2024
Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participantsADVANCED SPERM AGE ≥50 YEAR IS ASSOCIATED WITH AN INCREASE IN SEGMENTAL ANEUPLOIDY RATES: A MULTI-SITE DONOR OOCYTE POPULATION STUDY OF 2124 BIOPSIED EMBRYOS WITH PGTSEQ
Barrett F, Kadesh A, Zhan Y, Gill P, Vessa B, Whitehead C, Puchalt N, Mounts E, Seli E, Werner M, Jalas C, Franasiak J. ADVANCED SPERM AGE ≥50 YEAR IS ASSOCIATED WITH AN INCREASE IN SEGMENTAL ANEUPLOIDY RATES: A MULTI-SITE DONOR OOCYTE POPULATION STUDY OF 2124 BIOPSIED EMBRYOS WITH PGTSEQ. Fertility And Sterility 2024, 122: e35. DOI: 10.1016/j.fertnstert.2024.07.164.Peer-Reviewed Original ResearchParent decisional regret regarding neonatal circumcision in an American outpatient pediatric urology clinic
Brutus N, Howe A, Rehfuss A, Giramonti K, Feustel P, Kogan B. Parent decisional regret regarding neonatal circumcision in an American outpatient pediatric urology clinic. Journal Of Pediatric Urology 2024, 20: 1192-1199. PMID: 39153922, DOI: 10.1016/j.jpurol.2024.07.018.Peer-Reviewed Original ResearchDecisional Regret ScalePediatric urology clinicRegret scoresModerate to strong regretNeonatal circumcisionUrology clinicCircumcision statusSurrogate decision makersRecruitment of participantsParent groupsParental decisional regretPhysician counselingDecisional regretParental regretStrong regretSurveyed parentsRegret ScaleIndependent decision makingCircumcision revisionOutcome variablesDecision makingPopulation studiesUncircumcised penisParental decisionsMedian 0Validation of biomarkers of aging
Moqri M, Herzog C, Poganik J, Ying K, Justice J, Belsky D, Higgins-Chen A, Chen B, Cohen A, Fuellen G, Hägg S, Marioni R, Widschwendter M, Fortney K, Fedichev P, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel D, Kennedy B, Cummings S, Slagboom P, Verdin E, Maier A, Sebastiano V, Snyder M, Gladyshev V, Horvath S, Ferrucci L. Validation of biomarkers of aging. Nature Medicine 2024, 30: 360-372. PMID: 38355974, PMCID: PMC11090477, DOI: 10.1038/s41591-023-02784-9.Peer-Reviewed Original ResearchEpidemiology of burns in a humanitarian setting: A national study among refugees in Lebanon
Presser E, Farhat M, Michael M, El Asmar K, Jaber L, Moustafa M, Mowafi H, Al-Hajj S. Epidemiology of burns in a humanitarian setting: A national study among refugees in Lebanon. Burns 2024, 50: 1145-1149. PMID: 38402117, DOI: 10.1016/j.burns.2024.02.005.Peer-Reviewed Original ResearchSurgeons OverSeas Assessment of Surgical NeedMonths prior to data collectionSocioeconomically disadvantaged individualsMulti-level interventionsEpidemiology of burnsReduce burn injuriesRisk factorsLogistic regression modelsSyrian refugee populationImprove careUnivariate logistic regression modelInformal settlementsHumanitarian settingsMedical careVulnerable populationsDisadvantaged individualsSurgical needsHot liquidFinancial burdenCommunity kitchensRefugee populationsRegression modelsPopulation studiesData collectionCare
2023
A nested case-control study of serum zinc and incident diabetes among Chinese adults: Effect modifications and mediation analysis
Yang J, Cheng Z, Zhang D, Zheng T, Yin C, Liu S, Zhang L, Wang Z, Wang Y, Chen R, Dou Q, Bai Y. A nested case-control study of serum zinc and incident diabetes among Chinese adults: Effect modifications and mediation analysis. The Science Of The Total Environment 2023, 910: 168678. PMID: 37981151, DOI: 10.1016/j.scitotenv.2023.168678.Peer-Reviewed Original ResearchConceptsSerum zinc levelsRisk of diabetesCase-control studySerum zincDiabetes riskEffect modificationZinc levelsMediation proportionBaseline serum zinc concentrationPositive linear dose-response relationshipConditional logistic regression modelsHistory of hypertensionProspective population studyBody mass indexCoronary heart diseasePotential effect modificationSerum zinc concentrationLinear dose-response relationshipPopulation studiesDose-response relationshipLogistic regression modelsIncident diabetesHighest quartileMass indexFourth quartilePrevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases
