2024
Predicting remission following CBT for childhood anxiety disorders: a machine learning approach
Bertie L, Quiroz J, Berkovsky S, Arendt K, Bögels S, Coleman J, Cooper P, Creswell C, Eley T, Hartman C, Fjermestadt K, In-Albon T, Lavallee K, Lester K, Lyneham H, Marin C, McKinnon A, McLellan L, Meiser-Stedman R, Nauta M, Rapee R, Schneider S, Schniering C, Silverman W, Thastum M, Thirlwall K, Waite P, Wergeland G, Wuthrich V, Hudson J. Predicting remission following CBT for childhood anxiety disorders: a machine learning approach. Psychological Medicine 2024, 54: 4612-4622. PMID: 39686883, DOI: 10.1017/s0033291724002654.Peer-Reviewed Original ResearchAnxiety disordersIdentification of predictors of treatment responseComorbid externalising disordersMultiple anxiety disordersPrimary anxiety disorderRisk of non-remissionChildhood anxiety disordersSocial anxiety disorderPredictors of treatment responseLikelihood of remissionHigher likelihood of remissionAnxious youthChildhood anxietyDisorder remissionComorbid depressionExternalising disordersGroup treatmentDepressive symptomsHigher anxietyImprove treatment outcomesPredicting remissionNon-remissionAnxietyRemission outcomesDisordersImpulsivity Impacts Suicidality in Patients with Alcohol Use Disorder with and without Comorbid Depression
Wang V, Liao D, Wu E, Li C. Impulsivity Impacts Suicidality in Patients with Alcohol Use Disorder with and without Comorbid Depression. Taiwanese Journal Of Psychiatry 2024, 38: 171-176. DOI: 10.4103/tpsy.tpsy_31_24.Peer-Reviewed Original ResearchBarratt Impulsiveness ScaleAlcohol use disorderSuicide attemptsUse disorderSuicidal tendenciesBarratt Impulsiveness Scale total scoreBarratt Impulsiveness Scale scoresHistory of suicide attemptsAlcohol use disorder patientsSeverity of alcohol useAssessment of impulsivityAlcohol use severitySeverity of depressionSuicide prevention effortsBarratt impulsivityImpulsiveness ScaleDepressive disorderNondepressed individualsAnxiety comorbiditiesAssess suicidalityDepression severityComorbid depressionHigher suicidalityPsychiatric comorbiditiesSevere alcoholismPotential Role for Buprenorphine in the Management of Comorbid Depression Among People with Chronic Pain and Long-Term Opioid Therapy Dependence
Manhapra A, Rosenheck R, Becker W. Potential Role for Buprenorphine in the Management of Comorbid Depression Among People with Chronic Pain and Long-Term Opioid Therapy Dependence. 2024, 148-164. DOI: 10.1093/9780197675250.003.0009.Peer-Reviewed Original ResearchLong-term opioid therapyKappa-opioid receptorsChronic painOpioid receptorsKappa-opioid receptor antagonismManagement of comorbid depressionTherapeutic agentsMOR agonismOpioid therapyOpioid taperAntidepressant effectsWorsening painOpioid dependenceSafety profileAgonist actionPoor outcomeClinical trialsAssociated with worsening depressionPainEtiological driversBuprenorphineReceptor affinityComorbid depressionOpioidReceptorsImpact of trauma exposure and depression comorbidity on response to transdiagnostic behavioral therapy for pediatric anxiety and depression
Angulo F, Goger P, Brent D, Rozenman M, Gonzalez A, Schwartz K, Porta G, Lynch F, Dickerson J, Weersing V. Impact of trauma exposure and depression comorbidity on response to transdiagnostic behavioral therapy for pediatric anxiety and depression. Npj Mental Health Research 2024, 3: 8. PMID: 38609501, PMCID: PMC10955846, DOI: 10.1038/s44184-023-00049-4.Peer-Reviewed Original ResearchBrief Behavioral TherapyTrauma exposureBehavioral therapyComorbid depressionModerators of treatment outcomeEffectiveness of psychotherapeutic interventionsDevelopment of comorbid depressionHistory of trauma exposureImpact of trauma exposureTherapist-rated measureTransdiagnostic behavior therapyMeasures of allianceSignificant three-way interactionClinically significant depressionThree-way interactionPresence of clinically significant depressionTransdiagnostic psychotherapyPediatric anxietyTransdiagnostic therapiesAnxiety symptomsDepression comorbidityPsychotherapeutic interventionsEmotional disordersHomework completionModel of learningSymptom distress and psychosocial functioning improve bidirectionally during cognitive-behavioral therapy for anxiety disorders
