Immune cells are an ally, not enemy, in battle against Alzheimer’s
In Alzheimer’s disease (AD), β-amyloid plaques are tightly enveloped by microglia but the significance of this phenomenon is unknown. Here the authors used confocal and in vivo two-photon imaging in AD mouse models and revealed that microglia constitute a physical barrier that prevents the formation of neurotoxic hotspots of protofibrillar β-amyloid and shields adjacent neurons and synapses from the toxic effect of amyloid plaques
Calorie Reduction Lowers Protein Linked to the Aging Process
In a new study, Yale researchers show that moderate calorie restriction in people reduces the production of a protein called SPARC, which then reins in harmful inflammation and improves health in the aged. It could be a target for extending human health span, they report.
Irina Krykbaeva, PhD, Awarded 2022 Milton C. Winternitz Prize in Pathology
Irina Krykbaeva, a recent PhD graduate in the Department of Pathology at Yale School of Medicine, is the winner of the 2022 Milton C. Winternitz Prize in Pathology. The prize is awarded annually to the student who, in the opinion of the department faculty and staff, has done outstanding work in the course.
Vishwa Deep Dixit, DVM, PhD, Appointed Director of the Yale Center for Research on Aging (Y-Age) and Professor of Pathology at Yale Pathology
Vishwa Deep Dixit, DVM, PhD, the Waldemar Von Zedtwitz Professor of Comparative Medicine and Immunobiology at Yale School of Medicine, will be appointed as Director of the Yale Center for Research on Aging (Y-Age) and Professor of Pathology on January 1, 2022.
Ask tough questions: PhD student Sebastian Diaz
Sebastian Diaz, a PhD student in immunobiology at Yale School of Medicine (YSM), said it’s hard to be among the pioneers, but because medical students from underrepresented backgrounds have pushed for greater emphasis on diversity, equity, and inclusion (DEI) supported by resources “We have a very robust system that is now becoming bigger and bigger every year.”
Common Cold Could Protect Against COVID In Early Stages Of Infection
t’s hard to envision the common cold, caused by rhinoviruses, as something of a superhero, but recent research from Yale University has found this bug to have an intriguing effect on the early success of the pathogen that causes COVID-19 in the body.Source: IFLScience
Women's Health in the Time of COVID-19 Webinar
Uncovering how the coronavirus affects the biology of women and men differently is teaching us new ways to fight COVID-19. Identifying how the stress of the pandemic is different for women and men is focusing mental health professionals on risk and resilience. Watch Women’s Health Research at Yale Director Carolyn M. Mazure, Ph.D, and leading immunologist Akiko Iwasaki, Ph.D., in conversation with Yale Medalist Susanna Krentz, '80, as they discuss a major new research finding and next steps in investigating sex differences to advance the health of women and men.
The Role of Viperin in Viral Protection with Dr. Chun-Chieh ‘Jack’ Hsu
Chun-Chieh ‘Jack’ Hsu, Ph.D., a CRI postdoctoral fellow in the lab of Peter Cresswell, Ph.D., at Yale University, is investigating a protein named viperin that helps promote the elimination of viral infection and is even found in some cancers. But much about viperin and its mechanisms remains unknown, so he’s exploring how it influences immune responses, which could pave the way for future strategies to protect against both viruses and cancers.Source: Cancer Research Institute
Why Is COVID-19 Striking Men Harder Than Women?
Women's Health Research at Yale Director Carolyn M. Mazure and Immunobiology Professor Akiko Iwasaki, discuss how understanding why men suffer more severe cases of COVID-19 and are more likely to die is vital for developing effective strategies that can produce better outcomes for everyone.Source: Time
How T Cells Make Sure They Have Quiet Time
All cells, like all people, need “quiet” time to function properly, and this is particularly true of T cells, one of the immune system’s main weapons. They must be ready for activation at all times, and primed to divide more rapidly than almost any cell in the body.
The harmful effects of stress during pregnancy can last a lifetime
Mice exposed to stress in the womb and soon after birth can expect a lifetime of immune system deficiencies that hinder the ability to ward off infections and cancer, Yale University researchers report March 5 in the journal Cell.
From Paradox to Breakthrough
Aaron Ring, MD, PhD, was hooked by a paradox. He had been studying cytokines to understand their potential to stimulate anti-tumor immunity. Though cytokines, such as interleukin-2, have been in clinical use for decades, they have historically shown only limited effectiveness. Dr. Ring was hunting for interleukins that could deliver a specific signal to activate TILs.
Richard Flavell Is Named a Distinguished Fellow by the American Association of Immunologists
Richard A. Flavell, PhD, is one of 20 scientists who have been named Distinguished Fellows by the American Association of Immunologists, which recognizes members for distinguished careers and outstanding scientific contributions, as well as their service to AAI and the immunology community. It is one of the highest honors that AAI bestows.