2025
Correlation of Milestone Ratings and Family Physicians' Early Diabetes Management.
Hogan S, Yamazaki K, Holmboe E. Correlation of Milestone Ratings and Family Physicians' Early Diabetes Management. Family Medicine 2025, 57: 83-90. PMID: 39954237, PMCID: PMC11922144, DOI: 10.22454/fammed.2025.980357.Peer-Reviewed Original ResearchConceptsFamily physiciansUnsupervised practiceEarly-career family physiciansDiabetes managementEarly career family physiciansManagement of chronic diseasesChronic disease managementCommercial insurance claimsDiabetic patientsDoctor careChronic illnessPatient needsEye examType 2 diabetes mellitusTreatment of patientsMilestone ratingsChronic diseasesMilestone evaluationsResidency programsFunctional examPhysiciansDisease managementDoctorsProvider identification numberAdministration of standardized tests
2024
Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design
Barron D, Saltoun K, Kiesow H, Fu M, Cohen-Tanugi J, Geha P, Scheinost D, Isaac Z, Silbersweig D, Bzdok D. Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design. BMC Medicine 2024, 22: 594. PMID: 39696368, PMCID: PMC11656997, DOI: 10.1186/s12916-024-03807-z.Peer-Reviewed Original ResearchConceptsChronic diseasesPain ProfileChronic conditionsPatient functionPain conditionsManagement of chronic diseasesChronic disease managementContinuum of careHealthcare delivery systemImprove quality of lifeQuality of lifePainful body partPain interferenceAssociated with clinical variablesUK BiobankWhole-body perspectiveHealth strategiesTreatment of individual patientsPain intensityClinically relevant differencesPatient wellbeingPain managementTreat painful conditionsICD codesMedical specialtiesProteolethargy is a pathogenic mechanism in chronic disease
Dall'Agnese A, Zheng M, Moreno S, Platt J, Hoang A, Kannan D, Dall'Agnese G, Overholt K, Sagi I, Hannett N, Erb H, Corradin O, Chakraborty A, Lee T, Young R. Proteolethargy is a pathogenic mechanism in chronic disease. Cell 2024, 188: 207-221.e30. PMID: 39610243, PMCID: PMC11724756, DOI: 10.1016/j.cell.2024.10.051.Peer-Reviewed Original ResearchPathogenic signalsExcessive reactive oxygen speciesMobility phenotypeCellular functionsAffected proteinsPathogenic mechanismsReactive oxygen speciesCysteine residuesSpectra of proteinsProtein mobilityPathogenic stimuliPathogenic featuresOxygen speciesMolecular levelCellular mechanismsDiverse chronic diseasesProteinChronic diseasesIdentifying diagnosed major chronic diseases associated with recent housing instability among aging adults: data from the ‘All of Us’ research program
Beydoun H, Vieytes C, Beydoun M, Lampros A, Tsai J. Identifying diagnosed major chronic diseases associated with recent housing instability among aging adults: data from the ‘All of Us’ research program. Journal Of Public Health 2024, 47: 15-23. PMID: 39586798, DOI: 10.1093/pubmed/fdae300.Peer-Reviewed Original ResearchUs Research ProgramHousing instabilityAging adultsChronic diseasesOdds ratioChronic disease preventionAssociated with lower oddsPsychiatric diagnosisConfidence intervalsElectronic health recordsAssociated with psychiatric diagnosesEstimate odds ratiosCardiovascular diseaseMultivariate logistic regression modelDiverse group of adultsLogistic regression modelsTreatment of chronic diseasesCross-sectional dataHealth recordsHealthcare utilizationLower oddsGroup of adultsYears of ageDiagnosed diabetesCancer diagnosisUsing Chronic Kidney Disease as a Model Framework to Estimate Healthcare-Related Environmental Impact
Garcia Sanchez J, Barraclough K, Cases A, Pecoits-Filho R, Germond-Duret C, Zoccali C, Embleton N, Wright A, Hubbert L, Nicholson L, Barone S, Budgen N, Cabrera C, Selvarajah V, Eckelman M. Using Chronic Kidney Disease as a Model Framework to Estimate Healthcare-Related Environmental Impact. Advances In Therapy 2024, 42: 348-361. PMID: 39541083, PMCID: PMC11782431, DOI: 10.1007/s12325-024-03039-w.Peer-Reviewed Original ResearchEnvironmental impactLife cycle stagesLife cycle assessment frameworkImpact assessment methodsReduce environmental burdenCycle stagesEnvironmental burdenCO2e emissionsCalculated impactAssessment frameworkEnvironmental benefitsProactive managementCO2eChronic kidney diseaseEffective managementHighest impactKidney replacement therapyEnvironmental dimensionsCare pathwaysAssessment methodsModeling frameworkDatabase inputChronic diseasesEffective management of chronic diseasesEmissionDistinct comorbidity phenotypes among post‐9/11 Veterans with epilepsy are linked to diverging outcomes and mortality risks