Lord K, Tolin D. Symptom distress and psychosocial functioning improve bidirectionally during cognitive-behavioral therapy for anxiety disorders. Journal Of Anxiety Disorders 2024, 103: 102843. PMID: 38310753, DOI: 10.1016/j.janxdis.2024.102843.Peer-Reviewed Original ResearchCognitive-behavioral therapyPsychosocial functioningAnxiety disordersSymptom distressEfficacy of cognitive-behavioral therapySessions of cognitive-behavioral therapyPresence of comorbid depressionIndicators of psychosocial functioningAnxiety disorder symptomsOutcome Questionnaire-45Measures of symptom distressCross-lagged analysisSocial role performanceInterpersonal problemsAnxiety symptomsDisorder symptomsComorbid depressionSymptom reductionSymptom ameliorationLow levels of severityLevels of severityAnxietyEffect sizeDistressAssociated with changesElevated phase amplitude coupling as a depression biomarker in epilepsy
Young J, Chan A, Jette N, Bender H, Saad A, Saez I, Panov F, Ghatan S, Yoo J, Singh A, Fields M, Marcuse L, Mayberg H. Elevated phase amplitude coupling as a depression biomarker in epilepsy. Epilepsy & Behavior 2024, 152: 109659. PMID: 38301454, PMCID: PMC10923038, DOI: 10.1016/j.yebeh.2024.109659.Peer-Reviewed Original ResearchBeck Depression Inventory-IIPhase-amplitude couplingComorbid depressionAssessment of depressive symptomsBeck Depression Inventory-II scoresAssociated with comorbid depressionAnterior cingulate cortexEpilepsy patientsAmplitude couplingPre-operative assessmentElevated phase-amplitude couplingSpectral powerOrbitofrontal cortexCingulate cortexPrimary depressionCase-control comparisonDepressive symptomsBrain regionsBrain activityDepression biomarkersAdult epilepsy patientsDepressionBrain recordingsPatient studiesTreatment targetComorbid psychiatric disease significantly mediates increased rates of alcohol use disorder among patients with inflammatory and pigmentary skin disorders: a case–control study in the All of Us Research Program
Kamal K, Xiang D, Young K, Mostaghimi A, Barbieri J, Cohen J, Theodosakis N. Comorbid psychiatric disease significantly mediates increased rates of alcohol use disorder among patients with inflammatory and pigmentary skin disorders: a case–control study in the All of Us Research Program. Archives Of Dermatological Research 2024, 316: 79. PMID: 38252292, DOI: 10.1007/s00403-023-02803-2.Peer-Reviewed Original ResearchConceptsAlcohol use disorderComorbid psychiatric diseaseUse disorderPsychiatric diseasesRates of alcohol use disordersOdds of alcohol use disordersContribution of depressionPhysical health effectsComorbid depressionMediation analysisAnxietyDepressionDisordersDermatological diseasesCase-control studyPigmentary skin disorderMultivariate logistic regressionHidradenitis suppurativaAtopic dermatitisSkin disordersPigmentary disordersCase-control modelIncreased oddsPatientsUs Research Program
2023
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.Peer-Reviewed Original ResearchPosttraumatic stress disorderStructural covariance networksCortical thicknessPTSD diagnosisInsular cortexPTSD patientsCingulate cortexSymptom severityBilateral superior frontal cortexStress disorderGreater cortical thicknessLower cortical thicknessChildhood trauma severitySuperior frontal cortexRegression analysisAnterior cingulate cortexTrauma-exposed controlsPosterior cingulate cortexPrefrontal regulatory regionsPTSD symptom severityComorbid depressionMotor cortexHealthy controlsFrontal cortexAlcohol abuseCharacteristics of complex posttraumatic stress disorder (PTSD) in young people with PTSD following multiple trauma exposure
Lofthouse K, Beeson E, Dalgleish T, Danese A, Hodgekins J, Mahoney‐Davies G, Smith P, Stallard P, Wilson J, Meiser‐Stedman R. Characteristics of complex posttraumatic stress disorder (PTSD) in young people with PTSD following multiple trauma exposure. Journal Of Child Psychology And Psychiatry 2023, 65: 822-831. PMID: 37994207, DOI: 10.1111/jcpp.13918.Peer-Reviewed Original ResearchPosttraumatic stress disorderNegative post-traumatic cognitionsComplex posttraumatic stress disorderPost-traumatic cognitionsMultiple traumatic eventsComplex PTSDSexual traumaCPTSD symptomsTraumatic eventsTrauma typesComorbid psychopathologyIntrafamilial abusePosttraumatic stress disorder (PTSD) diagnosisMultiple trauma exposuresPTSD-only groupCaregiver-reported questionnaireStress disorder diagnosisSocial factorsTrauma exposureStress disorderPTSD diagnosisTrauma characteristicsDisorder diagnosisPanic symptomsComorbid depressionMultimorbidity and Correlates of Comorbid Depression and Generalized Anxiety Disorder in a Nationally Representative US Sample
