2024
Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank
Jin W, Boss J, Bakulski K, Goutman S, Feldman E, Fritsche L, Mukherjee B. Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank. Journal Of Neurology 2024, 271: 6923-6934. PMID: 39249108, DOI: 10.1007/s00415-024-12644-2.Peer-Reviewed Original ResearchPolygenic risk scoresRisk scorePre-existing conditionsPhenome-wide association studyControls of European descentPhenotype risk scoreUK Biobank dataAmyotrophic lateral sclerosis riskRisk score distributionIncreased ALS riskInfluence of environmental exposuresExposure-related factorsCombined risk scoreUK BiobankAmyotrophic lateral sclerosisBaseline demographic covariatesBiobank dataPRS-CSALS riskAmyotrophic lateral sclerosis diagnosisDiagnosis 1Demographic covariatesAssociation studiesEuropean descentMethodsUtilizing data
2023
Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks
Fritsche L, Nam K, Du J, Kundu R, Salvatore M, Shi X, Lee S, Burgess S, Mukherjee B. Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks. PLOS Genetics 2023, 19: e1010907. PMID: 38113267, PMCID: PMC10763941, DOI: 10.1371/journal.pgen.1010907.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresMichigan Genomics InitiativeUK BiobankPre-existing conditionsPhenome-wide association studyAssociation studiesCohort-specific analysesPolygenic risk score approachUK Biobank cohortMeta-analysisIncreased risk of hospitalizationGenome-wide association studiesBody mass indexRisk of hospitalizationIdentified novel associationsRisk score approachCOVID-19 outcome dataCOVID-19 hospitalizationCOVID-19Mass indexRisk scoreBiobankCardiovascular conditionsCOVID-19 severityIncreased riskPersistent symptoms and conditions among children and adolescents hospitalised with COVID-19 illness: a qualitative study
Messiah S, Francis J, Weerakoon S, Mathew M, Shaikh S, Veeraswamy A, Lozano A, He W, Xie L, Polavarapu D, Ahmed N, Kahn J. Persistent symptoms and conditions among children and adolescents hospitalised with COVID-19 illness: a qualitative study. BMJ Open 2023, 13: e069073. PMID: 37734886, PMCID: PMC10514629, DOI: 10.1136/bmjopen-2022-069073.Peer-Reviewed Original ResearchConceptsCOVID-19 illnessIn-depth interviewsQualitative studyPaediatric healthcare systemHealth information sourcesLack of insurance coverageMental health impactsPrevalence of long COVIDPersistent symptomsPost-COVID-19 symptomsPost-traumatic stress disorderPersistent COVID-19 symptomsHealthcare systemCOVID-19 experiencePre-existing conditionsQualitative interviewsInsurance coverageCOVID-19Support strategiesWorsening pre-existing conditionsHealth impactsIllnessSupport systemInterviewsLong COVIDOpportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction
Swat S, Xu H, Allen L, Greene S, DeVore A, Matsouaka R, Goyal P, Peterson P, Hernandez A, Krumholz H, Yancy C, Fonarow G, Hess P, Program A. Opportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction. JACC Heart Failure 2023, 11: 918-929. PMID: 37318420, DOI: 10.1016/j.jchf.2023.04.015.Peer-Reviewed Original ResearchConceptsEvidence-based medicationsMedication initiationReduced ejection fractionNumber of medicationsMultivariable logistic regressionNumber of patientsPre-existing conditionsReduced ejectionEjection fractionHeart failureMultivariable analysisFemale sexLower oddsMedicationsMean net gainPatientsRural hospitalsAdmissionOlder ageLogistic regressionStudy periodMean numberOddsInitiationRural locations
2021
Editorial: Do lockdowns scar? Three putative mechanisms through which COVID‐19 mitigation policies could cause long‐term harm to young people's mental health