Chan N, Einstein A, Griffin J, Rosenblum H, Teruya S, Cuomo M, De Los Santos J, DeLuca A, Johnson L, Kinkhabwala M, Leb J, Mintz A, Fine D, Helmke S, Muralidhar V, Pandey S, Sabogal N, Saith S, Winburn M, Smiley D, Miller E, Ruberg F, Maurer M. Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases. Journal Of Nuclear Cardiology 2023, 30: 2531-2539. PMID: 37311914, DOI: 10.1007/s12350-023-03310-7.Peer-Reviewed Original ResearchConceptsExtracardiac uptakePYP uptakeCardiac amyloidosisBone uptakeActionable findingsTiming of scansTransthyretin cardiac amyloidosisHeart failureBreast uptakeMean ageBlack raceRenal uptakeHispanic ethnicityThyroid uptakeATTR-CANuclear scintigraphyHispanic participantsTechnetium pyrophosphateNuclear imagingPYP scanPopulation studiesSelf-identified BlackAdditional testingAmyloidosisSubjectsTranslating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer
Garcia M, Schadler K, Chandra J, Clinton S, Courneya K, Cruz‐Monserrate Z, Daniel C, Dannenberg A, Demark‐Wahnefried W, Dewhirst M, Fabian C, Hursting S, Irwin M, Iyengar N, McQuade J, Schmitz K, Basen‐Engquist K. Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer. CA A Cancer Journal For Clinicians 2023, 73: 425-442. PMID: 36825928, PMCID: PMC11225601, DOI: 10.3322/caac.21773.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsParallel studyHealthy survivorshipCancer outcomesDietary intakePhysical activityAnimal modelsClinical observationsAnimal studiesBody compositionCancer developmentPractice changeCancerPopulation studiesCancer researchEnergy balance researchEnergy balancePatientsSubstantial benefitsClinicStudyIntakeSLC26A1 is a major determinant of sulfate homeostasis in humans
Pfau A, López-Cayuqueo K, Scherer N, Wuttke M, Wernstedt A, Fassrainer D, Smith D, van de Kamp J, Ziegeler K, Eckardt K, Luft F, Aronson P, Köttgen A, Jentsch T, Knauf F. SLC26A1 is a major determinant of sulfate homeostasis in humans. Journal Of Clinical Investigation 2023, 133: e161849. PMID: 36719378, PMCID: PMC9888379, DOI: 10.1172/jci161849.Peer-Reviewed Original ResearchConceptsSulfate homeostasisIntervertebral disc disordersWhole-exome sequencingMajor determinantBack painPatient presentingMusculoskeletal healthDisc disordersPlasma sulfateSulfate reabsorptionFunctional expression assaysCartilage healthHomozygous mutationPotential targetPopulation studiesNumerous physiological processesRecent evidenceExome analysisHomeostasisHyposulfatemiaExpression assaysPivotal roleClinical geneticsAdditional variantsHumans
2019
Reduction in mental health treatment utilization among transgender individuals after gender-affirming surgeries: A total population study
Bränström R, Pachankis J. Reduction in mental health treatment utilization among transgender individuals after gender-affirming surgeries: A total population study. European Journal Of Public Health 2019, 29: ckz185.465. DOI: 10.1093/eurpub/ckz185.465.Peer-Reviewed Original ResearchGender-affirming surgeryMental health treatmentHealthcare visitsGender-affirming medical treatmentTotal population studyHealth treatmentAnxiolytic prescriptionsMedical treatmentMental health treatment utilizationSwedish Total Population RegisterPrescribed Drug RegisterGender dysphoriaNational Patient RegisterPrevalence of moodMain outcome measuresTotal Population RegisterPopulation studiesTransgender individualsEntire Swedish populationGender dysphoria diagnosisDrug RegisterPatient RegisterSurgical interventionTreatment utilizationOutcome measuresReduction in Mental Health Treatment Utilization Among Transgender Individuals After Gender-Affirming Surgeries: A Total Population Study
Bränström R, Pachankis JE. Reduction in Mental Health Treatment Utilization Among Transgender Individuals After Gender-Affirming Surgeries: A Total Population Study. American Journal Of Psychiatry 2019, 177: 727-734. PMID: 31581798, DOI: 10.1176/appi.ajp.2019.19010080.Peer-Reviewed Original ResearchConceptsGender-affirming hormonesHealth care visitsGender-affirming surgeryMental health treatmentCare visitsTotal population studyHealth treatmentAnxiolytic prescriptionsSurgical treatmentSuicide attemptsMental health treatment utilizationSwedish Total Population RegisterPrescribed Drug RegisterNational Patient RegisterPrevalence of moodTotal Population RegisterPopulation studiesGender incongruenceTransgender individualsEntire Swedish populationDrug RegisterPatient RegisterSurgical interventionTreatment utilizationOutcome measuresInteratrial Septum and Appendage Ostium in Atrial Fibrillation Patients: A Population Study
