2025
379. Potential clinical and economic impact of cutbacks in the United States President's Emergency Plan for AIDS Relief Program in South Africa: a modelling analysis
Gandhi A, Bekker L, Paltiel A, Hyle E, Ciaranello A, Pillay Y, Freedberg K, Neilan A. 379. Potential clinical and economic impact of cutbacks in the United States President's Emergency Plan for AIDS Relief Program in South Africa: a modelling analysis. Open Forum Infectious Diseases 2025, 12: ofae631.010. PMCID: PMC11778235, DOI: 10.1093/ofid/ofae631.010.Peer-Reviewed Original ResearchHIV care cascadeHIV-related deathsCost-effectiveness of Preventing AIDS ComplicationsCare cascadeHIV infectionPEPFAR fundingHIV care continuum outcomesCare continuum outcomesHIV epidemic controlLife expectancyNew HIV infectionsGlobal health initiativesModified societal perspectiveLifetime costsSouth African adultsHealth initiativesHIV diagnosisHIV programsHIV statusPrimary preventionAIDS complicationsPWHPEPFARHIV budgetLife years
2024
Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis
Holtgrewe L, Johnson A, Nyhan K, Boffa J, Shenoi S, Karat A, Davis J, Charalambous S. Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis. PLOS Global Public Health 2024, 4: e0003753. PMID: 39361564, PMCID: PMC11449336, DOI: 10.1371/journal.pgph.0003753.Peer-Reviewed Original ResearchLatent TB infection prevalenceLatent TB infectionUnderserved populationsTB prevalenceMeta-analysisSystematic reviewNational averagePrevalence of TB diseaseCalculate prevalence ratiosTB diseaseCase-finding strategiesPopulation of personsAssessed study qualityHigh TB prevalenceHigh-burden countriesBurden of tuberculosisTB interventionsPrevalence ratiosStudy qualityReduce tuberculosisHIV statusActive TB diseaseGeneral populationModerate heterogeneityTB incidenceDevelopment and feasibility of the peer and nurse-led HIV Self-Testing Education and Promotion (STEP) intervention among social networks of men in Dar es Salaam, Tanzania: application of the ADAPT-ITT model
Conserve D, Abu-Ba’are G, Janson S, Mhando F, Munisi G, Drezgic B, Rehani A, Sims W, Ritchwood T, Choko A, Mushy S, Johnson C, Jennings Mayo-Wilson L, Komba A, Urasa P, Nelson L, Mbita G. Development and feasibility of the peer and nurse-led HIV Self-Testing Education and Promotion (STEP) intervention among social networks of men in Dar es Salaam, Tanzania: application of the ADAPT-ITT model. BMC Health Services Research 2024, 24: 1166. PMID: 39358728, PMCID: PMC11445879, DOI: 10.1186/s12913-024-11586-9.Peer-Reviewed Original ResearchConceptsHIV self-testingFollow-up servicesADAPT-ITT modelHealthcare facilitiesADAPT-ITTPeer educatorsPromote HIV self-testingHIV self-test kitsDistribution of HIVST kitsTanzania HIV Impact SurveyIncrease HIV testingImplementation science projectSocial networks of menFollow-up surveyNational testing strategySelf-test resultsHIV testingHIVST kitsSelf-testingCommunity settingsMethodsThe developmentHIV statusDar es SalaamImpact SurveyNetworks of menPain, Substance Use Disorders, Mental Health, and Buprenorphine Treatment among Patients With and Without HIV