Pugh M, Clary H, Myers M, Kennedy E, Amuan M, Swan A, Hinds S, LaFrance W, Altalib H, Towne A, Henion A, White A, Baca C, Wang C. Distinct comorbidity phenotypes among post‐9/11 Veterans with epilepsy are linked to diverging outcomes and mortality risks. Epilepsia 2024, 66: 170-183. PMID: 39487827, PMCID: PMC11742646, DOI: 10.1111/epi.18170.Peer-Reviewed Original ResearchVeterans Health AdministrationCause of deathService membersLatent class analysisPost-9/11 service membersVeterans receiving careContinuity of careInterdisciplinary health teamComorbid phenotypesPost-9/11 veteransOverall patient careMitigate adverse outcomesHealth teamsEpilepsy diagnosisAssociated with mortalityHealth trajectoriesHealth AdministrationPatient carePost-traumatic stress disorderMortality outcomesDescriptive statisticsAnnual diagnosesChronic diseasesNational cohortMortality riskPrimary Prevention of Stroke: Identifying High-Risk Patients
Kaslow J, Kernan W. Primary Prevention of Stroke: Identifying High-Risk Patients. 2024, 431-443. DOI: 10.1007/978-3-031-66289-8_36.Peer-Reviewed Original ResearchRisk factorsPrimary careHealthy behaviorsPatient-centeredCoronary artery diseaseRisk of strokeChronic diseasesPreventable deathsMedical practicePublic healthUnhealthy onesIncreased riskRisk reductionHigh riskHigh-risk patientsStrokeRiskArtery diseaseCareHealthDisabilityPatientsMedicationFactorsGuidelinesUsing a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer
Siddique S, Baum L, Deziel N, Kelly J, Warren J, Ma X. Using a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer. PLOS ONE 2024, 19: e0311540. PMID: 39471191, PMCID: PMC11521299, DOI: 10.1371/journal.pone.0311540.Peer-Reviewed Original ResearchConceptsAge-of-onset colorectal cancerEarly-onset colorectal cancerEnd Results Program dataCenters for Disease Control and Prevention dataCounty-level factorsColorectal cancerHealth risk behaviorsIdentified principal componentsOdds of survivalPreventive servicesSurvival disparitiesLinear mixed modelsEOCRCChronic diseasesPreventive factorsUS countiesSalt Lake CountyCA residentsRisk behaviorsUnited StatesProgram dataCounty-levelOlder ageBayesian analytical approachYounger ageThe extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries
Dorr D, Markwardt S, Bobo M, Allore H, Botoseneanu A, Newsom J, Nagel C, Quiñones A. The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries. BMC Geriatrics 2024, 24: 777. PMID: 39304796, PMCID: PMC11414248, DOI: 10.1186/s12877-024-05329-y.Peer-Reviewed Original ResearchConceptsHigh multimorbidityMultimorbidity levelOlder adultsHigher levels of multimorbidityHealth and Retirement Study dataAssociated with sociodemographic characteristicsWell-being of older adultsLevels of multimorbidityProgression of multimorbidityImpact of multimorbidityBurden of multimorbidityHigher healthcare utilizationRetirement Study dataYounger birth cohortsMultimorbidity groupsHealthcare utilizationLower educationNon-HispanicMultimorbiditySociodemographic characteristicsMedicare beneficiariesSocioeconomic statusHealth indicatorsBirth cohortChronic diseasesSTABILITY (Symptomatic Review during Biologic Therapy) of Inflammatory Bowel Disease Patients Receiving Infusion Therapy Improves Clinical Outcomes
