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HIV, Aging and Critical Illness

Dr. Akgün's research has primarily focused on MICU admissions and outcomes in Veterans with particular focus on comparisons between HIV infected and uninfected patients in the current combination antiretroviral era. Using the Veterans Aging Cohort Study (VACS; PI: Amy Justice), a multicenter observational cohort study, Dr. Akgün and her research team have used a novel HIV-specific scoring system, the VACS Risk Index (VACS Index), to predict hospitalizations and MICU admission for HIV infected patients.

Current investigations include using the VACS Index on MICU admission to predict mortality for HIV infected and uninfected patients as well as using the VACS Index to predict patient-centered outcomes such as health-related quality of life and frailty-related phenotype among MICU survivors. We are also examining drug trajectories over nursing shifts in critically ill patients.

Publications

Akgun KM, Pisani MA, Butt AA, Gibert CL, Rodriguez-Barradas, MC, Justice AC, Rimland D, Crothers K. Incidence and Mortality of MICU Admission in HIV Infected (HIV+) and Non-Infected (HIV-) Veterans. AJRCCM May 2010 A5200.
Akgun KM, Pisani MA, Fried TR, Butt AA, Gibert CL, Rimland D, Justice AC, Rodriguez-Barradas, MC, Crothers K. Risk Factors for MICU Admission among HIV+ Patients. AJRCCM May 2010 A5199.
Akgun KM, Pisani M, Fried T, Butt AA, Gibert C, Rimland D, Huang L, Justice AC, Rodriguez-Barradas M, Crothers KA. Impact of age on medical intensive care unit admissions in HIV-infected patients. AJRCCM May 2011
Akgun KM, Tate JP, Pisani M, Butt AA, Gilbert C, Rimland D, Huang L, Justice AC, Rodriquez-Barradas MC, Crothers K. Is the VACS index responsive to acute critical illness? 16th Annual Instructional Workshop on HIV Observational Databases (IWHOD) March 2012 Athens, Greece, Abstract #16_173
Akgun KM, Tate JP, Pisani M. Butt AA, Gibert CL, Rimland D, Huang L, Justice AC, Rodriquez-Barradas MC, Crothers K. Prediction of 30-day mortality after MICU admission among HIV-infected patients. AJRCCM May 2012, Abstract #29293.