Flavell Lab Publications

2024

DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells.Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z, Li M, Pan W, Zhu S. Nat Commun. 2024 Apr 9; 2024 Apr 9. PMID: 38594251.
Gene trajectory inference for single-cell data by optimal transport metrics.Qu R, Cheng X, Sefik E, Stanley Iii JS, Landa B, Strino F, Platt S, Garritano J, Odell ID, Coifman R, Flavell RA, Myung P, Kluger Y. Nat Biotechnol. 2024 Apr 5; 2024 Apr 5. PMID: 38580861.
IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction.Shiri AM, Zhang T, Bedke T, Zazara DE, Zhao L, Lücke J, Sabihi M, Fazio A, Zhang S, Tauriello DVF, Batlle E, Steglich B, Kempski J, Agalioti T, Nawrocki M, Xu Y, Riecken K, Liebold I, Brockmann L, Konczalla L, Bosurgi L, Mercanoglu B, Seeger P, Küsters N, Lykoudis PM, Heumann A, Arck PC, Fehse B, Busch P, Grotelüschen R, Mann O, Izbicki JR, Hackert T, Flavell RA, Gagliani N, Giannou AD, Huber S. J Hepatol. 2024 Apr; 2023 Dec 30. PMID: 38160941.
IL-10 constrains sphingolipid metabolism to limit inflammation.York AG, Skadow MH, Oh J, Qu R, Zhou QD, Hsieh WY, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Smale ST, Crawford JM, Bensinger SJ, Flavell RA. Nature. 2024 Mar; 2024 Feb 21. PMID: 38383790.
Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection.Torcellan T, Friedrich C, Doucet-Ladevèze R, Ossner T, Solé VV, Riedmann S, Ugur M, Imdahl F, Rosshart SP, Arnold SJ, Gomez de Agüero M, Gagliani N, Flavell RA, Backes S, Kastenmüller W, Gasteiger G. Immunity. 2024 Jan 9; 2023 Dec 28. PMID: 38157853.
Bioactive signalling lipids as drivers of chronic liver diseases.Kaffe E, Tisi A, Magkrioti C, Aidinis V, Mehal WZ, Flavell RA, Maccarrone M. J Hepatol. 2024 Jan; 2023 Sep 21. PMID: 37741346.

2023

ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m(6)A modification-mediated RNA stability control.Gao Y, Zimmer JT, Vasic R, Liu C, Gbyli R, Zheng SJ, Patel A, Liu W, Qi Z, Li Y, Nelakanti R, Song Y, Biancon G, Xiao AZ, Slavoff S, Kibbey RG, Flavell RA, Simon MD, Tebaldi T, Li HB, Halene S. Cell Rep. 2023 Oct 31; 2023 Sep 23. PMID: 37742191.
New insights into programmed cell death protein 1 blockade-associated cutaneous immune-related adverse events.Micevic G, Daniels A, Flavell RA. Br J Dermatol. 2023 Sep 15. PMID: 37471669.
IL-6 trans-signaling in a humanized mouse model of scleroderma.Odell ID, Agrawal K, Sefik E, Odell AV, Caves E, Kirkiles-Smith NC, Horsley V, Hinchcliff M, Pober JS, Kluger Y, Flavell RA. Proc Natl Acad Sci U S A. 2023 Sep 12; 2023 Sep 5. PMID: 37669366.
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions.Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner DF, Mehal WZ, Yuval Kluger, Flavell RA. Cell. 2023 Aug 31; 2023 Aug 9. PMID: 37562401.
IL-7R licenses a population of epigenetically poised memory CD8(+) T cells with superior antitumor efficacy that are critical for melanoma memory.Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn HN, Sefik E, Cheung JF, Hornick NI, Aizenbud L, Joshi NS, Kluger H, Iwasaki A, Bosenberg MW, Flavell RA. Proc Natl Acad Sci U S A. 2023 Jul 25; 2023 Jul 17. PMID: 37459511.
METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells.Xiao Z, Wang S, Tian Y, Lv W, Sheng H, Zhan M, Huang Q, Zhang Z, Zhu L, Zhu C, Zhong H, Wen Q, Liu Z, Tan J, Xu Y, Yang M, Liu Y, Flavell RA, Yang Q, Cao G, Yin Z. Cell Rep. 2023 Jul 25; 2023 Jun 23. PMID: 37355989.
Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine.He K, Wan T, Wang D, Hu J, Zhou T, Tao W, Wei Z, Lu Q, Zhou R, Tian Z, Flavell RA, Zhu S. Cell. 2023 Jul 6; 2023 Jun 15. PMID: 37327784.
Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment.Chiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins KJ, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze LA, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure SP, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields RC, Flavell RA. J Immunother Cancer. 2023 Jul. PMID: 37487666.
A T(reg)-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver.Ding C, Yu Z, Sefik E, Zhou J, Kaffe E, Wang G, Li B, Flavell RA, Hu W, Ye Y, Li HB. Nat Aging. 2023 Jul; 2023 Jun 5. PMID: 37277640.
Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury.Hackstein CP, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus LM, Odainic A, Szlapa J, Kessler N, Beyer M, Schmithausen R, Latz E, Flavell RA, Garbi N, Kurts C, Kümmerer BM, Trebicka J, Roers A, Huber S, Schmidt SV, Knolle PA, Abdullah Z. J Hepatol. 2023 Jul; 2023 Mar 2. PMID: 36870611.
Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection.Song W, Sanchez GM, Mayer DP, Blackburn HN, Chernova I, Flavell RA, Weinstein JS, Craft J. J Immunol. 2023 Jun 15. PMID: 37133336.
Author Correction: LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.Wei Z, Oh J, Flavell RA, Crawford JM. Nature. 2023 Jun. PMID: 37231312.
A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis.Ma H, Hu T, Tao W, Tong J, Han Z, Herndler-Brandstetter D, Wei Z, Liu R, Zhou T, Liu Q, Xu X, Zhang K, Zhou R, Cho JH, Li HB, Huang H, Flavell RA, Zhu S. Cell Res. 2023 May; 2023 Apr 13. PMID: 37055591.
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation.Zheng D, Mohapatra G, Kern L, He Y, Shmueli MD, Valdés-Mas R, Kolodziejczyk AA, Próchnicki T, Vasconcelos MB, Schorr L, Hertel F, Lee YS, Rufino MC, Ceddaha E, Shimshy S, Hodgetts RJ, Dori-Bachash M, Kleimeyer C, Goldenberg K, Heinemann M, Stettner N, Harmelin A, Shapiro H, Puschhof J, Chen M, Flavell RA, Latz E, Merbl Y, Abdeen SK, Elinav E. Nat Immunol. 2023 Apr; 2023 Mar 20. PMID: 36941399.
Humanized MISTRG as a preclinical in vivo model to study human neutrophil-mediated immune processes.Martinez-Sanz P, Laurent ARG, Slot E, Hoogenboezem M, Bąbała N, van Bruggen R, Rongvaux A, Flavell RA, Tytgat GAM, Franke K, Matlung HL, Kuijpers TW, Amsen D, Karrich JJ. Front Immunol. 2023; 2023 Mar 8. PMID: 36969261.
NLRP6 deficiency expands a novel CD103(+) B cell population that confers immune tolerance in NOD mice.Pearson JA, Peng J, Huang J, Yu X, Tai N, Hu Y, Sha S, Flavell RA, Zhao H, Wong FS, Wen L. Front Immunol. 2023; 2023 Feb 23. PMID: 36911699.
Nucleic DHX9 cooperates with STAT1 to transcribe interferon-stimulated genes.Ren X, Wang D, Zhang G, Zhou T, Wei Z, Yang Y, Zheng Y, Lei X, Tao W, Wang A, Li M, Flavell RA, Zhu S. Sci Adv. 2023 Feb 3; 2023 Feb 3. PMID: 36735791.
