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Emily Branham

Biography

Emily Branham earned a BS in Chemistry, a Biology minor, and a Creative Writing minor from the University of North Carolina at Chapel Hill, where she graduated in 2017 with Highest Distinction overall and Honors in Chemistry. At Yale University, Emily is a Chemistry/Biology Interface (CBI) Training Program Scholar with support provided by the National Institute of Health. She received an Honorable Mention from the National Science Foundation Graduate Research Fellowship Program in 2019.

During her first few years at Yale, Emily was a graduate student in the Spiegel Lab, where she focused on synthetically engineering monoclonal antibodies with the goal of improved removal of circulating proteins and enriched therapeutic applications. Emily earned her MS in Chemistry and advanced to candidacy before joining the DiMaio lab in 2020, where she continues to pursue her PhD in Chemistry. Her current research focuses on engineering genetically expressible, small transmembrane proteins (traptamers) to facilitate the proteasomal degradation of disease-relevant, endogenous transmembrane proteins. She intends to extend this PROTAC-like technology to the study of HPV as a way to identify new candidate proteins involved in viral infection.

Emily’s varied research experiences, which span biology, biochemistry, chemical biology, and synthetic chemistry, helped her discover and tailor her interest in applying chemistry to the study of biologically and medically relevant problems. In her free time, Emily enjoys relaxing at home with her husband, teaching her three Australian Shepherds new tricks, watching tv with her cats, writing, cooking (and eating), and playing violin in the Hamden Symphony Orchestra.

Education & Training

  • MS
    Yale University, Chemistry (2019)
  • BS (Hon)
    The University of North Carolina at Chapel Hill, Chemistry (2017)

Activities

  • Chemistry PhD Candidate - Yale University
    New Haven, CT, United States 2020
    Joined Dr. Daniel DiMaio’s lab at Yale University as a Chemistry Ph.D. candidate. Thesis work will focus on engineering small, artificial transmembrane proteins (traptamers) to facilitate the degradation of disease-relevant, endogenous transmembrane proteins. Similar to PROTAC technology, a traptamer transmembrane protein-targeting motif will be linked to an E3 ubiquitin ligase recruiting moiety through genetic engineering. We anticipate use of this targeting and recruitment molecule will lead t
  • Chemistry PhD Student/PhD Candidate - Yale University
    New Haven, CT, United States (2017-2020)
    Joined Dr. David Spiegel’s lab at Yale University as a Ph.D. student. Broad project aims include harnessing the function of the asialoglycoprotein receptor (ASGPR) for targeted hepatocytic degradation of specific circulating proteins. My branch of this research project focuses on synthetically engineering of monoclonal antibodies toward improved removal of circulating proteins, characterization of synthesized conjugates, evaluation of effectiveness of conjugates in vitro (mammalian cell culture)
  • ACS International REU Scholar - Friedrich-Schiller-Universität Jena
    Jena, TH, Germany 2016
    Prof. Dr. Hans-Dieter Arndt's lab
  • Undergraduate Researcher - University of North Carolina at Chapel Hill
    Chapel Hill, NC, United States (2015-2017)
    Dr. Michael Crimmins’ lab
  • Chemical Biology REU Program Participant - Vanderbilt University
    Nashville, TN, United States 2015
    Dr. Gary Sulikowski’s lab
  • Undergraduate Researcher - UNC Eshelman School of Pharmacy
    Chapel Hill, NC, United States 2015
    Dr. Kuo-Hsiung Lee’s lab
  • Chemistry REU Program Participant - Georgia Institute of Technology
    Atlanta, GA, United States 2014
    Dr. Adegboyega Oyelere’s lab

Honors & Recognition

AwardAwarding OrganizationDate
Honorable Mention2019 National Science Foundation Graduate Research Fellowship Program (NSF GRFP)2019
Chemistry/Biology Interface (CBI) Training Program ScholarNational Institute of Health2017
Phi Beta Kappa InducteeThe Phi Beta Kappa Society2016
Colonel Robinson ScholarshipUniversity of North Carolina at Chapel Hill2013

Departments & Organizations