Publications

• Bacteria require phase separation for fitness in the mammalian gut.Krypotou E, Townsend GE, Gao X, Tachiyama S, Liu J, Pokorzynski ND, Goodman AL, Groisman EA. Science. 2023 Mar 17; 2023 Mar 16. PMID: 36927025.
• Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity.Han W, Peng BZ, Wang C, Townsend GE 2nd, Barry NA, Peske F, Goodman AL, Liu J, Rodnina MV, Groisman EA. EMBO J. 2023 Jan 16; 2022 Dec 6. PMID: 36472247.
• Degradation of gene silencer is essential for expression of foreign genes and bacterial colonization of the mammalian gut.Choi J, Schmukler M, Groisman EA. Proc Natl Acad Sci U S A. 2022 Oct 4; 2022 Sep 26. PMID: 36161931.
• Differential synthesis of novel small protein times Salmonella virulence program.Salvail H, Choi J, Groisman EA. PLoS Genet. 2022 Mar; 2022 Mar 4. PMID: 35245279.
• RNA chaperone activates Salmonella virulence program during infection.Choi J, Salvail H, Groisman EA. Nucleic Acids Res. 2021 Nov 18. PMID: 34751407.
• Cellular Adaptations to Cytoplasmic Mg(2+) Limitation.Groisman EA, Chan C. Annu Rev Microbiol. 2021 Oct 8. PMID: 34623895.
• The regulation of DNA supercoiling across evolution.Duprey A, Groisman EA. Protein Sci. 2021 Oct; 2021 Aug 23. PMID: 34398513.
• How the PhoP/PhoQ System Controls Virulence and Mg(2+) Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution.Groisman EA, Duprey A, Choi J. Microbiol Mol Biol Rev. 2021 Aug 18; 2021 Jun 30. PMID: 34191587.
• The Practice of Science as the Pursuit of Knowledge.Groisman EA. Yale J Biol Med. 2021 Jun; 2021 Jun 30. PMID: 34211357.
• Low Cytoplasmic Magnesium Increases the Specificity of the Lon and ClpAP Proteases.Yeom J, Groisman EA. J Bacteriol. 2021 Jun 22; 2021 Jun 22. PMID: 33941609.
• Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis.Bruna RE, Kendra CG, Groisman EA, Pontes MH. Proc Natl Acad Sci U S A. 2021 Mar 16. PMID: 33707210.
• How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues.Blanc-Potard AB, Groisman EA. Trends Microbiol. 2021 Feb; 2020 Aug 14. PMID: 32807623.
• Reduced ATP-dependent proteolysis of functional proteins during nutrient limitation speeds the return of microbes to a growth state.Yeom J, Groisman EA. Sci Signal. 2021 Jan 26; 2021 Jan 26. PMID: 33500334.
• Horizontally acquired regulatory gene activates ancestral regulatory system to promote Salmonella virulence.Choi J, Groisman EA. Nucleic Acids Res. 2020 Nov 4. PMID: 33045730.
• DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines.Duprey A, Groisman EA. PLoS Genet. 2020 Oct; 2020 Oct 30. PMID: 33125364.
• Small proteins regulate Salmonella survival inside macrophages by controlling degradation of a magnesium transporter.Yeom J, Shao Y, Groisman EA. Proc Natl Acad Sci U S A. 2020 Aug 18; 2020 Aug 4. PMID: 32753384.
• FEDS: a Novel Fluorescence-Based High-Throughput Method for Measuring DNA Supercoiling In Vivo.Duprey A, Groisman EA. mBio. 2020 Jul 28; 2020 Jul 28. PMID: 32723920.
• A Physiological Basis for Nonheritable Antibiotic Resistance.Pontes MH, Groisman EA. mBio. 2020 Jun 16; 2020 Jun 16. PMID: 32546621.
• The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica.Salvail H, Groisman EA. PLoS Genet. 2020 May; 2020 May 11. PMID: 32392214.
• Salmonella expresses foreign genes during infection by degrading their silencer.Choi J, Groisman EA. Proc Natl Acad Sci U S A. 2020 Apr 7; 2020 Mar 24. PMID: 32209674.
• Erratum for Townsend et al., "A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor".Townsend GE 2nd, Han W, Schwalm ND 3rd, Hong X, Bencivenga-Barry NA, Goodman AL, Groisman EA. mBio. 2020 Mar 17; 2020 Mar 17. PMID: 32184244.