Allobaculum mucilyticum sp. nov. and Allobaculum fili sp. nov., isolated from the human intestinal tract.van Muijlwijk GH, Rice TA, Flavell RA, Palm NW, de Zoete MR. Int J Syst Evol Microbiol. 2023 Feb. PMID: 36748696.
Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis.Nechanitzky R, Nechanitzky D, Ramachandran P, Duncan GS, Zheng C, Göbl C, Gill KT, Haight J, Wakeham AC, Snow BE, Bradaschia-Correa V, Ganguly M, Lu Z, Saunders ME, Flavell RA, Mak TW. Cell Death Differ. 2023 Feb; 2022 Dec 17. PMID: 36528755.
T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou AD, Schübel M, Jobst J, Zhang T, Dörr J, Märkl F, Majed L, Müller PJ, May P, Gottschlich A, Tokarew N, Lücke J, Oner A, Schwerdtfeger M, Andreu-Sanz D, Grünmeier R, Seifert M, Michaelides S, Hristov M, König LM, Cadilha BL, Mikhaylov O, Anders HJ, Rothenfusser S, Flavell RA, Cerezo-Wallis D, Tejedo C, Soengas MS, Bald T, Huber S, Endres S, Kobold S. Immunity. 2023 Jan 10. PMID: 36630913.
Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22.Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, Sabihi M, Huber FJ, Reeh M, Grass JK, Wahib R, Seese H, Stüben BO, Fard-Aghaie M, Duprée A, Scognamiglio P, Plitzko G, Meiners J, Soukou S, Wittek A, Manthey C, Maroulis IC, Arck PC, Perez D, Gao B, Zarogiannis SG, Strowig T, Pasqualini R, Arap W, Gosálvez JS, Kobold S, Prinz I, Guse AH, Tachezy M, Ghadban T, Heumann A, Li J, Melling N, Mann O, Izbicki JR, Pantel K, Schumacher U, Lohse AW, Flavell RA, Gagliani N, Huber S. Immunity. 2023 Jan 10. PMID: 36630911.
Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells.Tyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. J Exp Med. 2023 Jan 2; 2022 Oct 28. PMID: 36305874.

2022

Epiregulin is a dendritic cell-derived EGFR ligand that maintains skin and lung fibrosis.Odell ID, Steach H, Gauld SB, Reinke-Breen L, Karman J, Carr TL, Wetter JB, Phillips L, Hinchcliff M, Flavell RA. Sci Immunol. 2022 Dec 16; 2022 Dec 9. PMID: 36490328.
Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.Zhang X, Luo S, Wang M, Cao Q, Zhang Z, Huang Q, Li J, Deng Z, Liu T, Liu CL, Meppen M, Vromman A, Flavell RA, Hotamışlıgil GS, Liu J, Libby P, Liu Z, Shi GP. Nat Commun. 2022 Dec 8; 2022 Dec 8. PMID: 36482059.
Cellular Stress-Induced Metabolites in Escherichia coli.Gatsios A, Kim CS, York AG, Flavell RA, Crawford JM. J Nat Prod. 2022 Nov 25; 2022 Nov 8. PMID: 36346625.
N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling.Cho W, York AG, Wang R, Wyche TP, Piizzi G, Flavell RA, Crawford JM. Chembiochem. 2022 Nov 18; 2022 Oct 13. PMID: 36112057.
HIV-1 Vpu restricts Fc-mediated effector functions in vivo.Prévost J, Anand SP, Rajashekar JK, Zhu L, Richard J, Goyette G, Medjahed H, Gendron-Lepage G, Chen HC, Chen Y, Horwitz JA, Grunst MW, Zolla-Pazner S, Haynes BF, Burton DR, Flavell RA, Kirchhoff F, Hahn BH, Smith AB 3rd, Pazgier M, Nussenzweig MC, Kumar P, Finzi A. Cell Rep. 2022 Nov 8. PMID: 36351384.
