2025
Quality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial
Mark D, Li Y, Nanna M, Kelsey M, Daniels M, Rogers C, Patel M, Baloch K, Chow B, Anstrom K, Vemulapalli S, Weir-McCall J, Stone G, Chew D, Douglas P, Investigators O. Quality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011414. PMID: 39895494, PMCID: PMC11837958, DOI: 10.1161/circoutcomes.124.011414.Peer-Reviewed Original ResearchConceptsQuality of lifeSAQ Summary ScoreSummary scoreOveral quality of lifeAssess quality of lifeGeneric health statusQuality of life outcomesBaseline SAQ scoresCoronary artery diseaseQuality of life assessmentFollow-up time pointsClinically meaningful differencesStable patientsFollow-upArtery diseaseEQ-5DHealth statusMonths postrandomizationSuspected coronary diseaseComponent scoresSatisfaction surveySuspected coronary artery diseaseTrial participantsStable chest painTest groupHealth Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study
Mosarla R, Chowdhury M, Smolderen K, Mena-Hurtado C, Spertus J, Yeh R, Secemsky E. Health Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study. The American Journal Of Cardiology 2025, 243: 22-31. PMID: 39894333, DOI: 10.1016/j.amjcard.2025.01.017.Peer-Reviewed Original ResearchPredictor of health statusHealth statusEQ-VASAssociated with health statusHealth status measuresTarget vessel/lesion revascularizationTotal scoreBaseline health statusAll-cause deathImprove health statusPeripheral endovascular interventionsHealth status improvementChronic limb-threatening ischemiaRepeated measures modelPeripheral arterial disease severitySymptomatic peripheral arterial diseaseStatus measuresPeripheral arterial diseaseLimb-threatening ischemiaLong-term improvementPeripheral vascular interventionsStatus improvementHealthMultivariate regressionClaudicationDefining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting
Kluger J, Romain G, Mena‐Hurtado C, Grubman S, Pajarillo C, Cleman J, Scierka L, Smolderen K. Defining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting. Catheterization And Cardiovascular Interventions 2025, 105: 927-937. PMID: 39789704, DOI: 10.1002/ccd.31410.Peer-Reviewed Original ResearchConceptsMinimal clinically important differenceHealth status changesHealth statusSF-36Visual analog scaleEQ-5DDistribution-based MCIDPhysical component scoreCarotid artery stentingDisease-specific instrumentHealth status improvementTransfemoral carotid artery stentingSymptom statusClinically important differenceTF-CASStatus changesGeneric instrumentsArtery stentingRegistry dataComponent scoresImportant differencePatients no changeStatus improvementAsymptomatic carotid stenosisHealth
2024
Long-term associations between ambient air pollution and self-perceived health status: Results from the population-based KORA-Fit study
Liao M, Zhang S, Wolf K, Bolte G, Laxy M, Schwettmann L, Peters A, Schneider A, Kraus U. Long-term associations between ambient air pollution and self-perceived health status: Results from the population-based KORA-Fit study. International Journal Of Hygiene And Environmental Health 2024, 264: 114513. PMID: 39719813, DOI: 10.1016/j.ijheh.2024.114513.Peer-Reviewed Original ResearchConceptsSelf-perceived healthLong-term air pollution exposureSelf-perceived health statusAir pollution exposurePoor SRHHealth statusAssociated with poor self-perceived healthPoor self-perceived healthPollution exposureInterquartile rangeLand-use regression modelsLogistic regressionGeocoded residential addressesParticle number concentrationFace-to-face interviewsCooperative Health ResearchEQ-5D index valueSelf-perceived stressAmbient air pollutionEQ-VAS scoresIQR increaseAir pollutionCross-sectional studyBody mass indexMultinomial logistic regressionHealth status outcomes after acute myocardial infarction in patients without standard modifiable risk factors
