2024
The role of personality traits and life stress in alcohol use disorder: Insights from NGF gene polymorphisms of Han Chinese population in Taiwan
Kuo S, Lin C, Yeh Y, Chen C, Huang Y, Chang T, Yang Y, Huang J, Yang B, Huang S. The role of personality traits and life stress in alcohol use disorder: Insights from NGF gene polymorphisms of Han Chinese population in Taiwan. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 136: 111232. PMID: 39719220, DOI: 10.1016/j.pnpbp.2024.111232.Peer-Reviewed Original ResearchConceptsAlcohol use disorderLife Events QuestionnaireTridimensional Personality QuestionnaireHarm avoidancePersonality traitsLife stressUse disorderAssociated with alcohol use disorderAlcohol use disorder groupNegative Life Events QuestionnaireAlcohol use disorder patientsNerve growth factor geneChronic alcohol consumptionPersonality QuestionnaireNS scoresEvents QuestionnaireNeuropsychiatric conditionsBrain regionsNerve growth factor levelsSample of womenNerve growth factorPersonal characteristicsHan Chinese populationLEQ scoresAlcohol consumptionEnhancing Early Diagnosis of Bipolar Disorder in Adolescents Through Multimodal Neuroimaging
Wu J, Lin K, Lu W, Zou W, Li X, Tan Y, Yang J, Zheng D, Liu X, Lam B, Xu G, Wang K, McIntyre R, Wang F, So K, Wang J. Enhancing Early Diagnosis of Bipolar Disorder in Adolescents Through Multimodal Neuroimaging. Biological Psychiatry 2024, 97: 313-322. PMID: 39069165, DOI: 10.1016/j.biopsych.2024.07.018.Peer-Reviewed Original ResearchAt-risk adolescentsBipolar disorderBehavioral assessmentBD patientsDiagnosis of bipolar disorderEarly diagnosis of bipolar disordersSevere neuropsychiatric conditionMultimodal MRIAt-riskBehavioral attributesEnhancing early diagnosisSubthreshold symptomsClinical interviewPsychiatric symptomsNeuropsychiatric conditionsStructural equation modelingMultimodal neuroimagingGlobal functioningBrain healthBD diagnosisBD DiagnosticsAdvanced imaging techniquesSubgroup distinctionsAdolescentsRetrospective cohortVerbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis
Kennedy E, Liebel S, Lindsey H, Vadlamani S, Lei P, Adamson M, Alda M, Alonso-Lana S, Anderson T, Arango C, Asarnow R, Avram M, Ayesa-Arriola R, Babikian T, Banaj N, Bird L, Borgwardt S, Brodtmann A, Brosch K, Caeyenberghs K, Calhoun V, Chiaravalloti N, Cifu D, Crespo-Facorro B, Dalrymple-Alford J, Dams-O’Connor K, Dannlowski U, Darby D, Davenport N, DeLuca J, Diaz-Caneja C, Disner S, Dobryakova E, Ehrlich S, Esopenko C, Ferrarelli F, Frank L, Franz C, Fuentes-Claramonte P, Genova H, Giza C, Goltermann J, Grotegerd D, Gruber M, Gutierrez-Zotes A, Ha M, Haavik J, Hinkin C, Hoskinson K, Hubl D, Irimia A, Jansen A, Kaess M, Kang X, Kenney K, Keřková B, Khlif M, Kim M, Kindler J, Kircher T, Knížková K, Kolskår K, Krch D, Kremen W, Kuhn T, Kumari V, Kwon J, Langella R, Laskowitz S, Lee J, Lengenfelder J, Liou-Johnson V, Lippa S, Løvstad M, Lundervold A, Marotta C, Marquardt C, Mattos P, Mayeli A, McDonald C, Meinert S, Melzer T, Merchán-Naranjo J, Michel C, Morey R, Mwangi B, Myall D, Nenadić I, Newsome M, Nunes A, O’Brien T, Oertel V, Ollinger J, Olsen A, de la Foz V, Ozmen M, Pardoe H, Parent M, Piras F, Piras F, Pomarol-Clotet E, Repple J, Richard G, Rodriguez J, Rodriguez M, Rootes-Murdy K, Rowland J, Ryan N, Salvador R, Sanders A, Schmidt A, Soares J, Spalleta G, Španiel F, Sponheim S, Stasenko A, Stein F, Straube B, Thames A, Thomas-Odenthal F, Thomopoulos S, Tone E, Torres I, Troyanskaya M, Turner J, Ulrichsen K, Umpierrez G, Vecchio D, Vilella E, Vivash L, Walker W, Werden E, Westlye L, Wild K, Wroblewski A, Wu M, Wylie G, Yatham L, Zunta-Soares G, Thompson P, Pugh M, Tate D, Hillary F, Wilde E, Dennis E. Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis. Brain Sciences 2024, 14: 669. PMID: 39061410, PMCID: PMC11274572, DOI: 10.3390/brainsci14070669.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderVerbal learningNeuropsychiatric conditionsTraumatic brain injuryYears of educationMild cognitive impairmentComorbid disordersAttention-deficit/hyperactivityBipolar disorderMemory deficitsMemory performanceMemory recallClinical groupsMega-analysisCognitive impairmentEffects of dementiaAssociated with dementiaMemoryBrain injurySchizophreniaMemory impactDisordersDepressionParkinson's diseaseUnique participantsExplainable Multimodal Graph Isomorphism Network for Interpreting Sex Differences in Adolescent Neurodevelopment
Patel B, Orlichenko A, Patel A, Qu G, Wilson T, Stephen J, Calhoun V, Wang Y. Explainable Multimodal Graph Isomorphism Network for Interpreting Sex Differences in Adolescent Neurodevelopment. Applied Sciences 2024, 14: 4144. DOI: 10.3390/app14104144.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingBlood oxygen level-dependentGraph isomorphism networkGraph neural networksBrain networksFunctional magnetic resonance imaging paradigmFunctional magnetic resonance imaging blood oxygen level-dependentSex differencesClassification accuracyExploration of sex differencesInterpreting sex differencesOxygen level-dependentState-of-the-art algorithmsAdolescent neurodevelopmentState-of-the-artNeuropsychiatric conditionsFunctional connectivityTask-related dataDeep learning modelsLevel-dependentMouth movementsFMRI datasetsFunctional networksGraph structureAdolescentsPsychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial
Sloshower J, Zeifman R, Guss J, Krause R, Safi-Aghdam H, Pathania S, Pittman B, D’Souza D. Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial. Scientific Reports 2024, 14: 8833. PMID: 38632313, PMCID: PMC11024097, DOI: 10.1038/s41598-024-58318-x.Peer-Reviewed Original ResearchConceptsPsilocybin-assisted therapyPsychological flexibilityDepression severityModerate to severe MDDSpectrum of neuropsychiatric conditionsTarget psychological flexibilityIncrease psychological flexibilityMental health conditionsManualized psychotherapyPsilocybin treatmentSevere MDDDepressive disorderExperiential acceptanceCommitment therapyDosing sessionsNeuropsychiatric conditionsPsychedelic trialsPlacebo-controlled trialWithin-subjectMDDPsilocybinAdministered placeboPlacebo-controlledDepressionClinical samples
2022
Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies
Raval NR, Wetherill RR, Wiers CE, Dubroff JG, Hillmer AT. Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies. Seminars In Nuclear Medicine 2022, 53: 213-229. PMID: 36270830, PMCID: PMC11261531, DOI: 10.1053/j.semnuclmed.2022.08.008.Peer-Reviewed Original Research In PressConceptsNeuroimmune targetsImmune systemNeuropsychiatric conditionsSphingosine-1-phosphate receptor 1Brain immune systemPurinergic P2X7 receptorVivo positron emission tomography (PET) imagingNitric oxide synthasePurinergic P2Y12 receptorPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyTranslocator protein 18Neuroimmune responsePET findingsNeuroimmune systemP2X7 receptorCyclooxygenase-2Oxide synthaseP2Y12 receptorPET resultsMonoamine oxidase BCyclooxygenase-1Colony-stimulating factor-1Receptor 1
2021
Exploring the bidirectional relationship between chronic disease and depression among female Syrian refugees and Jordanians: a qualitative analysis.
