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Understanding living systems at the molecular level

The Aquilos™ Cryo-FIB is the first cryo-DualBeam™ (focused ion beam/scanning electron microscope) system dedicated to preparation of frozen, thin lamella samples from biological specimens for high-resolution tomographic imaging in a cryo-transmission electron microscope (cryo-TEM). Since Yale Aquilos was installed in April 2019 - as well as upgraded in December 2021 - we have prepared over ten different kinds of lamella samples, including bacterial, cell, and biofilm samples (Yeast, E. coli, Salmonella, F. novicida, Cos 7, Bacillus, Neutrophil, Chlorella, P gingivalis and Treponema denticola co-biofilm, et al). The Liu Lab welcomes research collaborations. Please contact Jennifer Aronson with any inquiries.

Yale Cryo-FIB Aquilos Protocol 1
Yale Cryo-FIB Aquilos Protocol 3