Ikemura N, Chan P, Gosch K, Nguyen D, Iv C, Khan M, Lu Y, Sawano M, Krumholz H, Spertus J. Health status outcomes after acute myocardial infarction in patients without standard modifiable risk factors. American Heart Journal 2024, 281: 123-132. PMID: 39638274, PMCID: PMC11810589, DOI: 10.1016/j.ahj.2024.11.018.Peer-Reviewed Original ResearchSeattle Angina QuestionnaireModifiable risk factorsHealth status outcomesBaseline SAQ scoresAcute myocardial infarctionStatus outcomesHealth statusRisk factorsSequential adjustmentSAQ scoresModifiable cardiovascular risk factorsHistory of coronary diseaseSAQ Summary ScoreHierarchical linear mixed modelsAcute myocardial infarction patientsCardiovascular risk factorsMyocardial infarctionSummary scoreSociodemographic characteristicsAngina QuestionnaireLinear mixed modelsDepressive symptomsU.S. hospitalsLong-term mortalitySecondary preventionCulturally adapted intervention regarding decision‐making on feeding options for Chinese American dementia caregivers: A human‐centered approach
Pei Y, Wang J, Schulman‐Green D, Fried T, Hanson L, Wu B. Culturally adapted intervention regarding decision‐making on feeding options for Chinese American dementia caregivers: A human‐centered approach. Alzheimer's & Dementia 2024, 20: e088317. PMCID: PMC11712302, DOI: 10.1002/alz.088317.Peer-Reviewed Original ResearchDementia caregiversFamily decision-makingFeeding optionsHealth statusEnd-of-life experiencesCultural adaptationDecision aid interventionTube feedingHealth care providersPatients' health statusDecision-making experiencesSemi-structured interviewsAdvanced dementiaHealthy eatingCare providersPLWDDecision-makingChinese versionDemographic questionnairePerception of comfortThematic analysisCaregiversCaregiving practicesAudio-recordedChinese AmericansReal-World Efficacy and Patient-Reported Quality of Life Outcomes with Daratumumab Regimens in Multiple Myeloma
Browning S, Li F, Theprungsirikul P, Parker T, Bar N, Giri S, Anderson T, Stevens E, Gorshein E, Sabbath K, Wei C, Ali S, Witt D, Persico J, Talsania A, Rahmat L, Kidwai W, Legare R, LaSala J, Austin M, Neparidze N. Real-World Efficacy and Patient-Reported Quality of Life Outcomes with Daratumumab Regimens in Multiple Myeloma. Blood 2024, 144: 7831. DOI: 10.1182/blood-2024-204150.Peer-Reviewed Original ResearchRelapsed/refractory multiple myelomaInternational Myeloma Working GroupAdverse eventsGlobal health statusFunctional scalesMultiple symptom scalesPartial responseProteasome inhibitorsMultiple myelomaHealth statusEastern Cooperative Oncology Group performance statusClinical trialsMonoclonal antibody targeting CD38Median progression free survivalRelapsed/refractory multiple myeloma patientsIntroduction of novel therapiesHealth-related quality of lifeClinical response assessmentDaratumumab-based regimensProgression free survivalInfusion-related reactionsLines of therapyPatient-reported quality of life outcomesMean fatigue scoreHealth-related qualityATHN Transcends Hemophilia Natural History Arm: Baseline Characteristics, Adverse Events, and Self-Reported Health Status of Individuals with Hemophilia A and B
Corrales-Medina F, Afari-Dwamena N, Blair A, Carpenter S, Chrisentery-Singleton T, Daoud N, Janbain M, Raffini L, Schwartz J, Zia A, Recht M. ATHN Transcends Hemophilia Natural History Arm: Baseline Characteristics, Adverse Events, and Self-Reported Health Status of Individuals with Hemophilia A and B. Blood 2024, 144: 1204. DOI: 10.1182/blood-2024-198548.Peer-Reviewed Original ResearchEQ-5D-5LHemophilia treatment centersAdverse eventsUpper respiratory infectionSevere haemophiliaSelf-careHealth statusSelf-reported health statusHealth status ratingsPrevalence of painReport problemsAssess health statusHealth status of individualsMonths of data collectionTherapy-related adverse eventsMental health concernsEuroQol-5D questionnaireCohort of PWHCongenital bleeding disordersProspective cohort studyB (HBLocal institutional review boardSevere hemophilia BUnited StatesBaseline medical historyBiases in COVID-19 vaccine effectiveness studies using cohort design