Sharp M, Kara J, Almidani S, Ahram M, Mahmoud R, Khoshnood K. Exploring the bidirectional relationship between chronic disease and depression among female Syrian refugees and Jordanians: a qualitative analysis. Eastern Mediterranean Health Journal 2021, 27: 1153-1161. PMID: 35137383, DOI: 10.26719/emhj.21.017.Peer-Reviewed Original ResearchConceptsChronic diseasesJordanian womenChronic illnessBidirectional relationshipMental healthIntersection of depressionNegative health care experiencesChronic disease interventionsHealth care experiencesSyrian womenContributors of morbidityComorbid depressionChronic conditionsFemale Syrian refugeesHealth care structuresMedical careNeuropsychiatric conditionsCare experiencesClinical settingDiseaseDisease interventionCare structuresWomenHealth careSensitive interventionsEmergent and Non-Emergent Agitation in the Older Adult: Evaluation and Management
Subramanian S, Fahed M, Dix E, Wilkins K. Emergent and Non-Emergent Agitation in the Older Adult: Evaluation and Management. Current Geriatrics Reports 2021, 10: 73-81. DOI: 10.1007/s13670-021-00358-6.Peer-Reviewed Original ResearchCohen-Mansfield Agitation InventoryElectroconvulsive therapyOlder adultsPsychiatric disordersNon-pharmacological managementAlcohol withdrawalDistressing symptomsBenzodiazepine usePharmacological treatmentTreatment optionsExcited catatoniaHeterogenous presentationSuccessful treatmentSignificant disabilitySubstance intoxicationNeuropsychiatric conditionsMotor behaviorCognitive enhancersPolypharmacyAdultsDeliriumPatientsCatatoniaReviewThis paperTreatment
2020
Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin
Schindler EAD, Sewell RA, Gottschalk CH, Luddy C, Flynn LT, Lindsey H, Pittman BP, Cozzi NV, D'Souza D. Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin. Neurotherapeutics 2020, 18: 534-543. PMID: 33184743, PMCID: PMC8116458, DOI: 10.1007/s13311-020-00962-y.Peer-Reviewed Original ResearchConceptsTherapeutic effectAdverse eventsSingle administrationPsychotropic effectsWeekly migraine daysSerious adverse eventsCross-over studyEffects of psilocybinOral placeboMigraine daysMigraine frequencyClinical effectsControlled StudyHeadache disordersMigraine headacheHeadache diaryDrug effectsDrug AdministrationNeuropsychiatric conditionsMigraineFinal analysisStudy proceduresReceptor ligandsWeeksAdministrationEarly-life trauma endophenotypes and brain circuit–gene expression relationships in functional neurological (conversion) disorder
Diez I, Larson A, Nakhate V, Dunn E, Fricchione G, Nicholson T, Sepulcre J, Perez D. Early-life trauma endophenotypes and brain circuit–gene expression relationships in functional neurological (conversion) disorder. Molecular Psychiatry 2020, 26: 3817-3828. PMID: 32051548, PMCID: PMC7423688, DOI: 10.1038/s41380-020-0665-0.Peer-Reviewed Original ResearchConceptsEarly-life maltreatmentAllen Human Brain AtlasPhysical abusePathophysiology of FNDFunctional connectivity architectureHuman Brain AtlasCognitive controlPsychiatric controlsMotor FNDAbuse severityLimbic/paralimbic areasNeuropsychiatric conditionsIndividual differencesPhysical neglectFunctional connectivitySubtype effectsGraph theory approachConnectivity profilesLeft-lateral structuresExploratory analysisCell motility genesEndophenotypesMotor cortexMotor phenotypeRight‐lateral structure
2018
Chapter 23 Tourette disorder and other tic disorders
