2024
Improving racial/ethnic health equity and naloxone access among people at risk for opioid overdose: A simulation modeling analysis of community‐based naloxone distribution strategies in Massachusetts, United States
Zang X, Skinner A, Li Z, Shaw L, Behrends C, Chatterjee A, Jalali A, Jordan A, Morgan J, Nolen S, Schackman B, Marshall B, Walley A. Improving racial/ethnic health equity and naloxone access among people at risk for opioid overdose: A simulation modeling analysis of community‐based naloxone distribution strategies in Massachusetts, United States. Addiction 2024, 120: 316-326. PMID: 39450522, PMCID: PMC11707306, DOI: 10.1111/add.16691.Peer-Reviewed Original ResearchRates of opioid overdose deathsOpioid overdose deathsEthnic disparitiesNaloxone availabilityHealth equityNaloxone distribution strategiesRacial/ethnic groupsHispanic/Latinx populationsHealthcare costsImprove overall population healthOverall population healthOverdose deathsRisk of opioid overdose deathCost per lifePopulation healthNaloxone kitsNaloxone accessSimulation model analysisOpioid overdoseDisparitiesIncremental costPopulation levelAnnual numberHealthcareEthnic groups“SafetyNet”: Evaluation of a Recovery Coach and Paramedic Intervention Following Naloxone Resuscitation From an Opioid Overdose
Joseph D, Brokowski C, D’Onofrio G, Bogucki S, McGovern J, Allen R, Dziura J, Cone D, Pantalon M. “SafetyNet”: Evaluation of a Recovery Coach and Paramedic Intervention Following Naloxone Resuscitation From an Opioid Overdose. Substance Use & Addiction Journal 2024, 46: 302-312. PMID: 39171791, DOI: 10.1177/29767342241266412.Peer-Reviewed Original ResearchOverdose eventsRecovery coachesOpioid overdoseFollow-up encountersReducing illicit drug useFifty-five participantsIllicit drug useParamedic interventionsTrained paramedicsPeer recoveryFollow-upHealth educationOpioid use disorderSample size estimationParamedicsOpioid-positive urine testsPositive urine toxicology screenMOUD engagementMedical concernsMOUDUrine toxicology screenDrug useParticipantsPositive urine testInterventionPeer support for patients with opioid use disorder in the emergency department: A narrative review
Jack H, Arif S, Moore M, Bhatraju E, Thompson J, Stewart M, Hawk K, Bartlett E. Peer support for patients with opioid use disorder in the emergency department: A narrative review. Journal Of The American College Of Emergency Physicians Open 2024, 5: e13253. PMID: 39144727, PMCID: PMC11322658, DOI: 10.1002/emp2.13253.Peer-Reviewed Original ResearchOpioid use disorderEmergency departmentPeer programsNarrative reviewOpioid overdose crisisED cliniciansED settingPeer supportPeer roleED administrationActive peersOverdose crisisOpioid overdosePeer supervisionExperience of addictionGrant fundingUse disorderClinical outcomesPeerProgramOpioidDepartmentPatientsCareSupportIdentifying facilitators and barriers to the uptake of medication for opioid use disorder in Washington, DC: A community-engaged concept mapping approach
Gullahorn B, Kuo I, Robinson A, Bailey J, Loken J, Taggart T. Identifying facilitators and barriers to the uptake of medication for opioid use disorder in Washington, DC: A community-engaged concept mapping approach. PLOS ONE 2024, 19: e0306931. PMID: 39028730, PMCID: PMC11259286, DOI: 10.1371/journal.pone.0306931.Peer-Reviewed Original ResearchConceptsConcept mapping approachOpioid use disorderUptake of medicationCommunity advisory boardStigma associated with substance useUse disorderPublic health challengeAwareness of treatmentMOUD deliverySense of hopelessnessIdentified barriersUnique statementsHealth challengesAdvisory boardOpioid overdoseProvidersCommunity membersMOUD engagementMOUDSubstance useTreatment programsHopelessnessMedicationPersonal motivationFacilitationUsing qualitative system dynamics modeling to understand overdose bystander behavior in the context of Connecticut’s Good Samaritan Laws and identify effective policy options