Agampodi S, Tadesse B, Sahastrabuddhe S, Excler J, Kim J. Biases in COVID-19 vaccine effectiveness studies using cohort design. Frontiers In Medicine 2024, 11: 1474045. PMID: 39540039, PMCID: PMC11557388, DOI: 10.3389/fmed.2024.1474045.Peer-Reviewed Original ResearchCohort designHealth-promoting behaviorsObservational studyPublic health strategiesPublic health policiesMiddle-income countriesPre-existing data sourcesHealthy user biasHealthy vaccinee effectSociodemographic disparitiesHealth strategiesHealth policyOutcome misclassificationSustaining public trustMisclassification biasHealth statusHealthcare systemVaccinee effectSusceptibility biasDiverse populationsCOVID-19Vaccine effectiveness studiesFrailty biasVaccine effectivenessCOVID-19 pandemicWhy do older adults stop cancer screening? Findings from the Medicare Current Beneficiary Survey
Belliveau O, Richman I. Why do older adults stop cancer screening? Findings from the Medicare Current Beneficiary Survey. Journal Of The American Geriatrics Society 2024, 73: 389-398. PMID: 39444166, DOI: 10.1111/jgs.19239.Peer-Reviewed Original ResearchMedicare Current Beneficiary SurveyCancer screeningHealth statusScreening cessationPhysician recommendationBeneficiary SurveyEducational attainmentHistory of breast cancerBreast cancer screeningHigher educational attainmentNationally representative dataHistory of prostate cancerDiscontinue screeningScreening mammographyOlder adultsImprove communicationPatient preferencesWeighted populationPrimary outcomeRepresentative dataPhysiciansHealthProstate cancerBreast cancerMedicarePrediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication
Peri-Okonny P, Romain G, Callegari S, Cleman J, Vashist A, Smolderen K, Mena-Hurtado C. Prediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication. Annals Of Vascular Surgery 2024, 110: 314-322. PMID: 39395588, DOI: 10.1016/j.avsg.2024.08.016.Peer-Reviewed Original ResearchHealth statusPeripheral arterial diseaseEQ-5D VASPeripheral vascular interventionsPredictor of future health statusPredictor of health statusDrug-coated balloonLower extremity peripheral arterial diseaseHealth status outcomesFuture health statusEQ-5D-3LHistory of deep venous thrombosisImprove patient outcomesStatus outcomesPrediction of health statusChronic lung diseaseDeep venous thrombosisPlain balloon angioplastyPatient outcomesDisease managementExtremity interventionsApproach to treatmentSD ageVenous thrombosisBaseline characteristicsAssociation of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry
Cleman J, Romain G, Scierka L, Labrosciano C, Bradley B, Fitridge R, Beltrame J, Shishehbor M, Spertus J, Mena-Hurtado C, Smolderen K. Association of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry. Vascular Medicine 2024, 29: 664-674. PMID: 39319857, DOI: 10.1177/1358863x241274758.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseED visitsHealth statusHospital admissionHealthcare utilizationPAD-specific health statusEmergency departmentCause-specific hospital admissionsAssociation of health statusPatient-reported outcome measuresPatient's risk of hospitalizationBaseline health statusAll-cause hospital admissionsCox proportional hazards modelsRisk of hospitalizationOverall summary scorePAQ scoresProportional hazards modelSummary scoreOutcome measuresHospitalization riskArtery diseaseVisitsHazards modelQualitative interview study of patient-reported symptoms, impacts and treatment goals of patients with obstructive hypertrophic cardiomyopathy