Fernandez TV, State MW, Pittenger C. Chapter 23 Tourette disorder and other tic disorders. Handbook Of Clinical Neurology 2018, 147: 343-354. PMID: 29325623, DOI: 10.1016/b978-0-444-63233-3.00023-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAssociation studiesLarge-effect variantsCandidate gene association studiesGene association studiesGenomewide association studiesSubstantial genetic contributionMultiple genesDevelopmental neuropsychiatric conditionsComplex neuropsychiatric disorderGenetic variantsGenetic contributionRare mutationsTic disordersGenomewide significanceTourette's disorderGenesEnvironmental factorsAccumulated evidenceLarge patient cohortPatient cohortMotor ticsInadequate sample sizePositive findingsNeuropsychiatric conditionsNeuropsychiatric disorders
2017
Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity
Flaherty E, Deranieh R, Artimovich E, Lee I, Siegel A, Levy D, Nestor M, Brennand K. Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity. Schizophrenia 2017, 3: 35. PMID: 28970473, PMCID: PMC5624885, DOI: 10.1038/s41537-017-0033-5.Peer-Reviewed Original ResearchNeural progenitor cellsGene expressionGlobal gene expressionNeuronal gene expressionPluripotent stem cellsNeuronal activityFamily triosCell adhesion moleculeNeurexin familyHiPSC neuronsMolecular mechanismsDeletion displayAxon guidanceNeuronal developmentGenetic backgroundStem cellsProgenitor cellsDeletionMultiple neuropsychiatric conditionsHeterozygous intragenic deletionDendritic arborizationGenesAnimal studiesAdhesion moleculesNeuropsychiatric conditionsBarratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field
Ide JS, Tung HC, Yang CT, Tseng YC, Li CR. Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field. Frontiers In Human Neuroscience 2017, 11: 222. PMID: 28522966, PMCID: PMC5415556, DOI: 10.3389/fnhum.2017.00222.Peer-Reviewed Original ResearchGray matter volumeGray matter concentrationPeripheral visual fieldOccipital cortexBarratt impulsivityVisual fieldYoung adultsPrefrontal cortical areasParietal-occipital cortexHigher impulsivity scoresMotor subscoresCortical volumeCortical areasMatter volumeCerebral structuresHealthy adultsClinical importanceHealthy populationNeuropsychiatric conditionsFrontal dysfunctionAlcohol useImpulsive individualsAdultsImpulsivity scoresNeural correlatesMagnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective
Uhlhaas P, Liddle P, Linden D, Nobre A, Singh K, Gross J. Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 235-244. PMID: 28424797, PMCID: PMC5387180, DOI: 10.1016/j.bpsc.2017.01.005.Peer-Reviewed Original ResearchPsychiatric researchAberrant rhythmic activityAbnormal brain dynamicsAutism spectrum disorderNeurobiological mechanismsPsychiatric conditionsCircuit dysfunctionNeuropsychiatric disordersNeuropsychiatric conditionsSpectrum disorderApplication of magnetoencephalographyNeural oscillationsBrain dynamicsMagnetoencephalographyNeuronal eventsPreclinical researchDisordersMEG signalsMillisecond resolutionDevelopment of biomarkersSchizophreniaPathophysiological mechanismsPsychiatricAutismTranslational researchSearching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders
Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biological Psychiatry 2017, 81: 848-861. PMID: 28434615, PMCID: PMC5436134, DOI: 10.1016/j.biopsych.2017.03.005.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderFunctional magnetic resonance imagingRecent theoretical accountsEarly course schizophreniaNeurodevelopmental disordersPharmacological challenge studiesNeural correlatesNeuroscience literatureTheoretical accountsNeural circuitryTheoretical neuroscienceNoninvasive neuroimagingBehavioral dysfunctionFuture researchNeuropsychiatric conditionsComputational modelSchizophreniaProton magnetic resonance spectroscopyDisordersInhibition imbalanceMagnetic resonance imagingDistinct modalitiesPoint of convergenceInhibition balance
2016
The Basal Ganglia and Decision-Making in Neuropsychiatric Disorders