• A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor.Townsend GE 2nd, Han W, Schwalm ND 3rd, Hong X, Bencivenga-Barry NA, Goodman AL, Groisman EA. mBio. 2020 Jan 28; 2020 Jan 28. PMID: 31992627.
• The expanded specificity and physiological role of a widespread N-degron recognin.Gao X, Yeom J, Groisman EA. Proc Natl Acad Sci U S A. 2019 Sep 10; 2019 Aug 26. PMID: 31451664.
• Activator of one protease transforms into inhibitor of another in response to nutritional signals.Yeom J, Groisman EA. Genes Dev. 2019 Sep 1; 2019 Aug 1. PMID: 31371438.
• Slow growth determines nonheritable antibiotic resistance in Salmonella enterica.Pontes MH, Groisman EA. Sci Signal. 2019 Jul 30; 2019 Jul 30. PMID: 31363068.
• Dietary sugar silences a colonization factor in a mammalian gut symbiont.Townsend GE 2nd, Han W, Schwalm ND 3rd, Raghavan V, Barry NA, Goodman AL, Groisman EA. Proc Natl Acad Sci U S A. 2019 Jan 2; 2018 Dec 17. PMID: 30559205.
• A protein that controls the onset of a Salmonella virulence program.Yeom J, Pontes MH, Choi J, Groisman EA. EMBO J. 2018 Jul 13; 2018 Jun 1. PMID: 29858228.
• Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane.Hong X, Chen HD, Groisman EA. Sci Signal. 2018 May 8; 2018 May 8. PMID: 29739882.
• Reduction in adaptor amounts establishes degradation hierarchy among protease substrates.Yeom J, Gao X, Groisman EA. Proc Natl Acad Sci U S A. 2018 May 8; 2018 Apr 23. PMID: 29686082.
• Protein synthesis controls phosphate homeostasis.Pontes MH, Groisman EA. Genes Dev. 2018 Jan 1; 2018 Feb 1. PMID: 29437726.
• Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp.Schwalm ND 3rd, Groisman EA. Trends Microbiol. 2017 Dec; 2017 Jul 18. PMID: 28733133.
• Activation of master virulence regulator PhoP in acidic pH requires the Salmonella-specific protein UgtL.Choi J, Groisman EA. Sci Signal. 2017 Aug 29; 2017 Aug 29. PMID: 28851823.
• Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate.Yeom J, Wayne KJ, Groisman EA. Mol Cell. 2017 Apr 20. PMID: 28431231.
• Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron.Schwalm ND 3rd, Townsend GE 2nd, Groisman EA. Mol Microbiol. 2017 Apr; 2017 Feb 3. PMID: 28009067.
• RNA secondary structures regulate three steps of Rho-dependent transcription termination within a bacterial mRNA leader.Kriner MA, Groisman EA. Nucleic Acids Res. 2017 Jan 25; 2016 Oct 5. PMID: 28123036.
• Reducing Ribosome Biosynthesis Promotes Translation during Low Mg(2+) Stress.Pontes MH, Yeom J, Groisman EA. Mol Cell. 2016 Nov 3; 2016 Oct 13. PMID: 27746019.
• Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron.Schwalm ND 3rd, Townsend GE 2nd, Groisman EA. mBio. 2016 Oct 11; 2016 Oct 11. PMID: 27729509.
• Feedback Control of Two-Component Regulatory Systems.Groisman EA. Annu Rev Microbiol. 2016 Sep 8. PMID: 27607549.
• Acidic pH sensing in the bacterial cytoplasm is required for Salmonella virulence.Choi J, Groisman EA. Mol Microbiol. 2016 Sep; 2016 Jul 8. PMID: 27282333.
• Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho.Kriner MA, Sevostyanova A, Groisman EA. Trends Biochem Sci. 2016 Aug; 2016 Jun 17. PMID: 27325240.
• An RNA motif advances transcription by preventing Rho-dependent termination.Sevostyanova A, Groisman EA. Proc Natl Acad Sci U S A. 2015 Dec 15; 2015 Nov 16. PMID: 26630006.