Miller E, McGinnis K, Edelman E, Feinberg T, Gordon K, Kerns R, Marshall B, Patterson J, McRae M. Pain, Substance Use Disorders, Mental Health, and Buprenorphine Treatment among Patients With and Without HIV. AIDS And Behavior 2024, 28: 3994-4004. PMID: 39264485, PMCID: PMC11586311, DOI: 10.1007/s10461-024-04494-w.Peer-Reviewed Original ResearchMental health classesSubstance use disordersOpioid use disorderHIV statusBuprenorphine initiationVeterans Aging Cohort StudyInitiate buprenorphineMental health diagnosesAging Cohort StudyBuprenorphine treatmentMultiple pain conditionsAssociated with HIV statusInfluence treatment retentionUse disorderTreatment of opioid use disorderHigher comorbidity burdenAge of patientsClinical encountersMental healthHealth diagnosisBlack veteransHealth classesLatent class analysisCohort studyPrescription dataReaching for 90:90:90 in Correctional Facilities in South Africa and Zambia: Virtual Cross-Section of Coverage of HIV Testing and Antiretroviral Therapy During Universal Test and Treat Implementation
Hoffmann C, Herce M, Chimoyi L, Smith H, Tlali M, Olivier C, Topp S, Muyoyeta M, Reid S, Hausler H, Charalambous S, Fielding K. Reaching for 90:90:90 in Correctional Facilities in South Africa and Zambia: Virtual Cross-Section of Coverage of HIV Testing and Antiretroviral Therapy During Universal Test and Treat Implementation. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 96: 465-471. PMID: 38985444, DOI: 10.1097/qai.0000000000003456.Peer-Reviewed Original ResearchHIV testingCross-sectional analysisAntiretroviral therapyCoverage of HIV testingHIV statusHIV testing coverageUniversal testingHIV epidemic controlTreatment dataCohort-based studyAntiretroviral therapy initiationRoutine dataUTT implementationBackground PeopleCorrectional facilitiesCensus listsZambian sitesHIVSouth AfricaSouth African sitesEpidemic controlUTTCorrectional settingsTherapyFacilitiesCOVID-19 Breakthrough Infection after Vaccination and Substance Use Disorders: A Longitudinal Cohort of People with and without HIV Receiving Care in the United States Veterans Health Administration
Soyer E, McGinnis K, Justice A, Hsieh E, Rodriguez-Barradas M, Williams E, Park L. COVID-19 Breakthrough Infection after Vaccination and Substance Use Disorders: A Longitudinal Cohort of People with and without HIV Receiving Care in the United States Veterans Health Administration. AIDS And Behavior 2024, 28: 3605-3614. PMID: 39046612, DOI: 10.1007/s10461-024-04449-1.Peer-Reviewed Original ResearchHIV statusSubstance use disordersBreakthrough infectionRisk of breakthroughAssociated with increased riskCOVID-19 breakthrough infectionsSARS-CoV-2Association of substance useSARS-CoV-2 infectionHIV treatment adherenceCD4 countHIV progressionSubstance useUnited States Veterans Health AdministrationHazard ratioIncreased riskPWHCD4PWoHHIVUse disorderVaccinated personsCohort of peopleTreatment adherenceLongitudinal cohortAlcohol Use Disorder and HIV Risk in a National Survey of Men Who Have Sex with Men in Ukraine
Gabriel W, Sazonova Y, Kulchynska R, LaMonaca K, Salyuk T, Smyrnov P, Altice F. Alcohol Use Disorder and HIV Risk in a National Survey of Men Who Have Sex with Men in Ukraine. International Journal Of Behavioral Medicine 2024, 1-17. PMID: 38914921, DOI: 10.1007/s12529-024-10272-8.Peer-Reviewed Original ResearchHIV transmission riskAssociated with HIV transmissionAlcohol use disorderHIV transmissionAlcohol consumptionTargeted HIV prevention strategiesPotential alcohol use disordersBehaviors associated with HIV transmissionRisk behaviors associated with HIV transmissionUnknown HIV statusHIV prevention strategiesPrevalent HIV infectionAssociated with increased likelihoodLikelihood of HIV acquisitionPre-exposure prophylaxisMultivariate regressionProblematic alcohol consumptionUse disorderConclusionThe high prevalenceMSM participantsHIV testingProblematic alcohol useHIV incidenceHIV statusHIV riskAssociation of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV
Schnittman S, Talathi R, Wilks M, Hedgire S, Lu M, Fourman L, Alagpulinsa D, Stockman S, White K, Wallis Z, Autissier P, Stanley T, Lee H, Honigberg M, El-Fakhri G, Williams K, Zanni M, Grinspoon S, Toribio M. Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV. AIDS 2024, 38: 1940-1946. PMID: 38905489, PMCID: PMC11701974, DOI: 10.1097/qad.0000000000003967.Peer-Reviewed Original ResearchArterial infiltrationCardiovascular diseaseIncreased risk of cardiovascular diseaseHuman immunodeficiency virusT cell subtypesT lymphocyte subpopulationsRisk of cardiovascular diseaseSystemic monocyte activationCardiovascular disease riskImmunodeficiency virusMonocyte activationHIV statusIncreased riskRelevant to atherogenesisHIVInfiltrationGeneral populationPWHEvidence of interactionSubtypesDiseaseSubpopulationsAtherogenesisIdentification of hepatic steatosis among persons with and without HIV using natural language processing
Torgersen J, Skanderson M, Kidwai-Khan F, Carbonari D, Tate J, Park L, Bhattacharya D, Lim J, Taddei T, Justice A, Re V. Identification of hepatic steatosis among persons with and without HIV using natural language processing. Hepatology Communications 2024, 8: e0468. PMID: 38896066, PMCID: PMC11186806, DOI: 10.1097/hc9.0000000000000468.Peer-Reviewed Original ResearchConceptsImaging ReportingSteatotic liver diseaseHIV statusHepatic steatosisPrevalence of metabolic comorbiditiesImaging studiesVeterans Aging Cohort StudyCompare patient characteristicsPositive predictive valueAlcohol use disorderAging Cohort StudyIdentification of hepatic steatosisHIV infectionHepatitis BMetabolic comorbiditiesNatural language processing algorithmsRadiological studiesCohort studyPatient characteristicsClinical reviewLiver diseaseHIVPredictive valueUse disorderClinical image reportsQualitative description of interpersonal HIV stigma and motivations for HIV testing among gays, bisexuals, and men who have sex with men in Ghana’s slums—BSGH-005
Abu-Ba’are G, Shamrock O, Zigah E, Ogunbajo A, Dakpui H, Agbemedu G, Boyd D, Ezechi O, Nelson L, Torpey K. Qualitative description of interpersonal HIV stigma and motivations for HIV testing among gays, bisexuals, and men who have sex with men in Ghana’s slums—BSGH-005. PLOS ONE 2024, 19: e0289905. PMID: 38837972, PMCID: PMC11152275, DOI: 10.1371/journal.pone.0289905.Peer-Reviewed Original ResearchConceptsHIV testingHIV stigmaHIV testing servicesLevel of stigmaFace-to-face interviewsHIV education interventionsHIV knowledge levelsSummative content analysisGBMSM livingEducational interventionHIV preventionHealthcare servicesHIV prevalenceCommunity partnersHIV responseTesting servicesHIV statusHIV vulnerabilityGBMSMSexual healthStigmaKnowledge levelContent analysisHIVSlumsSelf-injurious unnatural death among Veterans with HIV
Smith A, Goulet J, Vlahov D, Justice A, Womack J. Self-injurious unnatural death among Veterans with HIV. AIDS 2024, 38: 1570-1578. PMID: 38814683, DOI: 10.1097/qad.0000000000003940.Peer-Reviewed Original ResearchVeterans Aging Cohort StudyNested case-control studyModifiable risk factorsRisk of suicideCase-control studyRisk factorsIdentification of modifiable risk factorsCategorization of deathsIncidence density samplingAging Cohort StudyCohort of veteransIncreased risk of suicideConditional logistic regressionHigher pain levelsUse disorderPublic health burdenDrug use disordersUnnatural deathsDeath codesUnintentional causesInternational ClassificationHIV statusExcess deathsPrevention effortsAlcohol use disorderA retrospective cohort study describing chemotherapy-induced peripheral neuropathy in Non-Hodgkin lymphoma patients treated with EPOCH ± R: does HIV status matter?
