2025
Neonatal brain volumes and early parenting behavior as mediators in associations between prenatal social disadvantage and socioemotional problems in toddlers
Leverett S, Poolos O, Brady R, Tillman R, Lean R, Gerstein E, Anaya B, Triplett R, Alexopoulos D, Warner B, Luby J, Smyser C, Rogers C, Barch D. Neonatal brain volumes and early parenting behavior as mediators in associations between prenatal social disadvantage and socioemotional problems in toddlers. Biological Psychiatry 2025 PMID: 40414448, DOI: 10.1016/j.biopsych.2025.05.015.Peer-Reviewed Original ResearchNeonatal brain volumesAge 2 yearsEarly parenting behaviorsBrain volumeParenting behaviorsChildren aged 1 yearStructural magnetic resonance scansAge 1 yearMagnetic resonance scansSocioemotional difficultiesSocioemotional problemsBrain structural alterationsAssociated with increased externalizingChild socio-emotional problemsEarly risk factorsSocial disadvantageResonance scansRisk factorsMother-child dyadsSocio-emotional problemsPregnancyDysregulation symptomsExternalizing symptomsBrain metricsMediation modelClinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome
Zhang Z, Hu X, Du Q, Mo P, Chen X, Luo M, Jiang Q, Deng L, Xiong Y. Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome. BMC Infectious Diseases 2025, 25: 508. PMID: 40217170, DOI: 10.1186/s12879-025-10900-y.Peer-Reviewed Original ResearchConceptsDisseminated intravascular coagulationOutcomes of disseminated intravascular coagulationPresence of disseminated intravascular coagulationNon-DIC groupIndependent risk factorIntravascular coagulationClinical characteristicsRisk factorsDisseminated intravascular coagulation groupThrombocytopenia syndromeMultivariate logistic regression analysisAssociated with high mortalityIn-hospital mortality of patientsCumulative survival rateZhongnan Hospital of Wuhan UniversityMortality of patientsIn-hospital mortalitySevere feverLogistic regression analysisConsecutive patientsFerritin levelsD-dimerViral loadClinical dataCystatin CIdentifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana
Mensah B, Mensah-Brown H, Partey F, Addo C, Buah G, Afudego G, Okyere D, Tetteh M, Boateng E, Wilson M, Paintsil E. Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana. BMC Public Health 2025, 25: 1042. PMID: 40102895, PMCID: PMC11917097, DOI: 10.1186/s12889-025-22254-w.Peer-Reviewed Original ResearchConceptsFactors associated with LTFUHigh-burden districtsIdentified risk factorsRisk factorsAssociated with loss to follow-upPromote health literacyCare of personsBackgroundLoss to follow-upLoss to follow-upGlobal health initiativesAssociated with LTFULogistic regression modelsAntiretroviral therapyHealth literacyHIV careHealth initiativesFollow-upNo educationHIV clinicEffective interventionsEffectiveness of treatment strategiesLTFUHospital visitsCareMethodsA retrospective analysisThe Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review
Mahabamunuge J, Sekula N, Lepore C, Kudrimoti M, Upadhyay A, Alshowaikh K, Li H, Seifer D, AlAshqar A. The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review. Biomedicines 2025, 13: 709. PMID: 40149685, PMCID: PMC11940587, DOI: 10.3390/biomedicines13030709.Peer-Reviewed Original ResearchPolycystic ovary syndromeType 2 diabetes mellitusCardiometabolic morbidityIncreased cardiovascular riskDevelopment of hypertensionCardiovascular risk factorsNarrative reviewPotential clinical implicationsAndrogen excessEndothelial dysfunctionCardiovascular riskClinical conditionsPredisposed individualsTherapeutic strategiesAdipokine secretionRisk factorsInsulin resistanceCardiometabolic diseasesCardiovascular diseaseClinical implicationsMorbidityMellitusSyndromeMolecular mechanismsDiseaseThe burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study
Alhuneafat L, Al Ta'ani O, Arriola-Montenegro J, Al-Ajloun Y, Naser A, Chaponan-Lavalle A, Ordaya-Gonzales K, Pertuz G, Maaita A, Jabri A, Altibi A, Al-Abdouh A, Van't Hof J, Gutierrez Bernal A. The burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study. International Journal Of Cardiology 2025, 428: 133143. PMID: 40064205, DOI: 10.1016/j.ijcard.2025.133143.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsGlobal Burden of DiseaseBurden of cardiovascular diseaseCardiovascular diseaseRisk factorsMortality-to-incidence ratioGlobal burdenIschemic heart diseaseAge-standardized disability-adjusted life yearsGlobal Burden of Disease StudyDisability-adjusted life year ratesBurden of Disease StudyAge-standardized prevalenceComparative risk assessment frameworkCardiovascular disease prevalenceCardiovascular disease burdenBurden of diseaseLeading risk factorHeart diseaseTailored interventionsCountry-specific variationsElevated BMIRate of strokeHealthcare infrastructureSocio-economic factorsVoxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient ageValidation of the WIfI Classification in the Vascular Quality Initiative database
Alameddine D, Satam K, Slade M, Cardella J, Aboian E, Guzman R, Mills J, Chaar C. Validation of the WIfI Classification in the Vascular Quality Initiative database. Journal Of Vascular Surgery 2025 PMID: 40056961, DOI: 10.1016/j.jvs.2025.03.001.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaWIfI stageWIfI scoreWIfI classificationLower extremity revascularizationPeripheral vascular interventionsMajor amputationAssociated with major amputationWIfI clinical stagePredicting major amputationPeripheral vascular interventional proceduresAssociated with increased riskVascular Quality InitiativeRegression analysisAmputation groupAmputation resultsCox regression analysisLimb-threatening ischemiaCharacteristics of patientsAfrican AmericansQuality InitiativeAmputationRisk factorsExtremity revascularizationFoot Infection classificationGastrointestinal Bleeding in the Older Adult: Pathophysiology, Evaluation, and Management
Sobani Z, Hung K. Gastrointestinal Bleeding in the Older Adult: Pathophysiology, Evaluation, and Management. Current Treatment Options In Gastroenterology 2025, 23: 4. DOI: 10.1007/s11938-025-00469-5.Peer-Reviewed Original ResearchOlder individualsManagement of modifiable risk factorsRisk factorsModifiable risk factorsProportion of individualsOlder AdultsYears of ageBleeding riskGI bleedingManagement of GI bleedingRisk scoreTiming of endoscopic interventionPeri-procedural anticoagulation managementNovel risk scoreComorbid conditionsGastrointestinal (GI) bleedingReduce mortalityHelicobacter pylori infectionMitigate bleeding riskMortalityEndoscopic therapyRiskPrevent rebleedingGastrointestinal bleedingAnticoagulation managementSociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study.
Goldstein D, Jimenez N, Faulk D, Jones J, Reece-Nguyen T, Gooden C, Markowitz D, Dalal P. Sociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study. Anesthesia & Analgesia 2025 PMID: 40036165, DOI: 10.1213/ane.0000000000007451.Peer-Reviewed Original ResearchCase-control studySystemic risk factorsRisk factorsNPO guidelinesRetrospective multicenter case-control studyMulticenter retrospective case-control studyRetrospective case-control studyMulticenter case-control studySingle-center studyDay of procedureMultivariate logistic regressionPublic health insuranceYears of ageLanguage of carePediatric patientsMulticenter studyAffected patientsNoncompliance eventsHealth insurance typeIncreased riskMultivariate analysisPrimary outcomeSecondary outcomesElective proceduresHealth insuranceCardiovascular Event Prevalence in Type 1 Versus Type 2 Diabetes: Veradigm Metabolic Registry Insights
Goldsweig A, Knee A, Tak H, Desai N, Bradley S, Lotfi A, Spertus J, Goldsweig B. Cardiovascular Event Prevalence in Type 1 Versus Type 2 Diabetes: Veradigm Metabolic Registry Insights. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 102502. DOI: 10.1016/j.jscai.2024.102502.Peer-Reviewed Original ResearchIncident cardiovascular eventsPrevalence ratiosDiabetes mellitus type 1Risk of incident cardiovascular eventsCardiovascular diseaseCardiovascular eventsPrimary carePercutaneous coronary interventionMyocardial infarctionType 2 diabetesOutpatient facilitiesEvent prevalenceLimb ischemiaCoronary interventionAge categoriesStudy populationDM2 patientsRisk factorsHemoglobin A1cCarePrevalencePeripheral revascularizationInterventionComorbiditiesDM2Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data.
Shiomi Y, Miwa K, Jensen M, Inoue M, Yoshimura S, Kamogawa N, Fukuda-Doi M, Ma H, Ringleb P, Wu O, Schwamm L, Davis S, Donnan G, Gerloff C, Nakahara J, Toyoda K, Thomalla G, Koga M. Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data. International Journal Of Stroke 2025, 17474930251322034. PMID: 39921231, DOI: 10.1177/17474930251322034.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhagePrevalence of vascular risk factorsIntravenous alteplaseSafety of intravenous alteplaseIndividual participant dataEffect of intravenous alteplaseControl groupVascular risk factorsRandomized controlled trialsRisk of symptomatic intracranial hemorrhageDays post-strokeRate of symptomatic intracranial hemorrhagePost-strokeAlteplase groupAntiplatelet therapy groupParticipant dataSafety outcomesAntiplatelet therapyStroke thrombolysisAntiplatelet therapy patientsControlled trialsBaseline dataModified Rankin Scale scoreFavorable outcomeRisk factorsColorectal Neoplasia in Inflammatory Bowel Disease
Al Sulais E, AlAmeel T, Alenzi M, Shehab M, AlMutairdi A, Al-Bawardy B. Colorectal Neoplasia in Inflammatory Bowel Disease. Cancers 2025, 17: 665. PMID: 40002259, PMCID: PMC11853504, DOI: 10.3390/cancers17040665.Peer-Reviewed Original ResearchRisk of colonic neoplasiaColonic neoplasiaInflammatory bowel diseaseConcomitant primary sclerosing cholangitisRisk factorsMultiple risk factorsColorectal neoplasiaBowel diseaseHigh-risk featuresIncreased riskPrimary sclerosing cholangitisColonic Crohn's diseaseColonic dysplasiaDisease extentSclerosing cholangitisRiskCrohn's diseaseNeoplasiaUlcerative colitisDiseaseSurveillancePatientsColorectalEpidemiologyShort-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection
Jiang B, Ren P, He C, Wang M, Murtada S, Ruiz-Rodríguez M, Chen Y, Ramachandra A, Li G, Qin L, Assi R, Schwartz M, Humphrey J, Tellides G. Short-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection. JCI Insight 2025, 10 PMID: 39932797, PMCID: PMC11949005, DOI: 10.1172/jci.insight.182629.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsBlood pressureAortic dissectionAdult miceInherited connective tissue disorderConnective tissue disordersTGF-b signalingAccumulation of bloodHigh blood pressureAortic phenotypeTissue disordersMolecule expressionTGFB signalingMuscle cellsRisk factorsSynthesis of extracellular matrixSustained increaseTransient increaseBlood extravasationDissectionMedial injuryExtracellular matrix productionVascular degenerationExperimental modelMiceSilent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial.
Ridha M, Zhang C, McCullough S, Viscoli C, Sharma R, Kamel H, Merkler A. Silent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial. Journal Of The American Heart Association 2025, 14: e037663. PMID: 39921499, DOI: 10.1161/jaha.124.037663.Peer-Reviewed Original ResearchConceptsSilent MISilent myocardial infarctionStroke recurrenceClinical MIAssociated with stroke recurrenceFirst-ever strokeMyocardial infarctionIschemic strokeTailored prevention strategiesRecurrent strokeVascular risk factorsHistory of hospitalizationRisk of stroke recurrenceEvidence of MIUnadjusted analysisPrevention strategiesInclusion criteriaSecondary outcomesECG evidence of MIPrimary outcomeRisk factorsMultivariate Cox regression analysisPost hoc analysisStrokeRegression analysisRisk Factors and Hospitalizations Associated with Pediatric Adenovirus and Rotavirus Infections in Northern Lebanon
Khalife S, Osman M, Moubayed S, Kassem I, Safadi D. Risk Factors and Hospitalizations Associated with Pediatric Adenovirus and Rotavirus Infections in Northern Lebanon. Medicina 2025, 61: 296. PMID: 40005411, PMCID: PMC11857655, DOI: 10.3390/medicina61020296.Peer-Reviewed Original ResearchConceptsAcute gastroenteritisRotavirus infectionRisk factorsSusceptibility to rotavirus infectionAssociated with breastfeedingBurden of rotavirusInfection rateLevel of maternal educationCross-sectional studyClinical dataRotavirus vaccinePediatric departmentFrequent viral agentsPediatric morbidityStool samplesLow infection rateTargeted public health interventionsChromatographic immunoassayNorth LebanonViral agentsInfectionProtective effectAdenovirusMaternal educationRotavirusRisk factors for cut-throughs in intertrochanteric hip fracture fixation Tip-Apex Distance (TAD) <10 mm and Apex-to-Center <4 mm
