Michael H Nathanson, MD, PhD
Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell BiologyCards
About
Titles
Gladys Phillips Crofoot Professor of Medicine (Digestive Diseases) and Professor of Cell Biology
Co-Director, Yale Liver Center, Digestive Diseases; Director, Center for Cell and Molecular Imaging
Appointments
Digestive Diseases
ProfessorPrimaryCell Biology
ProfessorSecondary
Other Departments & Organizations
- Cancer Signaling Networks
- Cell Biology
- Confocal Microscopy
- Diabetes Research Center
- Digestive Diseases
- Gastrointestinal Procedure Center
- Hepatology
- Internal Medicine
- Liver Center
- Membrane Traffic
- Molecular Cell Biology, Genetics and Development
- Molecular Medicine, Pharmacology, and Physiology
- Obesity Research Working Group
- Transplantation Center
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale Ventures
Education & Training
- Postdoctoral Fellow
- Yale University (1990)
- Resident
- Columbia-Presbyterian Medical Center (1988)
- MD
- Case Western Reserve Univ (1985)
- PhD
- Case Western Reserve Univ (1983)
- MS
- Massachusetts Institute of Technology (1977)
- BS
- University of California, Berkeley (1976)
Research
Overview
- NIH P01 DK57751 (PI: M.H. Nathanson) 04/01/01-04/30/21 Title: Regulation of liver by nuclear calcium signaling Goals: The major goals of this project are to determine the mechanisms by which calcium is regulated in the nucleus of hepatocytes, and to determine the functional effects of nuclear calcium signals in liver. Dr. Nathanson directs Project 1 and the Administrative and Cell Imaging cores of this PPG.
- NIH P30 DK34989 (PI: M.H. Nathanson) 09/01/84-08/31/20 (NCE pending) Title: Digestive Diseases Research Core Center (Yale Liver Center) Goals: Dr. Nathanson is Director of the Liver Center as well as of the Morphology and Administrative Core components of the Center. The major goals of the Morphology Core are to provide a multidisciplinary center where the research focus is liver structure, function and disease.
- NIH R01 DK114041 (PI: M.H. Nathanson) 02/01/18-03/31/23 Title: Ca2+ waves in hepatocytes: Mechanisms and effects Goals: The major goals of this project are to determine the mechanisms by which the type 2 InsP3 receptor regulates calcium-mediated bile secretion by hepatocytes, and to determine the role that loss or mis-localization of this receptor plays in the pathogenesis of cholestatic liver disease.
- NIH R01 DK112797 (PI: M.H. Nathanson) 09/01/17-08/31/22 Title: Molecular regulation of cholestasis in cholangiocytes. Goals: Major goals are to understand the role of type 3 inositol trisphosphate receptor function in cholestatic liver disease
- NIH T32 DK007356 (PI: M.H. Nathanson) 7/1/84-6/30/24 Title: Investigative Training in Hepatology. Goals: This training grant provides 1) laboratory research training for physicians who have completed clinical training in Gastroenterology and are in preparation for careers as independent investigators in academic Hepatology and research training for recent Ph.D. graduates to prepare them for careers as independent investigators in basic liver-related research.
Medical Research Interests
Calcium Signaling; Cell Biology; Cell Nucleus; Digestive System Diseases; Hepatocytes; Liver
Academic Achievements & Community Involvement
Clinical Care
Overview
Michael H. Nathanson, MD, PhD, specializes in treating patients with liver disease.
He is a professor of medicine (digestive diseases) and of cell biology at Yale School of Medicine. In addition to his clinical work, he serves as co-director of the Yale Liver Center and director of the Center for Cellular and Molecular Imaging; he is also an active researcher.
Clinical Specialties
Internal Medicine; Hepatology
Fact Sheets
Alcohol-related Liver Disease
Learn More on Yale MedicineCirrhosis
Learn More on Yale MedicineAlcohol Use Disorder
Learn More on Yale MedicineFatty Liver Disease
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Board Certifications
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1988
Yale Medicine News
News & Links
News
- September 24, 2024
Neutrophils in the Immune System Do More Than Fight Bacteria and Viruses
- June 18, 2024
Now Accepting Applications for Yale Liver Center Pilot Funding
- September 19, 2023
Liver Center Retreat Highlights Breadth of Liver Research at Yale
- November 21, 2022
Dr. Michael Nathanson Receives AASLD Distinguished Service Award