Internal Medicine Faculty Honored by ASCI
Three faculty from Yale’s Department of Internal Medicine were recently nominated for election to the American Society for Clinical Investigation (ASCI). A total of 95 new members have been elected for 2022, and will officially inducted at the ASCI Dinner and New Member Induction Ceremony in April.
Scientists Apply High-resolution, Single-cell Profiling to Understand Immune Response in Severe COVID-19
A new study by Yale researchers provides a single-cell resolution profile of the inflammatory severe COVID-19 disease, and the loss of coordination between the innate and adaptive immune response. This loss of coordination has the potential to amplify a person’s immune response to COVID-19, delaying viral clearance.
Influencing the Next Generation of Physician-Scientists
There is not one set path to becoming a physician-scientist. Some physician-scientists attend medical school and obtain their PhD as part of an MD-PhD program. Some obtain their PhD prior to medical school or later during clinical fellowship. Others go to medical school, while simultaneously conducting research outside of a formal program. But there is one common thread—the love for both clinical care and scientific research.
Keeping Yale's COVID-19 Treatment Guidelines Up to Date
For the past year, experts across various disciplines have studied and carefully considered each new piece of evidence about treatment strategies for COVID-19 and translated it into standardized guidelines for Yale School of Medicine and Yale New Haven Health System clinicians
Yale Experts Discuss "Caring While Keeping Safe" During the COVID-19 Pandemic
The scientists and clinicians at Yale School of Medicine (YSM) and the Yale New Haven Health System (YNHHS) have performed herculean feats, and also faced daunting obstacles, as they work to tame the COVID-19 pandemic in Connecticut.
Resist the Script: Antibiotic Overuse in Pneumonia — An Expert Roundtable
Become educated about the role of climate change. Increases in coccidioidomycosis, avian influenza, Hantavirus, and aspergillosis have all been noted to increase in areas with changes in ambient temperature or rainfall.7 The old and young may be more susceptible to rapid changes in conditions. Climate change has already been found to increase rates of COPD and asthma, which increase the risk for infection.Source: PulmonologyAdvisor
Gene Deficiency Linked to Increased Pneumonia Survival
Klebsiella pneumoniae is a germ that causes pneumonia, with a mortality that can reach up to 70 percent when infection spreads to other organs. Current, antibiotic treatment often fails due to development of antibiotic resistance, so there is an urgent need for new therapies. We have found a deficiency in a gene called Chit1, present in up to 20 percent of humans, gives mice a significant advantage during pneumonia. Absence of this gene helps mice limit bacterial spread to other organs and increase survival with or without antibiotic use. Understanding the mechanisms of the advantage provided by Chit1 deficiency will help to develop new therapies that can boost the host defense against bacterial infection to reduce mortality.Source: American Lung Association
Q&A: New CPIRT director on lung infections, antibiotics, and climate change
This summer, the new Yale Center for Pulmonary Infection Research and Treatment (CPIRT) held its first meeting, with the goal of breathing fresh air into the science of lung infection. Conceived by associate professor Dr. Charles Dela Cruz as a cross-disciplinary hub for investigators, CPIRT brings together innovative minds from basic, translational, and clinical research areas across Yale. The center’s ultimate aim is to develop better treatments for both acute and chronic ailments — from pandemic flu to emphysema — that are affected by lung infections.
No Drop in VAP Rates, Study Contends
Contrary to previously reported numbers from the Centers for Disease Control and Prevention (CDC), ventilator-assisted pneumonia (VAP) rates have not declined, but have remained near 10% since 2005, according to data from the Medicare Patient Safety Monitoring System (MPSMS).Source: Medscape
Infections Linked to Hospital Respirators Still Pose Risks to Patients
A new report out of the University of Connecticut is raising concern about hospital-acquired infections from respirators. The paper looked at VAP or ventilator-associated pneumonia. That's an infection acquired in a hospital after a patient is put on a respirator, which can increase the length of stay, costs, and mortality.Source: wnpr Connecticut's Public Media Source for News and Ideas
What Pneumonia Experts Say About Clinton’s Case
If Hillary Clinton brushed aside medical advice to rest after getting a diagnosis of mild pneumonia, she was risking developing a more serious case, medical experts said Monday. Pneumonia — which leads to infiltration of fluid into the lungs, leaving a patient short of breath and often feverish but still able to function — can become serious or even fatal if it is not properly treated, doctors said.Source: The New York Times
WSJ: Lung protection: Scientists have identified a protein that may increase the risk of lung damage from cigarette smoke and respiratory infections
WSJ: Lung protection: Scientists have identified a protein that may increase the risk of lung damage from cigarette smoke and respiratory infectionsSource: Wall Street Journal