Discovery may help provide clues for fighting and treating HPV
Yale Cancer Center (YCC) scientists have filled in a key gap in understanding the unusual route by which the Human papillomavirus (HPV) infects cells. Their findings, published online today in the journal Cell, may eventually help to broaden the scope of defenses against HPV and provide valuable clues for delivering drugs into cells. HPV is a family of killers. Although there are effective vaccines against these viruses, they still cause about 5% of cancer deaths worldwide, including more than 250,000 women who die of cervical cancer each year.
Program Project Grant Renewed
The National Cancer Institute recently awarded a five-year, $4.7 million program project grant to investigators at Yale School of Medicine to continue studies on the role of viruses in tumorigenic transformation of cells. Virus infection is thought to account for approximately 15% of all human cancers worldwide, and studies of tumor viruses have historically provided insight into basic cellular processes including carcinogenesis, cell cycle control, and signal transduction.
Yale Study Seeks to Understand Neurobiology Underlying Bipolar Disorder Vs. Major Depressive Disorder
Yale scientists, including Sophie Holmes, PhD; Ruth Asch, PhD; and Irina Esterlis, PhD, used positron emission tomography to understand the neurobiology underlying bipolar disorder versus major depressive disorder. The findings were published in Biological Psychiatry.Source: Biological Psychiatry
Collaboration on NIH grant between Sullivan, Nez Henderson will create program to help Indigenous women experiencing domestic violence quit smoking
Tami Sullivan, PhD, associate professor of psychiatry at Yale School of Medicine, and Patricia Nez Henderson, MD, MPH, vice president for the Black Hills Center for American Indian Health (BHCAIH) and the first Indigenous woman to graduate from Yale School of Medicine, have been awarded a grant from the National Institutes of Health (NIH) to pilot a mindfulness-based, culturally-tailored smoking cessation intervention for Indigenous women who experience intimate partner violence (IPV).
A Randomized Clinical Trial to Evaluate an Atrial Fibrillation Stroke Prevention Shared Decision‐Making Pathway
Oral anticoagulation (OAC) reduces stroke and disability in atrial fibrillation (AF) but is underutilized. Researchers, including Julio Nunes, MD, first-year resident, evaluated the effects of a novel patient‐clinician shared decision‐making (SDM) tool in reducing OAC patient's decisional conflict as compared to usual care.Source: Journal of the American Heart Association
Does Street Outreach Engage Its Intended Target Population? Clinical Experience in the Veteran’s Health Administration Homeless Service Programs
Emma Lo, MD; Jack Tsai, PhD; Elina Stefanovics, PhD; and Robert Rosenheck, MD, are co-authors of a paper in Psychiatric Quarterly that found veterans engaged through clinical street outreach programs reported substantially more days of unsheltered homelessness than a clinic-referred group of veterans.Source: Psychiatric Quarterly
Yale Study Revises Understanding of How the Brain Processes and Responds to Rewards
A new Yale study of neuron activity in the brain has revised scientists’ understanding of how the brain processes and responds to rewards. Marina Picciotto, PhD, Charles B. G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology, is the study’s senior author.
Moderating the Relationship Between Ulcerative Colitis and Crohn’s Disease and Symptoms of PTSD
Alexandra Fuss, PhD, assistant professor of psychiatry, is first author of a paper in Journal of Clinical Gastroenterology that examines whether inflammatory bowel disease (IBD) patients endorse clinically significant symptoms of post-traumatic stress disorder (PTSD), and tests whether remission status and remission expectations effectively moderate the relationship between endorsements of PTSD symptoms and aspects of IBD.Source: Journal of Clinical Gastroenterology
Ketamine infusions improve symptoms of depression, anxiety and suicidal ideation, study says
People who got intravenous ketamine at three private ketamine infusion clinics had "significant improvement" in symptoms of depression, anxiety and suicidal ideation, according to a new study by Gerard Sanacora, PhD, MD George D. and Esther S. Gross Professor of Psychiatry, published in the Journal of Clinical Psychiatry.Source: CNN
De Aquino Awarded IMPOWR-YOU Grant to Study Pain Sensitivity, Opioid Use Disorder
Joao P. De Aquino, MD, assistant professor of psychiatry, has been awarded a pilot grant from the Integrative Management of Chronic Pain and Opioid Use Disorder for Whole Recovery-Yale and Organizations United (IMPOWR-YOU) Research Center to evaluate the relationship between pain sensitivity and brain synaptic density among people with opioid use disorder (OUD).
Impact of Cannabis Use, Substance Use Disorders, and Psychiatric Diagnoses on COVID-19 Outcomes: A Retrospective Cohort Study
COVID-19 patients with substance use disorders had greater likelihood of requiring critical interventions, such as ICU admission and ventilatory support. Substance use disorders and psychiatric diagnoses were also associated with a longer duration of hospitalization and greater number of hospital admissions.Source: The Journal of Clinical Psychiatry
Comparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans
Group cognitive processing therapy (CPT) was associated with a slightly smaller reduction of PTSD symptom severity than individual CPT or prolonged exposure (PE) in veterans at the end of residential treatment. There were no differences at 4-month follow-up.Source: Psychological Medicine
Association of Distress Due to Systemic Racism and Racial Disparities With Psychopathology and Suicidal Ideation Among US Veterans During the COVID-19 Pandemic
A team of Yale Psychiatry researchers analyzed data from a national sample of US veterans to examine the prevalence of perceived systemic racism and racial disparities in COVID-19–related health outcomes and the association of racism-related distress with internalizing and externalizing psychopathology and suicidal ideation during the pandemic.Source: The Journal of Clinical Psychiatry
Yale Scientists Identify Genetic Risk Factors for Opioid Use and Related Substance Use Disorders
A new human genomics study led by Yale scientists has identified genetic risk factors for opioid use disorder (OUD) and related substance use disorders according to a new large-scale genome-wide association study – increasing the number of risk genes known from 1 to 19.