Human neutrophil development and functionality are enabled in a humanized mouse model.Zheng Y, Sefik E, Astle J, Karatepe K, Öz HH, Solis AG, Jackson R, Luo HR, Bruscia EM, Halene S, Shan L, Flavell RA. Proc Natl Acad Sci U S A. 2022 Oct 25; 2022 Oct 21. PMID: 36269862.
tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis.Liu Y, Zhou J, Li X, Zhang X, Shi J, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zheng J, Liu RJ, Su B, Ye Y, Flavell RA, Yi C, Wu Y, Li HB. Nat Immunol. 2022 Oct; 2022 Sep 22. PMID: 36138184.
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation.Arumugam S, Qin Y, Liang Z, Han SN, Boodapati SLT, Li J, Lu Q, Flavell RA, Mehal WZ, Ouyang X. Cell Death Differ. 2022 Oct; 2022 Apr 27. PMID: 35477991.
LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.Wei Z, Oh J, Flavell RA, Crawford JM. Nature. 2022 Sep; 2022 Aug 17. PMID: 35978195.
RNA m(6)A demethylase ALKBH5 regulates the development of γδ T cells.Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W, Flavell RA, Li HB. Proc Natl Acad Sci U S A. 2022 Aug 16; 2022 Aug 8. PMID: 35939687.
Interspecies commensal interactions have nonlinear impacts on host immunity.Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Cell Host Microbe. 2022 Jul 13; 2022 May 30. PMID: 35640610.
Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9.Fu Y, Pajulas A, Wang J, Zhou B, Cannon A, Cheung CCL, Zhang J, Zhou H, Fisher AJ, Omstead DT, Khan S, Han L, Renauld JC, Paczesny S, Gao H, Liu Y, Yang L, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Sun J, Bilgicer B, Sears CR, Yang K, Kaplan MH. Nat Commun. 2022 Jul 1; 2022 Jul 1. PMID: 35778404.
IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells.Zhang X, Luo S, Wang M, Huang Q, Fang W, Li J, Liu T, Zhang Y, Deng Z, Liu CL, Guan S, Ayala JE, Flavell RA, Kulkarni RN, Libby P, Guo J, Liu Z, Shi GP. Dev Cell. 2022 Jun 20; 2022 Jun 7. PMID: 35675813.
Inhibition of type 1 immunity with tofacitinib is associated with marked improvement in longstanding sarcoidosis.Damsky W, Wang A, Kim DJ, Young BD, Singh K, Murphy MJ, Daccache J, Clark A, Ayasun R, Ryu C, McGeary MK, Odell ID, Fazzone-Chettiar R, Pucar D, Homer R, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B. Nat Commun. 2022 Jun 6; 2022 Jun 6. PMID: 35668129.
Inflammasome activation in infected macrophages drives COVID-19 pathology.Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Nature. 2022 Jun; 2022 Apr 28. PMID: 35483404.
A humanized mouse model of chronic COVID-19.Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, Song E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA. Nat Biotechnol. 2022 Jun; 2021 Dec 17. PMID: 34921308.
Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function.Martinek J, Lin J, Kim KI, Wang VG, Wu TC, Chiorazzi M, Boruchov H, Gulati A, Seeniraj S, Sun L, Marches F, Robson P, Rongvaux A, Flavell RA, George J, Chuang JH, Banchereau J, Palucka K. Cell Rep Med. 2022 May 17; 2022 Apr 27. PMID: 35584631.
In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2.Gbyli R, Song Y, Liu W, Gao Y, Biancon G, Chandhok NS, Wang X, Fu X, Patel A, Sundaram R, Tebaldi T, Mamillapalli P, Zeidan AM, Flavell RA, Prebet T, Bindra RS, Halene S. Leukemia. 2022 May; 2022 Mar 10. PMID: 35273342.
CD4(+) T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival.Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, Croxford AL, Nikolav A, Hövelmeyer N, von Stebut E, Prinz M, Ubeda C, Maloy KJ, Gagliani N, Flavell RA, Waisman A, Huber S. Cell Rep. 2022 Mar 29. PMID: 35354043.
m(6)A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated antiapoptotic pathway.Zhang T, Ding C, Chen H, Zhao J, Chen Z, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M, Flavell RA, Li HB. Sci Adv. 2022 Mar 25; 2022 Mar 25. PMID: 35333576.
