Jaime Grutzendler, MD

Dr. Harry M. Zimmerman and Dr. Nicholas and Viola Spinelli Professor of Neurology and Neuroscience; Director, Center for Experimental Neuroimaging

Research Interests

Alzheimer Disease; Astrocytes; Axons; Blood-Brain Barrier; Capillaries; Cerebrovascular Circulation; Microscopy; Nerve Fibers, Myelinated; Neuronal Plasticity; Regional Blood Flow; Microglia; Neurodegenerative Diseases; Pericytes

Research Organizations

Neurology: Alzheimer's Disease Research Center (ADRC) | Grutzendler Lab

Interdepartmental Neuroscience Program

Vascular Biology and Therapeutics Program

Yale Cancer Center

Office of Cooperative Research

Research Summary

The dynamics and logic of neuro-glio-vascular interactions in health and disease

The overall goal of our laboratory is to uncover rules that govern the complex interactions between all brain cell types in their unperturbed in vivo environment and to determine how these dynamic cell-cell interactions are disrupted in a variety of disease states.We utilize high-resolution cellular imaging in vivo and fixed tissues of single cells and small clusters of interacting cells combined with novel optical sensors of cellular physiology, optogenetics, chemogenetics, genome editing techniques and methods that we develop for improving the capacity to visualize and manipulate individual cells in their native environment. Our approach tends to be exploratory and hypothesis generating and thus, our results can take us in different directions such that projects in the lab can have a neuronal, glial or vascular focus and may be directed towards understanding normal physiology or neuropathology.

Extensive Research Description

  • IN VIVO IMAGING:The majority of projects in the laboratory are imaging-oriented. We use a variety of techniques including transcranial in vivo two photon microscopy, high-resolution confocal, spectral confocal reflectance microscopy (SCoRe) and electron microscopy in combination with differential fluorescent cell labeling and genetic/pharmacological manipulations. We aim at developeing novel imaging strategies and methods to better understand the pathophysiology of a variety of neurological disorders.
  • "NEURO-GLIO-VASCULAR UNIT" FUNCTION AND PATHOLOGY: Understanding the postnatal development and pathology of neuro-glio-vascualr interactions, neurovascular coupling, tissue oxygenation. Astrocyte physiology.
  • MICROVASCULAR PLASTICITY: microvascular recanalization and angioplasticity after cerebral embolic occlusion. We have recently described a new mechanism of microvascular plasticity which leads to vessel recanalization (Angiophagy). We are investigating the molecular control and physiological relevance of this novel mechanism.
  • AXONAL AND SYNAPTIC DEGENERATION/REGENERATION: We have recently developed a method for imaging myelinated axons in vivo (Spectral confocal reflectance microscopy SCoRe), which we are currently using to explore questions related to myelin's role in degeneration and regeneration.
  • ALZHEIMER"S DISEAESE: understanding the dynamics of neurodegenerative conditions such as Alzheimer's disease. We study the interactions between microglia, neurons and amyloid plaques to understand the sequence of events leading to neural dysfunction in AD.

Selected Publications

Full List of PubMed Publications

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Contact Info

Jaime Grutzendler, MD
Patient Care Location
Yale Memory ClinicYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
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Mailing Address
NeurologyPO Box 208018
New Haven, CT 06520-8018

Grutzendler Lab