2021
Bidirectional Connectivity Between Broca's Area and Wernicke's Area During Interactive Verbal Communication
Ono Y, Zhang X, Noah JA, Dravida S, Hirsch J. Bidirectional Connectivity Between Broca's Area and Wernicke's Area During Interactive Verbal Communication. Brain Connectivity 2021, 12: 210-222. PMID: 34128394, PMCID: PMC9058861, DOI: 10.1089/brain.2020.0790.Peer-Reviewed Original ResearchConceptsWernicke's areaNeural mechanismsBroca's areaDirectional connectivityHealthy adult participantsHemodynamic responseBidirectional connectivityFunctional connectivityNeural modulationBrainNeuronal informationSpeech areasNeural activityAdult participantsBrocaContrast findingsHuman brainImpact statementNeural dynamicsBrain modelFindingsWernicke'sSocial functionGranger causality analysisVerbal condition
2018
Functional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation
Galgano J, Pantazatos S, Allen K, Yanagihara T, Hirsch J. Functional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation. Brain Research 2018, 1707: 184-189. PMID: 30500402, PMCID: PMC7434632, DOI: 10.1016/j.brainres.2018.11.040.Peer-Reviewed Original ResearchConceptsPeriaqueductal gray regionPsychophysiological interaction analysisFunctional connectivityDiffusion tensor imaging (DTI) analysisTrend-level evidenceNeural mechanismsBilateral auditory corticesGreater functional connectivityAmygdala couplingWhole-brain resultsDorsomedial prefrontal cortexLimbic systemMotor areaAmygdala clustersAuditory cortexLaryngeal musculatureHealthy adultsPrefrontal cortexNeuroimaging studiesNeural activityVoice disordersStructural connectivityGray regionCortexMovement paradigm
2017
Distributed Neural Activity Patterns during Human-to-Human Competition
Piva M, Zhang X, Noah JA, Chang SWC, Hirsch J. Distributed Neural Activity Patterns during Human-to-Human Competition. Frontiers In Human Neuroscience 2017, 11: 571. PMID: 29218005, PMCID: PMC5703701, DOI: 10.3389/fnhum.2017.00571.Peer-Reviewed Original ResearchTemporal-parietal junctionAngular gyrusFusiform gyrusSupramarginal gyrusSocial cognitionSubcentral areaFunctional connectivityBilateral dorsolateral prefrontal cortexHuman social cognitionSocial cognition paradigmPrevious fMRI findingsFace interactionHuman social behaviorDorsolateral prefrontal cortexNeural activity patternsConventional neuroimaging techniquesBrain functional connectivitySomatosensory cortexCognition paradigmNeural coherenceRelevant cuesFMRI findingsLeft DLPFCNeural mechanismsFrontopolar area
2015
Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings
Geliebter A, Benson L, Pantazatos SP, Hirsch J, Carnell S. Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings. Appetite 2015, 96: 195-202. PMID: 26275334, PMCID: PMC4684801, DOI: 10.1016/j.appet.2015.08.009.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexHigh-calorie food cuesNon-BE groupFood cuesNeural responsesPsychophysiologic interactionsOrbitofrontal cortexFunctional connectivityGreater functional connectivityRegional brain activationAnterior cingulate activationHigh energy density foodsAnterior cingulate cortexLow-ED foodsAuditory cuesFMRI scanningActivation differencesBrain activationCingulate activationMore activationSupramarginal gyrusNeuroimaging studiesBE groupObese individualsCingulate cortex
2014
Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study
Karten A, Hirsch J. Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study. Journal Of Autism And Developmental Disorders 2014, 45: 1905-1914. PMID: 25526952, PMCID: PMC4441908, DOI: 10.1007/s10803-014-2344-y.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNegative BOLD responseASD participantsReceptive languageLanguage disabilitySpectrum disorderNeural deactivationInhibitory processesFunctional connectivityFunctional magnetic resonance imagingBlood oxygen level-dependent (BOLD) responseSuperior temporal gyrusFunctional MRI studyLevel-dependent responsesNeural mechanismsPassive listeningTemporal gyrusBOLD responseControl participantsParticipantsLanguageMagnetic resonance imagingExcitatory processesMRI studiesConnectivityAmodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity
Carnell S, Benson L, Pantazatos SP, Hirsch J, Geliebter A. Amodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity. Obesity 2014, 22: 2370-2378. PMID: 25098957, PMCID: PMC4224976, DOI: 10.1002/oby.20859.Peer-Reviewed Original ResearchConceptsFunctional connectivityObese individualsFood cuesEffect of obesityLow-ED foodsWhole-brain activationGreater functional connectivityLean womenDifferential neural responsesObesogenic environmentMidbrainExcessive foodVTABrain activationNeural responsesObeseFMRI scanningObesityPutamenCerebellumActivationResponseCue modalityIndividualsWomen
2013
Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment
Pantazatos SP, Talati A, Schneier FR, Hirsch J. Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment. Neuropsychopharmacology 2013, 39: 425-434. PMID: 24084831, PMCID: PMC3870777, DOI: 10.1038/npp.2013.211.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderFunctional connectivityAnxiety disordersFace perceptionTemporal poleFunctional magnetic resonance imaging studyPanic disorderSpecific anxiety disordersIndependent replication sampleHippocampal functional connectivityMagnetic resonance imaging studyFace processingPerceptual tasksResonance imaging studyBrain activationSAD diagnosisReplication sampleHIGH-SADSAD samplesSimilar tasksDisorder-specific biomarkersFC featuresSymptom severityAnterior temporalPerceptionEffects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans
Hinkle W, Cordell M, Leibel R, Rosenbaum M, Hirsch J. Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans. PLOS ONE 2013, 8: e59114. PMID: 23555620, PMCID: PMC3605420, DOI: 10.1371/journal.pone.0059114.Peer-Reviewed Original ResearchConceptsLeptin repletionRight hypothalamusFunctional connectivityFood cuesWeight lossGreater weight lossOrbital frontal cortexDorsal anterior cingulatePsychophysiological interaction analysisPlacebo injectionsObese subjectsObese populationLeptin injectionObese humansWeight maintenanceFrontal cortexAnterior cingulateHypothalamusFrontal poleInteroceptive systemPatient subjectsVisual areasDorsal ACCFood stimuliRepletion
2012
Frontal–Occipital Connectivity During Visual Search
Pantazatos SP, Yanagihara TK, Zhang X, Meitzler T, Hirsch J. Frontal–Occipital Connectivity During Visual Search. Brain Connectivity 2012, 2: 164-175. PMID: 22708993, PMCID: PMC3621345, DOI: 10.1089/brain.2012.0072.Peer-Reviewed Original ResearchConceptsLateral occipital cortexVisual searchVisual regionsPrefrontal cortexCategory-selective visual regionsFunctional magnetic resonance imagingVentromedial prefrontal cortexSimilar neural mechanismsVisual search processDynamic causal modelingMedial prefrontal cortexComplex natural scenesMultiple task-related componentsSpatial independent component analysisTask-related componentsVisual imageryPsychophysiological interactionNeural mechanismsSearch taskObject categoriesComplex search tasksCausal modelingConnectivity findingsFrontal regionsFunctional connectivityDecoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity
Pantazatos SP, Talati A, Pavlidis P, Hirsch J. Decoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity. PLOS Computational Biology 2012, 8: e1002441. PMID: 22479172, PMCID: PMC3315448, DOI: 10.1371/journal.pcbi.1002441.Peer-Reviewed Original ResearchConceptsFearful facesEmotional expressionBilateral middle temporal gyrusThreat-related stimuliUnattended fearful facesLarge-scale functional connectivityMultiple functional connectionsFunctional magnetic resonanceWhole-brain patternsMiddle temporal gyrusWhole-brain correlationActive research goalNeutral facesEmotion processingFear perceptionImplicit fearImplicit presentationAngular gyrusChance accuracyTemporal gyrusBrain activityFace presentationPrefrontal cortexParietal regionsFunctional connectivityCortical functional connectivity decodes subconscious, task-irrelevant threat-related emotion processing
Pantazatos SP, Talati A, Pavlidis P, Hirsch J. Cortical functional connectivity decodes subconscious, task-irrelevant threat-related emotion processing. NeuroImage 2012, 61: 1355-1363. PMID: 22484206, PMCID: PMC3393600, DOI: 10.1016/j.neuroimage.2012.03.051.Peer-Reviewed Original ResearchConceptsFunctional connectivityAffective stimuliCortical-subcortical functional connectivityFearful face processingFear-related stimuliAmygdala functional connectivityMiddle temporal gyrusCortical structuresKey limbic regionsFace processingEmotion processingFear conditionFear processingSubconscious processingAngular gyrusTemporal gyrusCortical functional connectivityRight amygdalaLimbic regionsFC featuresStimuliGyrusProcessingTraining dataPrecuneusNeural systems for speech and song in autism
Lai G, Pantazatos SP, Schneider H, Hirsch J. Neural systems for speech and song in autism. Brain 2012, 135: 961-975. PMID: 22298195, PMCID: PMC3286324, DOI: 10.1093/brain/awr335.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgingAnisotropyAttentionAutistic DisorderBrainChildDiffusion Tensor ImagingFemaleFunctional LateralityHead MovementsHumansImage Processing, Computer-AssistedInterview, PsychologicalLanguageMagnetic Resonance ImagingMaleMusicNerve NetNeural PathwaysNeuropsychological TestsPhotic StimulationRecruitment, NeurophysiologicalSpeechYoung AdultConceptsInferior frontal gyrusLeft inferior frontal gyrusFrontal gyrusAutistic childrenNeural systemsArcuate fasciculusFunctional magnetic resonanceSuperior temporal gyrusAge-matched control childrenLeft arcuate fasciculusPassive auditory stimulationMusic abilityLanguage disabilitySong conditionTemporal gyrusSpeech stimulationAuditory stimulationAutismFunctional connectivityNeural organizationBrain regionsSpeechControl childrenGyrusAutistic
2009
Effects of heartbeat and respiration on macaque fMRI: Implications for functional connectivity
Teichert T, Grinband J, Hirsch J, Ferrera VP. Effects of heartbeat and respiration on macaque fMRI: Implications for functional connectivity. Neuropsychologia 2009, 48: 1886-1894. PMID: 19969009, PMCID: PMC2876227, DOI: 10.1016/j.neuropsychologia.2009.11.026.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFunctional connectivityRespiratory artifactsAnesthetized macaque monkeysMagnetic resonance imagingNon-human primatesAwake humansMacaque monkeysResonance imagingFalse negative correlationNeuronal energy consumptionEffect of heartbeatNegative correlationAdequate replacementRespiratory activity