Thompson R, Sabounchi N, Ali S, Heimer R, D’Onofrio G, Heckmann R. Using qualitative system dynamics modeling to understand overdose bystander behavior in the context of Connecticut’s Good Samaritan Laws and identify effective policy options. Harm Reduction Journal 2024, 21: 124. PMID: 38937759, PMCID: PMC11210010, DOI: 10.1186/s12954-024-00990-3.Peer-Reviewed Original ResearchConceptsSamaritan lawsGood Samaritan lawsBystander behaviorGroup model buildingFear of legal consequencesKnowledge of protectionResponses to opioid overdosesCriminal liabilityDrug arrestsLegal consequencesLaw enforcementNaloxone useLawStakeholder-engaged processOpioid overdoseHealth care providersFatal opioid overdoseSustainable system changeOpioid-related outcomesBystander experiencesSamaritanCare providersHarm reductionPotential bystandersPolicy determinationEvaluation of Strategies to Enhance Community-Based Naloxone Distribution Supported by an Opioid Settlement
Zang X, Skinner A, Krieger M, Behrends C, Park J, Green T, Walley A, Morgan J, Linas B, Yedinak J, Schackman B, Marshall B. Evaluation of Strategies to Enhance Community-Based Naloxone Distribution Supported by an Opioid Settlement. JAMA Network Open 2024, 7: e2413861. PMID: 38814644, PMCID: PMC11140538, DOI: 10.1001/jamanetworkopen.2024.13861.Peer-Reviewed Original ResearchConceptsCommunity-based naloxone distributionOpioid overdose deathsNaloxone distributionSolitary drug useOpioid overdoseNaloxone distribution programsDecision analytical model studyDrug useNonfatal opioid overdoseReducing opioid overdose deathsIncreasing naloxone distributionHypothetical interventionMain OutcomesNaloxone availabilityCommunity-based naloxone distribution programsStudy populationOverdose deathsInterventionAnnual numberUS statesMisuse opioidsAnalytical model studyRhode IslandPublished simulation modelSynergistic associationLatinX harm reduction capital, medication for opioid use disorder, and nonfatal overdose: A structural equation model analysis among people who use drugs in Massachusetts
Shrestha S, Stopka T, Hughto J, Case P, Palacios W, Reilly B, Green T. LatinX harm reduction capital, medication for opioid use disorder, and nonfatal overdose: A structural equation model analysis among people who use drugs in Massachusetts. Drug And Alcohol Dependence 2024, 259: 111293. PMID: 38643530, PMCID: PMC11925145, DOI: 10.1016/j.drugalcdep.2024.111293.Peer-Reviewed Original ResearchStructural equation modeling analysisSubstance use historyOpioid use disorderUse disorderStructural equation modelingTreatment utilizationGeneralized structural equation modelMethadone treatmentLatent constructsBuprenorphine treatmentSelf-identificationNonfatal overdoseMeasured constructsEquation modelingLatinxMOUD useTreatment experienceOpioidMOUDTreatment differencesModel analysisOverdoseHarm reduction servicesOpioid overdoseDifferential utilizationPredictive Models to Assess Risk of Persistent Opioid Use, Opioid Use Disorder, and Overdose