Allergic airway recall responses require IL-9 from resident memory CD4(+) T cells.Ulrich BJ, Kharwadkar R, Chu M, Pajulas A, Muralidharan C, Koh B, Fu Y, Gao H, Hayes TA, Zhou HM, Goplen NP, Nelson AS, Liu Y, Linnemann AK, Turner MJ, Licona-Limón P, Flavell RA, Sun J, Kaplan MH. Sci Immunol. 2022 Mar 18; 2022 Mar 18. PMID: 35302861.
An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment.Fu Y, Wang J, Zhou B, Pajulas A, Gao H, Ramdas B, Koh B, Ulrich BJ, Yang S, Kapur R, Renauld JC, Paczesny S, Liu Y, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Tepper RS, Sun J, Kaplan MH. Sci Immunol. 2022 Feb 18; 2022 Feb 18. PMID: 35179949.
CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages.Evren E, Ringqvist E, Doisne JM, Thaller A, Sleiers N, Flavell RA, Di Santo JP, Willinger T. J Exp Med. 2022 Feb 7; 2022 Jan 12. PMID: 35019940.
m6A modifications regulate intestinal immunity and rotavirus infection.Wang A, Tao W, Tong J, Gao J, Wang J, Hou G, Qian C, Zhang G, Li R, Wang D, Ren X, Zhang K, Ding S, Flavell RA, Li H, Pan W, Zhu S. Elife. 2022 Jan 31; 2022 Jan 31. PMID: 35098923.
Zero-preserving imputation of single-cell RNA-seq data.Linderman GC, Zhao J, Roulis M, Bielecki P, Flavell RA, Nadler B, Kluger Y. Nat Commun. 2022 Jan 11; 2022 Jan 11. PMID: 35017482.
Development of Humanized Mouse Models for Studying Human NK Cells in Health and Disease.Shan L, Flavell RA, Herndler-Brandstetter D. Methods Mol Biol. 2022. PMID: 35344167.
CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T(H)1 and T(H)9 cells.Benoit-Lizon I, Jacquin E, Rivera Vargas T, Richard C, Roussey A, Dal Zuffo L, Martin T, Melis A, Vinokurova D, Shahoei SH, Baeza Garcia A, Pignol C, Giorgiutti S, Carapito R, Boidot R, Végran F, Flavell RA, Ryffel B, Nelson ER, Soulas-Sprauel P, Lawrence T, Apetoh L. J Immunother Cancer. 2022 Jan. PMID: 35091453.

2021

IL-17 Receptor C Signaling Controls CD4(+) T(H)17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases.Schmidt T, Luebbe J, Kilian C, Riedel JH, Hiekmann S, Asada N, Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A, Flavell RA, Gagliani N, Pelzcar P, Huber S, Huber TB, Turner JE, Paust HJ, Krebs CF, Panzer U. J Am Soc Nephrol. 2021 Dec. PMID: 35167487.
IL-27 signalling promotes adipocyte thermogenesis and energy expenditure.Wang Q, Li D, Cao G, Shi Q, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, Chen Y, Wang B, Li G, Liu Z, Yang C, Wu X, Zhou L, Zhou Q, Ju Z, Lu H, Xin Y, Yang X, Wang C, Liu Y, Shulman GI, Dixit VD, Lu L, Yang H, Flavell RA, Yin Z. Nature. 2021 Dec; 2021 Nov 24. PMID: 34819664.
Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response.Piepke M, Clausen BH, Ludewig P, Vienhues JH, Bedke T, Javidi E, Rissiek B, Jank L, Brockmann L, Sandrock I, Degenhardt K, Jander A, Roth V, Schädlich IS, Prinz I, Flavell RA, Kobayashi Y, Renné T, Gerloff C, Huber S, Magnus T, Gelderblom M. J Neuroinflammation. 2021 Nov 13; 2021 Nov 13. PMID: 34772416.