Goparaju A, Morris A, Csecs I, Bhalodia R, Ditter T, Fuimaono K, Kholmovski E, Marrouche N, Cates J, Elhabian S. Interatrial Septum and Appendage Ostium in Atrial Fibrillation Patients: A Population Study. 2016 Computing In Cardiology Conference (CinC) 2019, 46: 1-3. PMID: 32632372, PMCID: PMC7338039, DOI: 10.22489/cinc.2019.439.Peer-Reviewed Original ResearchLeft atrial appendageLeft atrial appendage closureAtrial fibrillationInteratrial septumAtrial fibrillation patientsFibrillation patientsPatient-specific implant selectionImage guidanceOstium planeAtrial appendagePopulation studiesImplant choiceImplant selectionPrevent strokeAppendage ostiumPatientsCatheter designSeptumOstiumOcclusionPopulation Health and Trauma‐Informed Practice: Implications for Programs, Systems, and Policies
Tebes JK, Champine RB, Matlin SL, Strambler MJ. Population Health and Trauma‐Informed Practice: Implications for Programs, Systems, and Policies. American Journal Of Community Psychology 2019, 64: 494-508. PMID: 31444915, PMCID: PMC7006880, DOI: 10.1002/ajcp.12382.Peer-Reviewed Original ResearchConceptsPopulation health perspectiveTrauma exposureHealth consequencesPopulation healthHealth perspectiveCurrent clinical perspectivesPopulation health impactPopulation health consequencesIndividual clinical problemsPopulation health scienceClinical problemTrauma-informed practiceHealth outcomesEffects of traumaHealth statusClinical perspectiveTraumaRoutine partSpecific populationsPopulation studiesTrauma-informed principlesHealth impactsExposureStudy of determinantsIntegrative response
2018
Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing
Rindflesch TC, Blake CL, Cairelli MJ, Fiszman M, Zeiss CJ, Kilicoglu H. Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing. Journal Of Biomedical Semantics 2018, 9: 25. PMID: 30587224, PMCID: PMC6307110, DOI: 10.1186/s13326-018-0192-y.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseInterleukin-1 betaBowel diseaseAdverse drug reactionsBetter healthcare outcomesElectronic health recordsDrug reactionsGlutamate levelsClinical dataEarlier population studiesStructured clinical dataEpilepsyHealthcare outcomesHealth recordsImproved treatmentDiseasePopulation studiesDrug developmentGlutamateBetaEtiologyMethodsInStudyPrevalência de problemas de saúde mental na infância na atenção primária
Fatori D, Brentani A, Grisi S, Miguel E, Graeff-Martins A. Prevalência de problemas de saúde mental na infância na atenção primária. Ciência & Saúde Coletiva 2018, 23: 3013-3020. PMID: 30281738, DOI: 10.1590/1413-81232018239.25332016.Peer-Reviewed Original ResearchConceptsMental health problemsPrimary healthcare unitsHealth professionalsHealth problemsPrimary care settingHealth service usePrevalence of internalizingPublic health problemPresent population studyMental health professionalsMedication treatmentYear old childrenHigh prevalenceCare settingsAtenção primáriaService useHealth servicesSample of childrenOlder childrenPrevalenceTreatment constituteDifficulties QuestionnairePopulation studiesHealthcare unitsChildren
2015
Assessment of critical exposure and outcome windows in time-to-event analysis with application to air pollution and preterm birth study
Chang HH, Warren JL, Darrow LA, Reich BJ, Waller LA. Assessment of critical exposure and outcome windows in time-to-event analysis with application to air pollution and preterm birth study. Biostatistics 2015, 16: 509-521. PMID: 25572998, PMCID: PMC5963471, DOI: 10.1093/biostatistics/kxu060.Peer-Reviewed Original ResearchConceptsPreterm birthAir pollution exposureGestational air pollution exposureRisk of PTBPollution exposurePreterm Birth StudyCourse of pregnancyTime-varying exposureOngoing pregnancyBirth StudyGestational exposureReproductive epidemiologyWeek 30PregnancyWeekly exposureBirth recordsVulnerable periodPopulation studiesPositive associationCritical periodExposureInconsistent findingsAssociationExposure lengthFine particulate matter