Tinaz S, Stern C. The Basal Ganglia and Decision-Making in Neuropsychiatric Disorders. Innovations In Cognitive Neuroscience 2016, 339-361. DOI: 10.1007/978-3-319-42743-0_15.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDecision-making deficitsGoal-directed actionsDecision-making researchDeficit hyperactivity disorderPotential neurophysiological mechanismsFunctional neuroimaging methodsObsessive-compulsive disorderNeuropsychiatric disordersNeural correlatesHyperactivity disorderBasic rewardsCompulsive disorderNeurophysiological mechanismsNeuroimaging methodsBasal ganglia-cortical circuitsOverview of termsNeuropsychiatric conditionsComputational modelDetailed computational modelDecision makingMood disordersDifferent neuropsychiatric disordersRewardDecision-making process
2015
Ethics of neuromodulation in psychiatry
Fins J, Pohl B. Ethics of neuromodulation in psychiatry. 2015, 15-26. DOI: 10.1002/9781118801086.ch2.Peer-Reviewed Original ResearchSevere psychiatric illnessHealth care systemNeuropsychiatric conditionsPsychiatric illnessPervasive stigmaMental illnessCare systemDeep brain stimulationBrain stimulationClinical ethicsMoral dilemmasDerivative questionsIllnessEthicsDevice regulationNeuromodulationTranslational researchClinical needPsychiatryStigmaHealthBrainInterventionFamilial Risks of Tourette Syndrome and Chronic Tic Disorders: A Population-Based Cohort Study
Mataix-Cols D, Isomura K, Pérez-Vigil A, Chang Z, Rück C, Larsson KJ, Leckman JF, Serlachius E, Larsson H, Lichtenstein P. Familial Risks of Tourette Syndrome and Chronic Tic Disorders: A Population-Based Cohort Study. JAMA Psychiatry 2015, 72: 787-793. PMID: 26083307, DOI: 10.1001/jamapsychiatry.2015.0627.Peer-Reviewed Original ResearchConceptsChronic tic disorderFirst-degree relativesTic disordersTourette syndromeFamilial riskSwedish National Patient RegisterNational Patient RegisterSecond-degree relativesRelatives of probandsPopulation-based twin sampleThird-degree relativesFamily studiesCohort studyPatient RegisterFemale patientsSpecialist clinicMAIN OUTCOMESimilar riskGeneral populationPopulation cohortHeritable neuropsychiatric conditionsNeuropsychiatric conditionsSimilar environmental exposuresEnvironmental exposuresDisordersModulation of aggressive behavior in mice by nicotinic receptor subtypes
Lewis AS, Mineur YS, Smith PH, Cahuzac EL, Picciotto MR. Modulation of aggressive behavior in mice by nicotinic receptor subtypes. Biochemical Pharmacology 2015, 97: 488-497. PMID: 26212554, PMCID: PMC4600457, DOI: 10.1016/j.bcp.2015.07.019.Peer-Reviewed Original ResearchConceptsAcute nicotine administrationNicotine administrationHypolocomotor effectNicotinic acetylcholine receptor agonist nicotineAgonist GTS-21Nicotinic receptor subtypesAnti-aggressive propertiesDihydro-β-erythroidineBALB/cNeurobiology of aggressionSocial interaction timeCurrent pharmacotherapyAntagonist methyllycaconitineC57BL/6 miceWorse outcomesGTS-21Receptor subtypesPathological aggressionAgonist nicotineΑ7 nAChRsSpecific treatmentSide effectsPharmacological studiesNeuropsychiatric conditionsNicotineInteractive eye tracking for gaze strategy modification
Wang Q, Celebi F, Flink L, Greco G, Wall C, Prince E, Lansiquot S, Chawarska K, Kim E, Boccanfuso L, DiNicola L, Shic F. Interactive eye tracking for gaze strategy modification. 2015, 247-250. DOI: 10.1145/2771839.2771888.Peer-Reviewed Original ResearchAutism spectrum disorderEye trackingAtypical visual attentionPost-training sessionsYoung childrenNeuropsychiatric conditionsNormative control groupAttentional biasesVisual attentionNeuropsychological processesSpectrum disorderSocial informationNormative groupVideo participantsViewer's attentionSensitive outcome measuresToddlersTraining systemChildrenLearning opportunitiesTypical fashionAttentionStrategy modificationOutcome measuresBiases
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