Song S, Dandapani H, Estrada R, Jones N, Samuels E, Ranney M. Predictive Models to Assess Risk of Persistent Opioid Use, Opioid Use Disorder, and Overdose. Journal Of Addiction Medicine 2024, 18: 218-239. PMID: 38591783, PMCID: PMC11150108, DOI: 10.1097/adm.0000000000001276.Peer-Reviewed Original ResearchPersistent opioid useOpioid use disorderPrediction model Risk Of Bias ASsessment ToolRisk of biasOpioid useRisk of persistent opioid useSystematic reviewRisk of bias assessment toolOpioid overdoseRisk of opioid use disorderUse disorderOpioid-related risksBias assessment toolFull-text reviewPreferred Reporting ItemsMeta-Analysis guidelinesSubstance use disorder historyPrediction Model RiskReporting ItemsElectronic databasesDiagnosis historyStudy selectionAbstract reviewPrimary outcomeData extraction“They make it too hard and too many hoops to jump”: system and organizational barriers to drug treatment during epidemic rates of opioid overdose
Dickson-Gomez J, Krechel S, Ohlrich J, Montaque H, Weeks M, Li J, Havens J, Spector A. “They make it too hard and too many hoops to jump”: system and organizational barriers to drug treatment during epidemic rates of opioid overdose. Harm Reduction Journal 2024, 21: 52. PMID: 38413972, PMCID: PMC10900746, DOI: 10.1186/s12954-024-00964-5.Peer-Reviewed Original ResearchConceptsOpioid use disorderDrug treatmentImprove treatment retentionTreat opioid use disorderAttended group treatmentOpioid overdoseMedically managed withdrawalHeightened risk of overdoseRates of opioid overdoseCourse of treatmentTreatment retentionGroup treatmentUse disorderRisk of overdoseTreatment participationAbstinence requirementRespiratory depressionManaged withdrawalOpioidInitiate MOUDMOUD initiationMOUD stigmaMOUD treatmentHeightened riskOpioid overdose crisis
2023
Mortality, incarceration and cost implications of fentanyl felonization laws: A modeling study
Savinkina A, Jurecka C, Gonsalves G, Barocas J. Mortality, incarceration and cost implications of fentanyl felonization laws: A modeling study. International Journal Of Drug Policy 2023, 121: 104175. PMID: 37729682, PMCID: PMC10840895, DOI: 10.1016/j.drugpo.2023.104175.Peer-Reviewed Original ResearchLong-Term Treatment of Opioid Use Disorder with Medications
Wolfgang A, Weimer M, Na P, Fiellin D, Muvvala S. Long-Term Treatment of Opioid Use Disorder with Medications. 2023, 631-661. DOI: 10.1093/oxfordhb/9780197618431.013.23.ChaptersOpioid use disorderMedical diseasesUse disordersChronic medical diseasesExtended-release naltrexoneLong-term treatmentCause mortalityOUD treatmentClinical outcomesOngoing treatmentOpioid overdoseTerm treatmentMedicationsPsychosocial outcomesAddiction treatmentDisease paradigmOutcomesTreatmentEvidence-based paradigmDiseaseDisordersNegative outcomesImproved retentionRemissionRelapsingLong-term opioid therapy trajectories and overdose in patients with and without cancer
Merlin J, Black A, Midboe A, Troszak L, Asch S, Bohnert A, Fenton B, Giannitrapani K, Glassman P, Kerns R, Silveira M, Lorenz K, Abel E, Becker W. Long-term opioid therapy trajectories and overdose in patients with and without cancer. BMJ Oncology 2023, 2: e000023. PMID: 38259328, PMCID: PMC10802123, DOI: 10.1136/bmjonc-2022-000023.Peer-Reviewed Original ResearchLong-term opioid therapyVeterans Health Administration databaseRetrospective cohort studyCornerstone of managementOpioid overdose riskHealth Administration databaseOpioid-related overdosesPresence of cancerRole of cancerOpioid receiptOpioid therapyCohort studyConclusions PatientsMost patientsObjective painOpioid risksDose/Opioid overdoseOverdose riskInternational ClassificationLower riskPatientsEffect of trajectoriesCancerAdministration databaseBreaking through social determinants of health: Results from a feasibility study of Imani Breakthrough, a community developed substance use intervention for Black and Latinx people
