2014
Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats
Cao C, Thomas CE, Insogna KL, O'Brien KO. Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats. Journal Of Nutrition 2014, 144: 1710-1717. PMID: 25332470, PMCID: PMC4195416, DOI: 10.3945/jn.114.197939.Peer-Reviewed Original ResearchConceptsNonheme iron absorptionDivalent metal transporter 1Tissue utilizationLiver hepcidinDietary hemeMale Sprague-Dawley ratsDuodenal iron transportersHeme iron absorptionSprague-Dawley ratsHepatic hepcidin expressionIron storage tissuesIron loadingElevated hepcidinIron intakeMetal transporter 1Duodenal absorptionIron dextranNonheme ironIron overloadRat modelHepcidin expressionHepatic hepcidinStable iron isotopesDuodenal expressionHepcidin
2013
Differential effects of hepcidin on heme and nonheme iron absorption in a rat model of iron overload
Cao C, Thomas C, Insogna K, O'Brien K. Differential effects of hepcidin on heme and nonheme iron absorption in a rat model of iron overload. The FASEB Journal 2013, 27: 634.18-634.18. DOI: 10.1096/fasebj.27.1_supplement.634.18.Peer-Reviewed Original ResearchFe overloadMale Sprague-Dawley ratsWeeks of treatmentFe absorptionBi-weekly injectionsNonheme iron absorptionRed cell incorporationSprague-Dawley ratsLiver hepcidinDawley ratsRat modelRats inhibitsIron overloadRodent modelsIron absorptionAlternate daysRegulatory hormonesHepcidin transcriptsHepcidinFpn degradationRatsCell incorporationGreater associationDifferential effectsPorcine RBCs
2011
Dietary protein increases intestinal calcium absorption in part by increasing tight junction expression of Claudin‐2
Gaffney‐Stomberg E, Cucchi C, Sun B, Bataille A, Renfro L, Kerstetter J, Insogna K. Dietary protein increases intestinal calcium absorption in part by increasing tight junction expression of Claudin‐2. The FASEB Journal 2011, 25: 983.30-983.30. DOI: 10.1096/fasebj.25.1_supplement.983.30.Peer-Reviewed Original ResearchHigh-protein dietCaco-2 BBe cellsClaudin-2 expressionCa absorptionCalcium absorptionProtein dietClaudin-2BBE cellsFemale Sprague-Dawley ratsIntestinal calcium absorptionDietary proteinSprague-Dawley ratsTight junction expressionCa transportTight junction proteinsTranscellular Ca transportDietary protein effectsCa-transporting proteinsDuodenal mucosaAcute effectsDay 7MRNA expressionJunction expressionJunction proteinsAmino acids
2010
The Effect of Dietary Protein on Intestinal Calcium Absorption in Rats
Gaffney-Stomberg E, Sun BH, Cucchi CE, Simpson CA, Gundberg C, Kerstetter JE, Insogna KL. The Effect of Dietary Protein on Intestinal Calcium Absorption in Rats. Endocrinology 2010, 151: 1071-1078. PMID: 20147526, PMCID: PMC2840679, DOI: 10.1210/en.2009-0744.Peer-Reviewed Original ResearchConceptsIntestinal Ca absorptionCa absorptionHigh-protein dietUrinary calciumBrush border membrane vesiclesProtein intakeFemale Sprague-Dawley ratsProtein dietProtein intake resultsIntestinal calcium absorptionDietary protein intakeHigh protein intakeSprague-Dawley ratsLow-protein groupHigh protein groupDietary protein effectsCalcium absorptionAcute increaseDawley ratsDuodenal mucosaIntake resultsRatsCa balanceTranscellular CaDietary protein
1997
Parathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy
Sun B, Mitnick M, Eielson C, Yao G, Paliwal I, Insogna K. Parathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy. Endocrinology 1997, 138: 3918-3924. PMID: 9275082, DOI: 10.1210/endo.138.9.5421.Peer-Reviewed Original ResearchConceptsLevels of fibronectinEffect of PTHAbility of PTHHuman PTHAdult female Sprague-Dawley ratsFemale Sprague-Dawley ratsCultured fetal rat bonesDiminished bone formationEstrogen-deficient stateHuman PTH-(1-34) infusionSprague-Dawley ratsFN productionFetal rat boneBisphosphonate APDHPTH groupPTH infusionCirculating LevelsAlzet minipumpsEstrogen deficiencyParathyroid hormoneEstrogen withdrawalBone resorptionAnabolic propertiesROS 17/2.8 cellsEffective agonistParathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy*
Sun B, Mitnick M, Eielson C, Yao G, Paliwal I, Insogna K. Parathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy*. Endocrinology 1997, 138: 3918-3924. DOI: 10.1210/en.138.9.3918.Peer-Reviewed Original ResearchResponse to PTHEffect of PTHHuman PTHCirculating levelsLevels of FNFN in vivoCultured fetal rat bonesAdult female Sprague-Dawley ratsFemale Sprague-Dawley ratsTreated with PTHVehicle infused groupFN productionEstrogen-deficient stateFetal rat bonesSignificant 2.4-fold increaseBlock bone resorptionSprague-Dawley ratsROS 17/2.8 cellsIn vitro studiesBisphosphonate APDEstrogen deficiencyAlzet minipumpsEstrogen withdrawalLevels in vivoBlunted response
1996
Effects of continuous glucocorticoid infusion on bone metabolism in the rat
King CS, Weir EC, Gundberg CW, Fox J, Insogna KL. Effects of continuous glucocorticoid infusion on bone metabolism in the rat. Calcified Tissue International 1996, 59: 184-191. PMID: 8694896, DOI: 10.1007/s002239900107.Peer-Reviewed Original ResearchConceptsDEX treatmentBone metabolismUrinary calcium/creatinine ratioCalcium/creatinine ratioIntact parathyroid functionLevels of PTHSprague-Dawley ratsTartrate-resistant acid phosphataseParathyroid functionTime-dependent mannerCreatinine ratioSerum calciumBone turnoverContinuous administrationParathyroidectomized animalsSerum concentrationsSupraphysiologic dosesGlucocorticoid infusionDawley ratsFemoral weightHistomorphometric findingsBone massPTX animalsBone volumeDexamethasone