2025
Microbiome's Effect on White Matter in Autism
Canada K, Evans T, Pelphrey K. Microbiome's Effect on White Matter in Autism. Journal Of Neurophysiology 2025 PMID: 39998297, DOI: 10.1152/jn.00607.2024.Peer-Reviewed Original ResearchAutism spectrum disorderCore ASD symptomsAutism spectrum disorder managementRepetitive behavior patternsBrain imaging dataWhite matter developmentDiffusion tensor imagingNeuroimaging studiesSymptom severitySpectrum disorderGut-brain axisSocial skillsLanguage acquisitionSensory processingSocial communicationBidirectional relationshipOligodendrocyte functionTensor imagingShort-chain fatty acidsLongitudinal studyMotor performanceAutismDevelopmental patternsReduced myelinationNeuroinflammatory pathwaysBidirectional relationship between epigenetic age and stroke, dementia, and late-life depression
Rivier C, Szejko N, Renedo D, Clocchiatti-Tuozzo S, Huo S, de Havenon A, Zhao H, Gill T, Sheth K, Falcone G. Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression. Nature Communications 2025, 16: 1261. PMID: 39893209, PMCID: PMC11787333, DOI: 10.1038/s41467-024-54721-0.Peer-Reviewed Original ResearchThis study shows a bidirectional link between accelerated epigenetic aging and brain health events like stroke, dementia, and depression, supporting new prevention strategies for aging-related conditions.Posttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets
Mitchell K, Scioli E, Galovski T, Belfer P, Cooper Z. Posttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets. 2025, 95-109. DOI: 10.4324/9781003607403-10.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderComorbid posttraumatic stress disorderPosttraumatic stress disorder symptomsExposure to interpersonal traumaCognitive behavioral theoryHistory of eating disordersLow self-worthEvidence-based treatmentsEmotion dysregulationHyperarousal symptomsInterpersonal traumaBinge eatingTrauma exposureED behaviorsLifetime historyEating disordersSelf-criticismSelf-worthEvidence-based therapiesTreatment of EDCoping strategiesBidirectional relationshipTreatment targetDisordersThe bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study
Costa G, Nunes J, Suh R, Sofuoglu M, Aquino J. The bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study. Drug And Alcohol Dependence 2025, 268: 112552. PMID: 39848133, PMCID: PMC11832315, DOI: 10.1016/j.drugalcdep.2025.112552.Peer-Reviewed Original ResearchConceptsDaily smokingDaily cigarette smokingChronic painDevelopment of painCigarette smokingTobacco smokePopulation Assessment of Tobacco and Health StudyBaseline painAlternative tobacco product usePersistent painTobacco product useDevelopment of persistent painYears of longitudinal dataHealth StudyTobacco useNo/low painPreventable causeSmoking outcomesBidirectional relationshipSurvival analysisSmokingPopulation AssessmentAge categoriesIncreased riskSurvey population
2024
The relationship between momentary experiential avoidance and anxiety symptoms
Sain K, Lord K, Knowles K, Everhardt K, Tolin D. The relationship between momentary experiential avoidance and anxiety symptoms. Anxiety Stress & Coping 2024, 38: 193-205. PMID: 39104256, DOI: 10.1080/10615806.2024.2383769.Peer-Reviewed Original ResearchEcological momentary assessmentExperiential avoidanceAnxiety-related disordersAnxiety symptomsClinical sample of participantsSample of treatment-seeking patientsAssociated with greater anxietyAnxiety-related psychopathologySocial anxiety disorderBidirectional relationshipTreatment-seeking patientsTrend-level associationsSample of participantsIn-the-momentNonclinical undergraduatesAnxiety disordersMomentary assessmentGreater anxietyPerceived stressAnxietyBaseline assessmentClinical samplesDisordersTime pointsAssessment periodFrailty and Cardiovascular Health.