Jordan A, Costa M, Nich C, Swarbrick M, Babuscio T, Wyatt J, O'Connell M, Guy K, Blackman K, Anderson R, Reis G, Ocasio L, Crespo M, Bellamy C. Breaking through social determinants of health: Results from a feasibility study of Imani Breakthrough, a community developed substance use intervention for Black and Latinx people. Journal Of Substance Use And Addiction Treatment 2023, 153: 209057. PMID: 37207836, DOI: 10.1016/j.josat.2023.209057.Peer-Reviewed Original ResearchConceptsSocial determinantsMental Health Services AdministrationDimensions of wellnessCommunity-based participatory research approachRate of deathHealth Services AdministrationDrug overdose ratesSubset of participantsSubstance use interventionsWeek 12Opioid overdoseOverdose ratesSubstance misuseEthnic disparitiesDisparity gapParticipatory research approachAddiction servicesSubstance abuseWeeks of educationHealth equityMental healthSubstance useLatinx peopleIntervention programsServices AdministrationPrevalence and correlates of experiencing drug-related discrimination among people who use drugs presenting at emergency department at high risk of opioid overdose
Nolen S, Wilson T, Jacka B, Li Y, Beaudoin F, Marshall B. Prevalence and correlates of experiencing drug-related discrimination among people who use drugs presenting at emergency department at high risk of opioid overdose. Addictive Behaviors Reports 2023, 17: 100496. PMID: 37249941, PMCID: PMC10213175, DOI: 10.1016/j.abrep.2023.100496.Peer-Reviewed Original ResearchEmergency departmentOpioid overdoseED-based interventionsRhode Island emergency departmentsSecondary analysis of dataSelf-reported discriminationRacial/ethnic minority groupsRisk of opioid overdoseHigh risk of opioid overdoseMedical communityHigh riskRandomized controlled trialsMultivariate regression modelSociodemographic covariatesSociodemographic characteristicsSecondary analysisWhite participantsBehavioral interventionsIndependent variablesControlled trialsStudy populationAnalysis of dataParticipantsRegression modelsMinority groups
2022
Electronic Advisories Increase Naloxone Prescribing Across Health Care Settings
Heiman E, Lanh S, Moran T, Steck A, Carpenter J. Electronic Advisories Increase Naloxone Prescribing Across Health Care Settings. Journal Of General Internal Medicine 2022, 38: 1402-1409. PMID: 36376626, PMCID: PMC9663180, DOI: 10.1007/s11606-022-07876-9.Peer-Reviewed Original ResearchConceptsNaloxone prescriptionsOpioid dosesRetrospective chart abstraction studyHigh-dose opioidsPrescribed opioid dosesEmergency department dischargeLarge county hospitalInpatient hospital dischargesInterrupted time series analysisHealth care settingsSystem-level interventionsDaily opioidsNaloxone prescribingPrescribers' practicesOpioid prescriptionsOutpatient medicationsAdult patientsHospital dischargeOpioid prescribersOutpatient clinicMain MeasuresWeCounty HospitalOpioid overdoseCare settingsHigh riskTake-home Naloxone at Opioid Treatment Programs: A Lifesaver
Katzman J, Bhatt S, Comerci G. Take-home Naloxone at Opioid Treatment Programs: A Lifesaver. Journal Of Addiction Medicine 2022, 16: 619-621. PMID: 35220332, PMCID: PMC9653102, DOI: 10.1097/adm.0000000000000983.Peer-Reviewed Original ResearchConceptsTreatment programsOpioid use disorderUse disorderOpioid treatment programsDisorder diagnosisFederal inmatesFederal police officersTake-home naloxoneNaloxoneHarm reduction strategiesAvailability of naloxonePolice officersDisordersOpioidOpioid substancesActive dutyOpioid-related overdose deathsElevated riskOverdose deathsGovernmental agenciesOverdoseMedical societiesEducation to patientsOpioid overdosePatientsComparing Projected Fatal Overdose Outcomes and Costs of Strategies to Expand Community-Based Distribution of Naloxone in Rhode Island