• The Bacterial Transcription Termination Factor Rho Coordinates Mg(2+) Homeostasis with Translational Signals.Kriner MA, Groisman EA. J Mol Biol. 2015 Dec 4; 2015 Oct 30. PMID: 26523680.
• When Too Much ATP Is Bad for Protein Synthesis.Pontes MH, Sevostyanova A, Groisman EA. J Mol Biol. 2015 Aug 14; 2015 Jul 4. PMID: 26150063.
• Species-specific dynamic responses of gut bacteria to a mammalian glycan.Raghavan V, Groisman EA. J Bacteriol. 2015 May; 2015 Feb 17. PMID: 25691527.
• Salmonella promotes virulence by repressing cellulose production.Pontes MH, Lee EJ, Choi J, Groisman EA. Proc Natl Acad Sci U S A. 2015 Apr 21; 2015 Apr 6. PMID: 25848006.
• Flagella-independent surface motility in Salmonella enterica serovar Typhimurium.Park SY, Pontes MH, Groisman EA. Proc Natl Acad Sci U S A. 2015 Feb 10; 2015 Jan 26. PMID: 25624475.
• Bacterial nucleoid-associated protein uncouples transcription levels from transcription timing.Zwir I, Yeo WS, Shin D, Latifi T, Huang H, Groisman EA. mBio. 2014 Oct 7; 2014 Oct 7. PMID: 25293763.
• Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium.Raghavan V, Lowe EC, Townsend GE 2nd, Bolam DN, Groisman EA. Mol Microbiol. 2014 Sep; 2014 Aug 12. PMID: 25041429.
• Unusually long-lived pause required for regulation of a Rho-dependent transcription terminator.Hollands K, Sevostiyanova A, Groisman EA. Proc Natl Acad Sci U S A. 2014 May 13; 2014 Apr 28. PMID: 24778260.
• Control of a Salmonella virulence operon by proline-charged tRNA(Pro).Lee EJ, Choi J, Groisman EA. Proc Natl Acad Sci U S A. 2014 Feb 25; 2014 Feb 10. PMID: 24516160.
• Signal-specific temporal response by the Salmonella PhoP/PhoQ regulatory system.Park SY, Groisman EA. Mol Microbiol. 2014 Jan; 2013 Nov 20. PMID: 24256574.
• A bacterial virulence protein promotes pathogenicity by inhibiting the bacterium's own F1Fo ATP synthase.Lee EJ, Pontes MH, Groisman EA. Cell. 2013 Jul 3. PMID: 23827679.
• The lipopolysaccharide modification regulator PmrA limits Salmonella virulence by repressing the type three-secretion system Spi/Ssa.Choi J, Groisman EA. Proc Natl Acad Sci U S A. 2013 Jun 4; 2013 May 20. PMID: 23690578.
• Conflicting roles for a cell surface modification in Salmonella.May JF, Groisman EA. Mol Microbiol. 2013 Jun; 2013 May 5. PMID: 23646936.
• Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems.Townsend GE 2nd, Raghavan V, Zwir I, Groisman EA. Proc Natl Acad Sci U S A. 2013 Jan 8; 2012 Dec 19. PMID: 23256153.
• Bacterial Mg2+ homeostasis, transport, and virulence.Groisman EA, Hollands K, Kriner MA, Lee EJ, Park SY, Pontes MH. Annu Rev Genet. 2013; 2013 Sep 20. PMID: 24079267.
• The biology of the PmrA/PmrB two-component system: the major regulator of lipopolysaccharide modifications.Chen HD, Groisman EA. Annu Rev Microbiol. 2013; 2013 Jun 17. PMID: 23799815.
• Expression of STM4467-encoded arginine deiminase controlled by the STM4463 regulator contributes to Salmonella enterica serovar Typhimurium virulence.Choi Y, Choi J, Groisman EA, Kang DH, Shin D, Ryu S. Infect Immun. 2012 Dec; 2012 Sep 24. PMID: 23006851.
• Tandem attenuators control expression of the Salmonella mgtCBR virulence operon.Lee EJ, Groisman EA. Mol Microbiol. 2012 Oct; 2012 Aug 26. PMID: 22857388.
• Reciprocal control between a bacterium's regulatory system and the modification status of its lipopolysaccharide.Kato A, Chen HD, Latifi T, Groisman EA. Mol Cell. 2012 Sep 28; 2012 Aug 23. PMID: 22921935.
• Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA.Lee EJ, Groisman EA. Nature. 2012 Jun 13; 2012 Jun 13. PMID: 22699622.
• Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator.Tang YT, Gao R, Havranek JJ, Groisman EA, Stock AM, Marshall GR. Chem Biol Drug Des. 2012 Jun; 2012 Mar 21. PMID: 22339993.
• The promoter architectural landscape of the Salmonella PhoP regulon.Zwir I, Latifi T, Perez JC, Huang H, Groisman EA. Mol Microbiol. 2012 May; 2012 Mar 27. PMID: 22435712.
• Riboswitch control of Rho-dependent transcription termination.Hollands K, Proshkin S, Sklyarova S, Epshtein V, Mironov A, Nudler E, Groisman EA. Proc Natl Acad Sci U S A. 2012 Apr 3; 2012 Mar 19. PMID: 22431636.
• Intrinsic negative feedback governs activation surge in two-component regulatory systems.Yeo WS, Zwir I, Huang HV, Shin D, Kato A, Groisman EA. Mol Cell. 2012 Feb 10. PMID: 22325356.
• An allele of an ancestral transcription factor dependent on a horizontally acquired gene product.Chen HD, Jewett MW, Groisman EA. PLoS Genet. 2012; 2012 Dec 27. PMID: 23300460.
• Genome-wide detection of novel regulatory RNAs in E. coli.Raghavan R, Groisman EA, Ochman H. Genome Res. 2011 Sep; 2011 Jun 10. PMID: 21665928.
• Ancestral genes can control the ability of horizontally acquired loci to confer new traits.Chen HD, Jewett MW, Groisman EA. PLoS Genet. 2011 Jul; 2011 Jul 21. PMID: 21811415.
• A bacterial mRNA leader that employs different mechanisms to sense disparate intracellular signals.Park SY, Cromie MJ, Lee EJ, Groisman EA. Cell. 2010 Sep 3. PMID: 20813261.
• Positive autoregulation shapes response timing and intensity in two-component signal transduction systems.Mitrophanov AY, Hadley TJ, Groisman EA. J Mol Biol. 2010 Aug 27; 2010 Jun 30. PMID: 20600106.
• Defining the plasticity of transcription factor binding sites by Deconstructing DNA consensus sequences: the PhoP-binding sites among gamma/enterobacteria.Harari O, Park SY, Huang H, Groisman EA, Zwir I. PLoS Comput Biol. 2010 Jul 22; 2010 Jul 22. PMID: 20661307.
• An antisense RNA that governs the expression kinetics of a multifunctional virulence gene.Lee EJ, Groisman EA. Mol Microbiol. 2010 May; 2010 Apr 14. PMID: 20398218.
• Orphan and hybrid two-component system proteins in health and disease.Raghavan V, Groisman EA. Curr Opin Microbiol. 2010 Apr; 2010 Jan 19. PMID: 20089442.
• Response acceleration in post-translationally regulated genetic circuits.Mitrophanov AY, Groisman EA. J Mol Biol. 2010 Mar 12; 2009 Nov 20. PMID: 19932119.
• Promoter and riboswitch control of the Mg2+ transporter MgtA from Salmonella enterica.Cromie MJ, Groisman EA. J Bacteriol. 2010 Jan; 2009 Nov 6. PMID: 19897653.
• Short-term signatures of evolutionary change in the Salmonella enterica serovar typhimurium 14028 genome.Jarvik T, Smillie C, Groisman EA, Ochman H. J Bacteriol. 2010 Jan; 2009 Nov 6. PMID: 19897643.
• Activated by different signals, the PhoP/PhoQ two-component system differentially regulates metal uptake.Choi E, Groisman EA, Shin D. J Bacteriol. 2009 Dec; 2009 Oct 2. PMID: 19801407.
• Evolution of transcriptional regulatory circuits in bacteria.Perez JC, Groisman EA. Cell. 2009 Jul 23. PMID: 19632175.
• Identifying promoter features of co-regulated genes with similar network motifs.Harari O, del Val C, Romero-Zaliz R, Shin D, Huang H, Groisman EA, Zwir I. BMC Bioinformatics. 2009 Apr 29; 2009 Apr 29. PMID: 19426448.