Morgan K, Morris J, Cai Q, Kilgore P, Cvek U, Trutschl M, Lofton K, Mavuram M, Ramesh P, Dao N, Alhaque A, Alexander J. STABILITY (Symptomatic Review during Biologic Therapy) of Inflammatory Bowel Disease Patients Receiving Infusion Therapy Improves Clinical Outcomes. Pathophysiology 2024, 31: 398-407. PMID: 39189166, PMCID: PMC11348379, DOI: 10.3390/pathophysiology31030030.Peer-Reviewed Original ResearchInflammatory bowel disease patientsInflammatory bowel diseaseFemale IBD patientsMale CD patientsMale IBD patientsCD patientsUC patientsTherapy visitsIBD patientsDisease severityInfusion therapyFemale UC patientsMale UC patientsRetrospective chart reviewIBD-related symptomsPhysician-patient contactLow disease activityPhysician-patient interviewImprove patient outcomesFemale CD patientsCare gapsImproving clinical outcomesDiagnosis dateMedication changesChronic diseasesAssociation between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study
Sun P, Guo X, Ding E, Li C, Ren H, Xu Y, Qian J, Deng F, Shi W, Dong H, Lin E, Guo P, Fang J, Zhang Q, Zhao W, Tong S, Lu X, Pollitt K, Shi X, Tang S. Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study. Environmental Health Perspectives 2024, 132: 077005. PMID: 39028628, PMCID: PMC11259245, DOI: 10.1289/ehp13865.Peer-Reviewed Original ResearchConceptsFat mass indicatorsHealthy older adultsBayesian kernel machine regressionVisceral fat areaOlder adultsPercent body fatBody compositionBody fat massExposome-wide association studyPrevention of chronic diseasesAir pollution exposureBody composition indicatorsMediation analysisInBody 770 deviceHealthy adultsAssociated with increased body fat massBody composition changesKernel machine regressionBayesian kernel machine regression modelsChronic diseasesPollution exposureBody fatAssociation studiesAdverse health effectsFat areaCombating Chronic Disease with Barbershop Health Interventions: A Review of Current Knowledge and Potential for Big Data
Khosla P, Amin K, Doshi R. Combating Chronic Disease with Barbershop Health Interventions: A Review of Current Knowledge and Potential for Big Data. The Yale Journal Of Biology And Medicine 2024, 97: 239-245. PMID: 38947107, PMCID: PMC11202109, DOI: 10.59249/otfp5065.Peer-Reviewed Original ResearchConceptsCommunity-based participatory researchPromote health equityHealth equityHealth disparitiesIncreasing awareness of cancer riskAwareness of cancer riskChronic diseasesPromote cancer screeningCultural appropriateness of interventionsMental health promotionChronic disease managementImprove diabetes awarenessIncrease testing ratesPromote preventive behaviorsCombat chronic diseasesAppropriateness of interventionsHealth promotionDiabetes awarenessScreening servicesCancer screeningHealth interventionsSelf-managementCancer riskCommunity settingsHealth educationThe Future of Kidney Care in Low- and Middle-Income Countries: Challenges, Triumphs, and Opportunities
Kalyesubula R, Aklilu A, Calice-Silva V, Kumar V, Kansiime G. The Future of Kidney Care in Low- and Middle-Income Countries: Challenges, Triumphs, and Opportunities. Kidney360 2024, 5: 1047-1061. PMID: 38922683, PMCID: PMC11296549, DOI: 10.34067/kid.0000000000000489.Peer-Reviewed Original ResearchKidney careMiddle-income countriesHealth system infrastructureResilient health care systemHealth care providersKidney healthHealth care systemChronic kidney diseaseCare providersUnique risk factorsHealth priorityCare systemLack of awarenessChronic diseasesGeneral populationCareLMICsKidney replacement therapyHealthRisk factorsGenetic predispositionEarly detectionMultidisciplinary followFinancing mechanismsHuman resourcesAdvantages and Limitations of the Body Mass Index (BMI) to Assess Adult Obesity
Wu Y, Li D, Vermund S. Advantages and Limitations of the Body Mass Index (BMI) to Assess Adult Obesity. International Journal Of Environmental Research And Public Health 2024, 21: 757. PMID: 38929003, PMCID: PMC11204233, DOI: 10.3390/ijerph21060757.Peer-Reviewed Original ResearchBody mass indexPopulation healthAdult obesityContext of population healthBody mass index cut-offsAssessment of physical functionMass indexRisk of chronic diseasesClinical screeningMeasures of body compositionAt-risk individualsIndividual risk predictionConsensus reviewExercise counselingFitness statusPhysical functionHealthcare professionalsHealthcare screeningOverweight personsClinical careIndividual healthChronic diseasesBody compositionPopulation surveyHealthSeksuell helse hos eldre.
