How Studying Cellular Senescence Can Help Researchers Learn to Delay Aging
Chronic inflammation, one of the major hallmarks of aging, is thought to be partly caused by senescent cells that may accumulate in older individuals. Now, Yale researchers have received a grant from the National Institutes of Health (NIH) Common Fund’s Cellular Senescence Network Program (SenNet) to study these specialized cells.
Yale Scientists Discover a New Pathogenic Mechanism in Hematological Malignancies
Scientists at Yale Cancer Center have discovered new consequences of specific gene mutations that play a role in the development of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Approximately half the patients diagnosed with MDS and 10% of patients with AML are found to have splicing factor mutations leading to ineffective blood cell production and malignancy. The new research revealed that mutations in the splicing factor U2AF1 improve the ability of the cancer cells to respond to and survive stress. The findings were published today in Molecular Cell.
Mice with Human Blood: A New Way to Study Blood Disorders
Researchers from the Yale Department of Immunology and Yale Cancer Center have recently developed a mouse model that displays enhanced human erythropoiesis and mature RBC survival to help them better study human blood disorders.Source: Yale Scientific
Bernard G. Forget Hematology Scholars Program Supported by Friends who Give
Mary Alice and Thomas O’Malley’s recent gift to support Yale’s Bernard G. Forget Hematology Scholars Program is rooted in multiple friendships. The couple learned about the program from their friend Alan Lebowitz, MD., who was Associate Clinical Professor of Medicine at Yale School of Medicine and is a retired Connecticut hematologist. Dr. Lebowitz, a champion of Yale Cancer Center, was also a close friend of the Scholars Program’s late namesake.
Yale Study Shows Combined Liver–Cytokine Humanization Rescues Circulating Red Blood Cells for Testing of Novel Therapeutics
In a new study by the Yale Department of Immunobiology and Yale Cancer Center, researchers report combined liver and growth factor humanization enhances human red blood cell production and survival in circulation the immunodeficient murine host.
Dr. Stephanie Halene Appointed Chief of Hematology at Yale Cancer Center and Smilow Cancer Hospital
Following an extensive national search, Stephanie Halene, MD, PhD, has been appointed Chief of Hematology at Yale Cancer Center, Smilow Cancer Hospital and the Yale School of Medicine Department of Internal Medicine.
With Barcoding, a Better Understanding of Life Forms
Because of the very complicated organization of tissues and cells, it’s still not entirely understood how tumors form, for instance, or how different organs emerge in early-stage embryos. To help answer these crucial questions, a team of researchers at Yale have developed a technology that gives a much clearer picture of the spatial relationships in biological systems. The process, which involves barcoding cells in tissue, was developed in the lab of Rong Fan, professor of biomedical engineering. The results were published Nov. 13 in Cell. The authors include Yale BME postdocs, graduate students, and undergraduate students in Fan lab and collaborators from Yale School of Medicine including Prof. Stephanie Halene, interim section chief of hematology.Source: Yale SEAS News
Humanized Mice Lead to Breakthroughs in Blood Cancers
Humanized mice created at Yale are opening new avenues of research into cancers caused by disorders in the production of blood, such as acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). Until recently, such research was hindered because human blood stem cells are difficult to grow in cell cultures or to engraft in mice.