Shore S, Ervin C, Kosa K, Fehnel S, Salberg L, Butzner M, Heitner S, Jacoby D, Saberi S. Qualitative interview study of patient-reported symptoms, impacts and treatment goals of patients with obstructive hypertrophic cardiomyopathy. BMJ Open 2024, 14: e081323. PMID: 39289016, PMCID: PMC11409399, DOI: 10.1136/bmjopen-2023-081323.Peer-Reviewed Original ResearchConceptsQualitative interview studyTreatment goalsShortness of breathTreatment goals of patientsInterview studyAffecting health statusGoals of patientsHypertrophic Cardiomyopathy AssociationPatient-reported symptomsSemi-structured interviewsPhysical functionPatient experiencePatient perspectiveSymptom burdenUS adultsObstructive HCMObstructive hypertrophic cardiomyopathyHealth statusTelephone interviewsPsychosocial impactChest pain/pressureLifestyle-limiting symptomsHypertrophic cardiomyopathyImproving shortness of breathDizziness/light-headednessImpact of Capacity Strain on the Health Status of Patients Discharged From an Intensive Care Unit
Kim S, Pinker E, Rimar J. Impact of Capacity Strain on the Health Status of Patients Discharged From an Intensive Care Unit. Production And Operations Management 2024, 34: 45-59. DOI: 10.1177/10591478241276134.Peer-Reviewed Original ResearchICU capacity strainCapacity strainPatient healthIntensive care unitHealth statusHealth status of patientsQuality of careShorter length of stayLength of stayStatus of patientsPatient dischargeOutcome measuresPatient admissionsTeaching hospitalHealthPatient statusCare unitPost hoc analysisHospitalPost-hocPatientsCareResearch approachEffect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy Results From SEQUOIA-HCM
Sherrod C, Saberi S, Nassif M, Claggett B, Coats C, Garcia-Pavia P, Januzzi J, Lewis G, Ma C, Maron M, Miao Z, Olivotto I, Veselka J, Butzner M, Jacoby D, Heitner S, Kupfer S, Malik F, Meng L, Wohltman A, Spertus J. Effect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy Results From SEQUOIA-HCM. Journal Of The American College Of Cardiology 2024, 84: 1773-1785. PMID: 39217569, DOI: 10.1016/j.jacc.2024.08.014.Peer-Reviewed Original ResearchKCCQ overall summary scoresKansas City Cardiomyopathy QuestionnaireObstructive hypertrophic cardiomyopathyHealth statusQuality of lifePatient-reported health statusParticipants' health statusHealth status outcomesHypertrophic cardiomyopathyHealth status benefitsHealth status improvementPatients' health statusClinically important changeProportion of participantsSymptoms of fatigueSymptomatic obstructive hypertrophic cardiomyopathyStatus outcomesSummary scoreImprove healthCardiac myosin inhibitorProportion of patientsBaseline scoresImportant changesShortness of breathStatus improvementEffects of Sotagliflozin on Health Status in Patients With Worsening Heart Failure Results From SOLOIST-WHF
Bhatt A, Bhatt D, Steg P, Szarek M, Cannon C, Leiter L, McGuire D, Lewis J, Riddle M, Voors A, Metra M, Lund L, Testani J, Wilcox C, Davies M, Pitt B, Kosiborod M. Effects of Sotagliflozin on Health Status in Patients With Worsening Heart Failure Results From SOLOIST-WHF. Journal Of The American College Of Cardiology 2024, 84: 1078-1088. PMID: 39260929, DOI: 10.1016/j.jacc.2024.06.036.Peer-Reviewed Original ResearchConceptsSodium-glucose cotransporter 2Effect of sotagliflozinKCCQ-12 scoreKCCQ-12Heart failureSOLOIST-WHFPrimary endpointSodium-glucose cotransporter 2 inhibitionLeft ventricular ejection fractionWorsening heart failureBaseline to monthVentricular ejection fractionHealth statusWorsening HFKansas City Cardiomyopathy Questionnaire-12Ejection fractionSecondary endpointsCotransporter 2Randomized patientsClinical characteristicsHF hospitalizationPlaceboCardiovascular deathHF episodeSotagliflozinTwelve-month health status response after peripheral vascular intervention for femoropopliteal lesions using Zilver PTX databases focusing on the role of preprocedural health status, comorbid risks, and global setting