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S, Wu H. Cell. 2021 Nov 11; 2021 Oct 21. PMID: 34678144.
m(6)A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X. Cell Rep. 2021 Nov 9. PMID: 34758326.
Role of MBD3-SOX2 axis in residual myeloma following pomalidomide.Verma R, Branagan AR, Xu ML, Flavell RA, Dhodapkar KM, Dhodapkar MV. Leukemia. 2021 Nov; 2021 Feb 18. PMID: 33603141.
METTL3-mediated m(6)A RNA methylation promotes the anti-tumour immunity of natural killer cells.Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H, Tian Z. Nat Commun. 2021 Sep 17; 2021 Sep 17. PMID: 34535671.
Reply to: Rectally shed SARS-CoV-2 lacks infectivity: time to rethink faecal-oral transmission?Guo M, Tao W, Flavell RA, Zhu S. Nat Rev Gastroenterol Hepatol. 2021 Sep. PMID: 34312525.
Vibrational optical coherence tomography detects unique skin fibrotic states: Preliminary results of animal and human studies.Odell ID, Flavell RA, Silver FH. J Am Acad Dermatol. 2021 Sep; 2020 Aug 26. PMID: 32860914.
CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity.Duan Y, Li G, Xu M, Qi X, Deng M, Lin X, Lei Z, Hu Y, Jia Z, Yang Q, Cao G, Liu Z, Wen Q, Li Z, Tang J, Zhang WK, Huang P, Zheng L, Flavell RA, Hao J, Yin Z. Cell Mol Immunol. 2021 Aug; 2020 Jul 15. PMID: 32669666.
m(6)A demethylase ALKBH5 controls CD4(+) T cell pathogenicity and promotes autoimmunity.Zhou J, Zhang X, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, Wang Z, Flavell RA, Li HB. Sci Adv. 2021 Jun; 2021 Jun 16. PMID: 34134995.
Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir.Rajashekar JK, Richard J, Beloor J, Prévost J, Anand SP, Beaudoin-Bussières G, Shan L, Herndler-Brandstetter D, Gendron-Lepage G, Medjahed H, Bourassa C, Gaudette F, Ullah I, Symmes K, Peric A, Lindemuth E, Bibollet-Ruche F, Park J, Chen HC, Kaufmann DE, Hahn BH, Sodroski J, Pazgier M, Flavell RA, Smith AB 3rd, Finzi A, Kumar P. Cell Host Microbe. 2021 Jun 9; 2021 May 20. PMID: 34019804.
Detection of differentially abundant cell subpopulations in scRNA-seq data.Zhao J, Jaffe A, Li H, Lindenbaum O, Sefik E, Jackson R, Cheng X, Flavell RA, Kluger Y. Proc Natl Acad Sci U S A. 2021 Jun 1. PMID: 34001664.
JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury.Grynberg K, Ozols E, Mulley WR, Davis RJ, Flavell RA, Nikolic-Paterson DJ, Ma FY. Am J Pathol. 2021 May; 2021 Feb 16. PMID: 33607044.
Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib.Wang A, Rahman NT, McGeary MK, Murphy M, McHenry A, Peterson D, Bosenberg M, Flavell RA, King B, Damsky W. J Allergy Clin Immunol. 2021 May; 2020 Dec 11. PMID: 33317858.
Pooled CRISPR screening identifies m(6)A as a positive regulator of macrophage activation.Tong J, Wang X, Liu Y, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Liu J, Zhou Y, Xia Q, Flavell RA, Zhu S, Li HB. Sci Adv. 2021 Apr; 2021 Apr 28. PMID: 33910903.
MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B. Nature. 2021 Apr; 2021 Mar 3. PMID: 33658717.
Potential intestinal infection and faecal-oral transmission of SARS-CoV-2.Guo M, Tao W, Flavell RA, Zhu S. Nat Rev Gastroenterol Hepatol. 2021 Apr; 2021 Feb 15. PMID: 33589829.