Sonuga‐Barke E, Fearon P. Editorial: Do lockdowns scar? Three putative mechanisms through which COVID‐19 mitigation policies could cause long‐term harm to young people's mental health. Journal Of Child Psychology And Psychiatry 2021, 62: 1375-1378. PMID: 34806768, PMCID: PMC9011706, DOI: 10.1111/jcpp.13537.Peer-Reviewed Original ResearchConceptsYoung people's mental healthPeople's mental healthMental healthLong-term effectsPutative mechanismsHigh-risk settingsParent mental healthPre-existing conditionsUse of lockdownsLong-term harmCOVID-19 mitigation policiesNegative psychological impactParticular riskCOVID-19Social isolationPsychological impactVulnerable individualsHealthEarly predictionDirect effectSuch long-term effectsIndirect effectsLockdownHarmPersonsUnderstanding the Patterns of Serological Testing for COVID-19 Pre- and Post-Vaccination Rollout in Michigan
Zhao Z, Salerno S, Shi X, Lee S, Mukherjee B, Fritsche L. Understanding the Patterns of Serological Testing for COVID-19 Pre- and Post-Vaccination Rollout in Michigan. Journal Of Clinical Medicine 2021, 10: 4341. PMID: 34640359, PMCID: PMC8509702, DOI: 10.3390/jcm10194341.Peer-Reviewed Original ResearchNon-Hispanic black race/ethnicityRegional health centersEver-smoking statusHealth centersBlack race/ethnicityAssociated with ageCirculatory diseasesSARS-CoV-2 antibody testingMichigan MedicinePre-existing conditionsNeighborhood variablesCOVID-19SARS-CoV-2 antibodiesSARS-CoV-2Vaccinated individualsVaccine-induced immunityRespiratory diseaseIndividualsCOVID-19 infectionExploratory analysisLiver diseaseAgeSerological testsData-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents
Geva A, Patel MM, Newhams MM, Young CC, Son MBF, Kong M, Maddux AB, Hall MW, Riggs BJ, Singh AR, Giuliano JS, Hobbs CV, Loftis LL, McLaughlin GE, Schwartz SP, Schuster JE, Babbitt CJ, Halasa NB, Gertz SJ, Doymaz S, Hume JR, Bradford TT, Irby K, Carroll CL, McGuire JK, Tarquinio KM, Rowan CM, Mack EH, Cvijanovich NZ, Fitzgerald JC, Spinella PC, Staat MA, Clouser KN, Soma VL, Dapul H, Maamari M, Bowens C, Havlin KM, Mourani PM, Heidemann SM, Horwitz SM, Feldstein LR, Tenforde MW, Newburger JW, Mandl KD, Randolph AG, Investigators O. Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents. EClinicalMedicine 2021, 40: 101112. PMID: 34485878, PMCID: PMC8405351, DOI: 10.1016/j.eclinm.2021.101112.Peer-Reviewed Original ResearchSARS-CoV-2 PCRCluster 1 patientsInflammatory syndromeClinical featuresPositive SARS-CoV-2 PCRAcute COVID-19 pneumoniaCOVID-19 pulmonary diseaseCOVID-19-related illnessChest radiograph infiltratesHigher inflammatory biomarkersPositive PCR testingAcute COVID-19Multisystem inflammatory syndromeCOVID-19 pneumoniaDiagnosis of MISCluster 3 patientsCluster 2 patientsClusters of patientsPre-existing conditionsPulmonary infiltratesInflammatory biomarkersMucocutaneous involvementPulmonary diseaseRadiographic findingsMean ageKnowledge and perceptions of COVID-19, prevalence of pre-existing conditions and access to essential resources in Somali IDP camps: a cross-sectional study
Alawa J, Al-Ali S, Walz L, Wiles E, Harle N, Awale MA, Mohamed D, Khoshnood K. Knowledge and perceptions of COVID-19, prevalence of pre-existing conditions and access to essential resources in Somali IDP camps: a cross-sectional study. BMJ Open 2021, 11: e044411. PMID: 34187818, PMCID: PMC8245279, DOI: 10.1136/bmjopen-2020-044411.Peer-Reviewed Original ResearchConceptsPre-existing conditionsMajority of participantsCOVID-19Preventative public health measuresCross-sectional studyPublic health measuresCross-sectional surveyCOVID-19 knowledgeIDP campsCOVID-19 preventionEssential preventionScreening examTreatment resourcesHealth servicesLimited accessHealth measuresVulnerable populationsCOVID-19 outbreakMedical servicesPrevalenceLack of accessHygiene facilitiesPreventionSocial distancingParticipantsSepsis Fluid Metric Compliance and its Impact on Outcomes of Patients with Congestive Heart Failure, End-Stage Renal Disease or Obesity