Sunde A, Sivertsen Ø, Skjellegrind H, Svendsen K, Berge S, Alsnes I. Seksuell helse hos eldre. Tidsskrift For Den Norske Legeforening 2024, 144 PMID: 38832621, DOI: 10.4045/tidsskr.23.0809.Peer-Reviewed Original ResearchConceptsOlder adultsSexual healthImprove sexual healthQuality of lifeClinical review articleAdverse effects of medicationsOlder adult sexualityEffects of medicationHealthcare personnelCoping skillsChronic diseasesSexual challengesCognitive failuresHealthAdult sexualityAdultsConjugal relationshipHealthcareCopingMedicationReview articleStigmatization and Mental Health Impact of Chronic Pediatric Skin Disorders
Paller A, Rangel S, Chamlin S, Hajek A, Phan S, Hogeling M, Castelo-Soccio L, Lara-Corrales I, Arkin L, Lawley L, Funk T, Lopes F, Antaya R, Ramien M, Vivar K, Teng J, Coughlin C, Rehmus W, Gupta D, Bercovitch L, Stein S, Boull C, Tom W, Liang M, Hunt R, Luu M, Holland K, Schoch J, Cella D, Lai J, Griffith J. Stigmatization and Mental Health Impact of Chronic Pediatric Skin Disorders. JAMA Dermatology 2024, 160: 621-630. PMID: 38656377, PMCID: PMC11044010, DOI: 10.1001/jamadermatol.2024.0594.Peer-Reviewed Original ResearchQuality of lifeAssociated with mental healthReduced quality of lifeStigma scoresDisease visibilityMental healthPhysician assessmentAssociated with stigmaExtent of stigmaPhysician assessment of disease severityMental health impactsPoor peer relationshipsModerate stigmaPatients aged 8Psychosocial interventionsChronic skin diseaseMain OutcomesIdentified stigmatizationSingle-visit studyChronic diseasesPediatric skin disordersStigmaModerate disease severityIncreased depressionSecondary outcomesClinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter
Lefaucheur J, Moro E, Shirota Y, Ugawa Y, Grippe T, Chen R, Benninger D, Jabbari B, Attaripour S, Hallett M, Paulus W. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter. Clinical Neurophysiology 2024, 164: 57-99. PMID: 38852434, PMCID: PMC11418354, DOI: 10.1016/j.clinph.2024.05.007.Peer-Reviewed Original ResearchTranscranial alternating current stimulationTranscranial direct current stimulationLow-intensity transcranial electrical stimulationRepetitive transcranial magnetic stimulationSpinal cord stimulationCurrent stimulationMovement disordersTreated with botulinum toxin injectionsPulse generatorTranscranial electrical stimulationBotulinum toxin injectionIdentification of musclesShort-term clinical impactDirect current stimulationDeep brain stimulationAt-home useTherapeutic neuromodulationChronic diseasesTranscranial applicationTranscranial magnetic stimulationSurgical implantation of electrodesTreatment of movement disordersFUS stimulationAxial signsNeuromodulation techniquesAssociations Between Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments
Wallach J, Yoon S, Doernberg H, Glick L, Ciani O, Taylor R, Mooghali M, Ramachandran R, Ross J. Associations Between Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments. JAMA 2024, 331: 1646-1654. PMID: 38648042, PMCID: PMC11036312, DOI: 10.1001/jama.2024.4175.Peer-Reviewed Original ResearchConceptsMeta-analysesChronic diseasesFood and Drug AdministrationMeta-regression analysisMeta-analyses of observational studiesSurrogate markerClinical outcomesClinical trialsMeta-analysisEvidence of associationPublished meta-analysesStrength of associationMeta-analyses of clinical trialsChronic disease treatmentFood and Drug Administration tableResults of meta-regression analysisOutcome pairsFood and Drug Administration approvalMain OutcomesData extractionSystematic reviewStatistically significant resultsObservational studyPooled analysisDrug Administration
2023
Beyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease
Kalra K, Moumneh M, Nanna M, Damluji A. Beyond MACE: a multidimensional approach to outcomes in clinical trials for older adults with stable ischemic heart disease. Frontiers In Cardiovascular Medicine 2023, 10: 1276370. PMID: 38045910, PMCID: PMC10690830, DOI: 10.3389/fcvm.2023.1276370.Peer-Reviewed Original ResearchStable ischemic heart diseaseIschemic heart diseaseClinical trialsOlder adult populationOlder adultsHeart diseaseHealth outcomesAdult populationMajor adverse cardiovascular outcomesHigh cardiovascular riskAdverse cardiovascular outcomesMultiple chronic diseasesPatient-centered approachCardiovascular clinical trialsPoor health outcomesMore effective careQuality of lifeHolistic health outcomesCardiovascular outcomesCardiovascular riskGeriatric syndromesRandomized trialsPatient populationPatient preferencesChronic diseasesAdvantages and Disadvantages of Nutraceuticals
Rajalakshmi R, Melians M, Pon F, Cosio D, Buvarahamurthy V, Jayakumar A, Paidas M. Advantages and Disadvantages of Nutraceuticals. Nutritional Neurosciences 2023, 245-286. DOI: 10.1007/978-981-99-0677-2_15.Peer-Reviewed Original ResearchEfficacy of nutraceuticalsHeavy metalsLimitations of nutraceuticalsPoor bioavailabilityDrug bioavailabilityBioavailabilityNutraceutical marketLack of experimental evidencePrevent chronic diseasesContaminationPatient health issuesSide effectsHealth professionalsNutrientsNutraceuticalsSide effect profileMetalChronic diseasesRaw materialsHealth issuesToxicityToxic side effectsCompoundsDrug-drug interactionsBlood-brain barrier
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