• Control of Salmonella pathogenicity island-2 gene expression.Fass E, Groisman EA. Curr Opin Microbiol. 2009 Apr; 2009 Mar 4. PMID: 19264535.
• Transcription factor function and promoter architecture govern the evolution of bacterial regulons.Perez JC, Groisman EA. Proc Natl Acad Sci U S A. 2009 Mar 17; 2009 Feb 27. PMID: 19251636.
• Evolution of a bacterial regulon controlling virulence and Mg(2+) homeostasis.Perez JC, Shin D, Zwir I, Latifi T, Hadley TJ, Groisman EA. PLoS Genet. 2009 Mar; 2009 Mar 20. PMID: 19300486.
• RstA-promoted expression of the ferrous iron transporter FeoB under iron-replete conditions enhances Fur activity in Salmonella enterica.Jeon J, Kim H, Yun J, Ryu S, Groisman EA, Shin D. J Bacteriol. 2008 Nov; 2008 Sep 12. PMID: 18790861.
• Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria.Mitrophanov AY, Jewett MW, Hadley TJ, Groisman EA. PLoS Genet. 2008 Oct; 2008 Oct 24. PMID: 18949034.
• Signal integration in bacterial two-component regulatory systems.Mitrophanov AY, Groisman EA. Genes Dev. 2008 Oct 1. PMID: 18832064.
• Positive feedback in cellular control systems.Mitrophanov AY, Groisman EA. Bioessays. 2008 Jun. PMID: 18478531.
• Overcoming H-NS-mediated transcriptional silencing of horizontally acquired genes by the PhoP and SlyA proteins in Salmonella enterica.Perez JC, Latifi T, Groisman EA. J Biol Chem. 2008 Apr 18; 2008 Feb 11. PMID: 18270203.
• The PhoQ/PhoP regulatory network of Salmonella enterica.Kato A, Groisman EA. Adv Exp Med Biol. 2008. PMID: 18792679.
• A connector of two-component regulatory systems promotes signal amplification and persistence of expression.Kato A, Mitrophanov AY, Groisman EA. Proc Natl Acad Sci U S A. 2007 Jul 17; 2007 Jul 5. PMID: 17615238.
• The intricate world of riboswitches.Coppins RL, Hall KB, Groisman EA. Curr Opin Microbiol. 2007 Apr; 2007 Mar 23. PMID: 17383225.
• Gene promoter scan methodology for identifying and classifying coregulated promoters.Zwir I, Harari O, Groisman EA. Methods Enzymol. 2007. PMID: 17628149.
• Acid pH activation of the PmrA/PmrB two-component regulatory system of Salmonella enterica.Perez JC, Groisman EA. Mol Microbiol. 2007 Jan. PMID: 17229213.
• A positive feedback loop promotes transcription surge that jump-starts Salmonella virulence circuit.Shin D, Lee EJ, Huang H, Groisman EA. Science. 2006 Dec 8. PMID: 17158330.
• The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica.Tu X, Latifi T, Bougdour A, Gottesman S, Groisman EA. Proc Natl Acad Sci U S A. 2006 Sep 5; 2006 Aug 28. PMID: 16938894.
• Sensing by bacterial regulatory systems in host and non-host environments.Groisman EA, Mouslim C. Nat Rev Microbiol. 2006 Sep; 2006 Aug 7. PMID: 16894339.
• Identification of the lipopolysaccharide modifications controlled by the Salmonella PmrA/PmrB system mediating resistance to Fe(III) and Al(III).Nishino K, Hsu FF, Turk J, Cromie MJ, Wösten MM, Groisman EA. Mol Microbiol. 2006 Aug; 2006 Jun 27. PMID: 16803591.
• An RNA sensor for intracellular Mg(2+).Cromie MJ, Shi Y, Latifi T, Groisman EA. Cell. 2006 Apr 7. PMID: 16615891.
• The PmrA/PmrB and RcsC/YojN/RcsB systems control expression of the Salmonella O-antigen chain length determinant.Delgado MA, Mouslim C, Groisman EA. Mol Microbiol. 2006 Apr. PMID: 16556219.
• A Mg2+-responding RNA that controls the expression of a Mg2+ transporter.Groisman EA, Cromie MJ, Shi Y, Latifi T. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381304.
• Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium.Nishino K, Latifi T, Groisman EA. Mol Microbiol. 2006 Jan. PMID: 16359323.