McNally G, Aossey C, Wiczer T, Sinnott L, Lustberg M, Baiocchi R, Lustberg M. A retrospective cohort study describing chemotherapy-induced peripheral neuropathy in Non-Hodgkin lymphoma patients treated with EPOCH ± R: does HIV status matter? Leukemia & Lymphoma 2024, 65: 1110-1116. PMID: 38648546, DOI: 10.1080/10428194.2024.2340051.Peer-Reviewed Original ResearchChemotherapy-induced peripheral neuropathyIncidence of chemotherapy-induced peripheral neuropathyHIV statusPeripheral neuropathyHIV-associated non-Hodgkin's lymphomaCohort studyDose-adjusted EPOCHNon-Hodgkin's lymphomaLong-term patient outcomesRetrospective cohort studyNon-HodgkinComprehensive cancer centerCancer CenterHIVPatientsNeuropathyPatient outcomesPropensity scoreLymphomaAdverse effectsIncidenceStatusRegimenVincristineNeurosyphilis is characterized by a compartmentalized and robust neuroimmune response but not by neuronal injury
Catalano A, Yoon J, Fertuzinhos S, Reisert H, Walsh H, Kosana P, Wilson M, Gisslen M, Zetterberg H, Marra C, Farhadian S. Neurosyphilis is characterized by a compartmentalized and robust neuroimmune response but not by neuronal injury. Med 2024, 5: 321-334.e3. PMID: 38513660, PMCID: PMC11216317, DOI: 10.1016/j.medj.2024.02.005.Peer-Reviewed Original ResearchMarker of neuronal injuryNeuronal injuryNeurological symptomsWhite blood cell count <Immune responsePresence of neurological symptomsNeuroinflammatory diseasesCell count <CSF-VDRL testPlasma reagin titerCNS immune responsesCNS-specific immune responseImmune cell activationCSF inflammatory responseCSF cellsNeurosyphilis casesAsymptomatic neurosyphilisCSF neopterinImmune profileNeuroimmune responseHIV statusNational Institutes of HealthNeurosyphilisCell activationInflammatory responseHIV Risk and Interest in Preexposure Prophylaxis in Justice-Involved Persons - Volume 30, Supplement—March 2024 - Emerging Infectious Diseases journal - CDC
Nijhawan A, Pulitzer Z, Torres B, Noreen N, Schultheis A, Frank C, Colon R, Brooks R, Proffitt R, Pankow J, Bennett A, Salyards M, Kuo I, Knight K, Springer S. HIV Risk and Interest in Preexposure Prophylaxis in Justice-Involved Persons - Volume 30, Supplement—March 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: s68-s74. PMID: 38561803, PMCID: PMC10986824, DOI: 10.3201/eid3013.230739.Peer-Reviewed Original ResearchConceptsHIV riskAssess HIV risk factorsPreexposure prophylaxisPartners of unknown HIV statusMobile health unitReport injection drug useUnknown HIV statusPerceived HIV riskRisk factorsHIV risk factorsRandomized controlled trialsPatient navigationPrEP indicationsInjection drug useHealth unitsJustice-involved personsHIV medicationsHIV statusCondomless sexPrEPEducational effortsDrug useHIVRiskPersonsImplementation of REDCap mobile app in an oral HIV clinical study
Seminario A, Karczewski A, Stanley S, Huamani J, Montenegro J, Tafur K, Julca A, Altice F. Implementation of REDCap mobile app in an oral HIV clinical study. BMC Public Health 2024, 24: 629. PMID: 38413910, PMCID: PMC10900554, DOI: 10.1186/s12889-024-17837-y.Peer-Reviewed Original ResearchConceptsAlcohol use disorderLow-middle income countriesOral healthAssociation of alcohol use disordersPerceived oral health statusAvailability of anti-retroviral therapyLevels of oral diseaseOral health statusAnti-retroviral therapyMobile appsElectronic data collection systemResultsThe mean ageHIV clinical studiesDietary supplement useClinical research staffHIV stigmaOral diseasesHIV clinicHIV casesHealth statusHIV statusMean ageClinical studiesParticipants' experiencesMedical historyCommunity-level variation in TB testing history in Blantyre, Malawi