James K, Jamil Y, Kumar M, Kwak M, Nanna M, Qazi S, Troy A, Butt J, Damluji A, Forman D, Orkaby A. Frailty and Cardiovascular Health. Journal Of The American Heart Association 2024, 13: e031736. PMID: 39056350, DOI: 10.1161/jaha.123.031736.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseRisk factorsCardiovascular disease risk factorsInfluence of frailtyIncidence of frailtySecondary prevention strategiesPrognostic markerCardiac interventionsClinical trialsCardiovascular disease managementPatientsModify frailtyPrevention strategiesBiological mechanismsFrailtyBidirectional relationshipFrailty detectionPopulation agingGenetic influences and causal pathways shared between cannabis use disorder and other substance use traits
Galimberti M, Levey D, Deak J, Zhou H, Stein M, Gelernter J. Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits. Molecular Psychiatry 2024, 29: 2905-2910. PMID: 38580809, PMCID: PMC11419938, DOI: 10.1038/s41380-024-02548-y.Peer-Reviewed Original ResearchSubstance use disordersProblematic alcohol useSubstance use traitsCannabis use disorderCannabis useOpioid use disorderUse disorderGenomic structural equation modelingSmoking initiationLifetime cannabis useLegalization of cannabis useGlobal genetic correlationsProblematic substance useStructural equation modelingNicotine dependenceGenetic influencesCannabisSubstance useFagerstrom TestAlcohol useMendelian randomizationBidirectional relationshipGenetic correlationsDisordersSmoking cessationScreening and Evaluation of Sleep Disturbances and Sleep Disorders in Children and Adolescents
Baddam S, Canapari C, Van de Grift J, McGirr C, Nasser A, Crowley M. Screening and Evaluation of Sleep Disturbances and Sleep Disorders in Children and Adolescents. Psychiatric Clinics Of North America 2024, 47: 65-86. PMID: 38302214, DOI: 10.1016/j.psc.2023.06.005.Peer-Reviewed Original ResearchConceptsSleep disturbancePediatric mental health clinicsPediatric mental healthPrimary care clinicsMental health clinicsMental health disordersSleep disordersEvaluation of sleep disturbancesCare clinicsHealth clinicsMental healthTreatment of sleep disturbancesHealth disordersConsumer wearablesPediatric clinicScreening toolUnder-recognizedEvaluation toolSleep assessmentChildren/adolescentsBidirectional relationshipClinicDisordersSleepSleep telemedicine
2022
Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther supportUnderstanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records
Polimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, PMCID: PMC10986859, DOI: 10.1038/s41380-022-01735-z.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePosttraumatic stress disorderElectronic health recordsMillion Veteran ProgramArtery diseaseTotal scoreCAD diagnosisPlatelet amyloid precursor proteinHealth recordsPosttraumatic stress severityAmyloid precursor proteinEarly CAD diagnosisUK BiobankBidirectional relationshipTwo-sample Mendelian randomization (MR) analysisMendelian randomization analysisCAD riskHigh morbidityPTSD symptom severityCARDIoGRAMplusC4D consortiumPleiotropic mechanismsSymptom severityLongitudinal changesDiscordant effectsStress disorder
2021
Sex Differences across Retrospective Transitions in Posttraumatic Stress and Substance Use Disorders
Peltier MR, Roberts W, Verplaetse TL, Zakiniaeiz Y, Burke C, Moore KE, McKee SA. Sex Differences across Retrospective Transitions in Posttraumatic Stress and Substance Use Disorders. Journal Of Dual Diagnosis 2021, 18: 11-20. PMID: 34965199, PMCID: PMC9086923, DOI: 10.1080/15504263.2021.2016027.Peer-Reviewed Original ResearchConceptsDrug use disordersOngoing posttraumatic stress disorderSubstance use disordersSUD/PTSDPosttraumatic stress disorderNew PTSD diagnosisImpact of sexUse disordersDiagnosis of SUDPast-year substance use disorderPTSD diagnosisConcurrent substance use disordersDiagnosis of PTSDPoor treatment outcomesNational Epidemiologic SurveyBidirectional relationshipSex-specific analysesPotential sex-specific differencesTreatment outcomesExploring the bidirectional relationship between chronic disease and depression among female Syrian refugees and Jordanians: a qualitative analysis.
