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Selected Publications

  1. Saito, J, Dave, JM, Lau FD, Greif, DM. Loss of presenilin-1 in smooth muscle cells ameliorates elastin aortopathy. iScience 2023; accepted on 12/1/2023.
  2. Kabir, I, Zhang, X, Dave, JM, Chakraborty, R, Qu, R, Chandran, RR, Ntokou, A, Gallardo-Vara, E, Aryal, B, Rotllan, N, Garcia-Milian, R, Hwa, J, Kluger, Y, Martin, KA, Fernández-Hernando, C, Greif, DM. Age of bone marrow dictates clonality of smooth muscle cell-derived cells in the atherosclerotic plaque. Nature Aging 2023, 3:64-81. doi: 10.1038/s43587-022-00342-5.
  3. Gallardo-Vara E, Ntokou A, Dave JM, Jovin DG, Saddouk FZ, Greif DM. Vascular pathobiology of pulmonary hypertension. J Heart Lung Transplant. 2022 Dec 21:S1053-2498(22)02256-2. doi: [10.1016/j.healun.2022.12.012
  4. Dave, JM, Saito, J, Mottola, G, Greif, DM. Invited chapter: Out to the tissues: the arterial side (arteries, arterioles – development, structure, functions, pathologies). In: Gallis, ZS, editor. The Vasculome: From Many, One. San Diego: Elsevier Inc./Academic Press, 2022, pp 89-98.
  5. Chakraborty, R, Ostriker, AC, Xie, Y, Dave, JM, Gamez-Mendez, A, Chatterjee, P, Abu, Y, Valentine, J, Lezon-Geyda, K, Greif, DM, Schulz, V, Gallagher, PG, Sessa, W, Hwa, J and Martin, KA. (2022). The histone acetyltransferases p300 and CBP coordinate distinct chromatin remodeling programs in vascular smooth muscle plasticity. Circulation 2022; 145:1720-37. doi: 10.1161/CIRCULATIONAHA.121.057599
  6. Dave, JM, Chakraborty, R, Ntokou, A, Saito, J, Saddouk, FZ, Feng, Z, Misra, A, Tellides, G, Riemer, RK, Urban, Z, Kinnear, C, Ellis, J, Mital, S., Mecham, R, Martin, KA, Greif, DM. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. Journal of Clinical Investigation 2022; 132(5):e142338. doi: 10.1172/JCI142338
  7. Chandran RR, Xie Y, Gallardo-Vara E, Adams T, Garcia-Milian R, Kabir I, Sheikh AQ, Kaminski N, Martin KA, Herzog EL, Greif DM. Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis. Nature Communications 2021; 12:7179. doi: 10.1038/s41467-021-27499-8
  8. Ntokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021; 6:139067. doi: 10.1172/jci.insight.139067
  9. Gao, R, Peng, X, Perry, C, Sun, H, Ntokou, A, Ryu, C, Gomez, JL, Reeves, BC, Walia, A, Kaminski, N, Neumark, N, Ishikawa, G, Black, KE, Hariri, LP, Moore, MW, Gulati, M, Homer, RJ, Greif, DM, Eltzschig, HK, Herzog, EL. Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. Journal of Clinical Investigation 2021; 131:e136542. doi: 10.1172/JCI136542
  10. Kwan, JM, Odanovic, N, Arbune, A, Higgins, A, Henry, M, Greif, D, Foss, F, Baldassarre, LA. Mogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell Lymphoma. JACC: Case Reports 2021; 3:1018-23. doi: 10.1016/j.jaccas.2021.04.001
  11. Chakraborthy, R, Chatterjee, P, Dave, JM, Ostriker, AC, Greif, DM, Rzucidlo, EM, Martin, KA. Targeting smooth muscle cell phenotypic switching in vascular disease. Journal of Vascular Surgery 2021, 2:79-94. doi: 10.1016/j.jvssci.2021.04.001
  12. Kabir, I, Greif, DM. SNCs meet SMCs in the atherosclerotic plaque. Nature Aging 2021; 1:631-633.
  13. Saddouk, FZ, Ntokou, A, Greif, DM. Invited chapter: Specialized smooth muscle cell progenitors in pulmonary hypertension. In: T. Naknishi, H. Baldwin, J. Fineman, and H. Yamagishi, editors. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension. Springer Nature, 2020, pp 25-30.
  14. Chakraborty, R, Saddouk, FZ, Carrao, AC, Krause, DS, Greif, DM, Martin, KA. Promoters to study vascular smooth muscle: mistaken identity? Arteriosclerosis, Thrombosis, and Vascular Biology 2019; 39:603-612. doi: 10.1161/ATVBAHA.119.312449
  15. Ntokou, A, Kabir, I, Saddouk FZ, Greif, DM. Invited chapter: Vascular embryology and angiogenesis. In: M.A. Creager, J.A. Beckman, and J. Loscalzo, editors. Vascular Medicine, A Companion to Braunwald’s Heart Disease, 3rd edition. Philadelphia, PA: Elsevier Inc.; 2019, pp 1-16.
  16. Ntokou, A, Greif, DM. (2018). Vagal nerve stimulation for pulmonary hypertension: some promise, some skepticism. Journal of the American College of Cardiology: Basic to Translational Science, 3:672.
  17. Dubrac A, Kunzel, SE, Kunzel, SH, Li, J, Chandran, RR, Martin, K, Greif, DM, Adams, R, Eichmann, A. (2018) Nck-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy. Nature Communications, 9:3463.
  18. Misra, A, Feng, Z, Chandran, RR, Kabir, I, Rotllan, N, Aryal, B, Sheikh, AQ, Ding, L, Qin, L, Fernandez-Hernando, C, Tellides, G, Greif, DM. (2018). Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells. Nature Communications, 9:2073. doi:10.1038/s41467.018.04447.7
  19. Sheikh, AQ, Saddouk, FZ, Ntokou, A., Mazurek, R, Greif, DM. (2018) Cell autonomous and non-cell autonomous regulation of SMC progenitors in pulmonary hypertension. Cell Reports, 23:1152. doi:10.1016/j.celrep.2018.03.043
  20. Ntokou, A, Kabir, I, Saddouk, FZ, Greif, DM. Invited chapter: Vascular embryology and angiogenesis. In: Vascular Medicine, A Companion to Braunwald's Heart Disease, 3rd edition. M. Creager, J. Beckham, J. Loscalzo, editors. Philadelphia, PA: Elsevier Inc., 2018, in press.
  21. Dave, JM, Mirabella, T, Greif, DM. (2018) ALK5/TIMP3 axis is pericytes contributes to endothelial morphogenesis in the developing brain. Developmental Cell, 44: 665-678. doi:10.1016/j/devcel.2018.01.018
  22. Greif, DM*, Eichmann, A*. (2017). Where do new endothelial cells come from in the injured heart? Nature Reviews. Cardiology, 14:507. (*Co-corresponding authors). doi:10.1038/nrcardio.2017.121
  23. Misra, A, Feng, Z, Zhang, J, Lou, Z, Greif, DM. (2017). Using in vivo and tissue cell explant approaches to study morphogenesis and pathogenesis of the embryonic and perinatal aorta. Journal of Visualized Experiments, 127, e56039. doi:10.3791/56039
  24. Jiao, Y, Li, G, Li, Q, Ali, R, Qin, L, Li, W, Qyang, Y, Greif, DM, Geirsson, A, Humphrey, JD and Tellides, G. (2017). mTOR inhibition decreases mechanosignaling, collagen accumulation, and stiffening of the aorta in elastin-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 37:1657-1666. https://doi.org/10.1161/ATVBAHA.117.309653
  25. Mazurek, R, Dave, JM, Chandran, RR, Misra, A, Sheikh, AQ, Greif, DM. Invited chapter: Vascular cells in blood vessel development and disease. In: Raouf A. Khalil, editor. Vascular Pharmacology, Vol 78, APHA, UK: Academic Press, 2017, pp. 323-350 doi.org/10.1016/bs.apha.2016.08.001
  26. Misra A, Sheikh AQ, Ding L, Kumar A, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. Integrin beta3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. Journal of Experimental Medicine. 2016, 213:451-463. doi:10.1084/jem.20150688
  27. Sheikh AQ, Misra A, Rosas IO, Adams RH, Greif DM. Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Science Translational Medicine. 2015, 7:308ra159. doi:10.1126/scitranslmed.aaa9712
  28. Sheikh AQ, Lighthouse JK, Greif DM. Recapitulation of developing artery muscularization in pulmonary hypertension. Cell Reports. 2014, 6:809-17. doi:10.1016/j.celrep.2014.01.04
  29. Seidelman S, Lighthouse JK, Greif DM. Development and pathologies of the arterial vascular wall. Cellular and Molecular Life Sciences. 2014, 71:1977-99. doi: 10.1007/s00018-013-1478-y
  30. Greif DM*, Eichmann A*. Vascular biology:brain vessels squeezed to death. Nature. 2014, 508:50-1. (*Co-corresponding authors). doi:10.1038/nature13217
  31. Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ. A novel endothelial Apelin-FGF link mediated by MicroRNAs 424 and 503 is disrupted in pulmonary arterial hypertension. Nature Medicine. 2013, 19:74-82. PMC3540168
  32. Greif DM. Invited chapter: Vascular embryology and angiogenesis. In: Vascular Medicine, A Companion to Braunwald's Heart Disease, 2nd edition. M. Creager, J. Beckman, J. Loscalzo, editors. Philadelphia, PA: Elsevier Inc., 2012, p. 1-13. doi:10.1016/B978-1-4377-2930-6.00001-X
  33. Greif DM*, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-horse K, Espinoza FH, Olson L, Offermanns S, Krasnow, MA*. Radial construction of an arterial wall. Developmental Cell. 2012, 23:482-93. (*Co-corresponding authors). PMC3500096
  34. London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY. Targeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza. Science Translational Medicine. 2010, 23ra19. PMC2875996
  35. Dudzinski DM, Igarashi J, Greif DM, Michel T. The regulation and pharmacology of endothelial nitric oxide synthase. Annual Review of Pharmacology and Toxicology. 2006, 46:235-76. doi:10.1146/annurev.pharmtox.44.101802.121844
  36. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Garcia-Cardena G, Gimbrone MA, Jain MK. KLF2 is a novel transcriptional regulator of proinflammatory activation. The Journal of Experimental Medicine. 2004, 199:1305-15. PMC2211816
  37. Greif DM, Sacks DB, Michel T. Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proceedings of the National Academy of Sciences. 2004, 101:1165-1170. PMC337024
  38. Greif DM, Kou R, Michel T. Regulation of eNOS dephosphorylation by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites. Biochemistry. 2002, 41:15845-53. doi:10.1021/bio26732g
  39. Kou R, Greif D, Michel, T. Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A. Journal of Biological Chemistry. 2002, 277:29669-73. doi: 10.1074/jbc.M204519200
  40. Goetz DJ, Greif DM, Shen J, Luscinskas FW. Cell-cell adhesive interactions in an in vitro fluid flow assay. Methods in Molecular Biology. 1999, 96:137-145. doi:10.1385/1-59259-258-9:137
  41. Greif DM+, Goetz DJ+, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW. Isolated PSGL-1 dynamic adhesion to P- and E-selectin. Journal of Cell Biology. 1997, 137:509-519. (+These authors contributed equally and are listed alphabetically on publication). PMC2139768
Muscularized pulmonary vasculature in pulmonary hypertension