Nightingale E, Feasey H, Khundi M, Soko R, Burke R, Nliwasa M, Twabi H, Mpunga J, Fielding K, MacPherson P, Corbett E. Community-level variation in TB testing history in Blantyre, Malawi. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 32-38. PMID: 38303035, DOI: 10.5588/ijtld.23.0213.Peer-Reviewed Original ResearchConceptsCluster-level variationsTB testCase-finding effortsCluster-level random interceptEver-testingHealth inequalitiesCommunity-level variationTB servicesTesting historyHIV statusSurvey participantsPoverty indicatorsRandom interceptAffluent householdsEquitable accessNeighborhood clustersDiagnostic servicesPoor communitiesBlantyre CityTB prevalenceSocio-economic driversBlantyrePovertyPrevalenceInequalitySex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia
Abelman R, Fitzpatrick J, Byanova K, Zawedde J, Sanyu I, Byanyima P, Musisi E, Hsieh J, Zhang M, Branchini J, Sessolo A, Hunt P, Lalitha R, Davis J, Crothers K, Worodria W, Huang L. Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia. Open Forum Infectious Diseases 2024, 11: ofae033. PMID: 38456193, PMCID: PMC10919919, DOI: 10.1093/ofid/ofae033.Peer-Reviewed Original ResearchPreserved ratio impaired spirometryAssociated with increased oddsFemale sexAssociated with lower oddsBiomass fuel exposureAssociated with increased mortalityBaseline participantsLower oddsDecreased oddsHIV statusPost-pneumoniaIncreased oddsGeneral populationImpaired spirometryLung function abnormalitiesFuel exposureIncreased riskEffects of sexTB statusHIVLow FEV1Normal spirometryParticipantsHIV effectsSpirometry
2023
Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience
Shabanova V, Emuren L, Gan G, Antwi S, Renner L, Amissah K, Kusah J, Lartey M, Reynolds N, Paintsil E. Pediatric HIV Disclosure Intervention Improves Immunologic Outcome at 48 Weeks: The Sankofa Trial Experience. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 371-380. PMID: 37643414, PMCID: PMC10617661, DOI: 10.1097/qai.0000000000003292.Peer-Reviewed Original ResearchConceptsHIV disclosure interventionsVirologic outcomesCD4 percentWeek 48HIV statusIntervention groupHIV disclosureDisclosure interventionDetectable viral loadWorld Health OrganizationAntiretroviral therapyImmunologic outcomesClinical outcomesIntervention armViral loadControl armClinical trialsTrial experienceSecondary analysisDisclosure statusHealth OrganizationCategorical variablesWeeksLinear mixed modelsBaselineRisk of death and readmission among individuals with heart failure and HIV: A systematic review and meta-analysis
Zhou Y, Zhang X, Gao Y, Alvi R, Erqou S, Chen Y, Wang H, Wang W, Li X, Zanni M, Neilan T, Vermund S, Qian H, Qian F. Risk of death and readmission among individuals with heart failure and HIV: A systematic review and meta-analysis. Journal Of Infection And Public Health 2023, 17: 70-75. PMID: 37992436, DOI: 10.1016/j.jiph.2023.11.004.Peer-Reviewed Original ResearchConceptsHeart failureHF patientsRisk of HFHuman immunodeficiency virus statusPoor HF outcomesRisk of deathWeb of ScienceCause deathCause readmissionHF outcomesAdult patientsCohort studyHIV infectionHIV statusCochrane LibraryIndependent associationVirus statusHigh riskDeath outcomesHIVReadmissionPatientsSystematic reviewSystematic searchRiskBrief Report: Changing Characteristics Among In-Hospital HIV Deaths: An 11-Year Retrospective Review of a Regional Hospital in South Africa
Lombardo A, Materi J, Caturegli G, Milovanovic M, Martinson N, Calver A, Nonyane B, Golub J, Hoffmann C, Variava E. Brief Report: Changing Characteristics Among In-Hospital HIV Deaths: An 11-Year Retrospective Review of a Regional Hospital in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 185-189. PMID: 37757855, DOI: 10.1097/qai.0000000000003249.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyExpansion of antiretroviral therapyHIV-positiveProportion of decedentsBurden of HIVAge groupsProportion of HIV patientsAge of decedentsHIV-associated mortalityProportion of HIV-positiveYounger age groupsOlder age groupsHealth facilitiesDecedent characteristicsLog-binomialAIDS-defining illnessRegional hospitalHIV deathsHIV statusAdvanced HIV diseaseRecord dataMultinomial regressionOlder individualsOpportunistic illnessesProportion of patients
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