (ASCVD) preventionAtherosclerotic cardiovascular disease preventionCategorical net reclassification indexSensitivity C-reactive proteinCategory-free net reclassification indexN-terminal prohormoneBrain natriuretic peptideAtherosclerotic cardiovascular diseaseC-reactive proteinCardiovascular disease preventionMulti-Ethnic StudyRate of incidentsASCVD preventionIndependent predictorsNet reclassificationNatriuretic peptideRisk reclassification
2016
Novel biomarkers with potential for cardiovascular risk reclassification
Mallikethi-Reddy S, Briasoulis A, Akintoye E, Afonso L. Novel biomarkers with potential for cardiovascular risk reclassification. Biomarkers 2016, 22: 189-199. PMID: 27299923, DOI: 10.1080/1354750x.2016.1201540.Peer-Reviewed Original ResearchConceptsRed cell distribution widthCardiovascular risk reclassificationRisk reclassificationNovel risk markersCardiovascular risk predictionCell distribution widthCardiovascular riskCVD eventsMultivariate risk modelIntermediate riskAbsolute riskAsymptomatic individualsSerum biomarkersRisk markersTreatment recommendationsRisk factorsCystatin CNovel biomarkersRisk modelDistribution widthBiomarkersRisk predictionPatientsRiskReclassificationVisual identification of coronary calcifications on attenuation correction CT improves diagnostic accuracy of SPECT/CT myocardial perfusion imaging
Patchett ND, Pawar S, Miller EJ. Visual identification of coronary calcifications on attenuation correction CT improves diagnostic accuracy of SPECT/CT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2016, 24: 711-720. PMID: 26850031, DOI: 10.1007/s12350-016-0395-5.Peer-Reviewed Original ResearchMeSH KeywordsArtifactsComputed Tomography AngiographyCoronary Artery DiseaseFemaleHumansImage EnhancementMaleMiddle AgedMyocardial Perfusion ImagingObserver VariationReproducibility of ResultsSensitivity and SpecificitySingle Photon Emission Computed Tomography Computed TomographyUser-Computer InterfaceVascular CalcificationConceptsCoronary artery calciumMyocardial perfusion imagingCT myocardial perfusion imagingSPECT/CT myocardial perfusion imagingInvasive coronary angiographyAttenuation correction CTCause mortalityLate revascularizationAbsence of CACAccuracy of MPIRetrospective chart reviewFalse-positive studiesCT myocardial perfusionArtery calciumChart reviewHazard ratioConsecutive patientsCoronary angiographyCoronary calcificationRisk stratificationRisk markersMore MIsCT scanMyocardial perfusionPatients
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