Sharp M, Kara J, Almidani S, Ahram M, Mahmoud R, Khoshnood K. Exploring the bidirectional relationship between chronic disease and depression among female Syrian refugees and Jordanians: a qualitative analysis. Eastern Mediterranean Health Journal 2021, 27: 1153-1161. PMID: 35137383, DOI: 10.26719/emhj.21.017.Peer-Reviewed Original ResearchConceptsChronic diseasesJordanian womenChronic illnessBidirectional relationshipMental healthIntersection of depressionNegative health care experiencesChronic disease interventionsHealth care experiencesSyrian womenContributors of morbidityComorbid depressionChronic conditionsFemale Syrian refugeesHealth care structuresMedical careNeuropsychiatric conditionsCare experiencesClinical settingDiseaseDisease interventionCare structuresWomenHealth careSensitive interventionsUrban rat exposure to anticoagulant rodenticides and zoonotic infection risk
Murray M, Sánchez C. Urban rat exposure to anticoagulant rodenticides and zoonotic infection risk. Biology Letters 2021, 17: 20210311. PMID: 34376077, PMCID: PMC8355682, DOI: 10.1098/rsbl.2021.0311.Peer-Reviewed Original ResearchConceptsPredictors of infectionNo significant associationIncreased infection riskAnticoagulant rodenticidesOld ratsRatsSignificant associationAnimal-to-humanInfectionRodent pest populationsInfection riskRisk of pathogenic infectionPathogen infectionRiskPest populationsPublic health riskDisease ecologyHealth risksBidirectional relationshipZoonotic pathogensNatural systemsAbsence seizures and their relationship to depression and anxiety: Evidence for bidirectionality
Gruenbaum BF, Sandhu MRS, Bertasi RAO, Bertasi TGO, Schonwald A, Kurup A, Gruenbaum SE, Freedman IG, Funaro MC, Blumenfeld H, Sanacora G. Absence seizures and their relationship to depression and anxiety: Evidence for bidirectionality. Epilepsia 2021, 62: 1041-1056. PMID: 33751566, PMCID: PMC8443164, DOI: 10.1111/epi.16862.Peer-Reviewed Original ResearchConceptsAbsence seizuresMood disordersChildhood epilepsyCommon manifestationInclusion criteriaEffective treatmentGenetic predispositionGreater oddsAnimal modelsAnatomical pathwaysSystematic reviewDepressionShort lossDisordersPatientsBidirectional relationshipSeizuresCurrent literatureAnxietySocial impairmentFurther researchReviewEpilepsyStrong correlationImpairmentPosttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets
Mitchell K, Scioli E, Galovski T, Belfer P, Cooper Z. Posttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets. Eating Disorders 2021, 29: 292-306. PMID: 33411646, DOI: 10.1080/10640266.2020.1869369.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderComorbid posttraumatic stress disorderCognitive-behavioral theoryImpulsivity/compulsivityEvidence-based treatmentsEmotion dysregulationInterpersonal traumaNegative affectTreatment targetsTrauma exposurePTSD symptomsHyperarousal symptomsED behaviorsBehavioral theoryPotential treatment targetBidirectional relationshipLifetime historyEvidence-based therapiesIntegrated modelFuture directionsDisordersTheoretical modelAngerCompulsivity
2020
KDIGO Controversies Conference on onco-nephrology: kidney disease in hematological malignancies and the burden of cancer after kidney transplantation
Małyszko J, Bamias A, Danesh F, Dębska-Ślizień A, Gallieni M, Gertz M, Kielstein J, Tesarova P, Wong G, Cheung M, Wheeler D, Winkelmayer W, Porta C, Participants C, Abu-Alfa A, Amer H, Beutel G, Chapman J, Chen X, Chudek J, Cosmai L, Danesi R, De Stefano F, Iseki K, Jaimes E, Jhaveri K, Jurczyszyn A, Kazancioğlu R, Kitchlu A, Kollmannsberger C, Lahoti A, Li Y, Macía M, Matsubara T, Mitropoulos D, Noiri E, Perazella M, Ronco P, Rosner M, Romeo M, Sprangers B, Stadler W, Stevens P, Tesař V, da Costa e Silva V, Vesole D, Vijayan A, Viklický O, Workeneh B, Yanagita M, Zakharova E. KDIGO Controversies Conference on onco-nephrology: kidney disease in hematological