Boccio E, Haimovich A, Jacob V, Maciejewski KR, Wira CR, Belsky J. Sepsis Fluid Metric Compliance and its Impact on Outcomes of Patients with Congestive Heart Failure, End-Stage Renal Disease or Obesity. Journal Of Emergency Medicine 2021, 61: 466-480. PMID: 34088547, DOI: 10.1016/j.jemermed.2021.03.004.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseCongestive heart failurePre-existing congestive heart failurePre-existing conditionsMultiple pre-existing conditionsShock patientsHeart failureRenal diseaseEmergency departmentED patient encountersOutcomes of patientsRetrospective chart reviewSeptic shock patientsFluid overload statesLength of stayUrban academic centerFluid goalChart reviewSeptic shockFluid administrationFluid bolusEmergency physiciansObesityPatientsAcademic centersA Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine
Salvatore M, Gu T, Mack J, Sankar S, Patil S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine. Journal Of Clinical Medicine 2021, 10: 1351. PMID: 33805886, PMCID: PMC8037108, DOI: 10.3390/jcm10071351.Peer-Reviewed Original ResearchPhenome-wide association studyCOVID-19 outcomesIntensive care unitAssociation studiesNon-Hispanic blacksNon-Hispanic whitesAcademic medical centerAssociated with hospitalizationHealthcare deliveryAssociated with mortalityMedicine backgroundPre-existing conditionsMedical phenomeDisease preventionVulnerable populationsPulmonary heart diseaseTargeted screeningMental disordersCOVID-19Associated with intensive care unitMedical CenterRecord DataCare unitGenitourinary conditionsHeart disease
2020
Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City
Paranjpe I, Russak A, De Freitas J, Lala A, Miotto R, Vaid A, Johnson K, Danieletto M, Golden E, Meyer D, Singh M, Somani S, Kapoor A, O'Hagan R, Manna S, Nangia U, Jaladanki S, O’Reilly P, Huckins L, Glowe P, Kia A, Timsina P, Freeman R, Levin M, Jhang J, Firpo A, Kovatch P, Finkelstein J, Aberg J, Bagiella E, Horowitz C, Murphy B, Fayad Z, Narula J, Nestler E, Fuster V, Cordon-Cardo C, Charney D, Reich D, Just A, Bottinger E, Charney A, Glicksberg B, Nadkarni G, Center M. Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City. BMJ Open 2020, 10: e040736. PMID: 33247020, PMCID: PMC7702220, DOI: 10.1136/bmjopen-2020-040736.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overC-Reactive ProteinComorbidityCOVID-19Critical CareFemaleFibrin Fibrinogen Degradation ProductsHospital MortalityHospitalizationHospitalsHumansLymphocytesMaleMiddle AgedNew York CityPandemicsProcalcitoninRetrospective StudiesRisk FactorsSARS-CoV-2Young AdultConceptsIn-hospital mortalityHospitalised patientsPre-existing conditionsInstitutional electronic health recordsElectronic health recordsHealth System hospitalsMount Sinai Health SystemUrban hospital systemMount Sinai Health System hospitalsSinai Health SystemStudy periodIntensive careHealth recordsInvestigate in-hospital mortalityCohort of hospitalised patientsPublic health crisisHealth systemRetrospective cohort studyHospital systemSystem hospitalsGlobal public health crisisClinical characteristicsCohort studyCOVID-19New York City
2012
Conditions That Predispose to Pulmonary Hypertension and Right Heart Failure in Persons Exposed to Household Air Pollution in LMIC
Bloomfield GS, Lagat DK, Akwanalo OC, Carter EJ, Lugogo N, Vedanthan R, Velazquez EJ, Kimaiyo S, Sherman CB. Conditions That Predispose to Pulmonary Hypertension and Right Heart Failure in Persons Exposed to Household Air Pollution in LMIC. Global Heart 2012, 7: 249-259. PMID: 23687634, PMCID: PMC3653331, DOI: 10.1016/j.gheart.2012.06.015.Peer-Reviewed Original ResearchRight heart failurePulmonary hypertensionHousehold air pollutionHeart failureMiddle-income countriesAdverse cardiovascular health effectsRight heart functionHealth effectsHuman immunodeficiency virusCardiovascular health effectsPre-existing conditionsCommon comorbiditiesTuberculosis infectionImmunodeficiency virusCommon causeHypertensionCommon conditionRespiratory conditionsHeart functionCommon exposureMultifactorial natureLarge burdenAir pollutionSignificant exposureExposure
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