Levine A, Klug T, Cross J, Salameh M, Riedel M, Leslie M. Risk factors for cut-throughs in intertrochanteric hip fracture fixation Tip-Apex Distance (TAD) <10 mm and Apex-to-Center <4 mm. Injury 2025, 56: 112205. PMID: 39954635, DOI: 10.1016/j.injury.2025.112205.Peer-Reviewed Original ResearchConceptsTip-apex distanceIntertrochanteric hip fracturesHip fractureRisk factorsAnterior-posteriorLevel 1 academic trauma centerSliding hip screwFracture reduction qualityNeck-shaft angleCut-out complicationsTrauma centerHip screwNeck-shaftIntramedullary nailingRetrospective reviewReduction qualityReduced riskIncreased riskFracture typeClinical outcomesRiskComplicationsCohortLateral viewFixation devicesDetection of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia using oxygen saturation data
Ramanand P, Indic P, Gentle S, Ambalavanan N. Detection of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia using oxygen saturation data. Pediatric Research 2025, 1-8. PMID: 39915610, DOI: 10.1038/s41390-025-03891-8.Peer-Reviewed Original ResearchDetection of pulmonary hypertensionBronchopulmonary dysplasiaPreterm infantsPulmonary hypertensionClinical risk factorsOxygen saturation dataBedside markersPresence of patent ductus arteriosusRisk factorsSignificant clinical risk factorsPatent ductus arteriosusIncreased risk of mortalityMultivariate logistic regression modelIdentification of PHPresence of PHRisk of mortalityOxygen saturation variabilityDuctus arteriosusClinical courseBackgroundPulmonary hypertensionClinical featuresPretermLogistic regression modelsAssociated PHIncreased riskIncidence and Risk Factors for Posttraumatic Osteoarthritis After Primary ACL Reconstruction in Pediatric Patients: A National Database Study
Moran J, Gouzoulis M, Kunze K, LaPrade C, Grauer J, Hewett T, Chahla J, Jimenez A, McKay S, Fabricant P, LaPrade R, Franklin C. Incidence and Risk Factors for Posttraumatic Osteoarthritis After Primary ACL Reconstruction in Pediatric Patients: A National Database Study. Orthopaedic Journal Of Sports Medicine 2025, 13: 23259671251313754. PMID: 39926589, PMCID: PMC11806457, DOI: 10.1177/23259671251313754.Peer-Reviewed Original ResearchPrimary ACLRAnterior cruciate ligament (ACL) reconstructionRisk factorsPosttraumatic osteoarthritisPediatric patientsMale sexRestorative proceduresTibial eminence avulsion fractureLysis of adhesionsYears of follow-up dataPrimary ACL reconstructionACL injury diagnosisMultiligament knee injuriesNational database studyCase-control studyConcomitant partial meniscectomyFollow-up dataMultivariate logistic regressionLevel of evidenceJuvenile idiopathic arthritisDevelopment of posttraumatic osteoarthritisInjury diagnosisKnee injuriesKnee osteoarthritisCartilage proceduresAnticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis
Chi K, Zarif T, Varrias D, Lee P, Chang Y, Song J, Osabutey A, Borkowski P, Chiang C, Chang Y, Lin Y, Nanna M, Nanna M. Anticoagulants or antiplatelets for secondary prevention of cryptogenic stroke: an updated systematic review and meta-analysis. Heart 2025, heartjnl-2024-325288. PMID: 39915077, DOI: 10.1136/heartjnl-2024-325288.Peer-Reviewed Original ResearchPresence of patent foramen ovaleOral anticoagulantsRandomised controlled trialsCryptogenic strokeAtrial cardiopathyIschaemic strokeIschaemic stroke riskSafety of oral anticoagulantsRisk factorsSecondary prevention of cryptogenic strokeStroke riskMeta-analysisOptimal antithrombotic strategyRisk of recurrent ischaemic strokePatent foramen ovaleInteraction p valuePersonalised treatment strategiesSystematic reviewRecurrent ischaemic strokePreventing ischaemic strokeBleeding riskNo significant differenceAntithrombotic strategiesClinical characteristicsForamen ovaleLong COVID Incidence Proportion in Adults and Children Between 2020 and 2024: An EHR-Based Study From the RECOVER Initiative
Mandel H, Yoo Y, Allen A, Abedian S, Verzani Z, Karlson E, Kleinman L, Mudumbi P, Oliveira C, Muszynski J, Gross R, Carton T, Kim C, Taylor E, Park H, Divers J, Kelly J, Arnold J, Geary C, Zang C, Tantisira K, Rhee K, Koropsak M, Mohandas S, Vasey A, Mosa A, Haendel M, Chute C, Murphy S, O'Brien L, Szmuszkovicz J, Guthe N, Santana J, De A, Bogie A, Halabi K, Mohanraj L, Kinser P, Packard S, Tuttle K, Hirabayashi K, Kaushal R, Pfaff E, Weiner M, Thorpe L, Moffitt R. Long COVID Incidence Proportion in Adults and Children Between 2020 and 2024: An EHR-Based Study From the RECOVER Initiative. Clinical Infectious Diseases 2025, ciaf046. PMID: 39907495, DOI: 10.1093/cid/ciaf046.Peer-Reviewed Original ResearchElectronic health recordsIncidence proportionIncidence estimatesComputable phenotypeEHR-based studiesLong COVIDPublic health priorityPost-acute sequelae of SARS-CoV-2 infectionHealth recordsSequelae of SARS-CoV-2 infectionHealth priorityProportion of individualsRetrospective cohort studyHarmonized definitionExcess incidenceCohort studyImprove preventionSARS-CoV-2 infectionResearch NetworkRisk factorsAdultsCOVID-19Control groupAcute SARS-CoV-2 infectionPediatric population
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