Zang X, Bessey S, Krieger M, Hallowell B, Koziol J, Nolen S, Behrends C, Murphy S, Walley A, Linas B, Schackman B, Marshall B. Comparing Projected Fatal Overdose Outcomes and Costs of Strategies to Expand Community-Based Distribution of Naloxone in Rhode Island. JAMA Network Open 2022, 5: e2241174. PMID: 36350649, PMCID: PMC9647481, DOI: 10.1001/jamanetworkopen.2022.41174.Peer-Reviewed Original ResearchConceptsOpioid overdose death ratesOpioid overdose deathsDecision analytical model studyNaloxone kitsHealth inequalitiesNaloxone distributionOpioid overdoseRhode IslandCommunity-based programsCommunity-based organizationsDistribution of naloxoneMean incremental costAnalytical model studyState of Rhode IslandIncreasing naloxone distributionMain OutcomesPriority settingBetween-group varianceOutcomes of alternative strategiesDemand-based approachGeospatial inequalityMisused prescription opioidsCurrent population dataOverdose deathsPrescription opioidsAssociations Between Inpatient Induction on Medications for Opioid Use Disorder and Postdischarge Medications for Opioid Use Disorder Adherence, Overdose, and Service Use
Noam K, Schmutte T, Pirard S, Bourdon C, Langless D, Plant R. Associations Between Inpatient Induction on Medications for Opioid Use Disorder and Postdischarge Medications for Opioid Use Disorder Adherence, Overdose, and Service Use. Journal Of Addiction Medicine 2022, 17: e199-e201. PMID: 37267183, DOI: 10.1097/adm.0000000000001092.Peer-Reviewed Original ResearchConceptsCause hospital readmissionOpioid use disorderHospital readmissionOdds ratioService utilizationMedical adviceOpioid overdoseUse disordersAcute service utilizationRetrospective cohort analysisContinuous Medicaid enrollmentSignificant reductionInpatient inductionPostdischarge medicationsAdherent patientsPostdischarge periodInpatient medicationsEmergency departmentMedicaid adultsInpatient careOpioid overdosesPreadmission periodCohort analysisHigher oddsInpatient daysLong-Term Opioid Therapy and Overdose in Patients With and Without Cancer (CO203A)
Merlin J, Black A, Troszak L, Giannitrapani K, Lorenz K. Long-Term Opioid Therapy and Overdose in Patients With and Without Cancer (CO203A). Journal Of Pain And Symptom Management 2022, 63: 1065-1066. DOI: 10.1016/j.jpainsymman.2022.04.013.Peer-Reviewed Original ResearchLong-term opioid therapyOpioid therapyOpioid prescriptionsOpioid overdoseElectronic health record databaseTerm opioid therapyCancer pain managementRetrospective cohort studyCox proportional hazardsOpioid overdose riskHealth record databaseYears of ageRole of cancerOpioid receiptCohort studyMost patientsPain managementOutpatient visitsInpatient admissionsVHA careOpioid risksDose/Inclusion criteriaOverdose riskLatent growth mixture modelingLong-term Opioid Therapy and Overdose in Patients with and without Cancer
Merlin J, Black A, Midboe A, Troszak L, Asch S, Bohnert A, Fenton B, Giannitrapani K, Glassman P, Kerns R, Silveira M, Lorenz K, Becker W. Long-term Opioid Therapy and Overdose in Patients with and without Cancer. Journal Of Pain 2022, 23: 60. DOI: 10.1016/j.jpain.2022.03.225.Peer-Reviewed Original ResearchLong-term opioid therapyOpioid therapyCox proportional hazard modelingElectronic health record databaseCancer pain managementRetrospective cohort studyProportional hazard modelingOpioid overdose riskHealth record databasePresence of cancerRole of cancerOpioid receiptCohort entryCohort studyHazard ratioMost patientsPain managementOpioid risksDose/Inclusion criteriaOpioid overdoseOverdose riskLatent growth mixture modelingLower riskPatients
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