malignancies and the burden of cancer after kidney transplantation. Kidney International 2020, 98: 1407-1418. PMID: 33276867, DOI: 10.1016/j.kint.2020.07.012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseKidney diseaseHematological malignanciesControversies ConferenceKidney transplantationModerate stage chronic kidney diseaseKDIGO Controversies ConferenceAcute kidney injuryKidney transplant recipientsBurden of cancerKidney injuryTransplant recipientsKidney transplantRegistry analysisMultiple myelomaClinical challengeCancer riskGlobal outcomeMalignancyCancerPatientsDiseaseTransplantationBidirectional relationshipRiskScreening and Evaluation of Sleep Disturbances and Sleep Disorders in Children and Adolescents
Baddam SKR, Canapari CA, Van de Grift J, McGirr C, Nasser AY, Crowley MJ. Screening and Evaluation of Sleep Disturbances and Sleep Disorders in Children and Adolescents. Child And Adolescent Psychiatric Clinics Of North America 2020, 30: 65-84. PMID: 33223069, DOI: 10.1016/j.chc.2020.09.005.Peer-Reviewed Original ResearchConceptsSleep disturbancesChildren/adolescentsSleep disordersPediatric mental health clinicsPediatric mental healthPrimary care clinicsMental health clinicsMental health disordersCare clinicsPediatric clinicHealth clinicsSleep telemedicineSleep assessmentHealth disordersScreening toolMental healthClinicDisordersBidirectional relationshipAdolescentsConsumer wearablesScreeningNeuropsychiatric Aspects of Epilepsy
Tolchin B, Hirsch LJ, LaFrance WC. Neuropsychiatric Aspects of Epilepsy. Psychiatric Clinics Of North America 2020, 43: 275-290. PMID: 32439022, DOI: 10.1016/j.psc.2020.02.002.Peer-Reviewed Original ResearchConceptsNeuropsychiatric disordersNeuropsychiatric aspectsCertain neuropsychiatric disordersAntiseizure medicationsClinical outcomesTherapeutic optionsEpidemiologic studiesEpilepsyMultidisciplinary teamNeuropsychiatric impactDisordersBidirectional relationshipTreatmentClose collaborationComorbiditiesMedicationsPathophysiologySocial factorsDiagnosis
2018
Bidirectionality of Pain Interference and PTSD Symptoms in Military Veterans: Does Injury Status Moderate Effects?
Lee SY, Finkelstein-Fox L, Park CL, Mazure CM, Huedo-Medina TB, Hoff R. Bidirectionality of Pain Interference and PTSD Symptoms in Military Veterans: Does Injury Status Moderate Effects? Pain Medicine 2018, 20: 934-943. PMID: 30016463, PMCID: PMC6497092, DOI: 10.1093/pm/pny133.Peer-Reviewed Original ResearchConceptsPain interferencePTSD symptomsInjury statusDeployment-related injuryCross-sectional studyPost-traumatic stress disorder symptomsPhysical symptom managementSubset of veteransBidirectional relationshipPotential bidirectional relationshipWorse PTSD symptomsOperation New DawnSymptom managementOperation Enduring FreedomVeteran populationFemale veteransSymptomsOperation Iraqi FreedomInjured veteransInjuryPresent longitudinal studyTime pointsPhone interviewsPsychological interventionsDisorder symptomsA review of brain insulin signaling in mood disorders: From biomarker to clinical target
Nguyen T, Chan L, Borreginne K, Kale R, Hu C, Tye S. A review of brain insulin signaling in mood disorders: From biomarker to clinical target. Neuroscience & Biobehavioral Reviews 2018, 92: 7-15. PMID: 29758232, DOI: 10.1016/j.neubiorev.2018.05.014.Peer-Reviewed Original ResearchConceptsMood disordersCentral insulin signalingInsulin signalingSevere mood disordersBrain insulin signalingSynaptic plasticity processesPoor treatment outcomesInsulin signaling pathwayMood regulationMetabolic dysfunctionNeurotrophic processesMoodSevere disease courseBidirectional relationshipCellular metabolismInsulin receptor expressionMetabolic homeostasisSignaling pathwayMetabolic processesPrecision medicine approachMechanistic overlapTreatment outcomesMetabolic functionsDisordersBiomarker-based diagnostics
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