Jegede O, Stefanovics E, Rhee T, Rosenheck R. Multimorbidity and Correlates of Comorbid Depression and Generalized Anxiety Disorder in a Nationally Representative US Sample. The Journal Of Nervous And Mental Disease 2023, 211: 355-361. PMID: 36807207, DOI: 10.1097/nmd.0000000000001625.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAdditional psychiatric diagnosesRepresentative US sampleComorbid groupPsychiatric disordersPsychiatric diagnosisPoor mental health qualityMental health-related qualityPoorer mental health-related qualityAnxiety disordersHealth-related qualityAdditional psychiatric disordersNationally Representative US SampleMental health qualityLogistic regression analysisSubstance use disordersNational Epidemiologic SurveyMDD-only groupRelated Conditions-IIISingle disorder groupsGeneralized anxiety disorderSingle diagnosis groupsPsychiatric comorbidityComorbid depressionDepressive disorderEffects of Electroconvulsive Therapy on Functional Outcomes Among Medicare Patients With Comorbid Depression and Dementia: A Nationwide 1-Year Follow-Up Study.
Wilkinson S, Sint K, Forester B, Rhee T. Effects of Electroconvulsive Therapy on Functional Outcomes Among Medicare Patients With Comorbid Depression and Dementia: A Nationwide 1-Year Follow-Up Study. The Journal Of Clinical Psychiatry 2023, 84 PMID: 36700843, DOI: 10.4088/jcp.22m14583.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyFunctional outcomeComorbid depressionPrincipal psychiatric diagnosisRandomized clinical trialsECT cohortECT patientsComparable cohortsSafe treatmentClinical trialsMedicare patientsCurrent treatmentFunctional declineLimited efficacyPropensity score methodsPsychiatric disordersSummary scoresPsychiatric diagnosisLarger sample sizeMultivariate analysisPsychological symptomsDementiaPatientsOlder adultsCohort
2022
Association of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide
Harris KM, Mena-Hurtado C, Burg MM, Vriens PW, Heyligers J, Smolderen KG. Association of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide. Journal Of Vascular Surgery 2022, 77: 480-489. PMID: 36115521, DOI: 10.1016/j.jvs.2022.09.008.Peer-Reviewed Original ResearchConceptsLength of stayChronic limb-threatening ischemiaAnxiety disorder diagnosisAssociation of depressionRevascularization cohortMajor amputationDisorder diagnosisSurgical revascularizationEndovascular revascularizationHigher oddsLonger median LOSMedian LOSLonger LOSAnxiety disordersDocumentation of depressionPeripheral artery diseaseLimb-threatening ischemiaRisk of amputationNational Inpatient SamplePatients' sociodemographic dataHigher median costArtery diseaseIllness severityPsychiatric comorbidityComorbid depressionShape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Brain Imaging Consortium
Fouche J, Groenewold N, Sevenoaks T, Heany S, Lochner C, Alonso P, Batistuzzo M, Cardoner N, Ching C, de Wit S, Gutman B, Hoexter M, Jahanshad N, Kim M, Kwon J, Mataix‐Cols D, Menchon J, Miguel E, Nakamae T, Phillips M, Pujol J, Sakai Y, Yun J, Soriano‐Mas C, Thompson P, Yamada K, Veltman D, van den Heuvel O, Stein D. Shape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Brain Imaging Consortium. Brain And Behavior 2022, 12: e2755. PMID: 36106505, PMCID: PMC9575597, DOI: 10.1002/brb3.2755.Peer-Reviewed Original ResearchConceptsCaudate nucleusHealthy controlsOCD patientsComorbid depressionMedication statusComorbid anxietySubcortical shapeSignificant differencesDeep gray matter structuresRight caudate nucleusCo-morbid anxietyLeft caudate nucleusObsessive-compulsive disorder patientsSubcortical brain morphologyGray matter structuresDisease durationMedication useObsessive-compulsive disorderSubgroup analysisBrain MRINucleus accumbensDisorder patientsPatientsBrain volumePutamenDorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients
Dhaher R, Bronen RA, Spencer L, Colic L, Brown F, Mian A, Sandhu M, Pittman B, Spencer D, Blumberg HP, Altalib H. Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients. Epilepsia 2022, 63: 2561-2570. PMID: 35883245, DOI: 10.1111/epi.17377.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyDorsal bed nucleusTLE patientsEpilepsy patientsBed nucleusHC subjectsStria terminalisTemporal lobe epilepsy patientsMini International Neuropsychiatric InterviewMagnetic resonance imaging (MRI) scansTreatment-resistant depressionComprehensive Epilepsy CenterHealthy control subjectsStructural magnetic resonance imaging (MRI) scansResonance imaging scansNumber of patientsCase-control studyInternational Neuropsychiatric InterviewMajor depressive disorderCommon comorbid disordersHuman clinical studiesEpilepsy centersLobe epilepsyComorbid depressionControl subjectsA Narrative Review of the Association Between Depression and Heart Disease Among Women: Prevalence, Mechanisms of Action, and Treatment
Rome D, Sales A, Leeds R, Usseglio J, Cornelius T, Monk C, Smolderen KG, Moise N. A Narrative Review of the Association Between Depression and Heart Disease Among Women: Prevalence, Mechanisms of Action, and Treatment. Current Atherosclerosis Reports 2022, 24: 709-720. PMID: 35751731, PMCID: PMC9398966, DOI: 10.1007/s11883-022-01048-0.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseCardiovascular diseaseMechanism of actionHeart diseaseNarrative reviewManagement of depressionPrevalence of depressionRecent FindingsWomenCardiovascular outcomesAutonomic factorsDepression treatmentComorbid depressionTreatment inertiaGreater prevalenceTherapeutic targetPrevalenceStrong associationWomenDepressionDiseaseGreater mortalityTreatment effectsAssociationMenTreatmentRemodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium
Sun D, Rakesh G, Clarke-Rubright EK, Haswell CC, Logue MW, O'Leary EN, Cotton AS, Xie H, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid FM, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein MB, Bomyea J, Koerte I, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog JI, Lebois LAM, Baker JT, Ressler KJ, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh LA, Forster G, Simons RM, Simons JS, Magnotta VA, Maron-Katz A, du Plessis S, Disner SG, Davenport ND, Grupe D, Nitschke JB, deRoon-Cassini TA, Fitzgerald J, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton ME, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Phan KL, McLaughlin KA, Davidson RJ, Larson C, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, Wang X, Thompson PM, Morey RA. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 935-948. PMID: 35307575, PMCID: PMC9835553, DOI: 10.1016/j.bpsc.2022.02.008.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCortical thicknessStructural covarianceComorbid depressionControl subjectsLarge effect sizesStress disorderEffect sizeTrauma-exposed control subjectsCase-control differencesCortical surface areaInflammatory processClinical dataResting-state functional connectivity networksPositive pairwise correlationsCortical differencesCortical regionsCortical neuroanatomyStress hormonesFunctional connectivity networksPTSD casesSmall effect sizesGroup differencesStructural networkStructural connectome
2021
Prevalence of and risk factors for depression among female Syrian refugees and Jordanians with chronic disease: a pilot study.
Sharp M, Parpia A, Ahram M, Mahmoud R, Khoshnood K. Prevalence of and risk factors for depression among female Syrian refugees and Jordanians with chronic disease: a pilot study. Eastern Mediterranean Health Journal 2021, 27: 1142-1152. PMID: 35137382, DOI: 10.26719/emhj.20.123.Peer-Reviewed Original ResearchConceptsChronic diseasesRisk factorsFemale Syrian refugeesGreater oddsDepression levelsChronic disease managementDeterminants of depressionChronic physical conditionsHealth intervention planningMultivariable ordinal regressionTimes greater oddsCross-sectional surveyMental health interventionsHigher depression levelsGenitourinary disordersComorbid depressionDisease burdenHealth characteristicsIdentified predictorsHealth statusHealth interventionsHigh levelsDiseasePilot studyDisorder statusExploring the bidirectional relationship between chronic disease and depression among female Syrian refugees and Jordanians: a qualitative analysis.
