The Microbiome and Cancer Treatment
Andrew Goodman, PhD, studies the abundant flora in the gut, but he initially trained in ecology and sees many parallels. He thinks of the microbiome as an ecosystem and the members of the ecosystem as bacteria. His recent research reveals that microbes are dynamic agents that should be considered in medical care.
Gut check: Yale researchers describe role of bacteria in drug response
Yale researchers identified human gut microbes that metabolize over 150 therapeutic drugs, a finding that highlights the role bacteria play in determining how well individuals respond to medications, they report June 3 in the journal Nature.
Microbiome could be culprit when good drugs do harm
People sometimes suffer toxic side effects from drugs that help many others. Yale scientists have identified a surprising explanation — the gut microbiome. The research, published Feb. 8 in the journal Science, describes how bacteria in the gut can transform three drugs into harmful compounds. “If we can understand the microbiome’s contributions to drug metabolism, we can decide which drugs to give to patients or even alter the microbiome so patients have a better response,” said co-lead author Michael Zimmermann, postdoctoral fellow in the lab of senior author Andrew Goodman in the Department of Microbial Pathogenesis and the Microbial Sciences Institute.
Study: Topical antibiotic triggers unexpected antiviral response
A Yale-led research team made a startling discovery while investigating the effect of bacteria on viral infections. When they applied a common topical antibiotic to mice before or shortly after infection with herpes and other viruses, they found that the antibiotic triggered an antiviral resistance in the animals, the researchers said. The study was published in Nature Microbiology.
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
Study reveals how altered gut microbes cause obesity
Obesity is linked to changes in our gut microbes — the trillions of tiny organisms that inhabit our intestines. But the mechanism has not been clear. In a new study published in Nature, a Yale-led team of researchers has identified how an altered gut microbiota causes obesity.
Bacterial brawls mark life in the gut’s microbiome
Bacterially speaking, it gets very crowded in the human gut, with trillions of cells jostling for a position to carry out a host of specialized and often crucial tasks. A new Yale study, published the week of March 7 in the journal of the Proceedings of the National Academy of Sciences suggests these “friendly” bacteria aggressively stake out their territory, injecting lethal toxins into any other cells that dare bump into them.
Research explains how we live in harmony with friendly gut bacteria
Stability in the composition of the hundred trillion bacterial cells in the human gastrointestinal tract is crucial to health, but scientists have been perplexed how our microbiota withstands an onslaught of toxins, dietary changes, and immune response to infections or antibiotics with little change.