Smolderen K, Romain G, Cleman J, Callegari S, Peri-Okonny P, Mena-Hurtado C. Twelve-month health status response after peripheral vascular intervention for femoropopliteal lesions using Zilver PTX databases focusing on the role of preprocedural health status, comorbid risks, and global setting. Journal Of Vascular Surgery 2024, 81: 210-220.e7. PMID: 39214426, DOI: 10.1016/j.jvs.2024.08.035.Peer-Reviewed Original ResearchMinimal clinically important differenceEQ-5D indexHealth statusPeripheral vascular interventionsPeripheral arterial diseaseEQ-5DNon-respondersValue-based careEuroQol-5D-3LClinically important differenceSecondary data analysisFemoropopliteal peripheral vascular interventionsStable health statusLogistic regression modelsArtery diseaseSymptomatic peripheral arterial diseaseStatus responseTailored resourcesVascular interventionsSingle-arm studyImportant differenceCarotid artery diseaseComorbidity riskEnrolling centersPatient characteristicsAssociation of social support and health status outcomes in peripheral artery disease
Callegari S, Romain G, Cleman J, Scierka L, Peri-Okonny P, Spertus J, Labrosciano C, Beltrame J, Abbott J, Fitridge R, Mena-Hurtado C, Smolderen K. Association of social support and health status outcomes in peripheral artery disease. Journal Of Vascular Surgery 2024, 80: 1824-1835.e7. PMID: 39151740, PMCID: PMC11585422, DOI: 10.1016/j.jvs.2024.08.010.Peer-Reviewed Original ResearchENRICHD Social Support InventoryLow social supportLow perceived social supportGeneric health statusHealth status outcomesPeripheral arterial diseaseSocial supportHealth statusBiopsychosocial variablesStatus outcomesAssociation with health status outcomesAssociated with lower health statusDisease-specific health statusBaseline perceived social supportImprove social supportLower health statusSocial Support InventoryImprove health statusPerceived social supportDisease-specificEQ-5D-3LCare of patientsQuality of lifeEQ-5D-3L indexBiopsychosocial factorsAssociation between air temperature and self-perceived health status in Southern Germany: Results from KORA FIT study
Sohail H, Zhang S, Kraus U, Mikkonen S, Breitner S, Wolf K, Nikolaou N, Peters A, Lanki T, Schneider A. Association between air temperature and self-perceived health status in Southern Germany: Results from KORA FIT study. International Journal Of Hygiene And Environmental Health 2024, 262: 114431. PMID: 39096579, DOI: 10.1016/j.ijheh.2024.114431.Peer-Reviewed Original ResearchSelf-perceived health statusCompare self-rated healthSelf-rated healthHealth-related quality of lifeHealth statusDistributed lag non-linear modelCooperative Health ResearchHealth-related qualityEQ-5D-5L dimensionsEuroQol visual analog scaleShort-term associationsCross-sectional analysisQuality of lifeFitness studiesAugsburg regionParticipants' homesPopulation-level studiesHealth careHealth researchVisual analog scaleAssociation of heatEQ-VASHealth measuresHealthAnalog scaleInternal Tremors and Vibrations in Long COVID: A Cross-Sectional Study
Zhou T, Sawano M, Arun A, Caraballo C, Michelsen T, McAlpine L, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz H. Internal Tremors and Vibrations in Long COVID: A Cross-Sectional Study. The American Journal Of Medicine 2024, 138: 1010-1018.e14. PMID: 39069199, PMCID: PMC12023347, DOI: 10.1016/j.amjmed.2024.07.008.Peer-Reviewed Original ResearchNew-onset conditionsInternal tremorLong COVID symptomsCOVID symptomsNon-Hispanic whitesCross-sectional studyQuality of lifeVisual analogue scaleWorse healthHealth statusStudy participantsDemographic characteristicsAnalogue scaleOutcome variablesNeurological conditionsLong COVIDMast cell disordersTreatment experienceHealthComorbiditiesSymptomsMedian agePeopleCell disorders
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