Sharp M, Kara J, Almidani S, Ahram M, Mahmoud R, Khoshnood K. Exploring the bidirectional relationship between chronic disease and depression among female Syrian refugees and Jordanians: a qualitative analysis. Eastern Mediterranean Health Journal 2021, 27: 1153-1161. PMID: 35137383, DOI: 10.26719/emhj.21.017.Peer-Reviewed Original ResearchConceptsChronic diseasesJordanian womenChronic illnessBidirectional relationshipMental healthIntersection of depressionNegative health care experiencesChronic disease interventionsHealth care experiencesSyrian womenContributors of morbidityComorbid depressionChronic conditionsFemale Syrian refugeesHealth care structuresMedical careNeuropsychiatric conditionsCare experiencesClinical settingDiseaseDisease interventionCare structuresWomenHealth careSensitive interventionsThe acceptability and feasibility of screening, brief intervention, and referral to treatment for pain management among new England veterans with chronic pain: A pilot study
Sellinger JJ, Martino S, Lazar C, Mattocks K, Rando K, Serowik K, Ablondi K, Fenton B, Gilstad‐Hayden K, Brummett B, Holtzheimer PE, Higgins D, Reznik TE, Semiatin AM, Stapley T, Ngo T, Rosen MI. The acceptability and feasibility of screening, brief intervention, and referral to treatment for pain management among new England veterans with chronic pain: A pilot study. Pain Practice 2021, 22: 28-38. PMID: 33934499, PMCID: PMC9084457, DOI: 10.1111/papr.13023.Peer-Reviewed Original ResearchConceptsMultimodal pain treatmentPain treatmentChronic painPilot studyMusculoskeletal disordersBrief interventionPain treatment modalitiesPainful musculoskeletal disordersSubstance usePain management interventionsTelephone-based counselingFeasibility of screeningPercent of participantsRisky substance useProblematic substance usePain managementWeek 12Study eligibilityComorbid depressionTreatment modalitiesMedical CenterDisability compensationCare servicesEarly interventionSubstance misuse
2020
Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis
Wang X, Xie H, Chen T, Cotton AS, Salminen LE, Logue MW, Clarke-Rubright EK, Wall J, Dennis EL, O’Leary B, Abdallah CG, Andrew E, Baugh LA, Bomyea J, Bruce SE, Bryant R, Choi K, Daniels JK, Davenport ND, Davidson RJ, DeBellis M, deRoon-Cassini T, Disner SG, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gomaa H, Gordon EM, Grupe D, Harpaz-Rotem I, Haswell CC, Herzog JI, Hofmann D, Hollifield M, Hosseini B, Hudson AR, Ipser J, Jahanshad N, Jovanovic T, Kaufman ML, King AP, Koch SBJ, Koerte IK, Korgaonkar MS, Krystal JH, Larson C, Lebois LAM, Levy I, Li G, Magnotta VA, Manthey A, May G, McLaughlin KA, Mueller SC, Nawijn L, Nelson SM, Neria Y, Nitschke JB, Olff M, Olson EA, Peverill M, Phan K, Rashid FM, Ressler K, Rosso IM, Sambrook K, Schmahl C, Shenton ME, Sierk A, Simons JS, Simons RM, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Suarez-Jimenez B, Tamburrino M, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Zhu Y, Zhu X, Thompson PM, Morey RA, Liberzon I. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis. Molecular Psychiatry 2020, 26: 4331-4343. PMID: 33288872, PMCID: PMC8180531, DOI: 10.1038/s41380-020-00967-1.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLateral orbitofrontal gyrusPTSD patientsCortical regionsComorbid depressionCortical volumeVolume abnormalitiesStress disorderSuperior parietal gyrusRegional cortical volumesSuperior temporal gyrusPrefrontal regulatory regionsCerebral cortexControl subjectsRight insularLimbic regionsParietal gyrusPosttraumatic stress symptom severityStress symptom severityDepression symptomsOrbitofrontal gyrusSymptom severityTemporal gyrusPatientsAbnormalities
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply