Genetics Department Seminar Series: "Hyperactive Ras Signaling in Developmental Disorders and Blood Cancer"
RAS and NF1 genes, which encode core components of the Ras/GTPase molecular switch, are frequently altered by somatic mutations in human cancer. These mutations increase Ras output and drive malignant growth. Germline NF1 mutations cause type 1 neurofibromatosis (NF1) a common dominant multi-system disorder that is the founding member of a group of related developmental disorders collectively called the “Rasopathies”. This seminar will focus on the role of Ras pathway mutations in these different clinical contexts and discuss emerging therapies.
UC San FranciscoKevin Shannon, PhDProfessor