Skin-resident innate lymphoid cells converge on a pathogenic effector state.Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA. Nature. 2021 Apr; 2021 Feb 3. PMID: 33536623.
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.Zhang Y, Varela L, Szigeti-Buck K, Williams A, Stoiljkovic M, Šestan-Peša M, Henao-Mejia J, D'Acunzo P, Levy E, Flavell RA, Horvath TL, Kaczmarek LK. Nat Commun. 2021 Mar 19; 2021 Mar 19. PMID: 33741962.
A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options.Sefik E, Israelow B, Zhao J, Qu R, Song E, Mirza H, Kaffe E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA. Res Sq. 2021 Mar 17; 2021 Mar 17. PMID: 33758831.
Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.Wu XS, Subramanian S, Zhang Y, Shi B, Xia J, Li T, Guo X, El-Hassar L, Szigeti-Buck K, Henao-Mejia J, Flavell RA, Horvath TL, Jonas EA, Kaczmarek LK, Wu LG. Neuron. 2021 Mar 17; 2021 Jan 27. PMID: 33508244.
Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.Song Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Science. 2021 Mar 5. PMID: 33674488.
The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases.Damsky W, Peterson D, Ramseier J, Al-Bawardy B, Chun H, Proctor D, Strand V, Flavell RA, King B. J Allergy Clin Immunol. 2021 Mar; 2020 Oct 28. PMID: 33129886.
The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.Wang Y, He K, Sheng B, Lei X, Tao W, Zhu X, Wei Z, Fu R, Wang A, Bai S, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li M, Zhang K, Li L, Yang H, Li HB, Flavell RA, Zhu S. Proc Natl Acad Sci U S A. 2021 Jan 26. PMID: 33483420.
An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.Harman CCD, Bailis W, Zhao J, Hill L, Qu R, Jackson RP, Shyer JA, Steach HR, Kluger Y, Goff LA, Rinn JL, Williams A, Henao-Mejia J, Flavell RA. Proc Natl Acad Sci U S A. 2021 Jan 19. PMID: 33446502.
Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease.Shapiro JM, de Zoete MR, Palm NW, Laenen Y, Bright R, Mallette M, Bu K, Bielecka AA, Xu F, Hurtado-Lorenzo A, Shah SA, Cho JH, LeLeiko NS, Sands BE, Flavell RA, Clemente JC. Cell Host Microbe. 2021 Jan 13; 2021 Jan 1. PMID: 33385335.
IL-4-BATF signaling directly modulates IL-9 producing mucosal mast cell (MMC9) function in experimental food allergy.Tomar S, Ganesan V, Sharma A, Zeng C, Waggoner L, Smith A, Kim CH, Licona-Limón P, Reinhardt RL, Flavell RA, Wang YH, Hogan SP. J Allergy Clin Immunol. 2021 Jan; 2020 Oct 15. PMID: 33069715.

2020

Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer.Perez LG, Kempski J, McGee HM, Pelzcar P, Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, Vesely MCA, Soukou S, Steglich B, Bedke T, Manthey C, Seiz O, Diercks BP, Gnafakis S, Guse AH, Perez D, Izbicki JR, Gagliani N, Flavell RA, Huber S. Nat Commun. 2020 Nov 6; 2020 Nov 6. PMID: 33159069.
Author Correction: metabolic signaling in T cells.Shyer JA, Flavell RA, Bailis W. Cell Res. 2020 Nov. PMID: 33028962.
Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli.Park HB, Wei Z, Oh J, Xu H, Kim CS, Wang R, Wyche TP, Piizzi G, Flavell RA, Crawford JM. Nat Microbiol. 2020 Nov; 2020 Jul 27. PMID: 32719505.
Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice.Yang L, Geng T, Yang G, Ma J, Wang L, Ketkar H, Yang D, Lin T, Hwang J, Zhu S, Wang Y, Dai J, You F, Cheng G, Vella AT, Flavell RA, Fikrig E, Wang P. Commun Biol. 2020 Oct 8; 2020 Oct 8. PMID: 33033362.