2013
Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma
González-Iglesias H, Álvarez L, García M, Escribano J, Rodríguez-Calvo PP, Fernández-Vega L, Coca-Prados M. Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma. Journal Of Proteomics 2013, 98: 65-78. PMID: 24355480, DOI: 10.1016/j.jprot.2013.12.006.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaOpen-angle glaucomaPseudoexfoliation glaucomaGlaucoma patientsInflammatory-related processesSera of patientsForms of glaucomaLarge population studiesPanel of candidatesAge-related blindnessSerum proteinsFunctional pathway analysisClinical manifestationsDietary agentsInflammatory processGlaucoma biomarkersHealthy controlsEarly diagnosisGlaucomaPatientsMajor causeSerumPopulation studiesTwo-dimensional fluorescent difference gel electrophoresisGenetic linkage studiesThe factor structure of the metabolic syndrome in obese individuals with binge eating disorder
Udo T, McKee SA, White MA, Masheb RM, Barnes RD, Grilo CM. The factor structure of the metabolic syndrome in obese individuals with binge eating disorder. Journal Of Psychosomatic Research 2013, 76: 152-157. PMID: 24439692, PMCID: PMC3953028, DOI: 10.1016/j.jpsychores.2013.10.007.Peer-Reviewed Original ResearchConceptsObese individualsMetabolic syndromeMetabolic measuresHigh-risk populationType II diabetesBlood pressurePatient groupExcess weightSubgroup analysisCardiovascular diseaseRisk populationsGlucose regulationTreatment studiesVARCLUS procedurePopulation studiesFactor structureSyndromeBingeDisordersMetSDiverse populationsFour-factor structureIndividualsStatistical Analysis SystemObesity
2007
Nephrogenic Systemic Fibrosis: A Population Study Examining the Relationship of Disease Development to Gadolinium Exposure
Deo A, Fogel M, Cowper SE. Nephrogenic Systemic Fibrosis: A Population Study Examining the Relationship of Disease Development to Gadolinium Exposure. Clinical Journal Of The American Society Of Nephrology 2007, 2: 264-267. PMID: 17699423, DOI: 10.2215/cjn.03921106.Peer-Reviewed Original ResearchConceptsNephrogenic systemic fibrosisGadolinium-containing contrast agentsGadolinium exposureIncidence of NSFSevere renal failurePopulation of patientsMajor risk factorOccurrence of NSFDevastating complicationESRD populationRenal failureSignificant morbidityRadiologic studiesRisk factorsSystemic fibrosisPopulation studiesESRDPatientsDisease developmentRecent reportsExposureContrast agentsRiskMorbidityComplications
2002
A Functional Neuropeptide Y Leu7Pro Polymorphism Associated With Alcohol Dependence in a Large Population Sample From the United States
Lappalainen J, Kranzler HR, Malison R, Price LH, Van Dyck C, Rosenheck RA, Cramer J, Southwick S, Charney D, Krystal J, Gelernter J. A Functional Neuropeptide Y Leu7Pro Polymorphism Associated With Alcohol Dependence in a Large Population Sample From the United States. JAMA Psychiatry 2002, 59: 825-831. PMID: 12215082, DOI: 10.1001/archpsyc.59.9.825.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAlcoholismBlack PeopleCase-Control StudiesComorbidityDepressive DisorderEthnicityEuropeFemaleGene FrequencyGenetic Predisposition to DiseaseGenetics, PopulationGenotypeHumansMaleNeuropeptide YPolymorphism, GeneticRacial GroupsSchizophreniaStress Disorders, Post-TraumaticUnited StatesConceptsAlcohol-dependent subjectsPro7 alleleAlcohol dependencePopulation sampleComorbid psychiatric disordersMain outcome measuresPopulation studiesEA controlsNeuropeptide Y geneRecent population studiesPosttraumatic stress disorderNPY polymorphismsRisk factorsAttributable fractionMajor depressionOutcome measuresLarge population samplePsychiatric disordersAlcohol consumptionPolymorphism AssociatedAlzheimer's diseaseAllele frequenciesStress disorderModulate riskEuropean Americans
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