Jeff Gehlhausen, MD, PhD

Dr. Gehlhausen is a dermatologist and physician-scientist in Dr. Iwasaki's lab working on autoimmune connective tissue diseases affecting the skin, including lupus erythematosus. His focus is on how type I interferons, which are essential innate antiviral pathways, mediate the pathophysiology of lupus disease. Though the association of type I interferons and lupus has been well established, the precise mechanism of how and which cell types mediate pathologic changes remains incompletely understood. Dr. Gehlhausen has a connective tissue disease clinic where he sees complex autoimmune cases and utilizes high dimensional techniques like single cell rna sequencing to profile the skin manifestations of these patients. Additionally, he makes heavy use of genetic mouse models of try to better understand the cellular and molecular effectors driving type I interferon-mediated disease.