A special collection of reviews on frontiers in immunology.Xu C, Li HB, Flavell RA. Cell Res. 2020 Oct. PMID: 32859992.
IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans.Kempski J, Giannou AD, Riecken K, Zhao L, Steglich B, Lücke J, Garcia-Perez L, Karstens KF, Wöstemeier A, Nawrocki M, Pelczar P, Witkowski M, Nilsson S, Konczalla L, Shiri AM, Kempska J, Wahib R, Brockmann L, Huber P, Gnirck AC, Turner JE, Zazara DE, Arck PC, Stein A, Simon R, Daubmann A, Meiners J, Perez D, Strowig T, Koni P, Kruglov AA, Sauter G, Izbicki JR, Guse AH, Rösch T, Lohse AW, Flavell RA, Gagliani N, Huber S. Gastroenterology. 2020 Oct; 2020 Jun 22. PMID: 32585307.
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses.Low JS, Farsakoglu Y, Amezcua Vesely MC, Sefik E, Kelly JB, Harman CCD, Jackson R, Shyer JA, Jiang X, Cauley LS, Flavell RA, Kaech SM. J Exp Med. 2020 Aug 3. PMID: 32525985.
NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells.Babic M, Dimitropoulos C, Hammer Q, Stehle C, Heinrich F, Sarsenbayeva A, Eisele A, Durek P, Mashreghi MF, Lisnic B, Van Snick J, Löhning M, Fillatreau S, Withers DR, Gagliani N, Huber S, Flavell RA, Polic B, Romagnani C. J Exp Med. 2020 Aug 3. PMID: 32453422.
Metabolic signaling in T cells.Shyer JA, Flavell RA, Bailis W. Cell Res. 2020 Aug; 2020 Jul 24. PMID: 32709897.
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome.Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, Bensinger SJ. Cell Metab. 2020 Jul 7; 2020 Jun 8. PMID: 32516576.
The induction and function of the anti-inflammatory fate of T(H)17 cells.Xu H, Agalioti T, Zhao J, Steglich B, Wahib R, Vesely MCA, Bielecki P, Bailis W, Jackson R, Perez D, Izbicki J, Licona-Limón P, Kaartinen V, Geginat J, Esplugues E, Tolosa E, Huber S, Flavell RA, Gagliani N. Nat Commun. 2020 Jul 3; 2020 Jul 3. PMID: 32620760.
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy.Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. Nature. 2020 Jul; 2020 Jun 24. PMID: 32581358.
m(6)A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. Immunity. 2020 Jun 16; 2020 Jun 3. PMID: 32497523.
Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice.Lysenko V, Wildner-Verhey van Wijk N, Zimmermann K, Weller MC, Bühler M, Wildschut MHE, Schürch P, Fritz C, Wagner U, Calabresi L, Psaila B, Flavell RA, Vannucchi AM, Mead AJ, Wild PJ, Dirnhofer S, Manz MG, Theocharides APA. Blood Adv. 2020 Jun 9. PMID: 32502268.
Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation.Mukherjee S, Kumar R, Tsakem Lenou E, Basrur V, Kontoyiannis DL, Ioakeimidis F, Mosialos G, Theiss AL, Flavell RA, Venuprasad K. Nat Immunol. 2020 Jun; 2020 May 18. PMID: 32424362.
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer.Perez LG, Kempski J, McGee HM, Pelzcar P, Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, Vesely MCA, Soukou S, Steglich B, Bedke T, Manthey C, Seiz O, Diercks BP, Gnafakis S, Guse AH, Perez D, Izbicki JR, Gagliani N, Flavell RA, Huber S. Nat Commun. 2020 May 25; 2020 May 25. PMID: 32451418.
Expression Efficiency of Multiple Il9 Reporter Alleles Is Determined by Cell Lineage.Kharwadkar R, Ulrich BJ, Abdul Qayum A, Koh B, Licona-Limón P, Flavell RA, Kaplan MH. Immunohorizons. 2020 May 21; 2020 May 21. PMID: 32439753.